History of Bipolar Disorder and the Risk of Dementia: A Systematic Review and Meta-Analysis
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Objective We carried out a systematic review and meta-analysis to evaluate whether history of bipolar disorder (BD) increases the risk of dementia.Methods We searched PubMed and Scopus to identify studies that evaluated the risk of dementia in individuals with a history of BD. A total of 6 studies including 3,026 individuals with history of BD and 191,029 non-BD individuals were included in the meta-analysis.Results History of BD significantly increased the risk of diagnosis of dementia (pooled odds ratio: 2.36; 95% confidence interval: 1.36-4.09; z = 3.07, p < 0.001). Evidence of heterogeneity and of publication bias in the analysis was found.Conclusion History of BD is associated with significantly higher risk of dementia in older adults. Future studies are necessary to evaluate the potential mediators of this association and to evaluate interventions that may reduce the risk of dementia in this population.
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- Authors
- Diniz, B. S., Teixeira, A. L., Cao, F., Gildengers, A., Soares, J. C., Butters, M. A., & Reynolds, C. F.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- University of Pittsburgh (US)
- Corresponding author
- Diniz, Breno S.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 25
- Issue
- 4
- Pages
- 357-362
- ISSN
- 1064-7481 (ISSN-L)
- PMC
- PMC5365367
- OpenAlex
- W2568850245
- Cited by
- 191
- References
- 34
- Citations by year
- 2026: 21 · 2025: 20 · 2024: 24 · 2023: 20 · 2022: 26 · 2021: 25 · 2020: 24 · 2019: 17 · 2018: 8 · 2017: 5 · 2016: 1
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIMH (P50 AG005133, P30 MH090333)
- UPMC Endowment in Geriatric Psychiatry
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, dementia risk, older adults, psychiatric comorbidity, cognitive decline
- MeSH terms
- Bipolar Disorder, Dementia, Humans, Risk, Comorbidity
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