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Near Infrared Light Triggered Release of Biomacromolecules from Hydrogels Loaded with Upconversion Nanoparticles
Abstract
Using a photosensitive hybrid hydrogel loaded with upconversion nanoparticles (UCNPs), we show that continuous-wave near-infrared (NIR) light (980 nm) can be used to induce the gel-sol transition and release large, inactive biomacromolecules (protein and enzyme) entrapped in the hydrogel into aqueous solution "on demand", where their bioactivity is recovered. This study is a new demonstration and development in harnessing the unique multiphoton effect of UCNPs for photosensitive materials of biomedical interest.
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Metadata
- Authors
- Yan, B., Boyer, J.-C., Habault, D., Branda, N. R., & Zhao, Y.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-09-28
- Volume
- 134
- Issue
- 40
- Pages
- 16558-16561
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2323069486
- Cited by
- 417
- References
- 63
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- closed
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