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Absorption, Metabolism, and Antioxidant Effects of Pomegranate (Punica granatum L.) Polyphenols after Ingestion of a Standardized Extract in Healthy Human Volunteers
Abstract
The intake of polyphenols has been demonstrated to have health-promoting and disease-preventive effects. The pomegranate (Punica granatum L.), which is rich in several polyphenols, has been used for centuries in ancient cultures for its medicinal purposes. The potential health benefits of pomegranate polyphenols have been demonstrated in numerous in vitro studies and in vivo experiments. This study investigated the absorption and antioxidant effects of a standardized extract from pomegranate in healthy human volunteers after the acute consumption of 800 mg of extract. Results indicate that ellagic acid (EA) from the extract is bioavailable, with an observed C(max) of 33 ng/mL at t(max) of 1 h. The plasma metabolites urolithin A, urolithin B, hydroxyl-urolithin A, urolithin A-glucuronide, and dimethyl ellagic acid-glucuronide were identified by HPLC-MS. The antioxidant capacity measured with the oxygen radical absorbance capacity (ORAC) assay was increased with a maximum effect of 32% after 0.5 h, whereas the generation of reactive oxygen species (ROS) was not affected. The inflammation marker interleukin-6 (IL-6) was not significantly affected after 4 h after the consumption of the extract. Overall, this study demonstrated the absorbability of EA from a pomegranate extract high in ellagitannin content and its ex vivo antioxidant effects.
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Cites
Ou, B., Hampsch-Woodill, M., & Prior, R. L. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010586o · Cited by 2,932
Gil, M. I., Tomás-Barberán, F. A., Hess-Pierce, B., Holcroft, D. M., & Kader, A. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000404a · Cited by 2,362
Wang, H., & Joseph, J. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00107-0 · Cited by 2,346
Oxygen-radical absorbance capacity assay for antioxidants
Cao, G., Alessio, H. M., & Cutler, R. G. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90027-r · Cited by 1,605
Seeram, N. P., Adams, L. S., Henning, S. M., Niu, Y., Zhang, Y., Nair, M. G., & Heber, D. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.01.006 · Cited by 1,112
Dietary Guidelines for Americans, 2005
Mosocco, D. J. (2006) · Home Healthcare Nurse: The Journal for the Home Care and Hospice Professional · doi:10.1097/00004045-200610000-00002 · Cited by 796
Polyphenols and prevention of cardiovascular diseases
Manach, C., Mazur, A., & Scalbert, A. (2005) · Current Opinion in Lipidology · doi:10.1097/00041433-200502000-00013 · Cited by 680
Aviram, M., Rosenblat, M., Gaitini, D., Nitecki, S., Hoffman, A., Dornfeld, L., Volkova, N., Presser, D., Attias, J., Liker, H., et al. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2003.10.002 · Cited by 622
Cao, G., Russell, R. M., Lischner, N., & Prior, R. L. (1998) · The Journal of Nutrition · doi:10.1093/jn/128.12.2383 · Cited by 502
Seeram, N. P., Henning, S. M., Zhang, Y., Suchard, M., Li, Z., & Heber, D. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.10.2481 · Cited by 475
Larrosa, M., Tomás-Barberán, F. A., & Espín, J. C. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.09.004 · Cited by 461
Seeram, N. P., Lee, R., & Heber, D. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.04.029 · Cited by 453
Cerdá, B., Tomás-Barberán, F. A., & Espín, J. C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049144d · Cited by 450
Cerd�, B., Esp�n, J. C., Parra, S., Mart�nez, P., & Tom�s-Barber�n, F. A. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0461-7 · Cited by 435
A new proposed guidance system for beverage consumption in the United States
Popkin, B. M., Armstrong, L. E., Bray, G. M., Caballero, B., Frei, B., & Willett, W. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.83.3.529 · Cited by 431
Aviram, M., & Dornfeld, L. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(01)00412-9 · Cited by 431
Cao, G., Booth, S. L., Sadowski, J. A., & Prior, R. L. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.5.1081 · Cited by 402
Azam, S., Hadi, N., Khan, N. U., & Hadi, S. M. (2004) · Toxicology in Vitro · doi:10.1016/j.tiv.2003.12.012 · Cited by 397
Henning, S. M., Niu, Y., Lee, N. H., Thames, G. D., Minutti, R. R., Wang, H., Go, V. L. W., & Heber, D. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1558 · Cited by 342
IL-6 and its circadian secretion in humans
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000084844 · Cited by 338
Cerdá, B., Cerón, J. J., Tomás-Barberán, F. A., & Espín, J. C. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020842c · Cited by 297
