The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan Composites
Abstract
Few-layered graphene sheets, synthesized by direct current arc-discharge method using NH(3) as one of the buffer gases, were dispersed in chitosan/acetic acid solutions. FTIR and X-ray photoelectron spectroscopy showed the presence of oxygen-containing functional groups on the surface of graphene sheets that may assist the good dispersion of graphene in chitosan solution. Graphene/chitosan films were produced by solution casting method. The mechanical properties of composite films were tested by nanoindentation method. With the addition of a small amount of graphene in chitosan (0.1-0.3 wt %), the elastic modulus of chitosan increased over ∼ 200%. The biocompatibility of graphene/chitosan composite films was checked by tetrazolium-based colorimetric assays in vitro. The cell adhesion result showed that the L929 cell can adhere to and develop on the graphene/chitosan composite films as well as on pure chitosan film, indicating that graphene/chitosan composites have good biocompatibility. Because there is no metallic impurity in graphene raw materials, the time-consuming purification process for removing metal nanoparticles entrapped in carbon nanotubes is thus avoided when graphene is used to prepare biomedical materials. Graphene/chitosan composites are potential candidates as scaffold materials in tissue engineering.
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Cites
Electric Field Effect in Atomically Thin Carbon Films
Novoselov, K. S., Geim, A. K., Morozov, S. V., Jiang, D., Zhang, Y., Dubonos, S. V., Grigorieva, I. V., & Firsov, A. A. (2004) · Science · doi:10.1126/science.1102896 · Cited by 66,834
Raman Spectrum of Graphene and Graphene Layers
Ferrari, A. C., Meyer, J. C., Scardaci, V., Casiraghi, C., Lazzeri, M., Mauri, F., Piscanec, S., Jiang, D., Novoselov, K. S., Roth, S., et al. (2006) · Physical Review Letters · doi:10.1103/physrevlett.97.187401 · Cited by 15,047
Graphene-based composite materials
Stankovich, S., Dikin, D. A., Dommett, G. H. B., Kohlhaas, K. M., Zimney, E. J., Stach, E. A., Piner, R. D., Nguyen, S. T., & Ruoff, R. S. (2006) · Nature · doi:10.1038/nature04969 · Cited by 12,922
Two-dimensional atomic crystals
Novoselov, K. S., Jiang, D., Schedin, F., Booth, T. J., Khotkevich, V. V., Morozov, S. V., & Geim, A. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502848102 · Cited by 11,788
Processable aqueous dispersions of graphene nanosheets
Li, D., Müller, M. B., Gilje, S., Kaner, R. B., & Wallace, G. G. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2007.451 · Cited by 9,114
Large Area, Few-Layer Graphene Films on Arbitrary Substrates by Chemical Vapor Deposition
Reina, A., Jia, X., Ho, J., Nezich, D., Son, H., Bulovic, V., Dresselhaus, M. S., & Kong, J. (2009) · Nano Letters · doi:10.1021/nl801827v · Cited by 5,881
Graphene: The New Two‐Dimensional Nanomaterial
Rao, C. N. R., Sood, A. K., Subrahmanyam, K. S., & Govindaraj, A. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901678 · Cited by 3,953
Single Sheet Functionalized Graphene by Oxidation and Thermal Expansion of Graphite
McAllister, M. J., Li, J.-L., Adamson, D. H., Schniepp, H. C., Abdala, A. A., Liu, J., Herrera-Alonso, M., Milius, D. L., Car, R., Prud'homme, R. K., et al. (2007) · Chemistry of Materials · doi:10.1021/cm0630800 · Cited by 3,569
Room-Temperature Quantum Hall Effect in Graphene
Novoselov, K. S., Jiang, Z., Zhang, Y., Morozov, S. V., Stormer, H. L., Zeitler, U., Maan, J. C., Boebinger, G. S., Kim, P., & Geim, A. K. (2007) · Science · doi:10.1126/science.1137201 · Cited by 3,090
Enhanced Mechanical Properties of Nanocomposites at Low Graphene Content
Reif, J., Rafiee, J., Wang, Z., Song, H., Yu, Z.-Z., & Koratkar, N. (2009) · ACS Nano · doi:10.1021/nn9010472 · Cited by 2,890
Graphene Oxide Dispersions in Organic Solvents
Paredes, J. I., Villar-Rodil, S., Martínez-Alonso, A., & Tascón, J. M. D. (2008) · Langmuir · doi:10.1021/la801744a · Cited by 2,804
