Photoincorporation of tetracycline into Escherichia coli ribosomes. Identification of the major proteins photolabeled by native tetracycline and tetracycline photoproducts and implications for the inhibitory action of tetracycline on protein synthesis
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoincorporation of tetracycline into Escherichia coli ribosomes. Identification of the major proteins photolabeled by native tetracycline and tetracycline photoproducts and implications for the inhibitory action of tetracycline on protein synthesisRobert A. Goldman, Tayyaba Hasan, Clifford C. Hall, William A. Strycharz, and Barry S. CoopermanCite this: Biochemistry 1983, 22, 2, 359–368Publication Date (Print):January 18, 1983Publication History Published online1 May 2002Published inissue 18 January 1983https://pubs.acs.org/doi/10.1021/bi00271a020https://doi.org/10.1021/bi00271a020research-articleACS PublicationsRequest reuse permissionsArticle Views348Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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The inhibitory effect of tetracycline on A site occupation is mediated by binding to a single high-affinity site (Kd = 1 to 20 μM) on the 30S ribosomal subunit.
“The inhibitory effect of tetracycline on A site occupation is presumed to be mediated by binding to a single high-affinity site ( Kd = 1 to 20 𝛍 M) on the 30S ribosomal subunit (20).”
From Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance (2003) · cites this paper as [20]
Cites
The Molecular Basis of Antibiotic Action
Gale, E. F. (1981) · Medical Entomology and Zoology · Cited by 1,217 · see citing works
Ribosomal proteins of Escherichia coli. I. Purification of the 30 S ribosomal proteins
HARDY, S. J. S., Kurland, C. G., Voynow, P., & Mora, G. (1969) · Biochemistry · doi:10.1021/bi00835a031 · Cited by 970 · see citing works
Bayley, H., & Knowles, J. R. (1977) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(77)46012-9 · Cited by 496 · see citing works
Proteolytic cleavage of bacteriophage lambda repressor in induction.
Roberts, J. W., & Roberts, C. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.1.147 · Cited by 326 · see citing works
[41] Reconstitution of ribosomes from subribosomal components
Traub, P., Mizushima, S.-I., Lowry, C. V., & Nomura, M. (1971) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(71)20043-4 · Cited by 290 · see citing works
McCormick, J. R. D., Fox, S. M., Smith, L. L., Bitler, B. A., Reichenthal, J., Origoni, V. E., Müller, W. H., Winterbottom, R., & Doerschuk, A. P. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01568a050 · Cited by 193 · see citing works
The Use of Acetone Precipitation in the Isolation of Ribosomal Proteins
Barritault, D., Expert-Bezançon, A., Guérin, M., & HAYES, D. H. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10215.x · Cited by 175 · see citing works
The Mechanism of Photoaffinity Labeling
Ruoho, A. E., Kiefer, H., Roeder, P. E., & Singer, S. J. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.9.2567 · Cited by 150 · see citing works
Lindahl, L., Post, L. E., Zengel, J., Gilbert, S. F., Strycharz, W. A., & Nomura, M. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)66975-9 · Cited by 87 · see citing works
Self-citationRibosome-tetracycline interactions
Tritton, T. R. (1977) · Biochemistry · doi:10.1021/bi00637a029 · Cited by 86 · see citing works
[32] GTP-dependent binding of aminoacyl-tRNA to Escherichia coli Ribosomes
Ravel, J. M., & Shorey, R. L. (1971) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(71)20034-3 · Cited by 78 · see citing works
Olson, H. M., Grant, P. G., Cooperman, B. S., & Glitz, D. G. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34973-1 · Cited by 69 · see citing works
Self-citationProteins at the tRNA Binding Sites of Escherichia coli Ribosomes
Czernilofsky, A. P., Collatz, E., Stöffler, G., & Kuechler, E. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.1.230 · Cited by 66 · see citing works
