Genetic Contributions to Understanding Polyketide Synthases

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584

Complete Genome Sequence of the Methanogenic Archaeon, Methanococcus jannaschii

Bult, C. J., White, O., Olsen, G. J., Zhou, L., Fleischmann, R. D., Sutton, G. G., Blake, J. A., FitzGerald, L. M., Clayton, R. A., Gocayne, J. D., et al. (1996) · Science · doi:10.1126/science.273.5278.1058 · Cited by 2,082

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J., & Katz, L. (1991) · Science · doi:10.1126/science.2024119 · Cited by 898

A new enzyme superfamily — the phosphopantetheinyl transferases

Lambalot, R. H., Gehring, A. M., Flugel, R. S., Zuber, P., LaCelle, M., Marahiel, M. A., Reid, R., Khosla, C., & Walsh, C. T. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90181-7 · Cited by 851

Fatty acid synthase, a proficient multifunctional enzyme

Wakil, S. J. (1989) · Biochemistry · doi:10.1021/bi00437a001 · Cited by 820

MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS

Hopwood, D. A., & Sherman, D. H. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.000345 · Cited by 684

Regulation of fatty acid biosynthesis in Escherichia coli

Magnuson, K. S., Jackowski, S., Rock, C. O., & Cronan, J. E. (1993) · Microbiological Reviews · doi:10.1128/mmbr.57.3.522-542.1993 · Cited by 654

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

Cortes, J., Haydock, S. F., Roberts, G. A., Bevitt, D. J., & Leadlay, P. F. (1990) · Nature · doi:10.1038/348176a0 · Cited by 624

The animal fatty acid synthase: one gene, one polypeptide, seven enzymes

Smith, S. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.15.8001737 · Cited by 598

A novel highly unsaturated fatty acid moiety of lipo-oligosaccharide signals determines host specificity of Rhizobium

Spaink, H. P., Sheeley, D. M., van Brussel, A. A. N., Glushka, J., York, W. S., Tak, T., Geiger, O., Kennedy, E. P., Reinhold, V. N., & Lugtenberg, B. J. J. (1991) · Nature · doi:10.1038/354125a0 · Cited by 532

Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans.

Brown, D. W., Yu, J. H., Kelkar, H. S., Fernandes, M., Nesbitt, T. C., Keller, N. P., Adams, T. H., & Leonard, T. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1418 · Cited by 507

Engineered Biosynthesis of Novel Polyketides

McDaniel, R. N., Ebert‐Khosla, S., Hopwood, D. A., & Khosla, C. (1993) · Science · doi:10.1126/science.8248802 · Cited by 472

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

Schwecke, T., Aparicio, J. F., Molnár, I., König, A., Khaw, L. E., Haydock, S. F., Oliynyk, M., Caffrey, P., Cortés, J., & Lester, J. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7839 · Cited by 445

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host

Malpartida, F., & Hopwood, D. A. (1984) · Nature · doi:10.1038/309462a0 · Cited by 401

POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics

Katz, L., & Donadio, S. (1993) · Annual Review of Microbiology · doi:10.1146/annurev.mi.47.100193.004303 · Cited by 371

The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of streptomyces

Fernández-Moreno, M. A., Caballero, J., Hopwood, D. A., & Malpartida, F. (1991) · Cell · doi:10.1016/0092-8674(91)90120-n · Cited by 361

Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host. 1984.

Malpartida, F., & Hopwood, D. A. (1992) · PubMed · Cited by 360

Genetics and Molecular Biology of Industrial Microorganisms

Hershberger, C. L., Queener, S. W., & Hegeman, G. D. (1989) · Cited by 328

The multifunctional 6‐methylsalicylic acid synthase gene of Penicillium patulum: Its gene structure relative to that of other polyketide synthases

BECK, J., RIPKA, S., SIEGNER, A., SCHILTZ, E., & SCHWEIZER, E. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19252.x · Cited by 302

Biological, Biochemical, and Biomedical Aspects of Actinomycetes

(1984) · Elsevier eBooks · doi:10.1016/c2013-0-11265-2 · Cited by 288

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

McDaniel, R., Ebert-Khosla, S., Hopwood, D. A., & Khosla, C. (1995) · Nature · doi:10.1038/375549a0 · Cited by 283

Repositioning of a Domain in a Modular Polyketide Synthase to Promote Specific Chain Cleavage

Cortés, J., Wiesmann, K. E. H., Roberts, G. A., Brown, M. J. B., Staunton, J., & Leadlay, P. F. (1995) · Science · doi:10.1126/science.7770773 · Cited by 251

POLYKETIDE SYNTHASE GENE MANIPULATION: A Structure-Function Approach in Engineering Novel Antibiotics

Hutchinson, C. R., & Fujii, I. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.001221 · Cited by 241

