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Cited by 170

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Translocation of Poly(ethylene glycol-co-hexadecyl)cyanoacrylate Nanoparticles into Rat Brain Endothelial Cells: Role of Apolipoproteins in Receptor-Mediated Endocytosis

Kim, Hyun R, Andrieux, Karine, Gil, Sophie, Taverna, Myriam, Chacun, Héléne, Desmaële, Didier, Taran, Fréderic, Georgin, Dominique, Couvreur, Patrick·2007·Biomacromolecules
DOI 10.1021/bm060711a
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Abstract

Previous in vivo observations in rats have shown that poly(ethylene glycol) polyhexadecylcyanoacrylate (PEG-PHDCA) nanoparticles could translocate into the brain after intravenous injection, which polyhexadecylcyanoacrylate (PHDCA) nanoparticles did not. Through the detailed analysis of the plasma protein adsorption onto the surface of PEG-PHDCA nanoparticles, the present study aimed at clarifying the mechanism by which nanoparticles could penetrate into rat brain endothelial cells (RBEC). Two-dimensional polyacrylamide gel electrophoresis and Western blotting revealed that, after incubation with rat serum, apolipoprotein E (ApoE) adsorbed more onto PEG-PHDCA than on PHDCA nanoparticles. Adsorption of apolipoprotein B-100 (ApoB-100) onto PEG-PHDCA nanoparticles was demonstrated by capillary electrophoresis experiments. Moreover, only when ApoE or ApoB-100 were preadsorbed onto PEG-PHDCA nanoparticles, nanoparticles were found to be more efficient than control nanoparticles for penetrating into RBEC, suggesting the involvement of a low density lipoprotein receptor in this process. Thus, these data clearly demonstrate the involvement of apolipoproteins in the brain transport of PEG-PHDCA nanoparticles, which may open interesting prospects for brain drug delivery.

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Research works printed but not linked: 25

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Metadata

Authors
Kim, H. R., Andrieux, K., Gil, S., Taverna, M., Chacun, H., Desmaële, D., Taran, F., Georgin, D., & Couvreur, P.
Affiliations
Laboratory of Biopharmacy and Pharmaceutical Technology, Laboratory of Biochemistry, Laboratory of Proteins and Nanotechnologies in Separation Sciences, and Laboratory of Organic Chemistry, IFR 141, CNRS, University of Paris-Sud, F-92296 Châtenay-Malabry, France, and CEA/Saclay, Department of Radiolabeled Molecules, F-91191 Gif sur Yvette, France
Venue
Biomacromolecules
Publisher
American Chemical Society (ACS)
Published
2007-02-20
Volume
8
Issue
3
Pages
793-799
ISSN
  • 1525-7797
  • 1526-4602
DOI
10.1021/bm060711a
Cited by
170
References
2
Language
en

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