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Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
Open accessAbstract
We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer.
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Cites
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104
Jain, P. K., Lee, K. S., El-Sayed, I. H., & El-Sayed, M. A. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp057170o · Cited by 4,603
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Strategies in the design of nanoparticles for therapeutic applications
Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651
Impact of Nanotechnology on Drug Delivery
Farokhzad, O. C., & Langer, R. (2009) · ACS Nano · doi:10.1021/nn900002m · Cited by 3,348
Self-citationDelivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,180
Biodegradable Long-Circulating Polymeric Nanospheres
Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V., Torchilin, V., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,920
Self-citationNanoparticle-mediated cellular response is size-dependent
Jiang, W., Kim, B. Y. S., Rutka, J. T., & Chan, W. C. W. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.30 · Cited by 2,776
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
Jain, R. K. (2001) · Nature Medicine · doi:10.1038/nm0901-987 · Cited by 2,184
Gradishar, W. J., Tjulandin, S., Davidson, N., Shaw, H., Desai, N., Bhar, P., Hawkins, M., & O'Shaughnessy, J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.937 · Cited by 2,153
(2016) · CRC Press eBooks · doi:10.1201/b12801 · Cited by 2,031
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,027
Gold nanostructures: engineering their plasmonic properties for biomedical applications
Hu, M., Chen, J., Li, Z.-Y., Au, L., Hartland, G. V., Li, X., Marquez, M., & Xia, Y. (2006) · Chemical Society Reviews · doi:10.1039/b517615h · Cited by 1,756
Force-induced activation of covalent bonds in mechanoresponsive polymeric materials
Davis, D. A., Hamilton, A., Yang, J., Cremar, L. D., Van Gough, D., Potisek, S. L., Ong, M. T., Braun, P. V., Martínez, T. J., White, S. R., et al. (2009) · Nature · doi:10.1038/nature07970 · Cited by 1,754
O’Brien, M. E. R., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., Catane, R., Kieback, D. G., Tomczak, P., Ackland, S. P., et al. (2004) · Annals of Oncology · doi:10.1093/annonc/mdh097 · Cited by 1,738
Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,711
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
Farokhzad, O. C., Cheng, J., Teply, B. A., Sherifi, I., Jon, S., Kantoff, P. W., Richie, J. P., & Langer, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601755103 · Cited by 1,663
Self-citationFreeze-drying of nanoparticles: Formulation, process and storage considerations
ABDELWAHED, W., DEGOBERT, G., STAINMESSE, S., & FESSI, H. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.017 · Cited by 1,611
Spiropyrans and Spirooxazines for Memories and Switches
Berkovic, G., Krongauz, V., & Weiss, V. (2000) · Chemical Reviews · doi:10.1021/cr9800715 · Cited by 1,588
Looking and listening to light: the evolution of whole-body photonic imaging
Ntziachristos, V., Ripoll, J., Wang, L. V., & Weissleder, R. (2005) · Nature Biotechnology · doi:10.1038/nbt1074 · Cited by 1,557
Mediating Tumor Targeting Efficiency of Nanoparticles Through Design
Perrault, S. D., Walkey, C., Jennings, T., Fischer, H. C., & Chan, W. C. W. (2009) · Nano Letters · doi:10.1021/nl900031y · Cited by 1,513
Three-Dimensional Optical Data Storage Using Photochromic Materials
Kawata, S., & Kawata, Y. (2000) · Chemical Reviews · doi:10.1021/cr980073p · Cited by 1,479
Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery
Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., & Farokhzad, O. C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.09.047 · Cited by 1,273
Self-citationPolymers for the sustained release of proteins and other macromolecules
LANGER, R., & FOLKMAN, J. (1976) · Nature · doi:10.1038/263797a0 · Cited by 1,182
Self-citationRole of extracellular matrix assembly in interstitial transport in solid tumors.
