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Untitled work

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Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue

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Azo-based near-infrared fluorescent theranostic probe for tracking hypoxia-activated cancer chemotherapy in vivo

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A lipophilic AIEgen for lipid droplet imaging and evaluation of the efficacy of HIF-1 targeting drugs

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Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles

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HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia

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The HIF-1 antagonist acriflavine: visualization in retina and suppression of ocular neovascularization

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The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer

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Host–Guest Induced Peptide Folding with Sequence-Specific Structural Chirality

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Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics

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NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model

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New Modalities, Technologies, and Partnerships in Probe and Lead Generation: Enabling a Mode-of-Action Centric Paradigm

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A Perspective on Synthetic Biology in Drug Discovery and Development—Current Impact and Future Opportunities

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The VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma

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Methods for the Creation of Cyclic Peptide Libraries for Use in Lead Discovery

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Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions

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Computational methods to design cyclic peptides

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From Concepts to Inhibitors: A Blueprint for Targeting Protein–Protein Interactions

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Neue Modalitäten für schwierige Zielstrukturen in der Wirkstoffentwicklung

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Advances in inhibition of protein-protein interactions targeting hypoxia-inducible factor-1 for cancer therapy

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Up-regulation of hypoxia-inducible factor antisense as a novel approach to treat ovarian cancer

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Custom‐Made Piezoelectric Solid Solution Material for Cancer Therapy

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Traceless Production of Cyclic Peptide Libraries in E. coli

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Ways into Understanding HIF Inhibition

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Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies

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Deregulated transcription factors and poor clinical outcomes in cancer patients

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Developing structure–activity relationships from an HTS hit for inhibition of the Cks1–Skp2 protein–protein interaction

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Designing Well-Structured Cyclic Pentapeptides Based on Sequence–Structure Relationships

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Identification and Development of Cyclic Peptide Inhibitors of Hypoxia Inducible Factors 1 and 2 That Disrupt Hypoxia-Response Signaling in Cancer Cells

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Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications

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A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT

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Design and applications of cyclic peptides

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Efficient genetic code expansion without host genome modifications

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Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display

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Gramicidin A Blocks Tumor Growth and Angiogenesis through Inhibition of Hypoxia-Inducible Factor in Renal Cell Carcinoma

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Expanded toolbox for directing the biosynthesis of macrocyclic peptides in bacterial cells

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Reprogramming the Transcriptional Response to Hypoxia with a Chromosomally Encoded Cyclic Peptide HIF-1 Inhibitor

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Inhibition of low-density lipoprotein receptor degradation with a cyclic peptide that disrupts the homodimerization of IDOL E3 ubiquitin ligase

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An overview of biological research on hypoxia-inducible factors (HIFs)

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HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2

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The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling

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Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands

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Intracellular enzyme-activatable prodrug for real-time monitoring of chlorambucil delivery and imaging

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Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2

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Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories

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Natural and Man-Made Cyclic Peptide-Based Antibiotics

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Targeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interaction

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Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors

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Inhibition of Hypoxia-Inducible Transcription Factor (HIF-1α) Signaling with Sulfonyl-γ-AApeptide Helices

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A Detailed Investigation on Conformation, Permeability and PK Properties of Two Related Cyclohexapeptides

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Specific inhibition of HIF activity: can peptides lead the way?

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Sensing an Oxygen Sensor: Development and Application of Activity-Based Assays Directly Monitoring HIF Heterodimerization

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A genetically selected cyclic peptide inhibitor of BCL6 homodimerization

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VHH212 nanobody targeting the hypoxia-inducible factor 1α suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer in vivo

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Towards a small molecule inhibitor of the HIF-1?/HIF-1? protein-protein interaction

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Identification and Development of Cyclic Peptide Inhibitors of Hypoxia Inducible Factors 1 and 2 That Disrupt Hypoxia-Response Signaling in Cancer Cells

Ball, A. T., Mohammed, S., Doigneaux, C., Gardner, R. M., Easton, J. W., Turner, S. J., Essex, J. W., Pairaudeau, G., & Tavassoli, A. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c10508 · Cited by 32 · see citing works

Development of second generation cyclic peptide inhibitors of hypoxia inducible factors

Ball, A. T. (2018) · ePrints Soton (University of Southampton)

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Reprogramming the cellular response to hypoxia

Mistry, I. N. (2016) · ePrints Soton (University of Southampton)