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Gain of Interaction with IRS1 by p110α-Helical Domain Mutants Is Crucial for Their Oncogenic Functions

Hao, Y., Wang, C., Cao, B., Hirsch, B. M., Song, J. K., Markowitz, S. D., Ewing, R. M., Sedwick, D., Liu, L., Zheng, W., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.03.021 · Cited by 110

Recent advances in helix–coil theory

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Synthesis and Nuclear Magnetic Resonance Structure Determination of an .alpha.-Helical, Bicyclic, Lactam-Bridged Hexapeptide

Bracken, C., Gulyás, J., Taylor, J. W., & Baum, J. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00093a052 · Cited by 97

Distinct BimBH3 (BimSAHB) Stapled Peptides for Structural and Cellular Studies

Bird, G. H., Gavathiotis, E., LaBelle, J. L., Katz, S. G., & Walensky, L. D. (2013) · ACS Chemical Biology · doi:10.1021/cb4003305 · Cited by 97

Direct Targeting of Rab‐GTPase–Effector Interactions

Spiegel, J., Cromm, P. M., Itzen, A., Goody, R. S., Grossmann, T. N., & Waldmann, H. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308568 · Cited by 88

Stereochemical effects of all-hydrocarbon tethers in i,i+4 stapled peptides

Kim, Y., & Verdine, G. L. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.03.022 · Cited by 86

Solution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 Capsid

Bhattacharya, S., Zhang, H., Debnath, A. K., & Cowburn, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800048200 · Cited by 86

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies

Bird, G. H., Irimia, A., Ofek, G., Kwong, P. D., Wilson, I. A., & Walensky, L. D. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2922 · Cited by 81

Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides

Wang, Y., Ho, T. G., Bertinetti, D., Neddermann, M., Franz, E., Mo, G. C. H., Schendowich, L. P., Sukhu, A., Spelts, R. C., Zhang, J., et al. (2014) · ACS Chemical Biology · doi:10.1021/cb400900r · Cited by 80

A Versatile Platform to Analyze Low-Affinity and Transient Protein-Protein Interactions in Living Cells in Real Time

Li, Y.-C., Rodewald, L. W., Hoppmann, C., Wong, E. T., Lebreton, S., Safar, P., Patek, M., Wang, L., Wertman, K. F., & Wahl, G. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.058 · Cited by 79

Biological Activities of Natural and Engineered Cyclotides, a Novel Molecular Scaffold for Peptide-Based Therapeutics

Garcia, A., & Camarero, J. A. (2010) · Current Molecular Pharmacology · doi:10.2174/1874-470211003030153 · Cited by 78

Macrocycles in Drug Discovery

Levin, J. I. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781782623113 · Cited by 76

Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection

Bird, G. H., Boyapalle, S., Wong, T. M., Opoku-Nsiah, K., Bedi, R., Crannell, W. C., Perry, A. F., Nguyen, H. D., Sampayo-Escobar, V., Devareddy, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71856 · Cited by 74

All-hydrocarbon stapled peptides as Synthetic Cell-Accessible Mini-Proteins

Verdine, G. L., & Hilinski, G. J. (2012) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2012.01.004 · Cited by 70

Regulation of the p53 pathway by ubiquitin and related proteins

Hock, A., & Vousden, K. H. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.06.011 · Cited by 70

Rational Optimization of Conformational Effects Induced By Hydrocarbon Staples in Peptides and their Binding Interfaces

Lama, D., Quah, S. T., Verma, C. S., Lakshminarayanan, R., Beuerman, R. W., Lane, D. P., & Brown, C. J. (2013) · Scientific Reports · doi:10.1038/srep03451 · Cited by 64

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

Zhang, H., Curreli, F., Zhang, X., Bhattacharya, S., Waheed, A. A., Cooper, A., Cowburn, D., Freed, E. O., & Debnath, A. K. (2011) · Retrovirology · doi:10.1186/1742-4690-8-28 · Cited by 63

Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia

Reynolds, C., Roderick, J. E., LaBelle, J. L., Bird, G. H., Mathieu, R., Bodaar, K., Colon, D., Pyati, U. J., Stevenson, K. E., Qi, J., et al. (2014) · Leukemia · doi:10.1038/leu.2014.78 · Cited by 59

Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera

Chapuis, H., Slaninová, J., Bednářová, L., Monincová, L., Buděšı́nský, M., & Čeřovský, V. (2012) · Amino Acids · doi:10.1007/s00726-012-1283-1 · Cited by 57

Assembly of Human Immunodeficiency Virus Precursor Gag Proteins

Huseby, D. L., Barklis, R. L., Alfadhli, A., & Barklis, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412325200 · Cited by 57

Crystal Structures of Stapled and Hydrogen Bond Surrogate Peptides Targeting a Fully Buried Protein–Helix Interaction

Douse, C. H., Maas, S. J., Thomas, J. C., Garnett, J. A., Sun, Y., Cota, E., & Tate, E. W. (2014) · ACS Chemical Biology · doi:10.1021/cb500271c · Cited by 57