Day, L. E. (1966) · Journal of Bacteriology · doi:10.1128/jb.91.5.1917-1923.1966 · Cited by 60 · see citing works
Binding of tetracycline to the 30S ribosomes and to polyuridylic acid
Connamacher, R. H., & Mandel, H. G. (1965) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(65)90954-x · Cited by 59 · see citing works
Maassen, J. A., & Möller, W. J. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.4.1277 · Cited by 58 · see citing works
Oxidation Photosensitized by Tetracyclines
Wiebe, J. A., & Moore, D. E. (1977) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600660213 · Cited by 54 · see citing works
Photoinduced affinity labeling of the Escherichia coli ribosome puromycin site
Jaynes, E. N., Grant, P. G., Giangrande, G., Wieder, R., & Cooperman, B. S. (1978) · Biochemistry · doi:10.1021/bi00597a001 · Cited by 48 · see citing works
Self-citationCooperman, B. S., Jaynes, E. N., Brunswick, D. J., & Luddy, M. A. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.2974 · Cited by 45 · see citing works
Self-citationDraper, D. E., & von Hippel, P. H. (1979) · Biochemistry · doi:10.1021/bi00572a003 · Cited by 44 · see citing works
Mas, M. T., Wang, J. K., & Hargrave, P. A. (1980) · Biochemistry · doi:10.1021/bi00545a012 · Cited by 44 · see citing works
Photoincorporation of tetracycline into Escherichia coli ribosomes
Goldman, R. A., Cooperman, B. S., Strycharz, W. A., Williams, B. A., & Tritton, T. R. (1980) · FEBS Letters · doi:10.1016/0014-5793(80)81230-0 · Cited by 40 · see citing works
Self-citationNicholson, A. W., Hall, C. C., Strycharz, W. A., & Cooperman, B. S. (1982) · Biochemistry · doi:10.1021/bi00259a013 · Cited by 37 · see citing works
Self-citationAntibiotic effects on the photoinduced affinity labeling of Escherichia coli ribosomes by puromycin
Grant, P. G., Strycharz, W. A., Jaynes, E. N., & Cooperman, B. S. (1979) · Biochemistry · doi:10.1021/bi00578a003 · Cited by 36 · see citing works
Self-citationStudies on the intracellular localization of tetracycline in bacteria
Connamacher, R. H., & Mandel, H. G. (1968) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(68)90235-9 · Cited by 30 · see citing works
Photoincorporation of Tetracycline into Rat‐Liver Ribosomes and Subunits
Reboud, A., DUBOST, S., & Reboud, J. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb06605.x · Cited by 29 · see citing works
Photoaffinity labeling of rat alpha-fetoprotein.
Payne, D. W., Katzenellenbogen, J. A., & Carlson, K. E. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70473-6 · Cited by 25 · see citing works
An Investigation of the Conformational Properties of Ribosomes Using N‐Ethylmalemide as a Probe
GHOSH, N., & Moore, P. B. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb12805.x · Cited by 25 · see citing works
Nicholson, A. W., Hall, C. C., Strycharz, W. A., & Cooperman, B. S. (1982) · Biochemistry · doi:10.1021/bi00259a014 · Cited by 23 · see citing works
Self-citationCooperman, B. S., Expert-Bezançon, A., Kahan, L., DONDON, J., & GRUNBERG‐MANAGO, M. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90544-0 · Cited by 22 · see citing works
Self-citationOlson, H. M., Grant, P. G., Glitz, D. G., & Cooperman, B. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.2.890 · Cited by 20 · see citing works
Self-citation[35] Preparation of ribosomal subunits by large-scale zonal centrifugation
Sypherd, P. S., & Wireman, J. W. (1974) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(74)30037-7 · Cited by 16 · see citing works
The accessibility of antigenic determinants of ribosomal protein s4 in situ
Winkelmann, D. A., & Kahan, L. (1979) · Journal of Supramolecular Structure · doi:10.1002/jss.400100407 · Cited by 14 · see citing works
Photolabile Antibiotics as Probes of Ribosomal Structure and Function *
Cooperman, B. S. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb22105.x · Cited by 12 · see citing works
Self-citationYaguchi, M., Lanka, E., Dworniczak, B., Kiltz, H., & Pongs, O. (1978) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1978.tb12742.x · Cited by 11 · see citing works