Evidence that stilbene synthases have developed from chalcone synthases several times in the course of evolution

Tropf, S., Lanz, T., Rensing, S. A., Schr�der, J., & Schr�der, G. (1994) · Journal of Molecular Evolution · doi:10.1007/bf00175881 · Cited by 234

Structural analysis of PKS1, a polyketide synthase gene involved in melanin biosynthesis in Colletotrichum lagenarium

Takano, Y., Kubo, Y., Shimizu, K., Mise, K., Okuno, T., & Furusawa, I. (1995) · Molecular and General Genetics MGG · doi:10.1007/bf00290362 · Cited by 231

Cloning of antibiotic resistance and nutritional genes in streptomycetes

Thompson, C. J., Ward, J. M., & Hopwood, D. A. (1982) · Journal of Bacteriology · doi:10.1128/jb.151.2.668-677.1982 · Cited by 230

Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

Sherman, D. H., Malpartida, F., Bibb, M. J., Kieser, H. M., Bibb, M. J., & Hopwood, D. A. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08413.x · Cited by 230

Engineered Biosynthesis of a Complete Macrolactone in a Heterologous Host

Kao, C. M., Katz, L., & Khosla, C. (1994) · Science · doi:10.1126/science.8036492 · Cited by 229

Industrial Microorganisms : Basic and Applied Molecular Genetics

Baltz, R. H., Hegeman, G. D., & Skatrud, P. L. (1993) · Cited by 225

Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.

Fernández-Moreno, M. A., Martínez, E., Boto, L., Hopwood, D. A., & Malpartida, F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41772-3 · Cited by 225

Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternata

Kimura, N., & Tsuge, T. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.14.4427-4435.1993 · Cited by 216

Structural, enzymatic, and genetic studies of beta-ketoacyl-acyl carrier protein synthases I and II of Escherichia coli.

Garwin, J. L., Klages, A. L., & Cronan, J. E. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70226-9 · Cited by 207

The developmentally regulated Aspergillus nidulans wA gene encodes a polypeptide homologous to polyketide and fatty acid synthases

Mayorga, M. E., & Timberlake, W. E. (1992) · Molecular and General Genetics MGG · doi:10.1007/bf00279362 · Cited by 203

Genetics of Actinorhodin Biosynthesis by Streptomyces coelicolor A3(2)

RUDD, B. A. M., & HOPWOOD, D. A. (1979) · Journal of General Microbiology · doi:10.1099/00221287-114-1-35 · Cited by 198

The Streptomyces plasmid SCP2∗: its functional analysis and development into useful cloning vectors

Lydiate, D. J., Malpartida, F., & Hopwood, D. A. (1985) · Gene · doi:10.1016/0378-1119(85)90001-0 · Cited by 196

Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered.

Chater, K. F., & Bruton, C. J. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03866.x · Cited by 189

An erythromycin analog produced by reprogramming of polyketide synthesis.

Donadio, S., McAlpine, J. B., Sheldon, P. J., JACKSON, M., & Katz, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.7119 · Cited by 188

Physical and genetic characterisation of the gene cluster for the antibiotic actinorhodin inStreptomyces coelicolor A3(2)

Malpartida, F., & Hopwood, D. A. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf02428033 · Cited by 186

A hybrid modular polyketide synthase obtained by domain swapping

Oliynyk, M., Brown, M. J. B., Cortés, J., Staunton, J., & Leadlay, P. F. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90069-1 · Cited by 184

Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

MacNeil, D. J., Occi, J. L., Gewain, K. M., MacNeil, T., Gibbons, P. H., Ruby, C. L., & Danis, S. J. (1992) · Gene · doi:10.1016/0378-1119(92)90549-5 · Cited by 181

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor

Hallam, S. E., Malpartida, F., & Hopwood, D. A. (1988) · Gene · doi:10.1016/0378-1119(88)90165-5 · Cited by 177

Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase

Kao, C. M., Luo, G., Katz, L., Cane, D. E., & Khosla, C. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00140a043 · Cited by 167

Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase

Marsden, A. F. A., Caffrey, P., Aparicio, J. F., Loughran, M. S., Staunton, J., & Leadlay, P. F. (1994) · Science · doi:10.1126/science.8278811 · Cited by 165

Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.

Amy, C. M., Witkowski, A., Naggert, J., Williams, B., Randhawa, Z., & Smith, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3114 · Cited by 161

Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases

Haydock, S. F., Dowson, J. A., Dhillon, N., Roberts, G. A., Cortés, J., & Leadlay, P. F. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00290659 · Cited by 157

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.

