The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates
Open accessAbstract
Efficient drug delivery to tumors is of ever-increasing importance. Single-visit diagnosis and treatment sessions are the goal of future theranostics. In this work, a noncovalent PDT cancer drug-gold nanoparticle (Au NP) conjugate system performed a rapid drug release and deep penetration of the drug into tumors within hours. The drug delivery mechanism of the PDT drug through Au NPs into tumors by passive accumulation was investigated via fluorescence imaging, elemental analysis, and histological staining. The pharmacokinetics of the conjugates over a 7-day test period showed rapid drug excretion, as monitored via the fluorescence of the drug in urine. Moreover, the biodistribution of Au NPs in this study period indicated clearance of the NPs from the mice. This study suggests that noncovalent delivery via Au NPs provides an attractive approach for cancer drugs to penetrate deep into the center of tumors.
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Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Maeda, H. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00013-3 · Cited by 2,495
High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy
Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1456 · Cited by 2,222
Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications
Gao, J., Gu, H., & Xu, B. (2009) · Accounts of Chemical Research · doi:10.1021/ar9000026 · Cited by 1,907
Exploiting the enhanced permeability and retention effect for tumor targeting
Iyer, A. K., Khaled, G., Fang, J., & Maeda, H. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.07.005 · Cited by 1,846
Cited by
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Li, H.-J., Du, J.-Z., Liu, J., Du, X.-J., Shen, S., Zhu, Y.-H., Wang, X., Ye, X., Nie, S., & Wang, J. (2016) · ACS Nano · doi:10.1021/acsnano.6b02326 · Cited by 537
Ling, D., Park, W., Park, S.-J., Lu, Y., Kim, K. S., Hackett, M. J., Kim, B. H., Yim, H., Jeon, Y. S., Na, K., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4108287 · Cited by 517
Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy
Qian, C., Yu, J., Chen, Y., Hu, Q., Xiao, X., Sun, W., Wang, C., Feng, P., Shen, Q., & Gu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201505869 · Cited by 466
Advance in Photosensitizers and Light Delivery for Photodynamic Therapy
Yoon, I., Li, J. Z., & Shim, Y. K. (2013) · Clinical Endoscopy · doi:10.5946/ce.2013.46.1.7 · Cited by 425
Metadata
- Authors
- Cheng, Y., Meyers, J. D., Broome, A.-M., Kenney, M. E., Basilion, J. P., & Burda, C.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-04
- Volume
- 133
- Issue
- 8
- Pages
- 2583-2591
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2094449638
- Cited by
- 290
- References
- 7
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheng, Y., Meyers, J. D., Broome, A.-M., Kenney, M. E., Basilion, J. P., & Burda, C. (2011). Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates. Journal of the American Chemical Society. https://doi.org/10.1021/ja108846h
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