The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Multivariate Metal–Organic Frameworks for Dialing-in the Binding and Programming the Release of Drug Molecules
Abstract
We report the control of guest release profiles by dialing-in desirable interactions between guest molecules and pores in metal–organic frameworks (MOFs). The interactions can be derived by the rate constants that were quantitatively correlated with the type of functional group and its proportion in the porous structure; thus the release of guest molecules can be predicted and programmed. Specifically, three probe molecules (ibuprofen, rhodamine B, and doxorubicin) were studied in a series of robust and mesoporous MOFs with multiple functional groups [MIL-101(Fe)-(NH 2 ) x, MIL-101(Fe)-(C 4 H 4 ) x, and MIL-101(Fe)-(C 4 H 4 ) x (NH 2 ) 1– x ]. The release rate can be adjusted by 32-fold [rhodamine from MIL-101(Fe)-(NH 2 ) x ], and the time of release peak can be shifted by up to 12 days over a 40-day release period [doxorubicin from MIL-101(Fe)-(C 4 H 4 ) x (NH 2 ) 1– x ], which was not obtained in the physical mixture of the single component MOF counterparts nor in other porous materials. The corelease of two pro-drug molecules (ibuprofen and doxorubicin) was also achieved.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Chromium Terephthalate-Based Solid with Unusually Large Pore Volumes and Surface Area
Férey, G., Mellot-Draznieks, C., Serre, C., Millange, F., Dutour, J., Surblé, S., & Margiolaki, I. (2005) · Science · doi:10.1126/science.1116275 · Cited by 5,430
Metal–Organic Frameworks in Biomedicine
Horcajada, P., Gref, R., Baati, T., Allan, P. K., Maurin, G., Couvreur, P., Férey, G., Morris, R. E., & Serre, C. (2012) · Chemical Reviews · doi:10.1021/cr200256v · Cited by 4,168
Multiple Functional Groups of Varying Ratios in Metal-Organic Frameworks
Deng, H., Doonan, C. J., Furukawa, H., Ferreira, R. B., Towne, J., Knobler, C. B., Wang, B., & Yaghi, O. M. (2010) · Science · doi:10.1126/science.1181761 · Cited by 1,917
Self-citationLarge-scale screening of hypothetical metal–organic frameworks
Wilmer, C. E., Leaf, M., Lee, C. Y., Farha, O. K., Hauser, B. G., Hupp, J. T., & Snurr, R. Q. (2012) · Nature Chemistry · doi:10.1038/nchem.1192 · Cited by 1,439
Cation-Triggered Drug Release from a Porous Zinc−Adeninate Metal−Organic Framework
An, J., Geib, S. J., & Rosi, N. L. (2009) · Journal of the American Chemical Society · doi:10.1021/ja902972w · Cited by 1,076
He, C., Liu, D., & Lin, W. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00125 · Cited by 1,001
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Metal‐Organic Framework Nanoparticles in Photodynamic Therapy: Current Status and Perspectives
Lismont, M., Dreesen, L., & Wuttke, S. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201606314 · Cited by 622
Bauer, S., Serre, C., Devic, T., Horcajada, P., Marrot, J., Férey, G., & Stock, N. (2008) · Inorganic Chemistry · doi:10.1021/ic800538r · Cited by 620
Binding Affinities of Host–Guest, Protein–Ligand, and Protein–Transition‐State Complexes
Houk, K. N., Leach, A. G., Kim, S. P., & Zhang, X. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200565 · Cited by 586
Self-citation
Cited by
Metal–Organic Frameworks for Food Safety
Wang, P.-L., Xie, L.-H., Joseph, E. A., Li, J.-R., Su, X.-O., & Zhou, H.-C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00257 · Cited by 533
Pore Chemistry of Metal–Organic Frameworks
Ji, Z., Wang, H., Canossa, S., Wuttke, S., & Yaghi, O. M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000238 · Cited by 459
Sequencing of metals in multivariate metal-organic frameworks
Ji, Z., Li, T., & Yaghi, O. M. (2020) · Science · doi:10.1126/science.aaz4304 · Cited by 272
Metadata
- Authors
- Dong, Z., Sun, Y., Chu, J., Zhang, X., & Deng, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-09-28
- Volume
- 139
- Issue
- 40
- Pages
- 14209-14216
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2755132509
- Cited by
- 282
- References
- 30
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Multivariate Metal–Organic Frameworks for Dialing-in the Binding and Programming the Release of Drug Molecules. https://app.cochat.ai/papers/10.1021/jacs.7b07392
- The paper
- Dong, Z., Sun, Y., Chu, J., Zhang, X., & Deng, H. (2017). Multivariate Metal–Organic Frameworks for Dialing-in the Binding and Programming the Release of Drug Molecules. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.7b07392
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
