The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.
Hydrocarbon Stapled Peptides as Modulators of Biological Function
Abstract
Peptide-based drug discovery has experienced a significant upturn within the past decade since the introduction of chemical modifications and unnatural amino acids has allowed for overcoming some of the drawbacks associated with peptide therapeutics. Strengthened by such features, modified peptides become capable of occupying a niche that emerges between the two major classes of today's therapeutics-small molecules (<500 Da) and biologics (>5000 Da). Stabilized α-helices have proven particularly successful at impairing disease-relevant PPIs previously considered "undruggable." Among those, hydrocarbon stapled α-helical peptides have emerged as a novel class of potential peptide therapeutics. This review provides a comprehensive overview of the development and applications of hydrocarbon stapled peptides discussing the benefits and limitations of this technique.
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Metadata
- Authors
- Cromm, P. M., Spiegel, J., & Grossmann, T. N.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-03-31
- Volume
- 10
- Issue
- 6
- Pages
- 1362-1375
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W2076083257
- Cited by
- 290
- References
- 154
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
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