The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Hydrogels for Protein Delivery
Abstract
This review describes injectable polymeric delivery systemsused for the controlled release of pharmaceutical proteins, withspecial focus on hydrogels. We shortly overview the currentlyavailable technologies other than hydrogels, which includelipid-based delivery systems, nano/microparticles based ondegradable hydrophobic polymers, highlighting their rationale,characteristics, and shortcomings in protein delivery. In thisreview, hydrogels are extensively described, from their generalfeatures to recent advances in synthesis and pharmaceutical andclinical applications. The discussion covers injectable systemsbased on nano- and particularly microparticles as well asphysical and chemical cross-linking methods used for in situgelling systems and environmentally responsive hydrogels andtheir use for protein release. Some limitations of hydrogels inprotein delivery (e.g., burst and incomplete release, proteindamage due to encapsulation) are also discussed and ways totackle these are provided. Emerging techniques to study releasefrom hydrogels are illustrated and current applied hydrogelsystems are discussed. Finally, hydrogel/protein formulationsthat have reached clinical trials are summarized and discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Effect of pegylation on pharmaceuticals
Harris, J. M., & Chess, R. B. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1033 · Cited by 3,431
Hydrophilic gels for biological use
WICHTERLE, O., & LÍM, D. (1960) · Nature · doi:10.1038/185117a0 · Cited by 2,996
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617
Photopolymerizable hydrogels for tissue engineering applications
Nguyen, K. T., & West, J. L. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00175-8 · Cited by 1,669
Main properties and current applications of some polysaccharides as biomaterials
Rinaudo, M. (2008) · Polymer International · doi:10.1002/pi.2378 · Cited by 1,028
Stimulus responsive nanogels for drug delivery
Zha, L., Banik, B., & Alexis, F. (2011) · Soft Matter · doi:10.1039/c0sm01307b · Cited by 391
Hsieh, P. C. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25878 · Cited by 357
Tan, M. L., Choong, P. F. M., & Dass, C. R. (2010) · Peptides · doi:10.1016/j.peptides.2009.10.002 · Cited by 350
Tsuji, H., Hyon, S. H., & Ikada, Y. (1991) · Macromolecules · doi:10.1021/ma00020a026 · Cited by 334
pH sensitive alginate–guar gum hydrogel for the controlled delivery of protein drugs
George, M., & Abraham, T. E. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.11.009 · Cited by 322
The Role of Surface Functionalization in the Design of PLGA Micro- and Nanoparticles
Ratzinger, G., Fillafer, C., Kerleta, V., Wirth, M., & Gabor, F. (2010) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v27.i1.10 · Cited by 22
Cited by
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
25th Anniversary Article: Engineering Hydrogels for Biofabrication
Malda, J., Visser, J., Melchels, F. P., Jüngst, T., Hennink, W. E., Dhert, W. J. A., Groll, J., & Hutmacher, D. W. (2013) · Advanced Materials · doi:10.1002/adma.201302042 · Cited by 1,901
Self-citationStrategies for the Conversion of Lignin to High-Value Polymeric Materials: Review and Perspective
Upton, B. M., & Kasko, A. M. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00345 · Cited by 1,519
Hydrogels in a historical perspective: From simple networks to smart materials
Buwalda, S. J., Boere, K. W. M., Dijkstra, P. J., Feijen, J., Vermonden, T., & Hennink, W. E. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.052 · Cited by 994
Self-citationSelf-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Metadata
- Authors
- Vermonden, T., Censi, R., & Hennink, W. E.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-02-23
- Volume
- 112
- Issue
- 5
- Pages
- 2853-2888
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W2032306620
- Cited by
- 1,091
- References
- 14
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