McDaniel, R. N., Ebert‐Khosla, S., Fu, H., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11542 · Cited by 154

β-ketoacyl-ACP synthase I of Escherichia coli: Nucleotide sequence of thefabB gene and identification of the cerulenin binding residue

Kauppinen, S., Siggaard-Andersen, M., & von Wettstein‐Knowles, P. (1988) · Carlsberg Research Communications · doi:10.1007/bf02983311 · Cited by 148

The polyketide metabolites

(1992) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(92)90302-7 · Cited by 146

TheAspergillus parasiticus polyketide synthase genepksA, a homolog ofAspergillus nidulans wA, is required for aflatoxin B1 biosynthesis

Chang, P., Cary, J. W., Yu, J., Bhatnagar, D., & Cleveland, T. E. (1995) · Molecular and General Genetics MGG · doi:10.1007/bf02191593 · Cited by 138

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin‐producing polyketide synthase from Saccharopolyspora erythraea

Caffrey, P., Bevitt, D. J., Staunton, J., & Leadlay, P. F. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80624-p · Cited by 138

The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains

Schweizer, M., Roberts, L. M., Höltke, H.-J., Takabayashi, K., Höllerer, E., Hoffmann, B., Muller, G. H., Köttig, H., & Schweizer, E. (1986) · Molecular and General Genetics MGG · doi:10.1007/bf00422073 · Cited by 127

Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens.

Motamedi, H., & Hutchinson, C. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.13.4445 · Cited by 126

Genetic Engineering of Microorganisms for Chemicals

Hollaender, A., Demoss, R. D., Kaplan, S., Konisky, J., Savage, D. C., & WOLFE, R. S. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4142-0 · Cited by 125

Evidence for a double-helical structure for modular polyketide synthases

Staunton, J., Caffrey, P., Aparicio, J. F., Roberts, G. A., Saalau-Bethell, S. M., & Leadlay, P. F. (1996) · Nature Structural Biology · doi:10.1038/nsb0296-188 · Cited by 122

Primary structure of the multifunctional alpha subunit protein of yeast fatty acid synthase derived from FAS2 gene sequence.

Mohamed, A. H., Chirala, S. S., Mody, N. H., Huang, W.-M., & Wakil, S. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37757-3 · Cited by 121

Properties of Streptomyces fradiae Mutants Blocked in Biosynthesis of the Macrolide Antibiotic Tylosin

Baltz, R. H., & Seno, E. T. (1981) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.20.2.214 · Cited by 121

Production of a novel polyketide through the construction of a hybrid polyketide synthase

Kuhstoss, S. A., Huber, M., Turner, J. R., Paschal, J. W., & Rao, R. N. (1996) · Gene · doi:10.1016/s0378-1119(96)00565-3 · Cited by 112

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

Pieper, R., Luo, G., Cane, D. E., & Khosla, C. (1995) · Nature · doi:10.1038/378263a0 · Cited by 111

Generation of polyketide libraries via combinatorial biosynthesis

Khosla, C., & Zawada, R. J. X. (1996) · Trends in biotechnology · doi:10.1016/0167-7799(96)10046-9 · Cited by 111

N-methyl transferase of Streptomyces erythraeus that confers resistance to the macrolidelincosamide-streptogramin B antibiotics: amino acid sequence and its homology to cognate R-factor enzymes from pathogenic bacilli and cocci

Uchiyama, H., & Weisblum, B. (1985) · Gene · doi:10.1016/0378-1119(85)90208-2 · Cited by 107

Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)

Bedford, D. J., Schweizer, E., Hopwood, D. A., & Khosla, C. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.15.4544-4548.1995 · Cited by 104

Organisation and functions of the actV A region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor

Caballero, J. L., Martinez, E., Malpartida, F., et al. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00280297 · Cited by 100

Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively

McDaniel, R. N., Ebert‐Khosla, S., Hopwood, D. A., et al. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00103a001 · Cited by 100

Characterization of the polyketide synthase gene (pksL1) required for aflatoxin biosynthesis in Aspergillus parasiticus

Feng, G. H., & Leonard, T. J. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.21.6246-6254.1995 · Cited by 100

Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase

Summers, R. G., Wendt-Pienkowski, E., Motamedi, H., & Hutchinson, C. R. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.6.1810-1820.1992 · Cited by 99

Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant

Revill, W. P., Bibb, M. J., & Hopwood, D. A. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.14.3946-3952.1995 · Cited by 98

DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2).

