Total synthesis of qinghaosu

Cited by (327)

Items 101–200 of 327

1. Qinghaosu (Artemisinin) as an Antimalarial Drug
   P. I. Trigg · 1989 · Elsevier eBooks
2. Antioxidant and Anticancer Activities of Artemisia annua L. and Determination of Functional Compounds
   류지현, Soo-Jung Lee, 김미주 · 2011 · Journal of the Korean Society of Food Science and Nutrition
3. In vitro Evaluation of Hydroxyl and Nitric Oxide Radical Scavenging Activities of Artemether
   B. M. Olabinr, O. O. Odedire, Mary Tolulope Olaleye · 2010 · Research Journal of Biological Sciences
4. Progress in the research of artemisinin and its analogues as antimalarials: an update
   Dharmarajan Sriram, Vajja Sambasiva Rao, Kondapalli Venkata Gowri Chandra Sekhar, Perumal Yogeeswari · 2004 · Natural Product Research
5. Artemisiaannua: Botany, Horticulture, Pharmacology
   Jorge Ferreira, James Edward Simon, Jules Janick · 1996 · Horticultural reviews
6. Quantification of artemisinin in Artemisia annua extracts by 1H‐NMR
   Paula C. Castilho, Sandra C. Gouveia, Ana Isabel Rodrigues · 2008 · Phytochemical Analysis
7. Synthetic Strategies for Peroxide Ring Construction in Artemisinin
   Виль Вера Андреевна, Ivan Andreevich Yaremenko, Alexey Igorevich Ilovaisky, Alexander Olegovich Terent'ev · 2017 · Molecules
8. Total Synthesis and Biological Investigation of (−)‐Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific
   Johannes Krieger, Toni Smeilus, Marcel Kaiser, Ean‐Jeong Seo, Thomas Efferth, Athanassios Giannis · 2018 · Angewandte Chemie International Edition
9. Total synthesis of (+)-Yingzhaosu A
   Xingxiang Xu, Jie Zhu, Huang Da-Zhong, Wei‐Shan Zhou · 1991 · Tetrahedron Letters
10. An efficient synthesis of qinghaosu and deoxoginghaosu from arteannuic acid
    Ye, Bin, Wu, Yu-Lin · 1990 · Journal of the Chemical Society, Chemical Communications
11. Singlet Oxygen: Discovery, Chemistry, C 60 ‐Sensitization †
    Michael Orfanopoulos · 2021 · Photochemistry and Photobiology
12. Abschätzung der konfigurativen Stabilität chiraler Organometallreagentien
    Reinhard W. Hoffmann, Joachim W. Lanz, Rainer E. Metternich · 1987 · Angewandte Chemie
13. In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum
    Sonja Maerki · 2006 · Journal of Antimicrobial Chemotherapy
14. A Hydrogen Peroxide Based Access to Qinghaosu (Artemisinin)
    Hong‐Dong Hao, Yun Li, Wei‐Bo Han, Yikang Wu · 2011 · Organic Letters
15. Experimental Determination and Correlation of Artemisinin's Solubility in Supercritical Carbon Dioxide
    Patrícia Coimbra, Miguel R. Blanco, Hélio S. R. Costa Silva · 2006 · Journal of Chemical & Engineering Data
16. Potent Antimalarial 1,2,4‐Trioxanes through Perhydrolysis of Epoxides
    Hong‐Dong Hao, Sergio Wittlin, Yikang Wu · 2013 · Chemistry - A European Journal
17. An efficient partial synthesis of (+)-artemisinin and (+)-deoxoartemisinin
    Peter T. Lansbury, Deanne M. Nowak · 1992 · Tetrahedron Letters
18. Production of artemisinin by shoot cultures of Artemisia annua L. in a modified inner-loop mist bioreactor
    Chunzhao Liu, Yuchun Wang, Chen Guo, Fan Ouyang, Hechun Ye, Guofeng Li · 1998 · Plant Science
19. Cadinanes from Artemisia annua that may be intermediates in the biosynthesis of artemisinin
