DNA Polymerase γ in Mitochondrial DNA Replication and Repair

Sequence and organization of the human mitochondrial genome

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Rapid evolution of animal mitochondrial DNA

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Mitochondrial diseases in man and mouse

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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DNA repair and mutagenesis

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

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Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

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Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

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Computational method to predict mitochondrially imported proteins and their targeting sequences.

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Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice

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Biogenesis of Mitochondria

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

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Diseases of the mitochondrial DNA

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Replication of animal mitochondrial DNA

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

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MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES

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Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation

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Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline

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Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder

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The proteome of Saccharomyces cerevisiae mitochondria

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Human mitochondrial DNA deletions associated with mutations in the gene encoding twinkle, a phage T7 gene 4-like protein localized in mitochondria

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Eukaryotic DNA mismatch repair

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Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

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Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions

Van Goethem, G., Dermaut, B., Löfgren, A., Martin, J.-J., & Van Broeckhoven, C. (2001) · Nature Genetics · doi:10.1038/90034 · Cited by 841 · see citing works

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

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Detection of a specific mitochondrial DNA deletion in tissues of older humans

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Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication

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Mitochondrial Genome Evolution and the Origin of Eukaryotes

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Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

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Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation

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Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

Matsumoto, Y., & Kim, K. (1995) · Science · doi:10.1126/science.7624801 · Cited by 683 · see citing works

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

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An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

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Role of Adenine Nucleotide Translocator 1 in mtDNA Maintenance

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Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity

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Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.-G., & Gustafsson, C. M. (2002) · Nature Genetics · doi:10.1038/ng909 · Cited by 598 · see citing works

Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

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Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair

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Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study

Luoma, P., Melberg, A., Rinne, J. O., Kaukonen, J. A., Nupponen, N. N., Chalmers, R. M., Oldfors, A., Rautakorpi, I., Peltonen, L., Majamaa, K., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16983-3 · Cited by 548 · see citing works

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

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Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal

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Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells

Croteau, D. L., & Bohr, V. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25409 · Cited by 512 · see citing works

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

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Mitochondrial toxicity of nrti antiviral drugs: an integrated cellular perspective

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MOLECULAR GENETIC ASPECTS OF HUMAN MITOCHONDRIAL DISORDERS

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EUKARYOTIC DNA POLYMERASES

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Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA

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Energetics in the pathogenesis of neurodegenerative diseases

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POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion

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Mammalian DNA Mismatch Repair

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A conserved 3′→5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases

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Replication and Transcription of Mammalian Mitochondrial Dna

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Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA

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DNA Polymerase γ, The Mitochondrial Replicase

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Reconstitution of a minimal mtDNA replisome in vitro

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Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase

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Expression and Differential Intracellular Localization of Two Major Forms of Human 8-Oxoguanine DNA Glycosylase Encoded by Alternatively Spliced OGG1 mRNAs

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Composition and dynamics of human mitochondrial nucleoids.

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THE STRUCTURE AND REPLICATION OF KINETOPLAST DNA

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Individual microtubules in the axon consist of domains that differ in both composition and stability.

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Crystal structure of Thermus aquaticus DNA polymerase

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Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice

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Rapid regulation of steroidogenesis by mitochondrial protein import

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Heteroduplex repair in extracts of human HeLa cells

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Animal Mitochondrial DNA: An Extreme Example of Genetic Economy

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Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

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A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides.

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Priming of human mitochondrial DNA replication occurs at the light-strand promoter.

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Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

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Methyl-directed repair of DNA base-pair mismatches in vitro.

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Compilation and alignment of DNA polymerase sequences

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Linkage Disequilibrium and Recombination in Hominid Mitochondrial DNA

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Structure of Taq polymerase with DNA at the polymerase active site

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Mitochondrial DNA Polymerase W748S Mutation: A Common Cause of Autosomal Recessive Ataxia with Ancient European Origin

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Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

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Recombination of Human Mitochondrial DNA

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TWINKLE Has 5' −>3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein

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Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase- A

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Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage

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Cloning and Characterization of the Human Mitochondrial DNA Polymerase, DNA Polymerase γ

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Animal Cell Dna Polymerases

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In situ localization of mitochondrial DNA replication in intact mammalian cells.

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Biased Incorporation of Ribonucleotides on the Mitochondrial L-Strand Accounts for Apparent Strand-Asymmetric DNA Replication

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The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit

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Mutations of mitochondrial DNA polymerase γA are a frequent cause of autosomal dominant or recessive progressive external ophthalmoplegia

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Mammalian Mitochondria Possess Homologous DNA Recombination Activity

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Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells

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Mutagenesis by transient misalignment.

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<i>POLG</i> mutations in neurodegenerative disorders with ataxia but no muscle involvement

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Functions of DNA polymerases

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DNA mismatch repair and mutation avoidance pathways

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Autosomal recessive mitochondrial ataxic syndrome due to mitochondrial polymerase γ mutations

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Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia

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The Human DNA Ligase III Gene Encodes Nuclear and Mitochondrial Proteins

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Mitochondrial DNA repair pathways

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DNA polymerase of mitochondria is a gamma-polymerase.

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Mitochondrial DNA Is a Major Cellular Target for a Dihydrodiol-Epoxide Derivative of Benzo[ a ]pyrene

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Differential Incorporation and Removal of Antiviral Deoxynucleotides by Human DNA Polymerase γ

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Susquehanna Chorale Spring Concert "Roots and Wings"

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