Cranberry proanthocyanidins: Natural weapons against periodontal diseases

Feghali, Karine; Feldman, Mark; La, Vu Dang; Santos, Juliana; Grenier, Daniel

doi:10.1021/jf203304v

Cited by 114Oral microbiology and periodontitis researchPhytochemicals and Antioxidant ActivitiesPomegranate: compositions and health benefits

Cranberry proanthocyanidins: Natural weapons against periodontal diseases

Feghali, Karine, Feldman, Mark, La, Vu Dang, Santos, Juliana, Grenier, Daniel·2012·Journal of Agricultural and Food Chemistry

DOI 10.1021/jf203304v

Open this paper in CoChat — free account

Abstract

Cranberry ( Vaccinium macrocarpon ) is known to have a beneficial effect on several aspects of human health. Proanthocyanidins (PACs), the most abundant flavonoids extracted from red cranberry fruits, have been reported to possess antimicrobial, antiadhesion, antioxidant, and anti-inflammatory properties. Recent in vitro studies have shown that cranberry PACs may be potential therapeutic agents for the prevention and management of periodontitis, an inflammatory disease of bacterial origin affecting tooth-supporting tissues. After presenting an overview of cranberry phytochemicals and their potential for human health benefits, this review will focus on the effects of cranberry PACs on connective tissue breakdown and alveolar bone destruction, as well as their potential for controlling periodontal diseases. Possible mechanisms of action of cranberry PACs include the inhibition of (i) bacterial and host-derived proteolytic enzymes, (ii) host inflammatory response, and (iii) osteoclast differentiation and activity. Given that cranberry PACs have shown interesting properties in in vitro studies, clinical trials are warranted to better evaluate the potential of these molecules for controlling periodontal diseases.

Integrity signals

Registry

Crossref · 10.1021/jf203304v

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In a recent in vitro study, treatment of multi-species biofilms with N-acetyl-D-mannosamine, succinic acid, and the di-peptide Met-Pro resulted in a significant increase in the proportion of beneficial species in the oral microbiota and a concomitant reduction in the proportion of pathogenic species.
“A recent in vitro study showed that treatment of multi-species biofilms with N-acetyl-D-mannosamine, succinic acid, and the di-peptide Met-Pro resulted in a significant increase in the proportion of beneficial species in the oral microbiota and a concomitant reduction in the proportion of pathogenic species.”
From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [152]

Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962 · see citing works
Periodontal diseases
Pihlstrom, B. L., Michalowicz, B. S., & Johnson, N. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67728-8 · Cited by 3,718 · see citing works
Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,634 · see citing works
Activation mechanisms of matrix metalloproteinases.
Nagase, H. (1997) · PubMed · Cited by 1,124 · see citing works
Concentrations of Proanthocyanidins in Common Foods and Estimations of Normal Consumption
Kelm, M. A., Hammerstone, J. F., Beecher, G. R., Holden, J., Haytowitz, D. B., Gebhardt, S. E., Gu, L., & Prior, R. L. (2004) · Journal of Nutrition · doi:10.1093/jn/134.3.613 · Cited by 941 · see citing works
Destructive Periodontal Disease in Adults 30 Years of Age and Older in the United States, 1988‐1994
Albandar, J. M., Brunelle, J. A., & Kingman, A. (1999) · Journal of Periodontology · doi:10.1902/jop.1999.70.1.13 · Cited by 793 · see citing works
Inflammation and Bone Loss in Periodontal Disease
Cochran, D. L. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.080233 · Cited by 732 · see citing works
Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis
Humphrey, L. L., Fu, R. F., Buckley, D., Freeman, M., & Helfand, M. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0787-6 · Cited by 723 · see citing works
Role of Matrix Metalloproteinases in Human Periodontal Diseases
Birkedal‐Hansen, H. (1993) · Journal of Periodontology · doi:10.1902/jop.1993.64.5s.474 · Cited by 670 · see citing works
The host response to the microbial challenge in periodontitis: assembling the players
Kornman, K. S., Page, R. C., & Tonetti, M. S. (1997) · Periodontology 2000 · doi:10.1111/j.1600-0757.1997.tb00191.x · Cited by 652 · see citing works
Matrix metalloproteinases (MMPs) in oral diseases
Sorsa, T. A., Tjäderhane, L., & Salo, T. A. (2004) · Oral Diseases · doi:10.1111/j.1601-0825.2004.01038.x · Cited by 620 · see citing works
Role of cytokines and inflammatory mediators in tissue destruction
Birkedal‐Hansen, H. (1993) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1993.tb02113.x · Cited by 618 · see citing works
Cytokine Expression in Periodontal Health and Disease
Okada, H., & Murakami, S. (1998) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411980090030101 · Cited by 576 · see citing works
Clinical significance of non‐surgical periodontal therapy: an evidence‐based perspective of scaling and root planing
Cobb, C. M. (2002) · Journal of Clinical Periodontology · doi:10.1034/j.1600-051x.29.s2.4.x · Cited by 566 · see citing works
Global epidemiology of periodontal diseases: an overview
Albandar, J. M., & Rams, T. E. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.290101.x · Cited by 525 · see citing works
A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity
Howell, A. B., Reed, J. D., Krueger, C. G., Winterbottom, R., Cunningham, D. G., & Leahy, M. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.05.022 · Cited by 524 · see citing works
Associations Between Periodontal Disease and Risk for Nosocomial Bacterial Pneumonia and Chronic Obstructive Pulmonary Disease. A Systematic Review
Scannapieco, F. A., Bush, R. B., & Paju, S. (2003) · Annals of Periodontology · doi:10.1902/annals.2003.8.1.54 · Cited by 503 · see citing works
Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases
Neto, C. C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600279 · Cited by 460 · see citing works
I nteraction of P lant P olyphenols with S alivary P roteins
Bennick, A. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300208 · Cited by 441 · see citing works
Systemic Anti‐Infective Periodontal Therapy. A Systematic Review
Haffajee, A. D., Socransky, S. S., & Gunsolley, J. C. (2003) · Annals of Periodontology · doi:10.1902/annals.2003.8.1.115 · Cited by 441 · see citing works
The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro
Foo, L. Y., Lu, Y., Howell, A. B., & Vorsa, N. (2000) · Phytochemistry · doi:10.1016/s0031-9422(99)00573-7 · Cited by 440 · see citing works
The role of matrix metalloproteinases in the oral environment
Hannas, A. R., Pereira, J. C., Granjeiro, J. M., & Tjäderhane, L. (2006) · Acta Odontologica Scandinavica · doi:10.1080/00016350600963640 · Cited by 411 · see citing works
Modulation of Host PGE2 Secretion as a Determinant of Periodontal Disease Expression
Offenbacher, S., Heasman, P. A., & Collins, J. G. (1993) · Journal of Periodontology · doi:10.1902/jop.1993.64.5s.432 · Cited by 354 · see citing works
Vitamin P: Flavonols as Vitamins
Rusznyák, S., & Szent‐Györgyi, A. (1936) · Nature · doi:10.1038/138027a0 · Cited by 312 · see citing works
Phytochemicals of Cranberries and Cranberry Products: Characterization, Potential Health Effects, and Processing Stability
Pappas, E. L., & Schaich, K. M. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390802145377 · Cited by 301 · see citing works
Cranberry and Its Phytochemicals: A Review of In Vitro Anticancer Studies
Neto, C. C. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.186s · Cited by 295 · see citing works
EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair
Gabison, E. E., Hoang-Xuan, T., Mauviel, A., & Ménashi, S. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.023 · Cited by 286 · see citing works
Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis
Stabholz, A., Soskolne, W. A., & Shapira, L. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00340.x · Cited by 282 · see citing works
Antioxidant Activities and Antitumor Screening of Extracts from Cranberry Fruit ( Vaccinium macrocarpon )
Yan, X., Murphy, B. T., Hammond, G. B., Vinson, J. A., & Neto, C. C. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0202234 · Cited by 282 · see citing works
Bioactive compounds in cranberries and their role in prevention of urinary tract infections
Howell, A. B. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700038 · Cited by 277 · see citing works
Role of bacteria in health and disease of periodontal tissues
Feng, Z., & Weinberg, A. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00148.x · Cited by 267 · see citing works
Cranberry and Urinary Tract Infections
Guay, D. R. P. (2009) · Drugs · doi:10.2165/00003495-200969070-00002 · Cited by 244 · see citing works
A high molecular mass constituent of cranberry juice inhibits Helicobacter pylori adhesion to human gastric mucus
Burger, O., Ofek, I., Tabak, M., Weiss, E. I., Sharon, N., & Neéman, I. (2000) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2000.tb01537.x · Cited by 235 · see citing works
The Relationship Between Infections and Adverse Pregnancy Outcomes: An Overview
Gibbs, R. S. (2001) · Annals of Periodontology · doi:10.1902/annals.2001.6.1.153 · Cited by 183 · see citing works
Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation
Yamanaka, A., Kimizuka, R., Kato, T., & Okuda, K. (2004) · Oral Microbiology and Immunology · doi:10.1111/j.0902-0055.2004.00130.x · Cited by 167 · see citing works
A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite
Weiss, E. I., Kozlovsky, A., Steinberg, D., Lev-Dor, R., Greenstein, R. B., Feldman, M., Sharon, N., & Ofek, I. (2004) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(04)00035-7 · Cited by 165 · see citing works
In Vitro Models of Tissue Penetration and Destruction by Porphyromonas gingivalis
Andrian, E., Grenier, D., & Rouabhia, M. (2004) · Infection and Immunity · doi:10.1128/iai.72.8.4689-4698.2004 · Cited by 153 · see citing works
Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: Evidence that breakdown is mediated by metal loproteinases
Meikle, M. C., Atkinson, S. J., Ward, R. V., Murphy, G., & Reynolds, J. J. (1989) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1989.tb02007.x · Cited by 147 · see citing works
Anti-inflammatory Activity of a High-molecular-weight Cranberry Fraction on Macrophages Stimulated by Lipopolysaccharides from Periodontopathogens
Bodet, C., Chandad, F., & Grenier, D. (2006) · Journal of Dental Research · doi:10.1177/154405910608500306 · Cited by 144 · see citing works
Cranberries (Vaccinium macrocarpon) and Cardiovascular Disease Risk Factors
McKay, D. L., & Blumberg, J. B. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00273.x · Cited by 142 · see citing works
Periodontal disease and diabetes-Review of the literature
Martínez, A. B., Matesanz, P., Escribano-Bermejo, M., González‐Moles, M. Á., Bascones-Ilundáin, J., & Meurman, J. H. (2011) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.17032 · Cited by 142 · see citing works
Possible interaction between warfarin and cranberry juice
Suvarna, R., Pirmohamed, M., & Henderson, L. (2003) · BMJ · doi:10.1136/bmj.327.7429.1454 · Cited by 137 · see citing works
Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm
Steinberg, D. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh254 · Cited by 136 · see citing works
Expression of mRNA for matrix metalloproteinases and tissue inhibitors of metalloproteinases in periodontitis-affected human gingival tissue
Kubota, T., Nomura, T., Takahashi, T., & Hara, K. (1996) · Archives of Oral Biology · doi:10.1016/0003-9969(95)00126-3 · Cited by 130 · see citing works
Mediators of Periodontal Osseous Destruction and Remodeling: Principles and Implications for Diagnosis and Therapy
McCauley, L. K., & Nohutçu, R. M. (2002) · Journal of Periodontology · doi:10.1902/jop.2002.73.11.1377 · Cited by 122 · see citing works
Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men
Ruel, G., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061814 · Cited by 122 · see citing works
Associations between dietary flavonoid intakes and bone health in a scottish population
Hardcastle, A. C., Aucott, L. S., Reid, D. M., & Macdonald, H. M. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.285 · Cited by 117 · see citing works
Crevicular interleukin‐1β in moderate and severe periodontitis patients and the effect of phase I periodontal treatment
Hou, L., Liu, C., & Rossomando, E. F. (1995) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1995.tb00128.x · Cited by 115 · see citing works
Cathepsin C, Matrix Metalloproteinases, and their Tissue Inhibitors in Gingiva and Gingival Crevicular Fluid from Periodontitis-affected Patients
Soell, M., Elkaïm, R., & Tenenbaum, H. (2002) · Journal of Dental Research · doi:10.1177/154405910208100306 · Cited by 115 · see citing works
Antigens of bacteria associated with periodontitis
O’brien-simpson, N. M., Veith, P. D., Dashper, S. G., & Reynolds, E. C. (2004) · Periodontology 2000 · doi:10.1111/j.0906-6713.2004.003559.x · Cited by 114 · see citing works
Subantimicrobial Dose Doxycycline Enhances the Efficacy of Scaling and Root Planing in Chronic Periodontitis: A Multicenter Trial
