Myc’s broad reach
Open accessAbstract
The role of the myc gene family in the biology of normal and cancer cells has been intensively studied since the early 1980s. myc genes, responding to diverse external and internal signals, express transcription factors (c-, N-, and L-Myc) that heterodimerize with Max, bind DNA, and modulate expression of a specific set of target genes. Over the last few years, expression profiling, genomic binding studies, and genetic analyses in mammals and Drosophila have led to an expanded view of Myc function. This review is focused on two major aspects of Myc: the nature of the genes and pathways that are targeted by Myc, and the role of Myc in stem cell and cancer biology.
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G4s have been predominantly associated with the promoters of oncogenes such as MYC, KIT or KRAS, where their stabilization is associated with suppressed oncogene expression.
“While G4s have been predominantly associated with the promoters of oncogenes such as MYC, KIT or KRAS (23–25), where their stabilization is associated with suppressed oncogene expression”
From G-quadruplex-mediated genomic instability drives SNVs in cancer (2024) · cites this paper as [23]
The passages from “Transcriptional regulation by Myc” and “In and out of the E-box?” discuss Myc’s effects on gene expression and its binding to promoter sequences, but not G-quadruplexes. Searches for G4s in MYC, KIT, or KRAS promoters and for suppression of oncogene expression through G4 stabilization found no passage addressing the claim. (LLM, conf=0.75)
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- Authors
- Eilers, M., & Eisenman, R. N.
- Affiliations
- Fred Hutch Cancer Center (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-10-15
- Volume
- 22
- Issue
- 20
- Pages
- 2755-2766
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC2751281
- OpenAlex
- W2112738731
- Cited by
- 927
- References
- 6
- Citations by year
- 2026: 13 · 2025: 21 · 2024: 23 · 2023: 36 · 2022: 32 · 2021: 54 · 2020: 43 · 2019: 45 · 2018: 45 · 2017: 53 · 2016: 53 · 2015: 65 · 2014: 86 · 2013: 67 · 2012: 81
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Genes & Development (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL084205)
- National Cancer Institute (R01CA057138, R01CA57138, R01CA020525, R01-CA20525)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- c-Myc, MYCN, L-myc, transcriptional regulation, MYC target genes, stem cell biology, tumor biology, Drosophila, gene expression profiling
- MeSH terms
- Animals, Humans, Neoplasms, Neoplastic Stem Cells, Proto-Oncogene Proteins c-myc
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