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Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design
Open accessAbstract
Unimolecular parallel-stranded G-quadruplex structures are found to be prevalent in gene promoters. The nuclease hypersensitivity element III(1) (NHE III(1)) of the c-MYC promoter can form transcriptionally active and silenced forms, and the formation of DNA G-quadruplex structures has been shown to be critical for c-MYC transcriptional silencing. The solution structure of a 2:1 quindoline-G-quadruplex complex has been solved and shows unexpected features, including the drug-induced reorientation of the flanking sequences to form a new binding pocket. While both 3' and 5' complexes show overall similar features, there are identifiable differences that emphasize the importance of both stacking and electronic interactions. For the first time, we describe the importance of the shape of the ligand as well as the two flanking bases in determining drug binding specificity. These structures provide important insights for the structure-based rational design of drugs that bind to unimolecular parallel G-quadruplexes commonly found in promoter elements.
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Cites
X-PLOR Version 3.1: A System for X-ray Crystallography and NMR
Brünger, A. T. (1992) · Medical Entomology and Zoology · Cited by 3,424
Siddiqui-Jain, A., Grand, C. L., Bearss, D. J., & Hurley, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182256799 · Cited by 2,238
Self-citationMolecular structure of a left-handed double helical DNA fragment at atomic resolution
Wang, A. H.-J., Quigley, G. J., Kolpak, F. J., Crawford, J. L., van Boom, J. H., van der Marel, G., & Rich, A. (1979) · Nature · doi:10.1038/282680a0 · Cited by 2,118
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.1 · Cited by 1,715
Eilers, M., & Eisenman, R. N. (2008) · Genes & Development · doi:10.1101/gad.1712408 · Cited by 927
Gene regulation by riboswitches
Mandal, M., & Breaker, R. R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1403 · Cited by 903
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Kumari, S., Bugaut, A., Huppert, J. L., & Balasubramanian, S. (2007) · Nature Chemical Biology · doi:10.1038/nchembio864 · Cited by 822
Marcu, K. B., Bossone, S. A., & Patel, A. J. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.004113 · Cited by 802
Ambrus, A., Chen, D., Dai, J., Jones, R. A., & Yang, D. (2005) · Biochemistry · doi:10.1021/bi048242p · Cited by 683
Self-citationTelomere maintenance as a target for anticancer drug discovery
Neidle, S., & Parkinson, G. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd793 · Cited by 624
Control of c-myc Regulation in Normal and Neoplastic Cells
(1991) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60476-5 · Cited by 618
Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
Drygin, D., Siddiqui-Jain, A., O'Brien, S., Schwaebe, M., Lin, A., Bliesath, J., Ho, C. B., Proffitt, C., Trent, K., Whitten, J. P., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1304 · Cited by 588
Targeting telomeres and telomerase
De Cian, A., Lacroix, L., Douarre, C., Temime-Smaali, N., Trentesaux, C., Riou, J.-F., & Mergny, J.-L. (2008) · Biochimie · doi:10.1016/j.biochi.2007.07.011 · Cited by 572
Dai, J., Carver, M., Punchihewa, C., Jones, R. A., & Yang, D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm522 · Cited by 551
Self-citationPhan, A. T., Kuryavyi, V., Gaw, H. Y., & Patel, D. J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio723 · Cited by 519
Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus
Shin-ya, K., Wierzba, K., Matsuo, K.-I., Ohtani, T., Yamada, Y., Furihata, K., Hayakawa, Y., & Seto, H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja005780q · Cited by 509
Propeller-Type Parallel-Stranded G-Quadruplexes in the Human c-myc Promoter
Phan, A. T., Modi, Y. S., & Patel, D. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048805k · Cited by 501
Qin, Y., & Hurley, L. H. (2008) · Biochimie · doi:10.1016/j.biochi.2008.02.020 · Cited by 450
Self-citationLazzeretti, P. (2000) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/s0079-6565(99)00021-7 · Cited by 439
The structures of quadruplex nucleic acids and their drug complexes
Neidle, S. (2009) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2009.04.001 · Cited by 433
Dai, J., Dexheimer, T. S., Chen, D., Carver, M., Ambrus, A., Jones, R. A., & Yang, D. (2006) · Journal of the American Chemical Society · doi:10.1021/ja055636a · Cited by 413
Self-citationSun, D., & Hurley, L. H. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900055s · Cited by 397