Preshaw, P. M., Hefti, A. F., Novak, M. J., Michalowicz, B. S., Pihlstrom, B. L., Schoor, R., Trummel, C. L., Dean, J. W., Dyke, T. E. V., Walker, C., et al. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.8.1068 · Cited by 112 · see citing works
Proteolytic and hydrolytic enzymes from putative periodontal pathogens: characterization, molecular genetics, effects on host defenses and tissues and detection in gingival crevice fluid
Eley, B. M., & Cox, S. W. (2003) · Periodontology 2000 · doi:10.1034/j.1600-0757.2003.03107.x · Cited by 109 · see citing works
Cranberries (Vaccinium macrocarpon) and Cardiovascular Disease Risk Factors
McKay, D. L., & Blumberg, J. B. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.nov.490-502 · Cited by 109 · see citing works
Cranberry Proanthocyanidins Inhibit MMP Production and Activity
La, V. D., Howell, A. B., & Grenier, D. (2009) · Journal of Dental Research · doi:10.1177/0022034509339487 · Cited by 107 · see citing works
Cell populations and episodic periodontal attachment loss in humans*
Zappa, U. E., Reinking‐Zappa, M., Graf, H. A., & Espeland, M. A. (1991) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1991.tb00082.x · Cited by 104 · see citing works
Effectiveness of mechanical nonsurgical pocket therapy
Suvan, J. E. (2005) · Periodontology 2000 · doi:10.1111/j.1600-0757.2004.03794.x · Cited by 103 · see citing works
Production of inflammatory mediators and cytokines by human gingival fibroblasts following bacterial challenge
Dongari‐Bagtzoglou, A. I., & Ebersole, J. L. (1996) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1996.tb00469.x · Cited by 101 · see citing works
Cranberry polyphenols: potential benefits for dental caries and periodontal disease.
Bonifait, L., & Grenier, D. (2010) · PubMed · Cited by 98 · see citing works
Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress
Shukitt‐Hale, B., Galli, R. L., Meterko, V., Carey, A. N., Bielinski, D. F., McGhie, T. K., & Joseph, J. A. (2005) · AGE · doi:10.1007/s11357-005-4004-9 · Cited by 97 · see citing works
INHIBITING INTERSPECIES COAGGREGATION OF PLAQUE BACTERIA WITH A CRANBERRY JUICE CONSTITUENT
Weiss, E., Lev-Dor, R., Kashamn, Y., Goldhar, J., Sharon, N., & Ofek, I. (1998) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1998.0141 · Cited by 94 · see citing works
Position paper: epidemiology of periodontal diseases. American Academy of Periodontology.
Aap (1996) · PubMed · Cited by 93 · see citing works
Potentiel pathogénique de Porphyromonas gingivalis, Treponema denticola et Tannerella forsythia, le complexe bactérien rouge associé à la parodontite
Bodet, C., Chandad, F., & Grenier, D. (2007) · Pathologie Biologie · doi:10.1016/j.patbio.2006.07.045 · Cited by 92 · see citing works
Cranberry components inhibit interleukin‐6, interleukin‐8, and prostaglandin E 2 production by lipopolysaccharide‐activated gingival fibroblasts
Bodet, C., Chandad, F., & Grenier, D. (2007) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2007.00415.x · Cited by 91 · see citing works
Susceptibility of Helicobacter pylori isolates to the antiadhesion activity of a high-molecular-weight constituent of cranberry
Shmuely, H., Burger, O., Néeman, I., Yahav, J., Samra, Z., Niv, Y., Sharon, N., Weiss, E., Athamna, A., Tabak, M., et al. (2004) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2004.08.011 · Cited by 90 · see citing works
Effects of Daily Ingestion of Cranberry Juice on the Pharmacokinetics of Warfarin, Tizanidine, and Midazolam—Probes of CYP2C9, CYP1A2, and CYP3A4
Lilja, J. J., Backman, J. T., & Neuvonen, P. J. (2007) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100149 · Cited by 90 · see citing works
Evidences of the cardioprotective potential of fruits: The case of cranberries
Ruel, G., & Couillard, C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600286 · Cited by 87 · see citing works
Cathepsin C, Matrix Metalloproteinases, and their Tissue Inhibitors in Gingiva and Gingival Crevicular Fluid from Periodontitis-affected Patients
Soell, M., Elkaïm, R., & Tenenbaum, H. (2002) · Journal of Dental Research · doi:10.1177/0810174 · Cited by 87 · see citing works
When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols
Trzeciakiewicz, A., Habauzit, V., & Horcajada, M.-N. (2009) · Nutrition Research Reviews · doi:10.1017/s095442240926402x · Cited by 86 · see citing works
Cranberry juice constituents affect influenza virus adhesion and infectivity
Weiss, E., Houri‐Haddad, Y., Greenbaum, E., Hochman, N., Ofek, I., & Zakay‐Rones, Z. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2004.12.011 · Cited by 85 · see citing works
Interleukin 1 stimulation of plasminogen activator production in cultured gingival fibroblasts
Mochan, E., Armor, L., & Sporer, R. (1988) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1988.tb01023.x · Cited by 82 · see citing works
Antiviral effects on bacteriophages and rotavirus by cranberry juice
Lipson, S. M., Sethi, L., Cohen, P., Gordon, R. E., Tan, I. P., Burdowski, A., & Stotzky, G. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.11.009 · Cited by 80 · see citing works
Anti-Porphyromonas gingivalisand Anti-Inflammatory Activities of A-Type Cranberry Proanthocyanidins
La, V. D., Howell, A. B., & Grenier, D. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01432-09 · Cited by 75 · see citing works
Inhibition of periodontopathogen-derived proteolytic enzymes by a high-molecular-weight fraction isolated from cranberry
Bodet, C., Piché, M., Chandad, F., & Grenier, D. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl031 · Cited by 72 · see citing works
Inhibition of host extracellular matrix destructive enzyme production and activity by a high‐molecular‐weight cranberry fraction
Bodet, C., Chandad, F., & Grenier, D. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00929.x · Cited by 59 · see citing works
The relationship between periodontal diseases and respiratory diseases.
Scannapieco, F. A., & Rethman, M. P. (2003) · PubMed · Cited by 59 · see citing works
The Absence of an Interaction Between Warfarin and Cranberry Juice: A Randomized, Double‐Blind Trial
Ansell, J., McDonough, M., Zhao, Y., Harmatz, J. S., & Greenblatt, D. J. (2009) · The Journal of Clinical Pharmacology · doi:10.1177/0091270009337510 · Cited by 56 · see citing works
Fruit extracts antagonize Aβ- or DA-induced deficits in Ca2+ flux in M1-transfected COS-7 cells
Joseph, J. A., Fisher, D. R., & Carey, A. N. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6408 · Cited by 54 · see citing works
Interleukin‐1 regulation of procollagenase mRNA and protein in periodontal fibroblasts in vitro
Richards, D. A. J., & Rutherford, R. B. (1990) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1990.tb00908.x · Cited by 54 · see citing works
MMP-9/TIMP-1imbalance induced in human dendritic cells byPorphyromonas gingivalis
Jotwani, R., Eswaran, S. V. K., Moonga, S. S., & Cutler, C. W. (2009) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2009.00637.x · Cited by 53 · see citing works
Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in exjreimental jreiodontal disease
Ramamurthy, N. S., Xu, J., Bird, J., Baxter, A. R. W., Bhogal, R., Wills, R. E., Watson, B. A., Owen, D. A., Wolff, M. S., & Greenwald, R. A. (2002) · Journal of Periodontal Research · doi:10.1034/j.1600-0765.2002.00342.x · Cited by 51 · see citing works
Warfarin-Cranberry Juice Interaction
Hamann, G. L., Campbell, J. D., & George, C. M. (2011) · Annals of Pharmacotherapy · doi:10.1345/aph.1p451 · Cited by 49 · see citing works
Safety and efficacy of cranberry (vaccinium macrocarpon) during pregnancy and lactation.
Dugoua, J.-J., Seely, D., Perri, D., Mills, E. J., & Koren, G. (2008) · PubMed · Cited by 45 · see citing works
Vaccinium macrocarpon: An interesting option for women with recurrent urinary tract infections and other health benefits
Pérez-López, F. R., Haya, J., & Chedraui, P. A. (2009) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1447-0756.2009.01026.x · Cited by 45 · see citing works
Cranberry Juice and Warfarin: When Bad Publicity Trumps Science
Zikria, J., Goldman, R., & Ansell, J. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.08.019 · Cited by 41 · see citing works
A-Type Cranberry Proanthocyanidins Inhibit the RANKL-Dependent Differentiation and Function of Human Osteoclasts
Tanabe, S., Santos, J. C., La, V. D., Howell, A. B., & Grenier, D. (2011) · Molecules · doi:10.3390/molecules16032365 · Cited by 39 · see citing works
Inhibition of metalloproteinase-9 activity and gene expression by polyphenolic compounds isolated from the bark of Tristaniopsis calobuxus (Myrtaceae)
Bellosta, S., Dell’Agli, M., Canavesi, M., Mitro, N., Monetti, M., Crestani, M., Verotta, L., Fuzzati, N., Bernini, F., & Bosisio, E. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3119-3 · Cited by 38 · see citing works
Cranberry cocktail juice, cranberry concentrates, and proanthocyanidins reduce reovirus infectivity titers in African green monkey kidney epithelial cell cultures
Lipson, S. M., Cohen, P., Zhou, J., Burdowski, A., & Stotzky, G. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600276 · Cited by 38 · see citing works
[Flavonoids and pycnogenols].
Masquelier, J., Michaud, J., Laparra, J., & Dumon, M.-C. (1979) · PubMed · Cited by 35 · see citing works
Effect of high‐dose cranberry juice on the pharmacodynamics of warfarin in patients
Mellen, C. K., Ford, M. A., & Rindone, J. P. (2010) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03674.x · Cited by 32 · see citing works
North American Cranberry (Vaccinium Macrocarpon) Stimulates Apoptotic Pathways in DU145 Human Prostate Cancer Cells In Vitro
MacLean, M. A., Scott, B., Deziel, B., Nunnelley, M., Liberty, A. M., Gottschall‐Pass, K. T., Neto, C. C., & Hurta, R. A. R. (2010) · Nutrition and Cancer · doi:10.1080/01635581.2010.516876 · Cited by 32 · see citing works
Cytoprotective effect of Proanthocyanidin‐rich cranberry fraction against bacterial cell wall‐mediated toxicity in macrophages and epithelial cells
La, V. D., Labrecque, J., & Grenier, D. (2009) · Phytotherapy Research · doi:10.1002/ptr.2799 · Cited by 25 · see citing works
Porphyromonas gingivalis-mediated shedding of extracellular matrix metalloproteinase inducer (EMMPRIN) by oral epithelial cells: a potential role in inflammatory periodontal disease
Feldman, M., La, V. D., Bedran, T. B. L., Spolidório, D. M. P., & Grenier, D. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.07.009 · Cited by 24 · see citing works
Antigen-presenting properties of gingival fibroblasts in chronic adult periodontitis
Wassenaar, A., Snijders, A. J., Abraham-Inpijn, L., Kapsenberg, M. L., & Kievits, F. (1997) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1997.tb08328.x · Cited by 22 · see citing works