Fernández‐Moreno, M. Á., Martínez, E., Caballero, J. L., Ichinose, K., Hopwood, D. A., & Malpartida, F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31469-2 · Cited by 97

Fatty acid synthase — an example of protein evolution by gene fusion

McCarthy, A. D., & Hardie, D. G. (1984) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(84)90184-1 · Cited by 95

Production of a hybrid macrolide antibiotic in Streptomyces ambofaciens and Streptomyces lividans by introduction of a cloned carbomycin biosynthetic gene from Streptomyces thermotolerans

Epp, J. K., Huber, M. L. B., Turner, J. R., Goodson, T. G., III, & Schoner, B. E. (1989) · Gene · doi:10.1016/0378-1119(89)90421-6 · Cited by 95

Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase

Kao, C. M., Luo, G., Katz, L., Cane, D. E., & Khosla, C. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00104a069 · Cited by 93

Polyketide synthesis in vitro on a modular polyketide synthase

Wiesmann, K. E. H., Cortés, J., Brown, M. J. B., Cutter, A. L., Staunton, J., & Leadlay, P. F. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90122-1 · Cited by 86

Polyketide synthase com plexes: their structure and function in antibiotic biosynthesis

Robinson, J. A. (1991) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1991.0038 · Cited by 84

Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase

Kao, C. M., Luo, G., Katz, L., Cane, D. E., & Khosla, C. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9617552 · Cited by 81

Molecular cloning of resistance genes and architecture of a linked gene cluster involved in biosynthesis of oxytetracycline by Streptomyces rimosus

Butler, M. J., Friend, E. J., Hunter, I. S., Kaczmarek, F. S., Sugden, D. A., & Warren, M. (1989) · Molecular and General Genetics MGG · doi:10.1007/bf00339722 · Cited by 76

Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA

Schweizer, M., Takabayashi, K., Laux, T., Beck, K., & Schreglmann, R. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.2.567 · Cited by 75

Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein

Khosla, C., Ebert‐Khosla, S., & Hopwood, D. A. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb01778.x · Cited by 74

Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli

Paulus, T. J., Tuan, J. S., Luebke, V. E., Maine, G. T., DeWitt, J. P., & Katz, L. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.5.2541-2546.1990 · Cited by 68

Biosynthesis of polyketide metabolites

O’Hagan, D. (1992) · Natural Product Reports · doi:10.1039/np9920900447 · Cited by 63

Organization and regulation of genes encoding biosynthetic enzymes in Bacillus subtilis.

Zalkin, H., & Ebbole, D. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77917-4 · Cited by 61

Biosynthesis of actinorhodin. Determination of the point of dimerization

Gorst‐Allman, C. P., Rudd, B. A. M., Chang, C., et al. (1981) · The Journal of Organic Chemistry · doi:10.1021/jo00315a046 · Cited by 61

Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus

Yu, T. W., Bibb, M. J., Revill, W. P., & Hopwood, D. A. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.9.2627-2634.1994 · Cited by 60

Repeated polyketide synthase modules involved in the biosynthesis of a heptaene macrolide by Streptomyces sp. FR‐008

Hu, Z., Bao, K., Zhou, X., Zhou, Q., Hopwood, D. A., Kieser, T., & Deng, Z. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01276.x · Cited by 58

Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates

Pieper, R., Ebert‐Khosla, S., Cane, D. E., & Khosla, C. (1996) · Biochemistry · doi:10.1021/bi952860b · Cited by 58

Cloning, sequencing and characterization of a fatty acid synthase-encoding gene from Mycobacterium tuberculosis var. bovis BCG

Fernandes, N. D., & Kolattukudy, P. E. (1996) · Gene · doi:10.1016/0378-1119(95)00842-x · Cited by 47

Analysis of a polyketide synthesis-encoding gene cluster of Streptomyces curacoi

Bergh, S., & Uhlén, M. (1992) · Gene · doi:10.1016/0378-1119(92)90501-f · Cited by 44

Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents

Blanco, G., Fu, H., Méndez, C., Khosla, C., & Salas, J. A. (1996) · Chemistry & Biology · doi:10.1016/s1074-5521(96)90262-8 · Cited by 42

Comparison of multicyclic polyketides by folding analysis: a novel approach to recognize biosynthetic and/or evolutionary interrelationships of the natural products or intermediates and its exemplification on hepta-, octa-, and decaketides

Rohr, J. (1992) · The Journal of Organic Chemistry · doi:10.1021/jo00045a040 · Cited by 23

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847

Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)

Bentley, S. D., Chater, K. F., Cerdeño-Tárraga, A.-M., Challis, G. L., Thomson, N. R., James, K. D., Harris, D. E., Quail, M. A., Kieser, H., Harper, D., et al. (2002) · Nature · doi:10.1038/417141a · Cited by 3,233

Polyketide biosynthesis: a millennium review

Staunton, J., & Weissman, K. J. (2001) · Natural Product Reports · doi:10.1039/a909079g · Cited by 1,641

The influence of natural products upon drug discovery (Antiquity to late 1999)

Newman, D. J., Cragg, G. M., & Snader, K. M. (2000) · Natural Product Reports · doi:10.1039/a902202c · Cited by 1,293

Pathogenic fungus harbours endosymbiotic bacteria for toxin production

Partida-Martinez, L. P., & Hertweck, C. (2005) · Nature · doi:10.1038/nature03997 · Cited by 677