Photoinactivation of Venezuelan Equine Encephalitis Virus Mediated by Tetracyclines
Esparza, J., PiÑa, C. I., & Novo, E. (1976) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.10.1.176 · Cited by 6 · see citing works
[57] Photoaffinity labeling of ribosomes
Cooperman, B. S., Grant, P. G., Goldman, R. A., Luddy, M. A., Minnella, A., Nicholson, A. W., & Strycharz, W. A. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)59126-5 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
Pioletti, M., Schlünzen, F., Harms, J., Zarivach, R., Glühmann, M., Avila, H., Bashan, A., Bartels, H., Auerbach, T., Jacobi, C., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.8.1829 · Cited by 527 · see citing works
Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance
Speer, B. S., Shoemaker, N. B., & Salyers, A. A. (1992) · Clinical Microbiology Reviews · doi:10.1128/cmr.5.4.387 · Cited by 511 · see citing works
Tetracyclines: Antibiotic action, uptake, and resistance mechanisms
Schnappinger, D., & Hillen, W. (1996) · Archives of Microbiology · doi:10.1007/s002030050339 · Cited by 484 · see citing works
The history of the tetracyclines
Nelson, M. L., & Levy, S. B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06354.x · Cited by 462 · see citing works
Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
Connell, S. R., Tracz, D. M., Nierhaus, K. H., & Taylor, D. E. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.12.3675-3681.2003 · Cited by 449 · see citing works
Griffin, M. O., Fricovsky, E. S., Ceballos, G. M., & Villarreal, F. J. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00047.2010 · Cited by 414 · see citing works
Tetracyclines metal complexation: Significance and fate of mutual existence in the environment
Pulicharla, R., Hegde, K., Brar, S. K., & Surampalli, R. Y. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.12.017 · Cited by 277 · see citing works
Resistance mechanisms in Campylobacter jejuni
Iovine, N. M. (2013) · Virulence · doi:10.4161/viru.23753 · Cited by 274 · see citing works
Shima, J., Hesketh, A. R., Okamoto, S., Kawamoto, S., & Ochi, K. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.24.7276-7284.1996 · Cited by 244 · see citing works
rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines
Chukwudi, C. U. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00594-16 · Cited by 208 · see citing works
A tetracycline-binding RNA aptamer
Berens, C., Thain, A., & Schroeder, R. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00063-3 · Cited by 199 · see citing works
Griffin, M. O., Ceballos, G. M., & Villarreal, F. J. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.10.004 · Cited by 182 · see citing works
Immunochemistry of Elastotic Material in Sun-Damaged Skin
Chen, V. L., Fleischmajer, R., Schwartz, E., Palaia, M., & Timpl, R. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12524421 · Cited by 164 · see citing works
Bergeron, J., Ammirati, M., Danley, D., James, L., Norcia, M., Retsema, J., Strick, C. A., Su, W. G., Sutcliffe, J., & Wondrack, L. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.9.2226 · Cited by 157 · see citing works
Burdett, V (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49928-0 · Cited by 141 · see citing works
Tetracyclines in veterinary medicine and bacterial resistance to them
Michalova, E., Pnovotna, P., & Schlegelová, J. (2004) · Veterinární Medicína · doi:10.17221/5681-vetmed · Cited by 135 · see citing works
TESTA, R. T., Petersen, P. J., Jacobus, N. V., Sum, P., LEE, V. J., & Tally, F. P. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.11.2270 · Cited by 121 · see citing works
Resistance to the Tetracyclines
Levy, S. B. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-138120-2.50012-5 · Cited by 121 · see citing works
Iinuma, S., Schomacker, K. T., Wagnières, G., Rajadhyaksha, M. M., BAMBERG, M., Momma, T., & Hasan, T. G. (1999) · PubMed · Cited by 120 · see citing works
Self-citationOxygen-Independent Antimicrobial Photoinactivation: Type III Photochemical Mechanism?