Flagged first, then by citations

Sorted by citations

Advancing antimicrobial strategies for managing oral biofilm infections
Jiao, Y., Tay, F. R., Niu, L.-N., & Chen, J.-H. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0062-1 · Cited by 280 · see citing works
Drug resistance of bacterial dental biofilm and the potential use of natural compounds as alternative for prevention and treatment
Kouidhi, B., Qurashi, Y. M. A. A., & Chaieb, K. (2015) · Microbial Pathogenesis · doi:10.1016/j.micpath.2015.02.007 · Cited by 204 · see citing works
A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis
Santonocito, S., Giudice, A., Polizzi, A., Troiano, G., Merlo, E. M., Sclafani, R., Grosso, G., & Isola, G. (2022) · Nutrients · doi:10.3390/nu14122426 · Cited by 144 · see citing works
Periodontal disease: the influence of metabolic syndrome
Marchetti, E., Monaco, A., Procaccini, L., Mummolo, S., Gatto, R., Tetè, S., Baldini, A., Tecco, S., & Marzo, G. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-88 · Cited by 146 · see citing works
Novel Approaches to the Control of Oral Microbial Biofilms
Kuang, X., Chen, V., & Xu, X. (2018) · BioMed Research International · doi:10.1155/2018/6498932 · Cited by 143 · see citing works
Epigallocatechin gallate-based nanoparticles with reactive oxygen species scavenging property for effective chronic periodontitis treatment
Tian, M., Chen, G., Xu, J., Lin, Y., Zeng, Y., Chen, X., Li, X., & Chen, S. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132197 · Cited by 137 · see citing works
Vaccinium Species (Ericaceae): Phytochemistry and Biological Properties of Medicinal Plants
Martău, G. A., Teleky, B., Odocheanu, R., Soporan, D. A., Bochiș, M., Simon, E., & Vodnar, D. C. (2023) · Molecules · doi:10.3390/molecules28041533 · Cited by 92 · see citing works
Dual function of proanthocyanidins as both MMP inhibitor and crosslinker in dentin biomodification: A literature review
Balalaie, A., REZVANI, M. B., & Basir, M. M. (2017) · Dental Materials Journal · doi:10.4012/dmj.2017-062 · Cited by 83 · see citing works
Cranberry Polyphenols: Natural Weapons against Dental Caries
Philip, N. I., & Walsh, L. J. (2019) · Dentistry Journal · doi:10.3390/dj7010020 · Cited by 72 · see citing works
Dietary Polyphenols and Periodontitis—A Mini-Review of Literature
Basu, A., Masek, E., & Ebersole, J. L. (2018) · Molecules · doi:10.3390/molecules23071786 · Cited by 70 · see citing works
Anti-proteolytic capacity and bonding durability of proanthocyanidin-biomodified demineralized dentin matrix
Liu, R., Fang, M., Zhang, L., Tang, C., Dou, Q., & Chen, J. (2014) · International Journal of Oral Science · doi:10.1038/ijos.2014.22 · Cited by 70 · see citing works
Proanthocyanidins and Flavan-3-Ols in the Prevention and Treatment of Periodontitis—Antibacterial Effects
Nawrot-Hadzik, I., Matkowski, A., Hadzik, J., Dobrowolska-Czopor, B., Olchowy, C., Dominiak, M., & Kubasiewicz−Ross, P. (2021) · Nutrients · doi:10.3390/nu13010165 · Cited by 65 · see citing works
Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases
Lagha, A. B., Dudonné, S., Desjardins, Y., & Grenier, D. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01525 · Cited by 63 · see citing works
A comprehensive review on anthocyanin-rich foods: Insights into extraction, medicinal potential, and sustainable applications
Lakshmikanthan, M., Muthu, S., Krishnan, K., Altemimi, A. B., Haider, N. N., Govindan, L., Selvakumari, J., Alkanan, Z. T., Cacciola, F., & Francis, Y. M. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101245 · Cited by 61 · see citing works
Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages
Feldman, M., & Grenier, D. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05329.x · Cited by 59 · see citing works
The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases—A Literature Review
Szulc-Musioł, B., & Sarecka‐Hujar, B. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13040451 · Cited by 58 · see citing works
Structural Elucidation and Antioxidant Activities of Proanthocyanidins from Chinese Bayberry (Myrica rubra Sieb. et Zucc.) Leaves
Fu, Y., Qiao, L., Cao, Y., Zhou, X., Liu, Y., & Ye, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096162 · Cited by 55 · see citing works
Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms
Philip, N. I., Bandara, N., Leishman, S. J., & Walsh, L. J. (2018) · European Journal Of Oral Sciences · doi:10.1111/eos.12602 · Cited by 55 · see citing works
The antibiofilm activity of lingonberry flavonoids against oral pathogens is a case connected to residual complexity
Riihinen, K., Ou, Z. M., Gödecke, T., Lankin, D. C., Pauli, G. F., & Wu, C. D. (2014) · Fitoterapia · doi:10.1016/j.fitote.2014.05.012 · Cited by 54 · see citing works
Chapter 13: Diet and periodontal diseases
Woelber, J. P., & Tennert, C. (2020) · Monographs in Oral Science · doi:10.1159/000455380 · Cited by 54 · see citing works
Impact of Cranberry Juice Enriched with Omega-3 Fatty Acids Adjunct with Nonsurgical Periodontal Treatment on Metabolic Control and Periodontal Status in Type 2 Patients with Diabetes with Periodontal Disease
Javid, A. Z., Maghsoumi‐Norouzabad, L., Ashrafzadeh, E., Yousefimanesh, H. A., Zakerkish, M., Angali, K. A., Ravanbakhsh, M., & Babaei, H. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1357509 · Cited by 51 · see citing works
Green tea polyphenol epigallocatechin-3-gallate and cranberry proanthocyanidins act in synergy with cathelicidin (LL-37) to reduce the LPS-induced inflammatory response in a three-dimensional co-culture model of gingival epithelial cells and fibroblasts
Bedran, T. B. L., Spolidório, D. M. P., & Grenier, D. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2015.02.021 · Cited by 49 · see citing works
The Current Strategies in Controlling Oral Diseases by Herbal and Chemical Materials
Motallaei, M. N., Yazdanıan, M., Tebyanian, H., Tahmasebi, E., Alam, M. M. R., Abbasi, K., Seifalian, A. M., Ranjbar, R., & Yazdanian, A. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/3423001 · Cited by 50 · see citing works
Identification of Quercitrin as a Potential Therapeutic Agent for Periodontal Applications
Gómez‐Florit, M., Monjo, M., & Ramis, J. M. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.130438 · Cited by 47 · see citing works
Anti-aging and redox state regulation effects of A-type proanthocyanidins-rich cranberry concentrate and its comparison with grape seed extract in mice
Jiao, J., Wei, Y., Chen, J., Chen, X., & Zhang, Y. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2016.12.039 · Cited by 44 · see citing works
Extract from Rumex acetosa L. for Prophylaxis of Periodontitis: Inhibition of Bacterial In Vitro Adhesion and of Gingipains of Porphyromonas gingivalis by Epicatechin-3-O-(4β→8)-Epicatechin-3-O-Gallate (Procyanidin-B2-Di-Gallate)