    Geoffrey D. Brown · 1994 · Phytochemistry
20. Biosynthesis of artemisinic acid in Artemisia annua
    Anand Akhila, Kumkum Rani, Raghunath Singh Thakur · 1990 · Phytochemistry
21. Recovery of Artemisinin from a Complex Reaction Mixture Using Continuous Chromatography and Crystallization
    Zoltán Horváth, Elena Horosanskaia, Ju Weon Lee, Heike Lorenz, Kerry M. Gilmore, Peter H. Seeberger, Andreas Seidel‐Morgenstern · 2015 · Organic Process Research & Development
22. Synthesis of (+)-8a,9-secoartemisinin and related analogs
    Mitchell A. Avery, Wesley K. M. Chong, George Detre · 1990 · Tetrahedron Letters
23. Apoptosis-induced effects of extract from Artemisia annua Linné by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells
    Eun Ji Kim, Guen Tae Kim, Bo Min Kim, Eun Gyeong Lim, Sang-Yong Kim, Young Min Kim · 2017 · BMC Complementary and Alternative Medicine
24. Phytochemical licochalcone A enhances antimalarial activity of artemisinin in vitro
    Lokesh Chandra Mishra, Amit Bhattacharya, Virendra K. Bhasin · 2008 · Acta Tropica
25. The pharmaceutical death-ride of dihydroartemisinin
    Frans Herwig Jansen · 2010 · Malaria Journal
26. Hepatic metabolism of artemisinin drugs—I. Drug metabolism in rat liver microsomes
    Vladimir Leskovac, Anthony D. Theoharides · 1991 · Comparative Biochemistry and Physiology Part C Comparative Pharmacology
27. Stereodivergente enantioselektive Synthese durch Nutzung ungewöhnlich großer kinetischer H/D‐Isotopeneffekte bei der Deprotonierung
    Dieter Hoppe, Mario Paetow, Folker Hintze · 1993 · Angewandte Chemie
28. The discovery of Qinghaosu (artemisinin) as an effective anti-malaria drug: A unique China story
    Zengyi Chang · 2015 · Science China Life Sciences
29. Use of Gamma Radiation Techniques in Peaceful Applications
    Basim A. Almayah · 2019 · IntechOpen eBooks
30. In Vitro Micropropagation and Flowering in Artemisia annua
    Anamika Gulati, Shalini Bharel, Swatantra Kumar Jain, Malik Zainul Abdin, P. S. Srivastava · 1996 · Journal of Plant Biochemistry and Biotechnology
31. Synthesis and structure-activity relationships of peroxidic antimalarials based on artemisinin
    Mitchell A. Avery, Maria Alvim‐Gaston, John R. Woolfrey · 1999 · Advances in medicinal chemistry
32. Advances in the Chemical Synthesis of Artemisinin
    Wang, Zhonglei, Yang, Liyan, Yang, Xiuwei, Zhang, Xiaohua · 2014 · Synthetic Communications
33. An artemisinic acid analogue from Tithonia diversifolia
    Manobjyoti Bordoloi, Nabin Chandra Barua, Anil C. Ghosh · 1996 · Phytochemistry
34. Effect of irradiated sodium alginate and phosphorus on biomass and artemisinin production in Artemisia annua
    Tariq Aftab, M. Masroor A. Khan, Muhammad Naeem, Mohd. Idrees, Tariq Omar Siddiqi, Moinuddin Moinuddin, Lalit Varshney · 2014 · Carbohydrate Polymers
35. Chemistry of artemisinin: an overview
    H. Kyle Webster, Erich K. Lehnert · 1994 · Transactions of the Royal Society of Tropical Medicine and Hygiene
36. Perspectives for Globalized Natural Medicines
    Thomas Efferth · 2011 · Chinese Journal of Natural Medicines
37. Solubility of Artemisinin in Ethanol + Water from (278.2 to 343.2) K
    Longhu Wang, Yanting Song, Yong Chen · 2007 · Journal of Chemical & Engineering Data