Hamblin, M. R., & Abrahamse, H. (2020) · Antibiotics · doi:10.3390/antibiotics9020053 · Cited by 117 · see citing works
Steiner, G. E., Kuechler, E., & Barta, A. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03281.x · Cited by 115 · see citing works
Ca2+ and Mg2+ bind tetracycline with distinct stoichiometries and linked deprotonation
Jin, L., Amaya-Mazo, X., Apel, M. E., Sankisa, S., Johnson, E. A., Zbyszynska, M. A., & Han, A. (2007) · Biophysical Chemistry · doi:10.1016/j.bpc.2007.04.005 · Cited by 114 · see citing works
Chemical and Biological Dynamics of Tetracyclines
Nelson, M. L. (1998) · Advances in Dental Research · doi:10.1177/08959374980120011901 · Cited by 108 · see citing works
Antibiotic drugs targeting bacterial RNAs
Hong, W., Zeng, J., & Xie, J. (2014) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2014.06.012 · Cited by 107 · see citing works
Antibiotic Resistance Determinants in a Pseudomonas putida Strain Isolated from a Hospital
Molina, L., Udaondo, Z., Duque, E., Fernández, M., Molina‐Santiago, C., Roca, A., Porcel, M., de la Torre, J., Segura, A., Plésiat, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0081604 · Cited by 97 · see citing works
Tetracyclines in Biology, Chemistry and Medicine
Nelson, M. J., Greenwald, R. A., & Hillen, W. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8306-1 · Cited by 97 · see citing works
Mechanism of Tetracycline Phototoxicity
Hasan, T. G., Kochevar, I. E., McAuliffe, D. J., Cooperman, B. S., & Ahdulah, D. (1984) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12263531 · Cited by 96 · see citing works
Self-citationNew perspectives in tetracycline resistance
Salyers, A. A., Speer, B. S., & Shoemaker, N. B. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb02025.x · Cited by 95 · see citing works
Virolainen, N., Pikkemaat, M. G., Elferink, J. W. A., & Karp, M. T. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801797z · Cited by 88 · see citing works
Sanchez-Pescador, R., Brown, J. T., Roberts, M., & Urdea, M. S. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1218 · Cited by 87 · see citing works
Spahn, C. M. T., Blaha, G., Agrawal, R. K., Penczek, P., Grassucci, R. A., Trieber, C. A., Connell, S. R., Taylor, D. E., Nierhaus, K. H., & Frank, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00238-6 · Cited by 81 · see citing works
Cohen, S., & Walker, G. C. (2010) · Current Biology · doi:10.1016/j.cub.2009.11.039 · Cited by 79 · see citing works
Molecular studies on the mechanism of tetracycline resistance mediated by Tet(O)
Manavathu, E. K., Fernandez, C. L., Cooperman, B. S., & Taylor, D. E. (1990) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.34.1.71 · Cited by 72 · see citing works
Self-citationTrieber, C. A., Burkhardt, N., Nierhaus, K. H., & Taylor, D. E. (1998) · bchm · doi:10.1515/bchm.1998.379.7.847 · Cited by 68 · see citing works
Tetracyclines, the old and the new: A narrative review
Pearson, J. C., Gillett, E. M., Gadri, N. D., & Dionne, B. (2025) · CMI Communications · doi:10.1016/j.cmicom.2025.105059 · Cited by 68 · see citing works
Photoaffinity labels as pharmacological tools
Fedan, J. S., Hogaboom, G. K., & O’Donnell, J. P. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90167-9 · Cited by 68 · see citing works
Reversed phase high-performance liquid chromatography of escherichia coli ribosomal proteins
Kerlavage, A. R., Weitzmann, C. J., Hasan, T. G., & Cooperman, B. S. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)90896-9 · Cited by 67 · see citing works
Self-citationInteraction of tetracycline with RNA: photoincorporation into ribosomal RNA of Escherichia coli
Oehler, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1219 · Cited by 66 · see citing works
Moen, B., Rudi, K., Bore, E., & Langsrud, S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13044101 · Cited by 61 · see citing works
Figueroa, J. E., Cárcamo, J. G., Yáñez, A. J., Olavarría, V. H., Ruíz, P., Manríquez, R. A., Muñoz, C., Romero, A., & Avendaño-Herrera, R. E. (2019) · Reviews in Aquaculture · doi:10.1111/raq.12333 · Cited by 60 · see citing works
Lau, A. C., Duong, T. T., Ito, S., Wilson, G. J., & Yeung, R. S. M. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03949.x · Cited by 57 · see citing works
