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Cited by 332

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders

Open access
Forlenza, O. V., De-Paula, V. J. R., Diniz, B. S. O.·2014·ACS Chemical Neuroscience
DOI 10.1021/cn5000309
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Abstract

Lithium is a well-established therapeutic option for the acute and long-term management of bipolar disorder and major depression. More recently, based on findings from translational research, lithium has also been regarded as a neuroprotective agent and a candidate drug for disease-modification in certain neurodegenerative disorders, namely, Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and, more recently, Parkinson's disease (PD). The putative neuroprotective effects of lithium rely on the fact that it modulates several homeostatic mechanisms involved in neurotrophic response, autophagy, oxidative stress, inflammation, and mitochondrial function. Such a wide range of intracellular responses may be secondary to two key effects, that is, the inhibition of glycogen synthase kinase-3 beta (GSK-3β) and inositol monophosphatase (IMP) by lithium. In the present review, we revisit the neurobiological properties of lithium in light of the available evidence of its neurotrophic and neuroprotective properties, and discuss the rationale for its use in the treatment and prevention of neurodegenerative diseases.

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Metadata

Authors
Forlenza, O. V., De-Paula, V. J. R., & Diniz, B. S. O.
Venue
ACS Chemical Neuroscience
Publisher
American Chemical Society (ACS)
Published
2014-05-06
Volume
5
Issue
6
Pages
443-450
ISSN
1948-7193 (ISSN-L)
DOI
10.1021/cn5000309
OpenAlex
W2022101023
Cited by
332
References
110
FWCI
13.22
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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