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Supramolecular Nanostructures Formed by Anticancer Drug Assembly
Open accessAbstract
We report here a supramolecular strategy to directly assemble the small molecular hydrophobic anticancer drug camptothecin (CPT) into discrete, stable, well-defined nanostructures with a high and quantitative drug loading. Depending on the number of CPTs in the molecular design, the resulting nanostructures can be either nanofibers or nanotubes, and have a fixed CPT loading content ranging from 23% to 38%. We found that formation of nanostructures provides protection for both the CPT drug and the biodegradable linker from the external environment and thus offers a mechanism for controlled release of CPT. Under tumor-relevant conditions, these drug nanostructures can release the bioactive form of CPT and show in vitro efficacy against a number of cancer cell lines. This strategy can be extended to construct nanostructures of other types of anticancer drugs and thus presents new opportunities for the development of self-delivering drugs for cancer therapeutics.
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Self-citation
Metadata
- Authors
- Cheetham, A. G., Zhang, P., Lin, Y.-A., Lock, L. L., & Cui, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-02-13
- Volume
- 135
- Issue
- 8
- Pages
- 2907-2910
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2034365540
- Cited by
- 517
- References
- 38
- FWCI
- 19.41
- Type
- journal article
- Language
- en
- Open access
- green
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