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Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
Abstract
Chronic wound is a common complication for diabetic patients, which entails substantial inconvenience, persistent pain, and significant economic burden to patients. However, current clinical treatments for diabetic chronic wounds remain unsatisfactory. A prolonged but ineffective inflammation phase in chronic wounds is the primary difference between diabetic chronic wounds and normal wounds. Herein, we present an effective antioxidative system (MOF/Gel) for chronic wound healing of diabetic rats through integrating a metal organic framework (MOF) nanozyme with antioxidant enzyme-like activity with a hydrogel (Gel). MOF/Gel can continuously scavenge reactive oxygen species to modulate the oxidative stress microenvironment in diabetic chronic wounds, which leads to a natural transition from the inflammation phase to the proliferation phase. Impressively, the efficacy of one-time-applied MOF/Gel was comparable to that of the human epidermal growth factor Gel, a widely used clinical drug for various wound treatments. Such an effective, safe, and convenient MOF/Gel system can meet complex clinical demands.
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Cited by
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Self-citation
Metadata
- Authors
- Chao, D., Dong, Q., Yu, Z., Qi, D., Li, M., Xu, L., Liu, L., Fang, Y., & Dong, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-12-13
- Volume
- 144
- Issue
- 51
- Pages
- 23438-23447
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W4311275416
- Cited by
- 317
- References
- 60
- FWCI
- 21.43
- Type
- journal article
- Language
- en
- Open access
- closed
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