38. Peroxidic Antimalarials
    Charles W. Jefford · 1997 · Advances in Drug Research
39. Synthesis of tricyclic arteannuin-like compounds
    Charles W. Jefford, Javier Velarde, Gérald H. Bernardinelli · 1989 · Tetrahedron Letters
40. Earlier Flowering Induced by Over‐Expression of CO Gene Does Not Accompany Increase of Artemisinin Biosynthesis in Artemisia annua
    H. Wang, Ying‐Gao Liu, Kang Chong · 2007 · Plant Biology
41. A brief overview of classical natural product drug synthesis and bioactivity
    Gen Li, Mingliang Lou, Xiangbing Qi · 2021 · Organic Chemistry Frontiers
42. The stereochemistry of the vinylogous Peterson elimination
    Ian Fleming, Ian T. Morgan, Achintya Kumar Sarkar · 1998 · Journal of the Chemical Society Perkin Transactions 1
43. Artemisinin — an innovative cornerstone for anti-malaria therapy
    Kuhn Thomas, Wang Ying · 2008 · Birkhäuser Basel eBooks
44. Antimalarial Natural Products
    David G. I. Kingston, María B. Cassera · 2022 · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products
45. Analysis of artemisinin by a packed-column supercritical fluid chromatography-atmospheric pressure chemical ionisation mass spectrometry technique
    Kenan Dost, G. Davidson · 2003 · The Analyst
46. The relative stereochemistry of some α-methyl-β-silylcarbonyl compounds produced by the diastereoselective alkylation of β-silylenolates
    Werner R. Bernhard, Ian Fleming · 1984 · Journal of Organometallic Chemistry
47. A combination of ultrasonic‐assisted extraction with RRLC‐QQQ method for the determination of artemisinin in the Chinese herb Artemisia annua L.
    Xiao Wang, Xian‐En Zhao, Bin Yang · 2011 · Phytochemical Analysis
48. Tricyclic analogues of artemisinin: synthesis and antimalarial activity of (+)-4,5-secoartemisinin and (–)-5-nor-4,5-secoartemisinin
    Mitchell A. Avery, Wesley K. M. Chong, James E. Bupp · 1990 · Journal of the Chemical Society Chemical Communications
49. Preparative UV-VIS laser photochemistry; molecular oxygen trapping of the Paterno-Büchi triplet diradicals derived from 1,4-dioxene.
    Waldemar Adam, Ulrike Kliem, Vittorio Lucchini · 1986 · Tetrahedron Letters
50. Novel Endoperoxide Antimalarials: Synthesis, Heme Binding, and Antimalarial Activity
    Dennis K. Taylor, Thomas D. Avery, Ben W. Greatrex, Edward R. T. Tiekink, Ian George Macreadie, Peter Ian Macreadie, Adam D. Humphries, Martha Kalkanidis, Emma Fox, Nectarios Klonis et al. · 2004 · Journal of Medicinal Chemistry
51. Exploring Chemical Reaction Space with Machine Learning Models: Representation and Feature Perspective
    Yuheng Ding, Bo Qiang, Qixuan Chen, Yiqiao Liu, Liangren Zhang, Zhenming Liu · 2024 · Journal of Chemical Information and Modeling
52. Response surface methodology to supercritical fluids extraction of artemisinin and the effects on rat hepatic stellate cell in vitro
    Young-Lung Lin, Chih-Chiang Yang, Hoang-Kao Hsu · 2006 · The Journal of Supercritical Fluids
53. A facile and scalable synthesis of qinghaosu (artemisinin)
    Hui-Jun Chen, Wei‐Bo Han, Hong‐Dong Hao, Yikang Wu · 2012 · Tetrahedron
54. Expanding the Therapeutic Spectrum of Artemisinin: Activity Against Infectious Diseases Beyond Malaria and Novel Pharmaceutical Developments
