The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Determinants of Fetal Exposure to Polyfluoroalkyl Compounds in Baltimore, Maryland
Abstract
Polyfluoroalkyl compounds (PFCs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), are ubiquitous, man-made chemicals. Human data suggest that in utero exposures to these chemicals occur and some evidence of developmental toxicity in animals exists. To assess the distribution and determinants of fetal exposure to PFCs, we analyzed cord serum samples from 299 singleton newborns delivered between 2004 and 2005 in Baltimore, MD for 10 PFCs by employing on-line solid-phase extraction coupled with reversed-phase high-performance liquid chromatography-tandem mass spectrometry. PFOS and PFOA were detected in 99 and 100% of umbilical cord sera, with geometric mean concentrations of 4.9 and 1.6 ng/mL, respectively. PFOS and PFOA concentrations were highly correlated (Pearson's r = 0.64 after natural log transformation, p < 0.01). Eight other PFCs were detected less frequently and at lower concentrations than PFOS and PFOA. Geometric mean concentrations of PFOS for Asians (6.0 ng/mL) and Blacks (5.1 ng/mL) were higher than those for Whites (4.2 ng/mL), while PFOA levels were more evenly distributed by race. Other maternal demographic and socioeconomic characteristics, including age, education, marital status, and living in the city limits were not significantly associated with cord concentrations. Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD.
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Cites
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Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
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The Developmental Toxicity of Perfluoroalkyl Acids and Their Derivatives
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The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742
Subchronic Toxicity Studies on Perfluorooctanesulfonate Potassium Salt in Cynomolgus Monkeys
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Neuroendocrine Effects of Perfluorooctane Sulfonate in Rats
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Significant Residual Fluorinated Alcohols Present in Various Fluorinated Materials
Dinglasan-Panlilio, M. J. A., & Mabury, S. A. (2006) · Environmental Science & Technology · doi:10.1021/es051619+ · Cited by 243
Covalent binding of perfluorinated fatty acids to proteins in the plasma, liver and testes of rats
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Cited by
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Risk to human health related to the presence of perfluoroalkyl substances in food
Panel), E. P. O. C. I. T. F. C. (. C., Schrenk, D., Bignami, M., Bodin, L., Chipman, J. K., del Mazo, J., Grasl‐Kraupp, B., Hogstrand, C., Hoogenboom, L. (., Leblanc, J., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6223 · Cited by 989
Prenatal Phenol and Phthalate Exposures and Birth Outcomes
Wolff, M. S., Engel, S. M., Berkowitz, G. S., Ye, X., Silva, M. J., Zhu, C., Wetmur, J., & Calafat, A. M. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11007 · Cited by 580
Self-citationNelson, J. W., Hatch, E. E., & Webster, T. F. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901165 · Cited by 538
Johnson, P. I., Sutton, P., Atchley, D. S., Koustas, E., Lam, J., Sen, S., Robinson, K. A., Axelrad, D. A., & Woodruff, T. J. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307893 · Cited by 449
“Study PFOA increase PFOA range (ng/mL) Covariates Apelberg et al. 2007 ln ng/mL 0.3–7.1 ga Apelberg et al. 2007 ln ng/mL 0.3–7.1 ga, ma, bmi, race, par, smk, sex, ht, wtg, dia, hyp Apelberg et al. 2007 25th to 75th percentile 1.2–2.1 ga Apelberg et al. 2007 25th to 75th percentile 1.2–2.1 ga, ma, bmi, race, par, smk,…”
BackgroundMethodInfluential
Metadata
- Authors
- Apelberg, B. J., Goldman, L. R., Calafat, A. M., Herbstman, J. B., Kuklenyik, Z., Heidler, J., Needham, L. L., Halden, R. U., & Witter, F. R.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-04-20
- Volume
- 41
- Issue
- 11
- Pages
- 3891-3897
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2010699098
- Cited by
- 222
- References
- 10
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
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