Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

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Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism

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Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours

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Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

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Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability

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The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans

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Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

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In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota

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A survey of modulation of gut microbiota by dietary polyphenols

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Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice

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Ellagitannins, ellagic acid and vascular health

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Absorption, Metabolism, and Antioxidant Effects of Pomegranate (Punica granatum L.) Polyphenols after Ingestion of a Standardized Extract in Healthy Human Volunteers

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Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans

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Farmers’ market use is associated with fruit and vegetable consumption in diverse southern rural communities

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Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella

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Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species

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Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds

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Repeated Oral Administration of High Doses of the Pomegranate Ellagitannin Punicalagin to Rats for 37 Days Is Not Toxic

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Pomegranate Ellagitannin-Derived Metabolites Inhibit Prostate Cancer Growth and Localize to the Mouse Prostate Gland

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Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy

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The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota

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Urolithins, Ellagic Acid-Derived Metabolites Produced by Human Colonic Microflora, Exhibit Estrogenic and Antiestrogenic Activities

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Urolithins, Intestinal Microbial Metabolites of Pomegranate Ellagitannins, Exhibit Potent Antioxidant Activity in a Cell-Based Assay

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The Prenylflavonoid Isoxanthohumol from Hops (Humulus lupulus L.) Is Activated into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in the Human Intestine

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Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

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Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects

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Pomegranate Ellagitannin–Derived Compounds Exhibit Antiproliferative and Antiaromatase Activity in Breast Cancer Cells In vitro

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Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites

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Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice

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Intestinal Bacterial Communities That Produce Active Estrogen-Like Compounds Enterodiol and Enterolactone in Humans

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NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts

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Time course production of urolithins from ellagic acid by human gut microbiota

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Hydroxycinnamic acid composition and in vitro antioxidant activity of selected grain fractions

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In vitro transformation of chlorogenic acid by human gut microbiota

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New insights into the bioavailability of red raspberry anthocyanins and ellagitannins

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Colon Cancer Chemopreventive Activities of Pomegranate Ellagitannins and Urolithins

Kasimsetty, S. G., Białońska, D., Reddy, M. K., Ma, G., Khan, S. I., & Ferreira, D. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903762h · Cited by 198 · see citing works

Enantioselective Synthesis of<i>S</i>-Equol from Dihydrodaidzein by a Newly Isolated Anaerobic Human Intestinal Bacterium

Wang, X.-L., Hur, H.-G., Lee, J. H., Kim, K. T., & Kim, S.-I. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.1.214-219.2005 · Cited by 196 · see citing works

Colonic Catabolism of Ellagitannins, Ellagic Acid, and Raspberry Anthocyanins: In Vivo and In Vitro Studies

González‐Barrio, R., Edwards, C. A., & Crozier, A. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.039651 · Cited by 194 · see citing works

Antiglycative and neuroprotective activity of colon‐derived polyphenol catabolites

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Identifying the limits for ellagic acid bioavailability: A crossover pharmacokinetic study in healthy volunteers after consumption of pomegranate extracts

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Talking microbes: When gut bacteria interact with diet and host organs

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UV and MS Identification of Urolithins and Nasutins, the Bioavailable Metabolites of Ellagitannins and Ellagic Acid in Different Mammals

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Concentrated Pomegranate Juice Improves Lipid Profiles in Diabetic Patients with Hyperlipidemia

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Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A , ameliorate TNF ‐α‐induced inflammation and associated molecular markers in human aortic endothelial cells

Giménez‐Bastida, J. A., González‐Sarrías, A., Larrosa, M., Tomás-Barberán, F. A., Espı́n, J. C., & García‐Conesa, M. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100677 · Cited by 166 · see citing works

Pomegranate Juice and Extracts Provide Similar Levels of Plasma and Urinary Ellagitannin Metabolites in Human Subjects

Seeram, N. P., Zhang, Y., McKeever, R., Henning, S. M., Lee, R., Suchard, M. A., Li, Z., Chen, S., Thames, G., Zerlin, A., et al. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2007.650 · Cited by 164 · see citing works

Fate of Microbial Metabolites of Dietary Polyphenols in Rats: Is the Brain Their Target Destination?

