The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Full-Range Intracellular pH Sensing by an Aggregation-Induced Emission-Active Two-Channel Ratiometric Fluorogen
Abstract
Intracellular pH (pHi) is an important parameter associated with cellular behaviors and pathological conditions. Sensing pHi and monitoring its changes in live cells are essential but challenging due to the lack of effective probes. We herein report a pH-sensitive fluorogen for pHi sensing and tracking. The dye is a tetraphenylethene-cyanine adduct (TPE-Cy). It is biocompatible and cell-permeable. Upon diffusing into cells, it responds sensitively to pHi in the entire physiological range, visualizing the acidic and basic compartments with intense red and blue emissions, respectively. The ratiometric signal of the red and blue channels can thus serve as an indicator for local proton concentration. The utility of TPE-Cy in pHi imaging and monitoring is demonstrated with the use of confocal microscopy, ratiometric analysis, and flow cytometry.
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Cites
Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15113d · Cited by 6,363
Self-citationAggregation-induced emission: phenomenon, mechanism and applications
Hong, Y., Lam, J. W. Y., & Tang, B. Z. (2009) · Chemical Communications · doi:10.1039/b904665h · Cited by 4,115
Self-citationRoos, A., & Boron, W. F. (1981) · Physiological Reviews · doi:10.1152/physrev.1981.61.2.296 · Cited by 2,511
Sensors and regulators of intracellular pH
Casey, J. R., Grinstein, S., & Orlowski, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2820 · Cited by 2,218
Fluorescent Indicators for Intracellular pH
Han, J., & Burgess, K. (2010) · Chemical Reviews · doi:10.1021/cr900249z · Cited by 1,620
Llopis, J., McCaffery, J. M., Miyawaki, A., Farquhar, M. G., & Tsien, R. Y. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6803 · Cited by 1,130
(1998) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199812)51:4<477::aid-mrd17>3.0.co;2-w · Cited by 548
Shi, W., Li, X., & Ma, H. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201202533 · Cited by 468
Imaging Intracellular pH in Live Cells with a Genetically Encoded Red Fluorescent Protein Sensor
Tantama, M., Hung, Y. P., & Yellen, G. (2011) · Journal of the American Chemical Society · doi:10.1021/ja202902d · Cited by 408
Zhou, K., Liu, H., Zhang, S., Huang, X., Wang, Y., Huang, G., Sumer, B. D., & Gao, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300176w · Cited by 344
Cited by
Aggregation-Induced Emission: Together We Shine, United We Soar!
Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270
Self-citationAggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
Mei, J., Hong, Y., Lam, J. W. Y., Qin, A., Tang, Y., & Tang, B. Z. (2014) · Advanced Materials · doi:10.1002/adma.201401356 · Cited by 3,381
Self-citationOptical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications
Steinegger, A., Wolfbeis, O. S., & Borisov, S. M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00451 · Cited by 622
Aggregation-Induced Emission Luminogens for Activity-Based Sensing
Wang, D., & Tang, B. Z. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00305 · Cited by 510
Self-citationProgress and Trends in AIE-Based Bioprobes: A Brief Overview
Mei, J., Huang, Y., & Tian, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b14343 · Cited by 384
Metadata
- Authors
- Chen, S., Hong, Y., Liu, Y., Liu, J., Leung, C. W. T., Li, M., Kwok, R. T. K., Zhao, E., Lam, J. W. Y., Yu, Y., & Tang, B. Z.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-26
- Volume
- 135
- Issue
- 13
- Pages
- 4926-4929
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2026227022
- Cited by
- 434
- References
- 17
- FWCI
- 22.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, S., Hong, Y., Liu, Y., Liu, J., Leung, C. W. T., Li, M., Kwok, R. T. K., Zhao, E., Lam, J. W. Y., Yu, Y., & Tang, B. Z. (2013). Full-Range Intracellular pH Sensing by an Aggregation-Induced Emission-Active Two-Channel Ratiometric Fluorogen. Journal of the American Chemical Society. https://doi.org/10.1021/ja400337p
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