Netti, P. A., Berk, D. A., Swartz, M. A., Grodzinsky, A. J., & Jain, R. K. (2000) · PubMed · Cited by 1,165
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Wong, C., Stylianopoulos, T., Cui, J., Martin, J., Chauhan, V. P., Jiang, W., Popović, Z., Jain, R. K., Bawendi, M. G., & Fukumura, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018382108 · Cited by 1,062
Photo-, Thermo-, Solvato-, and Electrochromic Spiroheterocyclic Compounds
Minkin, V. I. (2004) · Chemical Reviews · doi:10.1021/cr020088u · Cited by 937
Yuan, F., Leunig, M., Huang, S. K., Berk, D. A., Papahadjopoulos, D., & Jain, R. K. (1994) · PubMed · Cited by 908
Ultrafast Dynamics of Photochromic Systems
Tamai, N., & Miyasaka, H. (2000) · Chemical Reviews · doi:10.1021/cr9800816 · Cited by 840
Responsive polymeric delivery systems
Kost, J., & Langer, R. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00136-8 · Cited by 747
Self-citationYuan, F., Chen, Y., Dellian, M., Safabakhsh, N., Ferrara, N., & Jain, R. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14765 · Cited by 719
Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.
Kong, G., Braun, R. D., & Dewhirst, M. W. (2000) · PubMed · Cited by 633
Remotely Triggerable Drug Delivery Systems
Timko, B. P., Dvir, T., & Kohane, D. S. (2010) · Advanced Materials · doi:10.1002/adma.201002072 · Cited by 614
Self-citationDiffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium
Ramanujan, S., Pluen, A., McKee, T. D., Brown, E. B., Boucher, Y., & Jain, R. K. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)73933-7 · Cited by 552
Spiropyran-Based Photochromic Polymer Nanoparticles with Optically Switchable Luminescence
Zhu, M.-Q., Zhu, L., Han, J. J., Wu, W., Hurst, J. K., & Li, A. D. Q. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0567642 · Cited by 532
The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors
Primeau, A. J., Rendon, A., Hedley, D., Lilge, L., & Tannock, I. F. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1664 · Cited by 499
Light‐Induced Reversible Formation of Polymeric Micelles
Lee, H., Wu, W., Oh, J. K., Mueller, L., Sherwood, G., Peteanu, L., Kowalewski, T., & Matyjaszewski, K. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604278 · Cited by 401
McKee, T. D., Grandi, P., Mok, W., Alexandrakis, G., Insin, N., Zimmer, J. P., Bawendi, M. G., Boucher, Y., Breakefield, X. O., & Jain, R. K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2242 · Cited by 397
Photoswitchable Biomaterials: En Route to Optobioelectronic Systems
Willner, I. (1997) · Accounts of Chemical Research · doi:10.1021/ar9700062 · Cited by 372
Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes
Cao, Z., Tong, R., Mishra, A., Xu, W., Wong, G. C. L., Cheng, J., & Lu, Y. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901452 · Cited by 372
Self-citationCampbell, R. B., Fukumura, D., Brown, E. B., Mazzola, L. M., Izumi, Y., Jain, R. K., Torchilin, V. P., & Munn, L. L. (2002) · PubMed · Cited by 372
Reversibly Photoswitchable Dual-Color Fluorescent Nanoparticles as New Tools for Live-Cell Imaging
Zhu, L., Wu, W., Zhu, M.-Q., Han, J. J., Hurst, J. K., & Li, A. D. Q. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068452k · Cited by 356
Shao, N., Jin, J., Wang, H., Zheng, J., Yang, R., Chan, W., & Abliz, Z. (2010) · Journal of the American Chemical Society · doi:10.1021/ja908215t · Cited by 268
Srinivasan, S., Pogue, B. W., Jiang, S., Dehghani, H., Kogel, C., Soho, S., Gibson, J. J., Tosteson, T. D., Poplack, S. P., & Paulsen, K. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2032822100 · Cited by 267
Netti, P. A., Baxter, L. T., Boucher, Y., Skalak, R., & Jain, R. K. (1995) · PubMed · Cited by 263
Spatiotemporal controlled delivery of nanoparticles to injured vasculature