Synthesis of Water Soluble Graphene
Si, Y., & Samulski, E. T. (2008) · Nano Letters · doi:10.1021/nl080604h · Cited by 2,722
Stankovich, S., Piner, R. D., Chen, X., Wu, N., Nguyen, S. T., & Ruoff, R. S. (2006) · J. Mater. Chem. · doi:10.1039/b512799h · Cited by 2,590
Mechanically Strong, Electrically Conductive, and Biocompatible Graphene Paper
Chen, H., Müller, M. B., Gilmore, K. J., Wallace, G. G., & Li, D. (2008) · Advanced Materials · doi:10.1002/adma.200800757 · Cited by 2,040
Biased Bilayer Graphene: Semiconductor with a Gap Tunable by the Electric Field Effect
Castro, E. V., Novoselov, K. S., Morozov, S. V., Peres, N. M. R., dos Santos, J. M. B. L., Nilsson, J., Guinea, F., Geim, A. K., & Neto, A. H. C. (2007) · Physical Review Letters · doi:10.1103/physrevlett.99.216802 · Cited by 2,033
Wang, D.-W., Li, F., Zhao, J., Ren, W., Chen, Z.-G., Tan, J., Wu, Z.-S., Gentle, I., Lu, G. Q., & Cheng, H.-M. (2009) · ACS Nano · doi:10.1021/nn900297m · Cited by 1,517
Effect of Chemical Oxidation on the Structure of Single-Walled Carbon Nanotubes
Zhang, J., Zou, H., Qing, Q., Yang, Y., Li, Q., Liu, Z., Guo, X., & Du, Z. (2003) · The Journal of Physical Chemistry B · doi:10.1021/jp027500u · Cited by 1,152
The biocompatibility of carbon nanotubes
Smart, S. K., Cassady, A. I., Lu, G. Q., & Martin, D. J. (2006) · Carbon · doi:10.1016/j.carbon.2005.10.011 · Cited by 1,011
Wu, Z.-S., Ren, W., Gao, L., Zhao, J., Chen, Z., Liu, B., Tang, D., Yu, B., Jiang, C., & Cheng, H.-M. (2009) · ACS Nano · doi:10.1021/nn900020u · Cited by 937
Flash Reduction and Patterning of Graphite Oxide and Its Polymer Composite
Cote, L. J., Cruz-Silva, R., & Huang, J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902348k · Cited by 896
Graphene-based Composite Thin Films for Electronics
Eda, G., & Chhowalla, M. (2009) · Nano Letters · doi:10.1021/nl8035367 · Cited by 684
Bone Cell Proliferation on Carbon Nanotubes
Zanello, L. P., Zhao, B., Hu, H., & Haddon, R. C. (2006) · Nano Letters · doi:10.1021/nl051861e · Cited by 654
Functionalized Graphenes and Thermoplastic Nanocomposites Based upon Expanded Graphite Oxide
Steurer, P., Wissert, R., Thomann, R., & Mülhaupt, R. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800754 · Cited by 522
Effective elastic mechanical properties of single layer graphene sheets
Scarpa, F., Adhikari, S., & Srikantha Phani, A. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/6/065709 · Cited by 521
Synthesis of few-layer graphene via microwave plasma-enhanced chemical vapour deposition
Malesevic, A., Vitchev, R., Schouteden, K., Volodin, A., Zhang, L., Tendeloo, G. V., Vanhulsel, A., & Haesendonck, C. V. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/30/305604 · Cited by 503
Correa-Duarte, M. A., Wagner, N., Rojas-Chapana, J., Morsczeck, C., Thie, M., & Giersig, M. (2004) · Nano Letters · doi:10.1021/nl048574f · Cited by 481
Aqueous Stabilization and Self‐Assembly of Graphene Sheets into Layered Bio‐Nanocomposites using DNA
Patil, A. J., Vickery, J. L., Scott, T. B., & Mann, S. (2009) · Advanced Materials · doi:10.1002/adma.200803633 · Cited by 481
Large scale synthesis of N-doped multi-layered graphene sheets by simple arc-discharge method
Li, N., Wang, Z., Zhao, K., Shi, Z., Gu, Z., & Xu, S. (2010) · Carbon · doi:10.1016/j.carbon.2009.09.013 · Cited by 478
Self-citationNano-indentation studies on polymer matrix composites reinforced by few-layer graphene
Das, B., Eswar Prasad, K., Ramamurty, U., & Rao, C. N. R. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/12/125705 · Cited by 407
Shi, X., Sitharaman, B., Pham, Q. P., Liang, F., Wu, K., Edward Billups, W., Wilson, L. J., & Mikos, A. G. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.05.033 · Cited by 306
Prasad, K. E., Das, B., Maitra, U., Ramamurty, U., & Rao, C. N. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905844106 · Cited by 292
FTIR studies of nitrogen doped carbon nanotubes
Misra, A., Tyagi, P. K., Singh, M. K., & Misra, D. S. (2006) · Diamond and Related Materials · doi:10.1016/j.diamond.2005.08.013 · Cited by 284