Self-citationThe Dynamic Character of the G-Quadruplex Element in the c-MYC Promoter and Modification by TMPyP4
Seenisamy, J., Rezler, E. M., Powell, T. J., Tye, D., Gokhale, V., Joshi, C. S., Siddiqui-Jain, A., & Hurley, L. H. (2004) · Journal of the American Chemical Society · doi:10.1021/ja040022b · Cited by 389
Self-citationG-quadruplex DNA: A target for drug design
Mergny, J.-L., & Hélène, C. (1998) · Nature Medicine · doi:10.1038/3949 · Cited by 384
NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region
Dai, J., Chen, D., Jones, R. A., Hurley, L. H., & Yang, D. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl610 · Cited by 373
Self-citationSpin-echo water suppression for the generation of pure-phase two-dimensional NMR spectra
Sklenář, V., & Bax, A. (1987) · Journal of Magnetic Resonance (1969) · doi:10.1016/0022-2364(87)90269-1 · Cited by 340
Han, F. X., Wheelhouse, R. T., & Hurley, L. H. (1999) · Journal of the American Chemical Society · doi:10.1021/ja984153m · Cited by 336
Self-citationStructural Basis of DNA Quadruplex Recognition by an Acridine Drug
Campbell, N. H., Parkinson, G. N., Reszka, A. P., & Neidle, S. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8016973 · Cited by 326
Structural Insights into G-Quadruplexes: Towards New Anticancer Drugs
Yang, D., & Okamoto, K. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.09.172 · Cited by 322
Self-citationIdentification and Characterization of Nucleolin as a c-myc G-quadruplex-binding Protein
González, V., Guo, K., Hurley, L., & Sun, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018028 · Cited by 321
Self-citationTargeting MYC Expression through G-Quadruplexes
Brooks, T. A., & Hurley, L. H. (2010) · Genes & Cancer · doi:10.1177/1947601910377493 · Cited by 301
Self-citationBrooks, T. A., & Hurley, L. H. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2733 · Cited by 294
Self-citationStabilization of G-Quadruplex DNA and Down-Regulation of Oncogene c-myc by Quindoline Derivatives
Ou, T.-M., Lu, Y.-J., Zhang, C., Huang, Z.-S., Wang, X.-D., Tan, J.-H., Chen, Y., Ma, D.-L., Wong, K.-Y., Tang, J. C.-O., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm0610088 · Cited by 288
De Armond, R., Wood, S., Sun, D., Hurley, L. H., & Ebbinghaus, S. W. (2005) · Biochemistry · doi:10.1021/bi051618u · Cited by 285
Self-citationStructure of a G-quadruplex–Ligand Complex
Haider, S. M., Parkinson, G. N., & Neidle, S. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01354-2 · Cited by 275
Contributions of Myc to tumorigenesis
Lutz, W., Leon, J., & Eilers, M. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00036-7 · Cited by 177
Zhou, J.-L., Lu, Y.-J., Ou, T.-M., Zhou, J.-M., Huang, Z.-S., Zhu, X.-F., Du, C.-J., Bu, X.-Z., Ma, L., Gu, L.-Q., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050041b · Cited by 175
Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation
Daniely, Y., Dimitrova, D. D., & Borowiec, J. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.6014-6022.2002 · Cited by 171
Prochownik, E. V., & Vogt, P. K. (2010) · Genes & Cancer · doi:10.1177/1947601910377494 · Cited by 155
Guyen, B., Schultes, C. M., Hazel, P., Mann, J., & Neidle, S. (2004) · Organic & Biomolecular Chemistry · doi:10.1039/b316055f · Cited by 107
Dexheimer, T. S., Carey, S. S., Song, Z., Gokhale, V. M., Hu, X., Murata, L. B., Maes, E. M., Weichsel, A., Sun, D., Meuillet, E. J., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1093 · Cited by 103
Self-citationTherapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors
Punchihewa, C., & Yang, D. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-879-9_11 · Cited by 15
Self-citation
Cited by
Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390
NMR spectroscopy of G-quadruplexes
Adrian, M., Heddi, B., & Phan, A. T. (2012) · Methods · doi:10.1016/j.ymeth.2012.05.003 · Cited by 330
Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
Calabrese, D. R., Chen, X., Leon, E. C., Gaikwad, S. M., Phyo, Z., Hewitt, W. M., Alden, S., Hilimire, T. A., He, F., Michalowski, A. M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06315-w · Cited by 172
Hu, M.-H., Wang, Y.-Q., Yu, Z.-Y., Hu, L.-N., Ou, T.-M., Chen, S.-B., Huang, Z.-S., & Tan, J.-H. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01697 · Cited by 101
Metadata
- Authors
- Dai, J., Carver, M., Hurley, L. H., & Yang, D.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-10-14
- Volume
- 133
- Issue
- 44
- Pages
- 17673-17680
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2043720815
- Cited by
- 381
- References
- 42
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
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