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Isolation of a human intestinal bacterium capable of daidzein and genistein conversion

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Gene expression, cell cycle arrest and MAPK signalling regulation in Caco‐2 cells exposed to ellagic acid and its metabolites, urolithins

González‐Sarrías, A., Espı́n, J. C., Tomás-Barberán, F. A., & García‐Conesa, M. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800150 · Cited by 158 · see citing works

Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut

Selma, M. V., Tomás-Barberán, F. A., Beltrán, D., Garcı́a-Villalba, R., & Espı́n, J. C. (2014) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.055095-0 · Cited by 156 · see citing works

Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers

Li, Z., Henning, S. M., Lee, R., Lu, Q., Summanen, P. H., Thames, G., Corbett, K. M., Downes, J., Tseng, C., Finegold, S. M., et al. (2015) · Food & Function · doi:10.1039/c5fo00669d · Cited by 153 · see citing works

Validated Method for the Characterization and Quantification of Extractable and Nonextractable Ellagitannins after Acid Hydrolysis in Pomegranate Fruits, Juices, and Extracts

Garcı́a-Villalba, R., Espı́n, J. C., Aaby, K., Alasalvar, C., Heinonen, M., Jacobs, G., Voorspoels, S., Koivumäki, T., Kroon, P. A., Pelvan, E., et al. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02062 · Cited by 153 · see citing works

Effects of Fruit Ellagitannin Extracts, Ellagic Acid, and Their Colonic Metabolite, Urolithin A, on Wnt Signaling

Sharma, M., Li, L., Celver, J. P., Killian, C., Kovoor, A., & Seeram, N. P. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902857v · Cited by 150 · see citing works

Pomegranate: a fruit that ameliorates metabolic syndrome

Medjakovic, S., & Jungbauer, A. (2012) · Food & Function · doi:10.1039/c2fo30034f · Cited by 148 · see citing works

In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells

Qiu, Z., Zhou, B., Jin, L. G., Yu, H., Liu, L., Liu, Y., Qin, C., Xie, S., & Zhu, F. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.025 · Cited by 137 · see citing works

Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods

Garcia-Muñoz, C., & Vaillant, F. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.644643 · Cited by 133 · see citing works

Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid

Garcı́a-Villalba, R., Espı́n, J. C., & Tomás-Barberán, F. A. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.08.044 · Cited by 132 · see citing works

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

González‐Sarrías, A., Giménez‐Bastida, J. A., Núñez‐Sánchez, M. Á., Larrosa, M., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0589-4 · Cited by 132 · see citing works

In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

Ishimoto, H., Shibata, M., Myojin, Y., Ito, H., Sugimoto, Y., Tai, A., & Hatano, T. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.07.086 · Cited by 131 · see citing works

Structural Elucidation and Quantification of Phenolic Conjugates Present in Human Urine after Tea Intake

van der Hooft, J. J. J., de Vos, R. C. H., Mihaleva, V. V., Bino, R. J., Ridder, L., de Roo, N., Jacobs, D. M., van Duynhoven, J., & Vervoort, J. J. M. (2012) · Analytical Chemistry · doi:10.1021/ac3017339 · Cited by 131 · see citing works

Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial

Cerdá, B., Soto, C., Albaladejo, M. D., Martínez, P., Sánchez-Gascón, F., Tomás-Barberán, F. A., & Espı́n, J. C. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602309 · Cited by 130 · see citing works

Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial

Hazim, S., Curtis, P. J., Schär, M. Y., Ostertag, L. M., Kay, C. D., Minihane, A. M., & Cassidy, A. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.125690 · Cited by 130 · see citing works