Schmuch, J., Beckert, S., Brandt, S., Löhr, G., Herrmann, F. C., Schmidt, T. J., Beikler, T., & Hensel, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120130 · Cited by 43 · see citing works
Therapeutic potential of cranberry for kidney health and diseases
Amin, R., Thalluri, C., Docea, A. O., Sharifi‐Rad, J., & Călina, D. C. (2022) · eFood · doi:10.1002/efd2.33 · Cited by 42 · see citing works
Dual action of highbush blueberry proanthocyanidins on Aggregatibacter actinomycetemcomitans and the host inflammatory response
Lagha, A. B., LeBel, G., & Grenier, D. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-2072-x · Cited by 41 · see citing works
Determination of the effects of cinnamon bark fractions on Candida albicans and oral epithelial cells
Veilleux, M.-P., & Grenier, D. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2730-2 · Cited by 41 · see citing works
Relevance of Biofilm Models in Periodontal Research: From Static to Dynamic Systems
Sánchez, M. C., Alonso-Español, A., Ribeiro-Vidal, H., Alonso, B., Herrera, D., & Sanz, M. (2021) · Microorganisms · doi:10.3390/microorganisms9020428 · Cited by 39 · see citing works
New Evidences of Antibacterial Effects of Cranberry Against Periodontal Pathogens
Sánchez, M. C., Ribeiro‐Vidal, H., Bartolomé, B., Figuero, E., Moreno-Arribas, M. V., Sanz, M., & Herrera, D. (2020) · Foods · doi:10.3390/foods9020246 · Cited by 39 · see citing works
Proanthocyanidins and Flavan-3-ols in the Prevention and Treatment of Periodontitis—Immunomodulatory Effects, Animal and Clinical Studies
Nawrot-Hadzik, I., Matkowski, A., Kubasiewicz−Ross, P., & Hadzik, J. (2021) · Nutrients · doi:10.3390/nu13010239 · Cited by 39 · see citing works
Development and Validation of 697 Novel Polymorphic Genomic and EST-SSR Markers in the American Cranberry (Vaccinium macrocarpon Ait.)
Schlautman, B., Fajardo, D. A., Bougie, T., Wiesman, E., Polashock, J. J., Vorsa, N., Steffan, S. A., & Zalapa, J. E. (2015) · Molecules · doi:10.3390/molecules20022001 · Cited by 37 · see citing works
Cranberry (Vaccinium macrocarpon) extract treatment improves triglyceridemia, liver cholesterol, liver steatosis, oxidative damage and corticosteronemia in rats rendered obese by high fat diet
Peixoto, T. C., de Moura, E. G., OLIVEIRA, E. B. D., Soares, P. N., Guarda, D. S., Bernardino, D. N., Ai, X. X., Rodrigues, V. D. S. T., de Souza, G. R., da Silva, A. J. R., et al. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1467-2 · Cited by 38 · see citing works
Health benefits of co-supplementing mealworm protein hydrolysate and cranberry fruit extract
Park, J. H., Lee, S. I., Kwon, W., Cho, S., & Kim, I. H. (2023) · Italian Journal of Food Science · doi:10.15586/ijfs.v35i1.2264 · Cited by 35 · see citing works
Inhibitory effects of cranberry polyphenol and volatile extracts on nitric oxide production in LPS activated RAW 264.7 macrophages
Moore, K., Howard, L. R., Brownmiller, C., Gu, I., Lee, S., & Mauromoustakos, A. (2019) · Food & Function · doi:10.1039/c9fo01500k · Cited by 34 · see citing works
[Retracted] The Current Antimicrobial and Antibiofilm Activities of Synthetic/Herbal/Biomaterials in Dental Application
Moghaddam, A., Ranjbar, R., Yazdanıan, M., Tahmasebi, E., Alam, M. M. R., Abbasi, K., Hosseini, Z. S., & Tebyanian, H. (2022) · BioMed Research International · doi:10.1155/2022/8856025 · Cited by 32 · see citing works
Retracted
Highly Active Cranberry’s Polyphenolic Fraction: New Advances in Processing and Clinical Applications
Colletti, A., Sangiorgio, L., Martelli, A., Testai, L., Cicero, A. F. G., & Cravotto, G. (2021) · Nutrients · doi:10.3390/nu13082546 · Cited by 34 · see citing works
Effect of cinnamon (Cinnamomum verum) bark essential oil on the halitosis-associated bacterium Solobacterium moorei and in vitro cytotoxicity
LeBel, G., Haas, B., Adam, A.-A., Veilleux, M.-P., Lagha, A. B., & Grenier, D. (2017) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.07.005 · Cited by 31 · see citing works
Variability in the Qualitative and Quantitative Composition and Content of Phenolic Compounds in the Fruit of Introduced American Cranberry (Vaccinium macrocarpon Aiton)
Gudžinskaitė, I., Stackevičienė, E., Liaudanskas, M., Zymonė, K., Žvikas, V., Viškelis, J., Urbštaitė, R., & Janulis, V. (2020) · Plants · doi:10.3390/plants9101379 · Cited by 31 · see citing works
Phytochemicals as Modulators of Paraoxonase-1 in Health and Diseases
Arab, Z. N., Khayatan, D., Razavi, S. M., Zare, K., Kheradkhah, E., Momtaz, S., Ferretti, G., Bacchetti, T., Sathyapalan, T., Emami, S. A., et al. (2022) · Antioxidants · doi:10.3390/antiox11071273 · Cited by 31 · see citing works
Anti-Inflammatory and Wound Healing Potential of Citrus Auraptene
La, V. D., Жао, Л., Epifano, F., Genovese, S., & Grenier, D. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0029 · Cited by 31 · see citing works
Construction of a High-Density American Cranberry ( Vaccinium macrocarpon Ait.) Composite Map Using Genotyping-by-Sequencing for Multi-pedigree Linkage Mapping
Schlautman, B., Covarrubias-Pazaran, G. E., Diaz-Garcia, L. A., Iorizzo, M., Polashock, J. J., Grygleski, E., Vorsa, N., & Zalapa, J. E. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.037556 · Cited by 30 · see citing works
Natural Compounds for Preventing Ear, Nose, and Throat-Related Oral Infections
Niculescu, A.-G., & Grumezescu, A. M. (2021) · Plants · doi:10.3390/plants10091847 · Cited by 28 · see citing works
Application of 1H‐NMR‐based metabolomics to the analysis of cranberry ( Vaccinium macrocarpon ) supplements
Turbitt, J. R., Colson, K. L., Killday, K. B., Milstead, A., & Neto, C. C. (2019) · Phytochemical Analysis · doi:10.1002/pca.2867 · Cited by 28 · see citing works
High performance thin layer chromatography–densitometry: A step further for quality control of cranberry extracts
Boudesocque‐Delaye, L., Dorat, J., Pothier, J., Gueiffier, A., & Enguehard‐Gueiffier, C. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.02.002 · Cited by 26 · see citing works
The potential of berries to serve as selective inhibitors of pathogens and promoters of beneficial microorganisms
Lacombe, A., & Wu, V. C. H. (2017) · Food Quality and Safety · doi:10.1093/fqs/fyx001 · Cited by 25 · see citing works
Cranberry Proanthocyanidins Neutralize the Effects of Aggregatibacter actinomycetemcomitans Leukotoxin
Lagha, A. B., Howell, A. B., & Grenier, D. (2019) · Toxins · doi:10.3390/toxins11110662 · Cited by 23 · see citing works
Tart cherry ( Prunus cerasus L. ) fractions inhibit biofilm formation and adherence properties of oral pathogens and enhance oral epithelial barrier function
Lagha, A. B., LeBel, G., & Grenier, D. (2019) · Phytotherapy Research · doi:10.1002/ptr.6574 · Cited by 23 · see citing works