    Thomas Efferth, Marta R. Romero, Anna Rita Bilia, Ahmed Galal Osman, Mahmoud A. ElSohly, Michaël Wink, Rudolf Bauer, Ikhlas Ahmed Khan, Maria Camilla Bergonzi, José J.G. Marı́n · 2016 · World Journal of Traditional Chinese Medicine
55. Mechanistic and Synthetic Studies on the Formation of 1,2,4‐Trioxanes Related to Arteannuin. Photooxygenation of a bicyclic dihydropyran
    Charles W. Jefford, Ying Wang, Gérald Bernardinelli · 1988 · Helvetica Chimica Acta
56. Biopiracy versus One-World Medicine–From colonial relicts to global collaborative concepts
    Thomas Efferth, Mita Banerjee, Mohammad Sanad Abu-Darwish, Sara Abdelfatah, Madeleine Böckers, Dipita Bhakta-Guha, Vanderlan da Silva Bolzani, Salah Daak, Ömür L. Demirezer, Mona Dawood et al. · 2018 · Phytomedicine
57. An updated review on distribution, biosynthesis and pharmacological effects of artemisinin: A wonder drug
    Neelofer Nabi, Seema K. Singh, Peer Saffeullah · 2023 · Phytochemistry
58. A short conversion of cyclohexanones to cycloheptenones
    Shangjin Yang, Benno Hungerhoff, Peter Metz · 1998 · Tetrahedron Letters
59. Gomphostenins: two new antimalarial compounds from the leaves of Gomphostemma niveum.
    M. Sathe, M. P. Kaushik · 2010 · Bioorganic & Medicinal Chemistry Letters
60. Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin
    Jian‐Qiang Kong, Yan Yang, Wei Wang, Ke-Di Cheng, Ping Zhu · 2013 · RSC Advances
61. A convenient synthesis of substituted 1,2,4-trioxepanes via Co(II) catalyzed oxygenation of cinnamyl alcohol
    Chang Ho Oh, Ji Hye Kang · 1998 · Tetrahedron Letters
62. Artemisinin production strategies for industrial scale: Current progress and future directions
    Firdaus Qamar, Kudsiya Ashrafi, Anupam Singh, Prasanta Kumar Dash, Malik Zainul Abdin · 2024 · Industrial Crops and Products
63. Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha‐4,11‐diene
    Komori, Aya, Suzuki, Munenori, Seki, Hikaru, Nishizawa, Tomoko, Meyer, Jacobus Johannes Marion, Shimizu, Hideaki, Yokoyama, Shigeyuki, Muranaka, Toshiya · 2013 · FEBS Letters
64. Combating Malaria with Plant Molecules: A Brief Update
    Arvind Negi, Atul Gupta, A. Hamid · 2013 · Current Medicinal Chemistry
65. Syntheses of carba-analogues of qinghaosu
    Bin Ye, Yu‐Lin Wu · 1989 · Tetrahedron
66. High Peroxidase Activity In Cell Cultures of<i>Artemisia Annua</i>With Minute Artemisinin Contents
    Woerdenbag, Herman J., Pras, Niesko, Uden, Wim Van, Boer, Arno De, Batterman, Sieb, Visser, Jan F., Malingré, Theo M. · 1992 · Natural product letters
67. Preparative UV‐VIS laser photochemistry: Photocycloadditions of methylenelactones with benzophenone and <i>p</i>‐benzoquinone. Oxygen trapping of paterno‐Büchi triplet 1,4‐diradicals as model reactions for quinghaosu‐type 1,2,4‐trioxanes
    Adam, Waldemar, Kliem, Ulrike, Lucchini, Vittorio · 1988 · Liebigs Annalen der Chemie
68. New synthetic strategies towards (+)-artemisinin
    Bhonsle, Jayendra B., Pandey, Bipin, Deshpande, Vishnu H., Ravindranathan, T. · 1994 · Tetrahedron Letters
69. Reactions of Artemisinin and Arteether with Acid: Implications for Stability and Mode of Antimalarial Action
    Michael G. B. Drew, John Z. Metcalfe, Michael J. Dascombe, Fyaz M. D. Ismail · 2006 · Journal of Medicinal Chemistry