Chan, J. M., Zhang, L., Tong, R., Ghosh, D., Gao, W., Liao, G., Yuet, K. P., Gray, D., Rhee, J.-W., Cheng, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914585107 · Cited by 253
Self-citationVlassiouk, I., Park, C.-D., Vail, S. A., Gust, D., & Smirnov, S. (2006) · Nano Letters · doi:10.1021/nl060313d · Cited by 246
Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells
Marriott, G., Mao, S., Sakata, T., Ran, J., Jackson, D. K., Petchprayoon, C., Gomez, T. J., Warp, E., Tulyathan, O., Aaron, H. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808882105 · Cited by 220
Vinegoni, C., Botnaru, I., Aikawa, E., Calfon, M. A., Iwamoto, Y., Folco, E. J., Ntziachristos, V., Weissleder, R., Libby, P., & Jaffer, F. A. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001577 · Cited by 215
Polymer-controlled drug delivery systems
Langer, R. (1993) · Accounts of Chemical Research · doi:10.1021/ar00034a004 · Cited by 210
Self-citationFang, R. H., Aryal, S., Hu, C.-M. J., & Zhang, L. (2010) · Langmuir · doi:10.1021/la103576a · Cited by 206
Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
Netti, P. A., Hamberg, L. M., Babich, J. W., Kierstead, D., Graham, W., Hunter, G. J., Wolf, G. L., Fischman, A., Boucher, Y., & Jain, R. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3137 · Cited by 202
Delivery of molecular and cellular medicine to solid tumors
Jain, R. K. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00237-x · Cited by 186
Zhu, M.-Q., Zhang, G.-F., Li, C., Aldred, M. P., Chang, E., Drezek, R. A., & Li, A. D. Q. (2011) · Journal of the American Chemical Society · doi:10.1021/ja106895k · Cited by 180
Dvir, T., Banghart, M. R., Timko, B. P., Langer, R., & Kohane, D. S. (2009) · Nano Letters · doi:10.1021/nl903411s · Cited by 129
Self-citationTong, R., Yala, L., Fan, T. M., & Cheng, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.009 · Cited by 128
Self-citationPhotochromism of Spirooxazines in Homogeneous Solution and Phospholipid Liposomes
Khairutdinov, R. F., Giertz, K., Hurst, J. K., Voloshina, E. N., Voloshin, N. A., & Minkin, V. I. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9825985 · Cited by 108
Ouar, Z., Bens, M., Vignes, C., Paulais, M., PRINGEL, C., Fleury‐Feith, J., Cluzeaud, F., Lacave, R., & Vandewalle, A. (2003) · Biochemical Journal · doi:10.1042/bj20021411 · Cited by 100
Modulation of T2 Relaxation Time by Light-Induced, Reversible Aggregation of Magnetic Nanoparticles
Osborne, E. A., Jarrett, B. R., Tu, C., & Louie, A. Y. (2010) · Journal of the American Chemical Society · doi:10.1021/ja100254m · Cited by 84
Popielarski, S. R., Pun, S. H., & Davis, M. E. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050113d · Cited by 81
Chronopharmaceutical drug delivery systems: Hurdles, hype or hope?☆
Youan, B.-B. C. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.04.010 · Cited by 72
Mechanical properties of UV irradiated rat tail tendon (RTT) collagen
Sionkowska, A., & Wess, T. J. (2003) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2003.10.001 · Cited by 57
Yoder, E. J., & Kleinfeld, D. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10002 · Cited by 56
Movia, D., Prina‐Mello, A., Volkov, Y., & Giordani, S. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100123g · Cited by 43
Photocontrol of Ion Permeation through Bilayer Membranes Using an Amphiphilic Spiropyran
Khairutdinov, R. F., & Hurst, J. K. (2001) · Langmuir · doi:10.1021/la010756r · Cited by 42
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Self-citation
Metadata
- Authors
- Tong, R., Hemmati, H. D., Langer, R., & Kohane, D. S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-03-16
- Volume
- 134
- Issue
- 21
- Pages
- 8848-8855
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2130784417
- Cited by
- 477
- References
- 66
- FWCI
- 15.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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