Seeram, N., Lee, R., Hardy, M., & Heber, D. (2005) · Separation and Purification Technology · doi:10.1016/j.seppur.2004.04.003 · Cited by 293
Cocoa antioxidants and cardiovascular health
Keen, C. L., Holt, R. R., Oteiza, P. I., Fraga, C. G., & Schmitz, H. H. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.298s · Cited by 246
Fruit juice consumption modulates antioxidative status, immune status and DNA damage
Bub, A., Watzl, B., Blockhaus, M., Briviba, K., Liegibel, U., Müller, H., Pool-Zobel, B. L., & Rechkemmer, G. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00255-3 · Cited by 233
Lotito, S. B., & Frei, B. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.019 · Cited by 213
Aslam, M. N., Lansky, E. P., & Varani, J. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.07.027 · Cited by 197
Devaraj, S., Vega‐López, S., Kaul, N., Schönlau, F., Rohdewald, P., & Jialal, I. (2002) · Lipids · doi:10.1007/s11745-006-0982-3 · Cited by 195
Epigallocatechin, a Green Tea Polyphenol, Attenuates Myocardial Ischemia Reperfusion Injury in Rats
Aneja, R., Hake, P. W., Burroughs, T. J., Denenberg, A. G., Wong, H. R., & Zingarelli, B. (2004) · Molecular Medicine · doi:10.2119/2004-00032.aneja · Cited by 181
Dietary catechins in relation to coronary heart disease death among postmenopausal women
Arts, I. C. W., Jacobs, D. R., Harnack, L. J., Gross, M., & Folsom, A. R. (2001) · Epidemiology · doi:10.1097/00001648-200111000-00015 · Cited by 177
Henning, S. M., Niu, Y., Liu, Y., Lee, N. H., Hara, Y., Thames, G., Minutti, R. R., Carpenter, C. L., Wang, H., & Heber, D. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.03.003 · Cited by 155
Ellagic acid blocks activation of pancreatic stellate cells
Masamune, A., Satoh, M., Kikuta, K., Suzuki, N., Satoh, K., & Shimosegawa, T. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.06.008 · Cited by 123
Joubert, E., Winterton, P., Britz, T. J., & Gelderblom, W. C. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051355a · Cited by 108
β-Secretase(BACE1) inhibitors from pomegranate (Punica granatum) husk
Kwak, H.-M., Jeon, S.-Y., Sohng, B.-H., Kim, J.-G., Lee, J.-M., Lee, K., Jeong, H.-H., Hur, J.-M., Kang, Y., & Song, K. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977896 · Cited by 107
Sastravaha, G., Gaßmann, G., Sangtherapitikul, P., & Grimm, W. (2005) · PubMed · Cited by 105
Ellagic Acid and Ellagitannins Affect on Sedimentation in Muscadine Juice and Wine
Lee, J., & Talcott, S. T. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf011587j · Cited by 59
Chen, C. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i37.5777 · Cited by 52
Rogers, J., Perkins, I., van Olphen, A. L., Burdash, N. M., Klein, T., & Friedman, H. P. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000906 · Cited by 47
Inhibitory effects of catechins on neutrophil-dependent gastric inflammation
Handa, O., Naito, Y., Takagi, T., Ishikawa, T., Ueda, M., Matsumoto, N., Kokura, S., Ichikawa, H., Yoshida, N., Shimoi, K., et al. (2002) · Redox Report · doi:10.1179/135100002125000901 · Cited by 21
Naturoceutical Agents in the Management of Cardiovascular Disease
Hermann, D. D. (2002) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200202030-00005 · Cited by 20
Cited by
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
Perron, N. R., & Brumaghim, J. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9043-x · Cited by 1,370
Pomegranate and its many functional components as related to human health: a review
Viuda‐Martos, M., Fernández‐López, J., & Pérez‐Álvarez, J. A. (2010) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2010.00131.x · Cited by 768
Espín, J. C., Larrosa, M., García-Conesa, M. T., & Tomás-Barberán, F. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/270418 · Cited by 576
Tomás‐Barberán, F. A., González‐Sarrías, A., García‐Villalba, R., Núñez‐Sánchez, M. A., Selma, M. V., García‐Conesa, M. T., & Espín, J. C. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500901 · Cited by 465
Encapsulation of polyphenols and anthocyanins from pomegranate (Punica granatum) by spray drying
Robert, P., Gorena, T., Romero, N., Sepulveda, E., Chavez, J., & Saenz, C. (2010) · International Journal of Food Science & Technology · doi:10.1111/j.1365-2621.2010.02270.x · Cited by 454
Metadata
- Authors
- Mertens-Talcott, S. U., Jilma-Stohlawetz, P., Rios, J., Hingorani, L., & Derendorf, H.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-10-13
- Volume
- 54
- Issue
- 23
- Pages
- 8956-8961
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2010120018
- Cited by
- 354
- References
- 39
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
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