Stapled peptide-based membrane fusion inhibitors of hepatitis C virus

Cui, H., Qing, J., Guo, Y., Wang, Y., Cui, L., He, T., Zhang, L., & Liu, L. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.02.011 · Cited by 56

The Closed MTIP-Myosin A-Tail Complex from the Malaria Parasite Invasion Machinery

Bosch, J., Turley, S., Roach, C., Daly, T. M., Bergman, L. W., & Hol, W. G. J. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.06.016 · Cited by 56

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators

Szlyk, B., Braun, C. R., Ljubicic, S., Patton, E., Bird, G. H., Osundiji, M. A., Matschinsky, F. M., Walensky, L. D., & Danial, N. N. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2717 · Cited by 55

Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products

Nomura, W., Aikawa, H., Ohashi, N., Urano, E., Métifiot, M., Fujino, M., Maddali, K., Ozaki, T., Nozue, A., Narumi, T., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb400495h · Cited by 55

Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome

Braun, C. R., Mintseris, J., Gavathiotis, E., Bird, G. H., Gygi, S. P., & Walensky, L. D. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.09.015 · Cited by 53

Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A

Frank, A. O., Vangamudi, B., Feldkamp, M. D., de Souza-Fagundes, E. M., Luzwick, J. W., Cortez, D., Olejniczak, E. T., Waterson, A. G., Rossanese, O. W., Chazin, W., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401730y · Cited by 49

Dual-acting stapled peptides target both HIV-1 entry and assembly

Zhang, H., Curreli, F., Waheed, A. A., Mercredi, P. Y., Mehta, M., Bhargava, P., Scacalossi, D., Tong, X., Lee, S., Cooper, A., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-136 · Cited by 48

Design of Cell-Permeable Stapled Peptides as HIV-1 Integrase Inhibitors

Long, Y., Huang, S.-X., Zawahir, Z., Xu, Z.-L., Li, H., Sanchez, T. W., Zhi, Y., Houwer, S. D., Christ, F., Debyser, Z., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4006516 · Cited by 48

Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling

Hahne, G., & Grossmann, T. N. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.02.050 · Cited by 46

A New i, i + 3 Peptide Stapling System for α‐Helix Stabilization

Shim, S. Y., Kim, Y., & Verdine, G. L. (2013) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12231 · Cited by 45

End-capped α-helices as modulators of protein function

Mahon, A. B., & Arora, P. S. (2012) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2011.07.008 · Cited by 44

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2Agonism and Glucose-Dependent Insulin Secretion

Giordanetto, F., Revell, J. D., Knerr, L., Hostettler, M., Paunovic, A., Priest, C., Janefeldt, A., & Gill, A. L. (2013) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400257h · Cited by 44

Stapled BH3 Peptides against MCL-1: Mechanism and Design Using Atomistic Simulations

Joseph, T. L., Lane, D. P., & Verma, C. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043985 · Cited by 44

Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling

Cui, H.-K., Zhao, B., Li, Y., Guo, Y., Hu, H., Liu, L., & Chen, Y.-G. (2013) · Cell Research · doi:10.1038/cr.2013.30 · Cited by 42

Helix stabilization of amphipathic peptides by hydrocarbon stapling increases cholesterol efflux by the ABCA1 transporter

Sviridov, D. O., Ikpot, I. Z., Stonik, J. A., Drake, S. K., Amar, M. J., Osei-Hwedieh, D. O., Piszczek, G., Turner, S., & Remaley, A. T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.154 · Cited by 41

Truncated and constrained helical analogs of antimicrobial esculentin-2EM

Pham, T. K., Kim, D.-H., Lee, B., & Kim, Y. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.10.031 · Cited by 40

Structure of a Stapled Peptide Antagonist Bound to Nutlin-Resistant Mdm2

Chee, S. M. Q., Wongsantichon, J., Quah, S. T., Robinson, R. C., Joseph, T. L., Verma, C. S., Lane, D. P., Brown, C. J., & Ghadessy, F. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104914 · Cited by 39

Membrane Permeability of Hydrocarbon-Cross-Linked Peptides

Sun, T.-L., Sun, Y., Lee, C., & Huang, H. W. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.03.039 · Cited by 39

Sequence-Based Design and Discovery of Peptide Inhibitors of HIV-1 Integrase: Insight into the Binding Mode of the Enzyme

Li, H.-Y., Zawahir, Z., Song, L.-D., Long, Y., & Neamati, N. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060307u · Cited by 36

Protein–protein interactions in transcription: A fertile ground for helix mimetics

Guarracino, D. A., Bullock, B. N., & Arora, P. S. (2010) · Biopolymers · doi:10.1002/bip.21546 · Cited by 33

Efflux by Small Multidrug Resistance Proteins Is Inhibited by Membrane-interactive Helix-stapled Peptides

Bellmann‐Sickert, K., Stone, T. A., Poulsen, B. E., & Deber, C. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616185 · Cited by 31

Inhibiting Epidermal Growth Factor Receptor at a Distance

Sinclair, J. K.-L., Denton, E. V., & Schepartz, A. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504076t · Cited by 30

