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Living with Iron (and Oxygen): Questions and Answers about Iron Homeostasis

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Theil, Elizabeth C., Goss, Dixie J.·2009·Chemical Reviews
DOI 10.1021/cr900052gPMC PMC2919049
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ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTLiving with Iron (and Oxygen): Questions and Answers about Iron HomeostasisElizabeth C. Theil*† and Dixie J. Goss‡View Author Information CHORI (Children's Hospital Oakland Research Institute), Oakland, California 94609, Department of Nutritional Sciences & Toxicology, University of California, Berkeley, California 94720, and Chemistry Department, Hunter College, City University of New York, New York 10065* Corresponding author: Elizabeth C. Theil, Ph.D., Senior Scientist, CHORI, 5700 Martin Luther King Jr. Way, Oakland, CA 94609. Phone: 510-450-7670. Fax: 510-597-7131. E-mail: [email protected]†CHORI and University of California.‡City University of New York.Cite this: Chem. Rev. 2009, 109, 10, 4568–4579Publication Date (Web):August 28, 2009Publication History Received10 February 2009Published online28 August 2009Published inissue 14 October 2009https://pubs.acs.org/doi/10.1021/cr900052ghttps://doi.org/10.1021/cr900052greview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views3642Altmetric-Citations211LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Genetics,Iron,Oxygen,Peptides and proteins,Plants Get e-Alerts

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  • Free iron can catalyze formation of reactive oxygen species and must be safely bound by specialized proteins.

    “Also free iron can catalyze formation of reactive oxygen species (ROS) and must be safely bound by specialized proteins.”

    From Iron, Oxidative Stress and Health (2012) · cites this paper as Theil and Goss, 2009

    The Introduction describes iron in transit as bound to chaperone or carrier sites, and the Summary identifies ferritin as an iron-storage protein. The Summary also says damaged ferritin can support redox chemistry that produces reactive oxygen, but our copy does not specifically state that free iron catalyzes ROS formation. (LLM, conf=0.79)

    Experimental — accuracy not yet measured

  • Compared to other metals, the body contains much higher levels of iron (3.5-4 g versus 100 mg copper), aqueous ferric ions have low solubility, and excess iron is not actively excreted via the kidney.

    “However, compared to other metals, the body contains much higher levels of iron (3.5 -4 g of iron versus 100 mg of copper), aqueous ferric ions exhibit low solubility and unlike other metals, excess iron is not actively excreted via the kidney.”

    From Iron, Oxidative Stress and Health (2012) · cites this paper as Theil and Goss, 2009

    The Introduction (page not available in our copy) gives approximately 3.5 g of iron versus 100 mg of copper and describes the low solubility of aqueous ferric ions. Section 2.2, Organisms (page not available), says kidney excretion of iron from old red cells is precluded by its low solubility, but does not specifically discuss active kidney excretion of excess iron or establish the contrast with other metals. (LLM, conf=0.84)

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Authors
Theil, E. C., & Goss, D. J.
Affiliations
City University of New York (US)
Corresponding author
Theil, Elizabeth C.
ORCID
Goss, Dixie J.
Venue
Chemical Reviews
Publisher
American Chemical Society (ACS)
Published
2009-08-28
Volume
109
Issue
10
Pages
4568-4579
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
DOI
10.1021/cr900052g
PMC
PMC2919049
OpenAlex
W1989527051
Cited by
265
References
159
Citations by year
2026: 9 · 2025: 17 · 2024: 19 · 2023: 14 · 2022: 14 · 2021: 16 · 2020: 22 · 2019: 9 · 2018: 20 · 2017: 14 · 2016: 21 · 2015: 15 · 2014: 14 · 2013: 11 · 2012: 28
FWCI
2.42
Type
journal article
Language
en
Open access
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • City University of New York
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 20251, R56DK020251, R01DK020251)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
Keywords
iron homeostasis, iron metabolism, oxygen, iron transport, iron regulation, iron deficiency, iron overload, heme iron, non-heme iron, ferritin, transferrin, hepcidin, iron-sulfur clusters, iron-sulfur proteins, oxidative stress, iron deficiency anemia, iron overload anemia, infant iron deficiency
MeSH terms
Animals, Cells, Homeostasis, Humans, Iron, Oxygen, Transcription, Genetic, Protein Biosynthesis

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