Buck, M. A., & Cooperman, B. S. (1990) · Biochemistry · doi:10.1021/bi00474a024 · Cited by 57 · see citing works
Self-citationNonaka, L., Connell, S. R., & Taylor, D. E. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.11.3708-3712.2005 · Cited by 55 · see citing works
Role of oxygen radicals in the phototoxicity of tetracyclines toward Escherichia coli B
Martin, J. P., Colina, K., & Logsdon, N. J. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.6.2516-2522.1987 · Cited by 55 · see citing works
Kerlavage, A. R., Hasan, T. G., & Cooperman, B. S. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32410-4 · Cited by 52 · see citing works
Self-citationNoah, J. W., Dolan, M. A., Babin, P., & Wollenzien, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16576 · Cited by 46 · see citing works
Mechanism of DNA strand breakage induced by photosensitized tetracycline–Cu(II) complex
Khan, M. A., Mustafa, J. S., & Musarrat, J. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(03)00008-3 · Cited by 45 · see citing works
Epe, B., & Woolley, P. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01771.x · Cited by 44 · see citing works
Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them
Chopra, I. (1985) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-70304-1_6 · Cited by 44 · see citing works
Connell, S. R., Trieber, C. A., Stelzl, U., Einfeldt, E., Taylor, D. E., & Nierhaus, K. H. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03115.x · Cited by 42 · see citing works
Xuan, W., He, Y., Huang, L., Huang, Y., Bhayana, B., Xi, L., Gelfand, J. A., & Hamblin, M. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-35594-y · Cited by 42 · see citing works
Interactions of tetracycline and its derivatives with DNA in vitro in presence of metal ions
Khan, M. A., & Musarrat, J. (2003) · International Journal of Biological Macromolecules · doi:10.1016/s0141-8130(03)00066-7 · Cited by 42 · see citing works
Decoding at the ribosomal A site: antibiotics, misreading and energy of aminoacyl-tRNA binding
Hornig, H., Woolley, P., & Lührmann, R. (1987) · Biochimie · doi:10.1016/0300-9084(87)90207-0 · Cited by 40 · see citing works
Tetracyclines function as dual-action light-activated antibiotics
He, Y., Huang, Y., Xi, L., Gelfand, J. A., & Hamblin, M. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196485 · Cited by 38 · see citing works
Binding Interaction between Tet(M) and the Ribosome: Requirements for Binding
Dantley, K. A., Dannelly, H. K., & Burdett, V. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.16.4089-4092.1998 · Cited by 37 · see citing works
Ruan, H., Yu, Y., Liu, Y., Ding, X., Guo, X., & Jiang, Q. (2014) · Drug Delivery · doi:10.3109/10717544.2014.929195 · Cited by 37 · see citing works
Bargielowski, I., Kaufmann, C., Alphey, L., Reiter, P. L., & Koella, J. C. (2012) · Vector-Borne and Zoonotic Diseases · doi:10.1089/vbz.2012.0994 · Cited by 36 · see citing works
tRNA modification activity is necessary for Tet(M)-mediated tetracycline resistance
Burdett, V. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.22.7209-7215.1993 · Cited by 36 · see citing works
DNA Alterations Photosensitized by Tetracycline and Some of Its Derivatives
Piette, J. G., Decuyper, J., & VORST, A. V. D. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12275688 · Cited by 36 · see citing works
Cartes, C., Isla, A., Lagos, F., Castro, D., Muñoz-Uribe, M., Yáñez, A. J., Haussmann, D., & Figueroa, J. E. (2016) · Journal of Fish Diseases · doi:10.1111/jfd.12579 · Cited by 31 · see citing works
Sylvers, L. A., Kopylov, A. M., Wower, J., Hixson, S. S., & Zimmermann, R. A. (1992) · Biochimie · doi:10.1016/0300-9084(92)90116-v · Cited by 29 · see citing works
Ribosome structure: binding site of macrolides studied by photoaffinity labeling
Tejedor, F. J., & Ballesta, J. P. G. (1985) · Biochemistry · doi:10.1021/bi00323a033 · Cited by 29 · see citing works
Structural and Functional Interactions of the tRNA-Ribosome Complex
Ofengand, J., Ciesiołka, J., Denman, R. B., & Nurse, K. (1986) · Springer series in molecular biology · doi:10.1007/978-1-4612-4884-2_27 · Cited by 28 · see citing works
Tetracyclines: Light-Activated Antibiotics?