A Potential Peptide Therapeutic Derived from the Juxtamembrane Domain of the Epidermal Growth Factor Receptor

Boran, A. D. W., Seco, J., Jayaraman, V., Jayaraman, G., Zhao, S., Reddy, S., Chen, Y., & Iyengar, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049702 · Cited by 29

The Crystal Structures of the Calcium-Bound con-G and con-T[K7γ] Dimeric Peptides Demonstrate a Metal-Dependent Helix-Forming Motif

Cnudde, S. E., Prorok, M., Dai, Q., Castellino, F., & Geiger, J. H. (2007) · Journal of the American Chemical Society · doi:10.1021/ja065722q · Cited by 28

Novel structures of self‐associating stapled peptides

Bhattacharya, S., Zhang, H., Cowburn, D., & Debnath, A. K. (2011) · Biopolymers · doi:10.1002/bip.22015 · Cited by 27

Inhibition of Nutlin-Resistant HDM2 Mutants by Stapled Peptides

Wei, S. J., Joseph, T. L., Chee, S. M. Q., Li, L., Yurlova, L., Zolghadr, K., Brown, C. J., Lane, D. P., Verma, C. S., & Ghadessy, F. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081068 · Cited by 27

Hydrogen Exchange-Mass Spectrometry Measures Stapled Peptide Conformational Dynamics and Predicts Pharmacokinetic Properties

Shi, X. E., Wales, T. E., Elkin, C. D., Kawahata, N. H., Engen, J. R., & Annis, D. A. (2013) · Analytical Chemistry · doi:10.1021/ac403173p · Cited by 26

Influence of Macrocyclization on Allosteric, Juxtamembrane-Derived, Stapled Peptide Inhibitors of the Epidermal Growth Factor Receptor (EGFR)

Sinclair, J. K.-L., & Schepartz, A. (2014) · Organic Letters · doi:10.1021/ol502426b · Cited by 23

A minimal model for stabilization of biomolecules by hydrocarbon cross-linking

Hamacher, K., Hübsch, A., & McCammon, J. A. (2006) · The Journal of Chemical Physics · doi:10.1063/1.2185645 · Cited by 22

Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome

Zawahir, Z., & Neamati, N. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.07.022 · Cited by 21

Stapling Mimics Noncovalent Interactions of γ-Carboxyglutamates in Conantokins, Peptidic Antagonists of N-Methyl-d-Aspartic Acid Receptors

Platt, R. J., Han, T., Green, B. R., Smith, M. D., Skalicky, J. J., Gruszczyński, P., White, H. S., Olivera, B. M., Bulaj, G. W., & Gajewiak, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.350462 · Cited by 21

Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling

Green, B. R., Klein, B. D., Lee, H.-K., Smith, M. D., White, H. S., & Bulaj, G. W. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.10.026 · Cited by 16

Stabilized Helical Peptides: A Strategy to Target Protein–Protein Interactions

Klein, M. A. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml500235d · Cited by 16

Probing the Origin of Structural Stability of Single and Double Stapled p53 Peptide Analogs Bound to MDM 2

Guo, Z., Streu, K., Krilov, G., & Mohanty, U. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12284 · Cited by 15

Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix

Gavenonis, J., Jonas, N., & Kritzer, J. A. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.06.006 · Cited by 15

Mechanism of Stapled Peptide Binding to MDM2: Possible Consequences for Peptide Design

Sim, A. Y. L., Joseph, T. L., Lane, D. P., & Verma, C. S. (2014) · Journal of Chemical Theory and Computation · doi:10.1021/ct4009238 · Cited by 15

Inhibition of caspase‐9 by stabilized peptides targeting the dimerization interface

Huber, K. L., Ghosh, S., & Hardy, J. A. (2012) · Biopolymers · doi:10.1002/bip.22080 · Cited by 14

Advancements in Stapled Peptide Drug Discovery & Development

Guerlavais, V., & Sawyer, T. K. (2014) · Annual reports in medicinal chemistry · doi:10.1016/b978-0-12-800167-7.00021-3 · Cited by 13

Pharmaceutical Implications of Helix Length Control in Helix-Mediated Protein–Protein Interactions

Milroy, L. ‐., & Brunsveld, L. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.179 · Cited by 11

Coronavirus envelope protein: current knowledge

Schoeman, D., & Fielding, B. C. (2019) · Virology Journal · doi:10.1186/s12985-019-1182-0 · Cited by 2,074

New Modalities for Challenging Targets in Drug Discovery

Valeur, E., Guéret, S. M., Adihou, H., Gopalakrishnan, R., Lemurell, M., Waldmann, H., Grossmann, T. N., & Plowright, A. T. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201611914 · Cited by 382

Drugging Membrane Protein Interactions

Yin, H., & Flynn, A. D. (2016) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-092115-025322 · Cited by 339

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

Martinez Molina, D., & Nordlund, P. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103715 · Cited by 306

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

Cromm, P. M., Samarasinghe, K. T. G., Hines, J., & Crews, C. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08008 · Cited by 293