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High-Efficiency in Vitro and in Vivo Detection of Zn2+ by Dye-Assembled Upconversion Nanoparticles
Abstract
Development of highly sensitive and selective sensing systems of divalent zinc ion (Zn(2+)) in organisms has been a growing interest in the past decades owing to its pivotal role in cellular metabolism, apoptosis, and neurotransmission. Herein, we report the rational design and synthesis of a Zn(2+) fluorescent-based probe by assembling lanthanide-doped upconversion nanoparticles (UCNPs) with chromophores. Specifically, upconversion luminescence (UCL) can be effectively quenched by the chromophores on the surface of nanoparticles via a fluorescence resonant energy transfer (FRET) process and subsequently recovered upon the addition of Zn(2+), thus allowing for quantitative monitoring of Zn(2+). Importantly, the sensing system enables detection of Zn(2+) in real biological samples. We demonstrate that this chromophore-UCNP nanosystem is capable of implementing an efficient in vitro and in vivo detection of Zn(2+) in mouse brain slice with Alzheimer's disease and zebrafish, respectively.
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Metadata
- Authors
- Peng, J., Xu, W., Teoh, C. L., Han, S., Kim, B., Samanta, A., Er, J. C., Wang, L., Yuan, L., Liu, X., & Chang, Y.-T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-02-06
- Volume
- 137
- Issue
- 6
- Pages
- 2336-2342
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2171542167
- Cited by
- 257
- References
- 49
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- closed
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