The Protective Role of Cranberries and Blueberries in Oral Cancer
Esquivel-Chirino, C., Bolaños-Carrillo, M. A., Ruiz, D. C., López-Macay, Á., Hernández‐Sánchez, F., Montes-Sánchez, D. G., Escuadra-Landeros, M., Gaitán-Cepeda, L. A., Maldonado-Frías, S., Ocampo, B. R. Y., et al. (2023) · Plants · doi:10.3390/plants12122330 · Cited by 22 · see citing works
Application of Nanotechnology to Enhance Adsorption and Bioavailability of Procyanidins: A Review
Hou, K., & Wang, Z. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1888970 · Cited by 21 · see citing works
Polyphenols as Emerging Antimicrobial Agents
Ali, A., Parisi, A., & Normanno, G. (2022) · Springer eBooks · doi:10.1007/978-3-030-84126-3_10 · Cited by 19 · see citing works
Oligomeric proanthocyanidins ameliorates osteoclastogenesis through reducing OPG/RANKL ratio in chicken's embryos
Yu, G., Fu, X., Gong, A., Gu, J., Zou, H., Yuan, Y., Song, R., Ma, Y., Bian, J., Liu, Z., et al. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103706 · Cited by 19 · see citing works
Anti-histaminic Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts
Farzanegan, A., Shokouhian, M., Jafari, S., Shirazi, F. S., & Shahidi, M. (2019) · Inflammation · doi:10.1007/s10753-019-01023-z · Cited by 18 · see citing works
The role of intestinal microbiota and microRNAs in the anti-inflammatory effects of cranberry: from pre-clinical to clinical studies
Taïbi, A., Lofft, Z., Imbriaco, B. L., & Comelli, E. M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1092342 · Cited by 16 · see citing works
Effect of cranberry juice deacidification on its antibacterial activity against periodontal pathogens and its anti-inflammatory properties in an oral epithelial cell model
Pellerin, G., Bazinet, L., & Grenier, D. (2021) · Food & Function · doi:10.1039/d1fo01552d · Cited by 16 · see citing works
Fruit juices: chemical compositions and health benefits
Renda, G., & Şöhretoğlu, D. (2024) · Phytochemistry Reviews · doi:10.1007/s11101-024-10013-5 · Cited by 15 · see citing works
Effect of a Berry Polyphenolic Fraction on Biofilm Formation, Adherence Properties and Gene Expression of Streptococcus mutans and Its Biocompatibility with Oral Epithelial Cells
Souissi, M., Lagha, A. B., Chaieb, K., & Grenier, D. (2021) · Antibiotics · doi:10.3390/antibiotics10010046 · Cited by 15 · see citing works
D-Mannose prevents bone loss under weightlessness
Gu, R., Liu, H., Hu, M., Zhu, Y., Liu, X., Wang, F., Wu, L., Song, D., & Liu, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-022-03870-1 · Cited by 14 · see citing works
Berries and Their Active Compounds in Prevention of Age-Related Macular Degeneration
Li, X., Zhao, L., Zhang, B., & Wang, S. (2024) · Antioxidants · doi:10.3390/antiox13121558 · Cited by 14 · see citing works
Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review
Bakar, A., Yao, P.-C., Ningrum, V., Liu, C., & Lee, S.-C. (2020) · Biomedicines · doi:10.3390/biomedicines8010003 · Cited by 14 · see citing works
Beverages Containing Plant-Derived Polyphenols Inhibit Growth and Biofilm Formation of Streptococcus mutans and Children’s Supragingival Plaque Bacteria
Wu, C. D., Huang, E., Li, W., White, M., Jung, S., & Xie, Q. (2021) · Beverages · doi:10.3390/beverages7030043 · Cited by 13 · see citing works
Effects of a Berry Polyphenolic Fraction on the Pathogenic Properties of Porphyromonas gingivalis
Vaillancourt, K., Lagha, A. B., & Grenier, D. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.923663 · Cited by 12 · see citing works
Nupharidine enhances Aggregatibacter actinomycetemcomitans clearance by priming neutrophils and augmenting their effector functions
Levy, D. H., Chapple, I., Shapira, L., Golan‐Goldhirsh, A., Gopas, J., & Polak, D. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13036 · Cited by 12 · see citing works
The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review
Fakheran, O., Khademi, A., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-73234-9_5 · Cited by 12 · see citing works
Cranberry Polyphenols
Khoo, C., & Falk, M. (2013) · Polyphenols in Human Health and Disease · doi:10.1016/b978-0-12-398456-2.00081-5 · Cited by 12 · see citing works
Edible Berries-An Update on Nutritional Composition and Health Benefits-Part II
Thorakkattu, P., Jain, S., Sivapragasam, N., Maurya, A., Tiwari, S., Dwivedy, A. K., Koirala, P., & Nirmal, N. P. (2025) · Current Nutrition Reports · doi:10.1007/s13668-024-00608-x · Cited by 11 · see citing works
Ulcerative colitis results in differential metabolism of cranberry polyphenols by the colon microbiome in vitro
Sirven, M. A., Venâncio, V. P., Shankar, S., Klemashevich, C. L., Chicas, M. C., Fang, C., Mertens‐Talcott, S. U., & Talcott, S. T. (2021) · Food & Function · doi:10.1039/d1fo03047g · Cited by 11 · see citing works
Root canal disinfection and maintenance of the remnant tooth tissues by using grape seed and cranberry extracts
Febvey, A., Silva, F. S., Henriques, B. A. P. D. C., Özcan, M., Teughels, W., & Souza, J. C. M. (2022) · Odontology · doi:10.1007/s10266-022-00766-w · Cited by 11 · see citing works
Deacidification of Cranberry Juice Reduces Its Antibacterial Properties against Oral Streptococci but Preserves Barrier Function and Attenuates the Inflammatory Response of Oral Epithelial Cells
Pellerin, G., Bazinet, L., & Grenier, D. (2021) · Foods · doi:10.3390/foods10071634 · Cited by 10 · see citing works
Effect of the cranberry ( Vaccinium macrocarpon ) juice on reducing dentin erosion: an in vitro study
Kato, M. T., Cardoso, C. D. A. B., Jordão, M. C., GALVÃO, R. P. D. O., ISCUISSATI, A. G. S., Kinoshita, Â., & Buzalaf, M. A. R. (2022) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2022.vol36.0076 · Cited by 10 · see citing works
Effects of a tart cherry (Prunus cerasus L.) phenolic extract on Porphyromonas gingivalis and its ability to impair the oral epithelial barrier
Lagha, A. B., Pellerin, G., Vaillancourt, K., & Grenier, D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246194 · Cited by 10 · see citing works
Inhibition of α-Glucosidase and α-Amylase byVaccinium floribundumandAristotelia chilensisProanthocyanidins
Schreckinger, M. E., Lila, M. A., Yousef, G. G., & de Mejı́a, E. G. (2012) · ACS symposium series · doi:10.1021/bk-2012-1109.ch006 · Cited by 10 · see citing works
Natural Antidiabetic Agents: Insights into Ericaceae-Derived Phenolics and Their Role in Metabolic and Oxidative Modulation in Diabetes
Popescu, M., Radivojević, K., Trașcă, D.-M., Văruț, R. M., Enache, I., & Osman, A. (2025) · Pharmaceuticals · doi:10.3390/ph18050682 · Cited by 11 · see citing works
Inhibitory effect of cranberry extract on periodontopathogenic biofilm: An integrative review