70. Artemisinin: An Endoperoxidic Antimalarial from Artemisia annua L.
    Herman Ziffer, Robert J. Highet, Daniel L. Klayman · 1997 · Springer eBooks
71. The improvement of amorpha-4,11-diene production by a yeast-conform variant
    Jiang-Qiang, K., Wei, W., Li-Na, W., Xiao-Dong, Z., Ke-Di, C., Ping, Z. · 2009 · Journal of Applied Microbiology
72. Recent advances in plant biotechnology and genetic engineering for production of secondary metabolites
    Y. V. Sheludko · 2010 · Cytology and Genetics
73. A New Reaction of 1,2‐Dioxetanes. Formation of 1,2,4‐Trioxanes from Aldehydes
    Charles W. Jefford, John Boukouvalas, Shigeo Kohmoto · 1983 · Helvetica Chimica Acta
74. Artemisinin: present status and perspectives
    Vikas Dhingra, K. Vishweshwar Rao, Mangamoori Lakshmi Narasu · 1999 · Biochemical Education
75. The Formation of Bridged Bicyclic 1,2,4‐Trioxanes by Intramolecular Capture of β‐Hydroperoxy Cations
    Charles W. Jefford, France Favarger, Serenella Ferro, Daniel Chambaz, Alain O. Bringhen, Gérald Bernardinelli, John Boukouvalas · 1986 · Helvetica Chimica Acta
76. Enantiomeric Isopulegol as the Chiral Pool in the Total Synthesis of Bioactive Agents
    Tam Minh Le, Zsolt Szakonyi · 2021 · The Chemical Record
77. A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu
    Ying Li, Yu‐Lin Wu · 2010 · Frontiers of Chemistry in China
78. Landscape and opportunities for active pharmaceutical ingredient manufacturing in developing African economies
    Darren Lyall Riley, Ian Strydom, Rachel Kerina Chikwamba, Jenny‐Lee Panayides · 2019 · Reaction Chemistry & Engineering
79. Building a golden triangle for the production and use of artemisinin derivatives against falciparum malaria in Africa
    Ebiamadon Andi Brisibe, Edak Aniedi Uyoh, Fraideh Brisibe, Pedro M. Magalhães · 2008 · AFRICAN JOURNAL OF BIOTECHNOLOGY
80. Extraction and high-performance liquid chromatographic methods for the γ-lactones parthenolide (Chrysanthemum parthenium Bernh.), marrubiin (Marrubium vulgare L.) and artemisinin (Artemisia annua L.)