Hamblin, M. R., & Abrahamse, H. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0513 · Cited by 27 · see citing works
Phototoxicity of Lumidoxycycline
Shea, C. R., Olack, G. A., Morrison, H. A., Chen, N., & Hasan, T. G. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12365484 · Cited by 27 · see citing works
Self-citationAn In Vitro Model of Ciprofloxacin and Minocycline Transport by Oral Epithelial Cells
Brayton, J. J., Yang, Q., Nakkula, R. J., & Walters, J. D. (2002) · Journal of Periodontology · doi:10.1902/jop.2002.73.11.1267 · Cited by 24 · see citing works
Mapping of the second tetracycline binding site on the ribosomal small subunit of E.coli
Anokhina, M. M. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh583 · Cited by 24 · see citing works
Application of high-performance liquid chromatography to the reconstitution of ribosomal subunits
Kerlavage, A. R., Weitzmann, C. J., & Cooperman, B. S. (1984) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)91660-7 · Cited by 24 · see citing works
Self-citationThe Antibiotic and Nonantibiotic Tetracyclines
Nelson, M. L., & Ismail, M. Y. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00221-2 · Cited by 23 · see citing works
Stochastic simulations of the tetracycline operon
Biliouris, K., Daoutidis, P., & Kaznessis, Y. N. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-9 · Cited by 22 · see citing works
Willems, A., Gendt, K. D., Deboel, L., Swinnen, J. V., & Verhoeven, G. (2011) · Spermatogenesis · doi:10.4161/spmg.1.4.18740 · Cited by 22 · see citing works
Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu
Heffron, S. E., Mui, S., Aorora, A., Abel, K., Bergmann, E. M., & JURNAK, F. A. (2006) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444906035426 · Cited by 22 · see citing works
Mitochondrial Phototoxicity Sensitized by Doxycycline in Cultured Human Carcinoma Cells
Shea, C. R., Wimberly, J., & Hasan, T. G. (1986) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12524430 · Cited by 22 · see citing works
Self-citationPhotoaffinity labelling of Escherichia coli ribosomes
Cooperman, B. S. (1987) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(87)90014-3 · Cited by 22 · see citing works
Self-citationKerlavage, A. R., & Cooperman, B. S. (1986) · Biochemistry · doi:10.1021/bi00372a032 · Cited by 22 · see citing works
Self-citationOn the structural specificity of puromycin binding to Escherichia coli ribosomes
Weitzmann, C. J., & Cooperman, B. S. (1985) · Biochemistry · doi:10.1021/bi00330a022 · Cited by 21 · see citing works
Self-citationThe chemistry and cellular biology of the tetracyclines
Nelson, M. L. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8306-1_1 · Cited by 20 · see citing works
Kimura, T., & Yamaguchi, A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00514-5 · Cited by 20 · see citing works
[23] Affinity labeling of ribosomes
Cooperman, B. S. (1988) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(88)64054-7 · Cited by 18 · see citing works
Self-citationDoxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli
Chukwudi, C. U., & Good, L. (2019) · The Journal of Antibiotics · doi:10.1038/s41429-019-0149-0 · Cited by 17 · see citing works
Characterization of Minocycline Transport by Human Neutrophils
Walters, J. D. (2006) · Journal of Periodontology · doi:10.1902/jop.2006.060096 · Cited by 17 · see citing works
Analysis of the puromycin binding site in the 70 S ribosome of Escherichia coli at the peptide level
Bischof, O. F., Kruft, V., & Wittmann‐Liebold, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32308-6 · Cited by 17 · see citing works
Hasan, T. G., & Cooperman, B. S. (1985) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)90465-0 · Cited by 17 · see citing works
Self-citationGrewal, J., Manavathu, E. K., & Taylor, D. E. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.12.2645 · Cited by 16 · see citing works