de Melo, L., de Medeiros, A. B., Alves, R. A. H., Barbosa, G. A. S., de Lima, K. C., & Carreiro, A. D. F. P. (2016) · Journal of Indian Society of Periodontology · doi:10.4103/jisp.jisp_302_16 · Cited by 8 · see citing works
The use of fruit extracts for production of apple chips with enhanced antioxidant activity
Tarko, T., Duda‐Chodak, A., & Semik‐Szczurak, D. (2017) · PubMed · Cited by 8 · see citing works
UHPLC-HRMS (orbitrap) fingerprinting in the classification and authentication of cranberry-based natural products and pharmaceuticals using multivariate calibration methods
Barbosa, S., Pardo-Mates, N., Hidalgo‐Serrano, M., Saurina, J., Puignou, L., & Núñez, Ó. (2019) · Analytical Methods · doi:10.1039/c9ay00636b · Cited by 7 · see citing works
Cranberry Polyphenols: Effects on Cardiovascular Risk Factors
Khoo, C., Falk, M., & Zhang, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813008-7.00009-6 · Cited by 7 · see citing works
Study on Antioxidant Activity of Catalyzed Hydrogen Degradation Product of Polymeric Proanthocyanidins (LPPC) from Larix gmelinii Bark
Jiang, G., Fang, G., Li, L., Shi, Z.-X., & Zhang, Z.-R. (2013) · BioResources · doi:10.15376/biores.9.1.662-672 · Cited by 7 · see citing works
Argeloside I inhibits the pathogenicity of Porphyromonas gingivalis TDC60
Eltigani, S. A., Eltayeb, M. M., Bito, T., Ichiyanagi, T., Ishihara, A., & Arima, J. (2020) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2020.07.016 · Cited by 7 · see citing works
Chapter 81 – Cranberry Polyphenols: Effects on Cardiovascular Risk Factors
Khoo, C., & Falk, M. L. (2014) · Polyphenols in Human Health and Disease · Cited by 7 · see citing works
Silver nanoparticles stabilized by cranberry polyphenols exhibited enhanced protective effects against hemolysis and preservative effects on fresh blueberries
Wang, L., Wang, Y., Chen, Z., Zhu, L., Qin, D., Yang, Y., & Xu, Y. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105373 · Cited by 6 · see citing works
A Phenolic-rich Extract of Cocoa (Theobroma cacao L.) Beans Impairs the Pathogenic Properties of Porphyromonas gingivalis and Attenuates the Activation of Nuclear Factor Kappa B in a Monocyte Model
Vaillancourt, K., Lagha, A. B., & Grenier, D. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.867793 · Cited by 6 · see citing works
Phytochemicals A Novel Therapeutic Approach to Control Oral Biofilm
Kenganora, M., Rudraswamy, S., Hombarvali, J. S., & Doggalli, N. (2021) · Pharmacognosy Journal · doi:10.5530/pj.2021.13.93 · Cited by 5 · see citing works
Beneficial effects of cranberry juice enriched with omega-3 fatty acids in patients with type 2 diabetic and periodontal disease: A randomized pilot clinical trial
Ashrafzadeh, E., Babaei, H., Ravanbakhsh, M., Javid, A. Z., & Maghsoumi‐Norouzabad, L. (2024) · Journal of Advanced Periodontology & Implant Dentistry · doi:10.34172/japid.2024.019 · Cited by 4 · see citing works
Functional and Organic Foods in Enhancing the Oral and Dental Health and Hygiene—A Comprehensive Review
Aleebrahim‐Dehkordi, E., Sheibaninia, A., & Pirbalouti, A. G. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71433 · Cited by 4 · see citing works
Microbiome and Metabolome Alterations in Nrf2 Knockout Mice With Induced Gut Inflammation and Fed With Phenethyl Isothiocyanate and Cranberry Enriched Diets
Yin, R., Sargsyan, D., Wu, R.-Y., Hudlikar, R., Li, S.-Y., Kuo, H.-C. D., Sarwar, M. S., Zhou, Y., Gao, Z., Howell, A. B., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70283 · Cited by 2 · see citing works
Ягоды: химический состав, антиоксидантная активность. Влияние потребления ягод на здоровье человека
Яшин, А. Я., Vedenin, A. N., Яшин, Я. И., & Nemzer, B. V. (2019) · ANALYTICS Russia · doi:10.22184/2227-572x.2019.9.3.222.230 · Cited by 3 · see citing works
Assessment of Remineralisation Potential of Cranberry Extract and Grape Seed Extract Dentifrice on Primary Teeth Using Laser Fluorescence Device
Pushpalatha, C., Sneha, N., Deveswaran, R., & Anandakrishna, L. (2020) · Lecture notes in electrical engineering · doi:10.1007/978-981-15-3477-5_24 · Cited by 3 · see citing works
Polyphenols for Preventing Dental Erosion in Pre-clinical Studies with in situ Designs and Simulated Acid Attack
Leal, I. D. C., Rabelo, C. S., Melo, M. A. S., Silva, P. G. D. B., Costa, F. W. G., & Passos, V. F. (2023) · Planta Medica · doi:10.1055/a-2100-3542 · Cited by 3 · see citing works
Cranberry and Oral Health
Shigli, K., Nayak, S. S., Bolmal, U., & Shah, K. (2023) · doi:10.1002/9781394167197.ch18 · Cited by 3 · see citing works
Effects of Oligomeric Proanthocyanidins on Cadmium-Induced Extracellular Matrix Damage via Inhibiting the ERK1/2 Signaling Pathway in Chicken Chondrocytes
Gu, J., Liu, D., Gong, A., Zhao, X., Zhou, J., Wang, P., Xia, H., Song, R., Ma, Y., Zou, H., et al. (2025) · Veterinary Sciences · doi:10.3390/vetsci12040317 · Cited by 2 · see citing works
Phenolic compounds in Vaccinium spp.: diversity, biosynthesis, and molecular regulation
Jaakola, L. (2023) · Acta Horticulturae · doi:10.17660/actahortic.2023.1357.1 · Cited by 2 · see citing works
Cranberry Juice: Effects on Health
McKay, D. L., & Wilson, T. E. (2016) · Springer eBooks · doi:10.1007/978-3-319-23672-8_7 · Cited by 2 · see citing works
Liquid Chromatographic Fingerprints for the Characterization of Flavanol-Rich Nutraceuticals Based on 4-Dimethylaminocinnamaldehyde Precolumn Derivatization
Vidal-Casanella, O., Núñez, Ó., & Saurina, J. (2021) · Scientia Pharmaceutica · doi:10.3390/scipharm89020018 · Cited by 2 · see citing works
Epicatechin suppresses the expression of C-C motif chemokine ligand 19 and ameliorates periodontitis
Sano, T., Yuan, M., Li, R., Yasunaga, A., Mizokami, A., Nakatsu, Y., Asano, T., & Kanematsu, T. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106512 · Cited by 1 · see citing works
Traditional Foods, Oral Microbiome, and Systemic Health: Molecular Pathways Linking Nutrition and Oral Disease Prevention
Parise-Vasco, J., Angamarca-Iguago, J., Cagua-Ordoñez, J., Cabrera, B., Gavilanes, D. J., Horowitz, R., Reytor-González, C., & Simancas-Racines, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052412 · Cited by 1 · see citing works
Micronutrition in periodontal treatment: Antioxidants
Toker, H. (2016) · DergiPark (Istanbul University) · doi:10.7126/cdj.58140.5000003000 · Cited by 1 · see citing works
New Trends in Fruit Juices
López, F. (2014) · Contemporary food engineering · doi:10.1201/b16740-4 · Cited by 1 · see citing works
The Synergistic Impact of Vitamin D and Cranberry Coatings on the Antimicrobial Efficacy of Dental Implants
Gayathri, K., Suresh, N., Kaarthikeyan, G., Rakshagan, V., Ali, S., & Kannan, K. P. (2025) · Advances in Human Biology · doi:10.4103/aihb.aihb_205_24 · Cited by 1 · see citing works

