The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders
Open accessAbstract
Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. More recently, based on findings from translational research, lithium has also been regarded as a neuroprotective agent and a candidate drug for disease-modification in certain neurodegenerative disorders, namely, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and, more recently, Parkinson's disease (PD). The putative neuroprotective effects of lithium rely on the fact that it modulates several homeostatic mechanisms involved in neurotrophic response, autophagy, oxidative stress, inflammation, and mitochondrial function. Such a wide range of intracellular responses may be secondary to two key effects, that is, the inhibition of glycogen synthase kinase-3 beta (GSK-3β) and inositol monophosphatase (IMP) by lithium. In the present review, we revisit the neurobiological properties of lithium in light of the available evidence of its neurotrophic and neuroprotective properties, and discuss the rationale for its use in the treatment and prevention of neurodegenerative diseases.
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2 retracted
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The multifaceted roles of glycogen synthase kinase 3β in cellular signaling
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History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis
Diniz, B. S., Teixeira, A. L., Cao, F., Gildengers, A., Soares, J. C., Butters, M. A., & Reynolds, C. F. (2017) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.11.014 · Cited by 191
Self-citationForlenza, O. V., Radanovic, M., Talib, L. L., & Gattaz, W. F. (2019) · British Journal of Psychiatry · doi:10.1192/bjp.2019.76 · Cited by 171
Self-citationMood disorders in the elderly: prevalence, functional impact, and management challenges
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Self-citationLinking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration
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Age-related GSK3β overexpression drives podocyte senescence and glomerular aging
Fang, Y., Chen, B., Liu, Z., Gong, A. Y., Gunning, W. T., Ge, Y., Malhotra, D., Gohara, A. F., Dworkin, L. D., & Gong, R. (2022) · Journal of Clinical Investigation · doi:10.1172/jci141848 · Cited by 92
Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype
Diniz, B. S., Reynolds, C. F., Sibille, E., Lin, C.-W., Tseng, G., Lotrich, F., Aizenstein, H. J., & Butters, M. A. (2017) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2016.08.018 · Cited by 73
Self-citationQu, L., Li, S., Ji, L., Luo, S., Ding, M., Yin, F., Wang, C., Luo, H., Lu, D., Liu, X., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113889 · Cited by 61
Arsenic and Tau Phosphorylation: A Mechanistic Review
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Metadata
- Authors
- Forlenza, O. V., De-Paula, V. J. R., & Diniz, B. S. O.
- Venue
- ACS Chemical Neuroscience
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-05-06
- Volume
- 5
- Issue
- 6
- Pages
- 443-450
- ISSN
- 1948-7193 (ISSN-L)
- OpenAlex
- W2022101023
- Cited by
- 332
- References
- 110
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- green
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