    Jean-Pierre Rey, Joël Lévesque, Jean Louis Pousset · 1992 · Journal of Chromatography A
81. An unsuccessful approach to the framework of the antimalarial, arteether
    Falmai Binns, Timothy W. Wallace · 1989 · Tetrahedron Letters
82. Stereospecificity in the synthesis of allylsilanes from tertiary allylic acetates
    Ian Fleming, Nicholas Kenneth Terrett · 1983 · Tetrahedron Letters
83. The Oxidation of Alcohols by Modified Oxochromium( VI )–Amine Reagents
    Frederick A. Luzzio · 1998 · Organic reactions
84. Synthesis of 6,7-dehydroartemisinic acid
    Sy, Lai-King, Brown, Geoffrey D. · 2001 · Journal of the Chemical Society, Perkin Transactions 1
85. Design and De Novo Synthesis of 6-Aza-artemisinins
    Karunakar Reddy Bonepally, Takahisa Hiruma, Haruki Mizoguchi, Kyohei Ochiai, Shun Suzuki, Hideaki Oikawa, Aki Ishiyama, Rei Hokari, Masato Iwatsuki, Kazuhiko Otoguro et al. · 2018 · Organic Letters
86. Engineered Production of Bioactive Natural Products from Medicinal Plants
    Özkan Fidan, Jixun Zhan, Jie Ren · 2022 · World Journal of Traditional Chinese Medicine
87. Natural peroxides. Chemistry and biological activity
    Genrikh A. Tolstikov, Alexander G. Tolstikov, Olga V. Tolstikova · 1996 · Russian Chemical Reviews
88. Artemisinin and plant secondary metabolism
    Xiao‐Ya Chen, Zhihong Xu · 2016 · 中国科学通报：英文版
89. Skeletal and Stereochemical Diversification of Tricyclic Frameworks Inspired by Ca2+-ATPase Inhibitors, Artemisinin and Transtaganolide D
    Hiroki Oguri, Yutaka Yamagishi, Takahisa Hiruma, Hideaki Oikawa · 2008 · Organic Letters
90. Total Synthesis as a Vehicle for Collaboration
    Lucas A. Morrill, Robert B. Susick, Jason V. Chari, Neil K. Garg · 2019 · Journal of the American Chemical Society
91. Partial purification of proteins involved in the bioconversion of arteannuin B to artemisinin
    Dhingra, V · 2000 · Bioresource Technology
92. Longitudinal trend of global artemisinin research in chemistry subject areas (1983–2017)
    Wanqi Xu, Zhongmei Zou, Jin Pei, Linfang Huang · 2018 · Bioorganic & Medicinal Chemistry
93. Drugs for Treating Protozoan Infections
    Ruben Vardanyan, Victor J. Hruby · 2006 · Elsevier eBooks
94. Toward the production of artemisinin through tissue culture: Determining nutrient-hormone combinations suitable for cell suspension cultures
    Dominick V. Basile, Nasrin Akhtari, Yolanda Durand · 1993 · In Vitro Cellular & Developmental Biology - Plant
95. Recent Developments in Natural Product Inspired Synthetic 1,2,4-Trioxolanes (Ozonides): An Unusual Entry into Antimalarial Chemotherapy.
    Mohit K. Tiwari, D. Yadav, S. Chaudhary · 2019 · Current Topics in Medicinal Chemistry
96. The use of cyclic monoterpenoids as enantiopure starting materials in natural product synthesis
    Thomas Money, Michael Wong · 1995 · Studies in natural products chemistry
97. Enantioselective synthesis of functionalized 2-oxo-cyclohexane carbonitriles. Access to a trioxane analogue of artemisinin
    Mohamed Hamzaoui, Olivier Provot, Françoise Grégoire, Claude Riche, Angèle Chiaroni, Frédérick Gay, Henri Moskowitz, Joëlle Mayrargue · 1997 · Tetrahedron Asymmetry
98. An improved route to 1,2,4-trioxanes using tin(IV) as a hydrogen equivalent
    Jiaqiang Cai, Alwyn George Davies · 1992 · Journal of the Chemical Society Perkin Transactions 1
99. Rapid and Systematic Exploration of Chemical Space Relevant to Artemisinins: Anti-malarial Activities of Skeletally Diversified Tetracyclic Peroxides and 6-Aza-artemisinins
    Karunakar Reddy Bonepally, Norihito Takahashi, Naoya Matsuoka, Hikari Koi, Haruki Mizoguchi, Takahisa Hiruma, Kyohei Ochiai, Shun Suzuki, Yutaka Yamagishi, Hideaki Oikawa et al. · 2020 · The Journal of Organic Chemistry
100. Regioselective free radical phenylsulfenation of a non-activated δ-carbon atom by the photolysis of alkyl benzenesulfenate
     Goran R. Petrovic, Radomir N. Saičić, Živorad Čeković · 2003 · Tetrahedron