The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Changes in Antioxidant and Metabolite Profiles during Production of Tomato Paste
Open accessAbstract
Tomato products and especially concentrated tomato paste are important sources of antioxidants in the Mediterranean diet. Tomato fruit contain well-known antioxidants such as vitamin C, carotenoids, flavonoids, and hydroxycinnamic acids. The industrial processing of this fruit into tomato paste involves several treatments that potentially affect the final profile of antioxidants and other metabolites in the commercial product. Here we have used both biochemical and metabolomic techniques to assess the effect of each separate step in the industrial production chain starting from fresh fruit to the final tomato paste. Material was collected from five independent tomato paste production events spread over two successive years. Samples comprised the intact ripe fruits and semifinished products after fruit-breaking, separation of the pulp from skin and seeds, evaporation, and finally after canning and pasteurization. The effect of each processing step was determined by different types of analysis. First, the total antioxidant capacity and total phenolic content were determined by commonly used spectrophotometric methods. Second, individual antioxidants in the extracts were identified and compared using an HPLC with online antioxidant detection. Third, in each sample the levels of the major individual antioxidants present, i.e., vitamin C, phenolic compounds (such as rutin and chlorogenic acid), tocopherols, and carotenoids, were quantified. Fourth, an untargeted metabolomic approach using LC-QTOF-MS was used to identify those production steps that have the largest impact on the overall metabolic profile in the final paste as compared to the original fruits. This multifaceted approach has revealed that each processing step induces specific alterations in the metabolic profile, as determined by the different analysis procedures, and that in particular the fruit-breaking step and the removal of seed and skin significantly affect the levels of antioxidants and many other metabolites present in commercial tomato paste.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,165
The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay
Benzie, I. F. F., & Strain, J. J. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0292 · Cited by 22,951
The Chemistry behind Antioxidant Capacity Assays
Huang, D., Ou, B., & Prior, R. L. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030723c · Cited by 6,162
Dewanto, V., Wu, X., Adom, K. K., & Liu, R. H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0115589 · Cited by 3,458
Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048741x · Cited by 2,820
Apak, R., Güçlü, K., Demirata, B., Özyürek, M., Çelik, S. E., Bektaşoğlu, B., Berker, K. I., & Özyurt, D. (2007) · Molecules · doi:10.3390/12071496 · Cited by 1,248
Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry
De Vos, R. C., Moco, S., Lommen, A., Keurentjes, J. J., Bino, R. J., & Hall, R. D. (2007) · Nature Protocols · doi:10.1038/nprot.2007.95 · Cited by 1,032
Self-citationLycopene in Tomatoes: Chemical and Physical Properties Affected by Food Processing
Shi, J. (2000) · Critical Reviews in Biotechnology · doi:10.1080/07388550091144212 · Cited by 885
Rapid Determination of Polyphenols and Vitamin C in Plant-Derived Products
Georgé, S., Brat, P., Alter, P., & Amiot, M. J. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048396b · Cited by 804
Factors Influencing the Antioxidant Activity Determined by the ABTS•+Radical Cation Assay
Miller, N. J., & Rice-Evans, C. A. (1997) · Free Radical Research · doi:10.3109/10715769709097799 · Cited by 723
Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: A review
Rao, A. V., & Agarwal, S. (1999) · Nutrition Research · doi:10.1016/s0271-5317(98)00193-6 · Cited by 686
An industrial approach in the search of natural antioxidants from vegetable and fruit wastes
Peschel, W., Sánchez-Rabaneda, F., Diekmann, W., Plescher, A., Gartzía, I., Jiménez, D., Lamuela-Raventós, R., Buxaderas, S., & Codina, C. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2005.03.033 · Cited by 649
Arnao, M. B. (2000) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(01)00027-9 · Cited by 615
Muir, S. R., Collins, G. J., Robinson, S., Hughes, S., Bovy, A., Ric De Vos, C. H., van Tunen, A. J., & Verhoeyen, M. E. (2001) · Nature Biotechnology · doi:10.1038/88150 · Cited by 588
Antioxidant and free radical scavenging activity of an aqueous extract of Coleus aromaticus
Kumaran, A., & Joel karunakaran, R. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2005.03.032 · Cited by 585