The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism

Selma, M. V., Romo‐Vaquero, M., Garcı́a-Villalba, R., González‐Sarrías, A., Tomás-Barberán, F. A., & Espı́n, J. C. (2015) · Food & Function · doi:10.1039/c5fo01100k · Cited by 128 · see citing works

One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: A randomized placebo-controlled trial

Shema‐Didi, L., Sela, S., Ore, L., Shapiro, G., Geron, R., Goldfeld, M., & Kristal, B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.013 · Cited by 125 · see citing works

Urolithins, gut microbiota‐derived metabolites of ellagitannins, inhibit LPS‐induced inflammation in RAW 264.7 murine macrophages

Piwowarski, J. P., Kiss, A. K., Granica, S., & Moeslinger, T. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500264 · Cited by 124 · see citing works

Antiplasmodial activity of Punica granatum L. fruit rind

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The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells

González‐Sarrías, A., Tomé‐Carneiro, J., Bellesia, A., Tomás-Barberán, F. A., & Espı́n, J. C. (2015) · Food & Function · doi:10.1039/c5fo00120j · Cited by 119 · see citing works

Metabolites of the Ellagitannin Geraniin and Their Antioxidant Activities

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The effects of vegetarian and vegan diets on gut microbiota

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Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

Singh, R., Chandrashekharappa, S., Bodduluri, S. R., Baby, B. V., Hegde, B., Kotla, N. G., Hiwale, A. A., Saiyed, T., Patel, P., Vijay-Kumar, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07859-7 · Cited by 713 · see citing works

The gut microbiota: a key factor in the therapeutic effects of (poly)phenols

Espín, J. C., González-Sarrías, A., & Tomás-Barberán, F. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.033 · Cited by 603 · see citing works

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

Andreux, P. A., Blanco-Bose, W., Ryu, D., Burdet, F., Ibberson, M., Aebischer, P., Auwerx, J., Singh, A., & Rinsch, C. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0073-4 · Cited by 590 · see citing works

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

González-Sarrías, A., Núñez-Sánchez, M. A., Tomás-Barberán, F. A., & Espín, J. C. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04538 · Cited by 174 · see citing works

Linking dietary patterns with gut microbial composition and function

Sheflin, A. M., Melby, C. L., Carbonero, F., & Weir, T. L. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1270809 · Cited by 162 · see citing works

Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions

Hou, Y., Chu, X., Park, J., Zhu, Q., Hussain, M., Li, Z., Madsen, H. B., Yang, B., Wei, Y., Wang, Y., et al. (2024) · Alzheimer's &amp; Dementia · doi:10.1002/alz.13847 · Cited by 145 · see citing works

Food Design To Feed the Human Gut Microbiota

Ercolini, D., & Fogliano, V. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00456 · Cited by 146 · see citing works

Bifidobacterium pseudocatenulatum INIA P815: The first bacterium able to produce urolithins A and B from ellagic acid

Gaya, P., Peirotén, Á., Medina, M., Álvarez, I., & Landete, J. M. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.03.040 · Cited by 116 · see citing works

Methods and Trends for Water-Energy-Carbon Emissions Nexus Assessment

Wang, X., Klemeš, J. J., & Varbanov, P. S. (2021) · Chemical engineering transactions · doi:10.3303/cet2183025 · Cited by 1 · see citing works

Good practices & knowledge repository

(2019) · doi:10.18356/6556a659-en

Review of water-energy-food Nexus tools to improve the Nexus modelling approach for integrated policy making

Kaddoura, S., & Khatib, S. E. (2017) · Environmental Science & Policy · doi:10.1016/j.envsci.2017.07.007 · Cited by 228 · see citing works

Studying international doctoral researchers: nexus analysis as a mode of inquiry

Aarnikoivu, M. (2020) · Journal of Praxis in Higher Education · doi:10.47989/kpdc82 · Cited by 3 · see citing works

Challenges and Opportunities in Responding to Nexus Shocks

Howarth, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-94691-7_3