Shea, C. R., Whitaker, D., Murphy, G. F., & Hasan, T. G. (1988) · PubMed Central · Cited by 16 · see citing works
Self-citationTetracycline–Cu(II) photo-induced fragmentation of serum albumin
Khan, M. A., & Musarrat, J. (2002) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00033-9 · Cited by 15 · see citing works
Rate of Tetracycline Photolysis during Irradiation at 365 nm
Beliakova, M. M., Бессонов, С. И., Sergeyev, B. M., Смирнова, И. Г., Dobrov, E. N., & Kopylov, A. M. (2003) · Biochemistry (Moscow) · doi:10.1023/a:1022697312042 · Cited by 14 · see citing works
Photoaffinity labeling of the pactamycin binding site on eubacterial ribosomes
Tejedor, F. J., Amils, R., & Ballesta, J. P. G. (1985) · Biochemistry · doi:10.1021/bi00335a040 · Cited by 13 · see citing works
Negri, L. B., Korupolu, S., Farinelli, W. A., Jolly, A. K., Redmond, R. W., Aggarwal, S., Rahme, L. G., Gilchrist, K. H., Anderson, R. R., & Gelfand, J. A. (2025) · Cells · doi:10.3390/cells14030219 · Cited by 12 · see citing works
Wagar, E. A., & Pang, M. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01475.x · Cited by 12 · see citing works
Olah, T. V., Olson, H. M., Glitz, D. G., & Cooperman, B. S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68855-6 · Cited by 11 · see citing works
Self-citationWeitzmann, C. J., & Cooperman, B. S. (1990) · Biochemistry · doi:10.1021/bi00466a006 · Cited by 11 · see citing works
Self-citationPhotoaffinity labeling of the tetracycline binding site of the Escherichia coli ribosome
Hasan, T. G., Goldman, R. A., & Cooperman, B. S. (1985) · Biochemical Pharmacology · doi:10.1016/0006-2952(85)90610-0 · Cited by 10 · see citing works
Self-citationLIGHT EMISSION ACCOMPANIES OXYGEN UPTAKE DURING THE PEROXIDATIVE METABOLISM OF TETRACYCLINES
Gillo, V. E., & Cilento, G. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb09588.x · Cited by 10 · see citing works
Ziółkowski, H., Jasiecka-Mikołajczyk, A., Zuśka-Prot, M., Przybysz, J., Grabowski, T., & JAROSZEWSKI, J. J. (2016) · Poultry Science · doi:10.3382/ps/pew121 · Cited by 9 · see citing works
Tetracyclines — extending the atypical spectrum
Grassi, G. (1993) · International Journal of Antimicrobial Agents · doi:10.1016/0924-8579(93)90033-2 · Cited by 8 · see citing works
Tetraciclinas: un modelo de resistencia antimicrobiana
Jara, M. A. (2010) · Avances en Ciencias Veterinarias · doi:10.5354/0716-260x.2007.915 · Cited by 8 · see citing works
Tetracycline reduces fluoroquinolones-induced bleaching of Euglena gracilis
Ebringer, L., Krajčovič, J., Polónyi, J., Lahitová, N., Doupovcová, M., & Dobias, J. (1996) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/s0165-1110(96)90045-7 · Cited by 8 · see citing works
Pactamycin binding site on archaebacterial and eukaryotic ribosomes
Tejedor, F. J., Amils, R., & Ballesta, J. P. G. (1987) · Biochemistry · doi:10.1021/bi00376a042 · Cited by 8 · see citing works
Target Modification As A Mechanism Of Antimicrobial Resistance
Hooper, D. C. (2001) · CRC Press eBooks · doi:10.1201/9780824744939.ch7 · Cited by 8 · see citing works
- Authors
- Goldman, R. A., Hasan, T., Hall, C. C., Strycharz, W. A., & Cooperman, B. S.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1983-01-18
- Volume
- 22
- Issue
- 2
- Pages
- 359-368
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W2069479920
- Cited by
- 134
- References
- 37
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 6 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007229)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- tetracycline, ribosome, Escherichia coli, photolabeling, ribosomal proteins, protein synthesis inhibition, antibiotic mechanism of action
- MeSH terms
- Aging, Animals, Brain, Central Nervous System, Humans, Neurochemistry, Proteins
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