The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Curcumin Nanoparticles Improve the Physicochemical Properties of Curcumin and Effectively Enhance Its Antioxidant and Antihepatoma Activities
Abstract
Curcumin (CUR), a natural polyphenol isolated from tumeric ( Curcuma longa ), has been documented to possess antioxidant and anticancer activities. Unfortunately, the compound has poor aqueous solubility, which results in poor bioavailability following high doses by oral administration. To improve the solubility of CUR, we developed a novel curcumin nanoparticle system (CURN) and investigated its physicochemical properties as well as its enhanced dissolution mechanism. Our results indicated that CURN improved the physicochemical properties of CUR, including a reduction in particle size and the formation of an amorphous state with hydrogen bonding, both of which increased the drug release of the compound. Moreover, in vitro studies indicated that CURN significantly enhanced the antioxidant and antihepatoma activities of CUR (P < 0.05). Consequently, we suggest that CURN can be used to reduce the dosage of CUR and improve its bioavailability and merits further investigation for therapeutic applications.
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Cites
Bioavailability of curcumin: Problems and promises
Anand, P., Kunnumakkara, A. B., Newman, R. A., & Aggarwal, B. B. (2007) · Molecular Pharmaceutics · doi:10.1021/mp700113r · Cited by 5,543
Curcumin as “Curecumin”: From kitchen to clinic
Goel, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.016 · Cited by 2,214
Dose escalation of a curcuminoid formulation
Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-10 · Cited by 1,394
Nanosizing — Oral formulation development and biopharmaceutical evaluation
Kesisoglou, F., Panmai, S., & Wu, Y. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.003 · Cited by 1,055
Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective
Ratnam, D. V., Ankola, D. D., Bhardwaj, V., Sahana, D. K., & Kumar, M. N. V. R. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.015 · Cited by 885
Bilati, U., Allémann, E., & Doelker, E. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2004.09.011 · Cited by 686
Antioxidant Activity of a Flavonoid-Rich Extract of Hypericum perforatum L.in Vitro
Zou, Y., Lu, Y., & Wei, D. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049571r · Cited by 671
Priyadarsini, K. I., Maity, D. K., Naik, G. H., Kumar, M. S., Unnikrishnan, M. K., Satav, J. G., & Mohan, H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00325-3 · Cited by 665
Garcea, G., Jones, D. J. L., Singh, R., Dennison, A. R., Farmer, P. B., Sharma, R. A., Steward, W. P., Gescher, A. J., & Berry, D. P. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601623 · Cited by 425
Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles
Wu, T.-H., Yen, F.-L., Lin, L.-T., Tsai, T.-R., Lin, C.-C., & Cham, T.-M. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.06.036 · Cited by 384
Self-citationAntioxidant Activities of Different Colored Sweet Bell Peppers ( Capsicum annuum L.)
Sun, T., Xu, Z., Wu, C. ‐., Janes, M., Prinyawiwatkul, W., & No, H. K. (2007) · Journal of Food Science · doi:10.1111/j.1750-3841.2006.00245.x · Cited by 310
Role of curcumin in health and disease
Pari, L., Tewas, D., & Eckel, J. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802033958 · Cited by 245
Mitochondrial and Nuclear DNA Damage Induced by Curcumin in Human Hepatoma G2 Cells
Cao, J., Jia, L., Zhou, H.-M., Liu, Y., & Zhong, L.-F. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj153 · Cited by 233
Role of Nanotechnology in Pharmaceutical Product Development
Devalapally, H., Chakilam, A., & Amiji, M. M. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20875 · Cited by 230
Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats
Yen, F.-L., Wu, T.-H., Lin, L.-T., Cham, T.-M., & Lin, C.-C. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.01.021 · Cited by 167
Self-citationAnti-proliferative effect of apigenin and its apoptotic induction in human Hep G2 cells
Chiang, L., Ng, L., Lin, I.-C., Kuo, P., & Lin, C. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.06.002 · Cited by 150
Self-citationKe, W., Li, J., Wang, W., et al. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21598 · Cited by 119
Venkatesan, P., & Rao, M. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774886 · Cited by 118
Protective properties of melatonin-loaded nanoparticles against lipid peroxidation
Schaffazick, S. R., Pohlmann, A. R., de Cordova, C. A. S., Creczynski‐Pasa, T. B., & Guterres, S. S. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.11.003 · Cited by 88
Liang, H., Chen, S.-C., Chen, M., Lee, P.-W., Chen, C.-T., & Sung, H. (2006) · Bioconjugate Chemistry · doi:10.1021/bc0502107 · Cited by 78
Yen, F., Wu, T.-H., Lin, L., Cham, T., & Lin, C. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.10.077 · Cited by 73
Self-citationMasuda, T., Toi, Y., Bando, H., Maekawa, T., Takeda, Y., & Yamaguchi, H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf011601s · Cited by 71
Steward, W. P., & Gescher, A. J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700148 · Cited by 64
(2001) · PubMed
(2001) · PubMed
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Shishir, M. R. I., Xie, L., Sun, C., Zheng, X., & Chen, W. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.05.018 · Cited by 658
Thorat, A. A., & Dalvi, S. V. (2012) · Chemical Engineering Journal · doi:10.1016/j.cej.2011.12.044 · Cited by 438
Xie, X., Tao, Q., Zou, Y., Zhang, F., Guo, M., Wang, Y., Wang, H., Zhou, Q., & Yu, S. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202135j · Cited by 393
Chen, S., Li, Q., McClements, D. J., Han, Y., Dai, L., Mao, L., & Gao, Y. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105334 · Cited by 308
Everted gut sac model as a tool in pharmaceutical research: limitations and applications
Alam, M. A., Al-Jenoobi, F. I., & Al-mohizea, A. M. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01391.x · Cited by 221
Metadata
- Authors
- Yen, F.-L., Wu, T.-H., Tzeng, C.-W., Lin, L.-T., & Lin, C.-C.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-20
- Volume
- 58
- Issue
- 12
- Pages
- 7376-7382
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2039732615
- Cited by
- 295
- References
- 25
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
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