A Liquid Chromatography-Mass Spectrometry-Based Metabolome Database for Tomato
Moco, S., Bino, R. J., Vorst, O., Verhoeven, H. A., de Groot, J., van Beek, T. A., Vervoort, J., & de Vos, C. H. R. (2006) · Plant Physiology · doi:10.1104/pp.106.078428 · Cited by 577
Plant metabolomics: from holistic hope, to hype, to hot topic
Hall, R. D. (2006) · New Phytologist · doi:10.1111/j.1469-8137.2005.01632.x · Cited by 506
Self-citationCarrari, F., Baxter, C., Usadel, B., Urbanczyk-Wochniak, E., Zanor, M.-I., Nunes-Nesi, A., Nikiforova, V., Centero, D., Ratzka, A., Pauly, M., et al. (2006) · Plant Physiology · doi:10.1104/pp.106.088534 · Cited by 504
Bovy, A., de Vos, R., Kemper, M., Schijlen, E., Almenar Pertejo, M., Muir, S., Collins, G., Robinson, S., Verhoeyen, M., Hughes, S., et al. (2002) · The Plant Cell · doi:10.1105/tpc.004218 · Cited by 460
Self-citationAbushita, A. A., Daood, H. G., & Biacs, P. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990715p · Cited by 454
Berker, K. I., Güçlü, K., Tor, İ., & Apak, R. (2007) · Talanta · doi:10.1016/j.talanta.2007.01.019 · Cited by 303
Processing Effects on Lycopene Content and Antioxidant Activity of Tomatoes
Takeoka, G. R., Dao, L., Flessa, S., Gillespie, D. M., Jewell, W. T., Huebner, B., Bertow, D., & Ebeler, S. E. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0102721 · Cited by 271
Effect of semi-drying on the antioxidant components of tomatoes
Toor, R. K., & Savage, G. P. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2004.10.054 · Cited by 252
The light‐hyperresponsive high pigment‐2dg mutation of tomato: alterations in the fruit metabolome
Bino, R. J., De Vos, C. H. R., Lieberman, M., Hall, R. D., Bovy, A., Jonker, H. H., Tikunov, Y., Lommen, A., Moco, S., & Levin, I. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2005.01362.x · Cited by 223
Self-citationTissue specialization at the metabolite level is perceived during the development of tomato fruit
Moco, S., Çapanoğlu, E., Tikunov, Y. M., Bino, R. J., Boyacıoğlu, D., Hall, R. D., Vervoort, J. J. M., & de Vos, R. C. H. (2007) · Journal of Experimental Botany · doi:10.1093/jxb/erm271 · Cited by 205
Self-citationAgarwal, A., Shen, H., Agarwal, S., & Rao, A. V. (2001) · Journal of Medicinal Food · doi:10.1089/10966200152053668 · Cited by 168
Evaluation of extraction method for the analysis of carotenoids in fruits and vegetables
KAJADPHAI, A., Jones, G. P., Wahlqvist, M. L., & Briggs, D. R. (1998) · Food Chemistry · doi:10.1016/s0308-8146(98)00011-9 · Cited by 145
Identification and dietary relevance of antioxidants from raspberry
Beekwilder, J., Hall, R. D., & de Vos, C. H. (2005) · BioFactors · doi:10.1002/biof.5520230404 · Cited by 126
Self-citationHelsper, J. P. F. G., Vos, C. H. R. D., Maas, F. M., Jonker, H. H., van den Broeck, H. C., Jordi, W., Pot, C. S., Keizer, L. C. P., & Schapendonk, A. H. C. M. (2003) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2003.00037.x · Cited by 98
Effects of Food Processing on Flavonoids and Lycopene Status in a Mediterranean Tomato Variety
Re, R., Bramley, P. M., & Rice-Evans, C. A. (2002) · Free Radical Research · doi:10.1080/10715760290032584 · Cited by 91
Biological evaluation of tomato waste seed meals and protein concentrate
Sogi, D. S. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2004.01.083 · Cited by 71
Enzymes of secondary metabolism
Lea, P. J. (1993) · Academic Press eBooks · Cited by 19
Cited by
Fruit Antioxidants during Vinegar Processing: Changes in Content and in Vitro Bio-Accessibility
Bakir, S., Toydemir, G., Boyacioglu, D., Beekwilder, J., & Capanoglu, E. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101658 · Cited by 74
Self-citationDel Giudice, R., Petruk, G., Raiola, A., Barone, A., Monti, D. M., & Rigano, M. M. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7910 · Cited by 53
Phytochemomics and Other Omics for Permitting Health Claims Made on Foods
del Castillo, M. D., Martinez-Saez, N., Amigo-Benavent, M., & Silvan, J. M. (2013) · Food Research International · doi:10.1016/j.foodres.2013.05.014 · Cited by 26
Antioxidant Capacity, Nitrite and Nitrate Content in Beetroot-Based Dietary Supplements
Brzezińska-Rojek, J., Sagatovych, S., Malinowska, P., Gadaj, K., Prokopowicz, M., & Grembecka, M. (2023) · Foods · doi:10.3390/foods12051017 · Cited by 26
Metadata
- Authors
- Capanoglu, E., Beekwilder, J., Boyacioglu, D., Hall, R., & de Vos, R.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-02
- Volume
- 56
- Issue
- 3
- Pages
- 964-973
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2168400441
- Cited by
- 361
- References
- 32
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