Sitharaman, B., Shi, X., Walboomers, X. F., Liao, H., Cuijpers, V., Wilson, L. J., Mikos, A. G., & Jansen, J. A. (2008) · Bone · doi:10.1016/j.bone.2008.04.013 · Cited by 256
The mechanical properties and morphology of a graphite oxide nanoplatelet/polyurethane composite
Cai, D., Yusoh, K., & Song, M. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/8/085712 · Cited by 226
Shi, X., Hudson, J. L., Spicer, P. P., Tour, J. M., Krishnamoorti, R., & Mikos, A. G. (2006) · Biomacromolecules · doi:10.1021/bm060391v · Cited by 176
Isobe, H., Tanaka, T., Maeda, R., Noiri, E., Solin, N., Yudasaka, M., Iijima, S., & Nakamura, E. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601718 · Cited by 174
Conductive Macroporous Composite Chitosan−Carbon Nanotube Scaffolds
Lau, C., Cooney, M. J., & Atanassov, P. (2008) · Langmuir · doi:10.1021/la8005597 · Cited by 172
Tailored carbon nanotubes for tissue engineering applications
Veetil, J. V., & Ye, K. (2009) · Biotechnology Progress · doi:10.1002/btpr.165 · Cited by 169
Carbon nanotubes increase the electrical conductivity of fibroblast-seeded collagen hydrogels
MacDonald, R. A., Voge, C. M., Kariolis, M. S., & Stegemann, J. P. (2008) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.07.005 · Cited by 156
Ge, C., Lao, F., Li, W., Li, Y., Chen, C., Qiu, Y., Mao, X., Li, B., Chai, Z., & Zhao, Y. (2008) · Analytical Chemistry · doi:10.1021/ac801469b · Cited by 148
Graphene sheets via microwave chemical vapor deposition
Yuan, G. D., Zhang, W., Yang, Y. G., et al. (2008) · Chemical Physics Letters · doi:10.1016/j.cplett.2008.11.059 · Cited by 146
Carbon Nanotubes as Structural Nanofibers for Hyaluronic Acid Hydrogel Scaffolds
Bhattacharyya, S., Guillot, S., Dabboue, H., Tranchant, J., & Salvetat, J. (2008) · Biomacromolecules · doi:10.1021/bm7009976 · Cited by 145
Towards an Ultrasensitive Method for the Determination of Metal Impurities in Carbon Nanotubes
Kolodiazhnyi, T. V., & Pumera, M. (2008) · Small · doi:10.1002/smll.200800125 · Cited by 135
Choi, H. C., Bae, S. Y., Park, J., Seo, K., Kim, C., Kim, B., Song, H. J., & Shin, H. (2004) · Applied Physics Letters · doi:10.1063/1.1835994 · Cited by 114
Yang, Q., Shuai, L., & Pan, X. (2008) · Biomacromolecules · doi:10.1021/bm800964m · Cited by 57
Zange, R., & Kissel, T. (1997) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(97)00082-9 · Cited by 51
Manipulated dispersion of carbon nanotubes with derivatives of chitosan
Zhang, J., Wang, Q., Wang, L., & Wang, A. (2007) · Carbon · doi:10.1016/j.carbon.2007.05.007 · Cited by 32
Self-citation
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Nano-graphene in biomedicine: theranostic applications
Yang, K., Feng, L., Shi, X., & Liu, Z. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35342c · Cited by 1,634
Graphene-based nanomaterials for drug delivery and tissue engineering
Goenka, S., Sant, V., & Sant, S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.017 · Cited by 1,311
Functional Composite Materials Based on Chemically Converted Graphene
Bai, H., Li, C., & Shi, G. (2011) · Advanced Materials · doi:10.1002/adma.201003753 · Cited by 1,080
Graphene and graphene oxide as nanomaterials for medicine and biology application
Priyadarsini, S., Mohanty, S., Mukherjee, S., Basu, S., & Mishra, M. (2018) · Journal of Nanostructure in Chemistry · doi:10.1007/s40097-018-0265-6 · Cited by 570
Graphene-based materials biocompatibility: A review
Pinto, A. M., Gonçalves, I. C., & Magalhães, F. D. (2013) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2013.05.022 · Cited by 566
Metadata
- Authors
- Fan, H., Wang, L., Zhao, K., Li, N., Shi, Z., Ge, Z., & Jin, Z.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-05
- Volume
- 11
- Issue
- 9
- Pages
- 2345-2351
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2048474248
- Cited by
- 554
- References
- 48
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- closed
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