The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy
Abstract
Recent advances in nanomedicine have facilitated the development of potent nanomaterials with intrinsic enzyme-like activities (nanozymes) for cancer therapy. However, it remains a great challenge to fabricate smart nanozymes that precisely perform enzymatic activity in tumor microenvironment without inducing off-target toxicity to surrounding normal tissues. Herein, we report on designed fabrication of biodegradation-medicated enzymatic activity-tunable molybdenum oxide nanourchins (MoO 3– x NUs), which selectively perform therapeutic activity in tumor microenvironment via cascade catalytic reactions, while keeping normal tissues unharmed due to their responsive biodegradation in physiological environment. Specifically, the MoO 3– x NUs first induce catalase (CAT)-like reactivity to decompose hydrogen peroxide (H 2 O 2 ) in tumor microenvironment, producing a considerable amount of O 2 for subsequent oxidase (OXD)-like reactivity of MoO 3– x NUs; a substantial cytotoxic superoxide radical (·O 2 – ) is thus generated for tumor cell apoptosis. Interestingly, once exposed to neutral blood or normal tissues, MoO 3– x NUs rapidly lose the enzymatic activity via pH-responsive biodegradation and are excreted in urine, thus ultimately ensuring safety. The current study demonstrates a proof of concept of biodegradation-medicated in vivo catalytic activity-tunable nanozymes for tumor-specific cascade catalytic therapy with minimal off-target toxicity.
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Cited by
Jomova, K., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03696-4 · Cited by 1,445
Dong, S., Dong, Y., Jia, T., Liu, S., Liu, J., Yang, D., He, F., Gai, S., Yang, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.202002439 · Cited by 592
Yu, B., Wang, W., Sun, W., Jiang, C., & Lu, L. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c03510 · Cited by 331
Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy
Zhang, X., Chen, X., & Zhao, Y. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00828-2 · Cited by 304
Construction of Bio‐Piezoelectric Platforms: From Structures and Synthesis to Applications
Xu, Q., Gao, X., Zhao, S., Liu, Y., Zhang, D., Zhou, K., Khanbareh, H., Chen, W., Zhang, Y., & Bowen, C. (2021) · Advanced Materials · doi:10.1002/adma.202008452 · Cited by 298
Metadata
- Authors
- Hu, X., Li, F., Xia, F., Guo, X., Wang, N., Liang, L., Yang, B., Fan, K., Yan, X., & Ling, D.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-12-27
- Volume
- 142
- Issue
- 3
- Pages
- 1636-1644
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2998560245
- Cited by
- 309
- References
- 48
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hu, X., Li, F., Xia, F., Guo, X., Wang, N., Liang, L., Yang, B., Fan, K., Yan, X., & Ling, D. (2020). Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.9b13586
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