Cranberries: The Use of a Naturally Occurring Compound to Fight against Periodontopathogens
Darius, D. L. (2007) · NSUWorks (Nova Southeastern University)
Anti-Porphyromonas gingivalisand Anti-Inflammatory Activities of A-Type Cranberry Proanthocyanidins
La, V. D., Howell, A. B., & Grenier, D. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01432-09 · Cited by 75 · see citing works
Cranberry polyphenols: potential benefits for dental caries and periodontal disease.
Bonifait, L., & Grenier, D. (2010) · PubMed · Cited by 98 · see citing works
Therapeutic effects of proanthocyanidins on the pathogenesis of periodontitis--an overview.
Govindaraj, J., Emmadi, P., & Puvanakrishnan, R. (2011) · PubMed · Cited by 12 · see citing works
The Role of Proanthocyanidins in Treatment of Periodontal Disease
Das, M., Das, A. C., Panda, S., & Mohanty, R. (2019) · Indian Journal of Public Health Research & Development · doi:10.5958/0976-5506.2019.03627.1 · Cited by 1 · see citing works

Authors: Feghali, K., Feldman, M., La, V. D., Santos, J., & Grenier, D.
Affiliations: Université Laval (CA)
Corresponding author: Grenier, Daniel
ORCID: Feldman, Mark
Santos, Juliana
Grenier, Daniel
Venue: Journal of Agricultural and Food Chemistry
Publisher: American Chemical Society (ACS)
Published: 2011-11-29
Volume: 60
Issue: 23
Pages: 5728-5735
ISSN: 0021-8561 (ISSN-L)
1520-5118
DOI: 10.1021/jf203304v
OpenAlex: W2082221617
Cited by: 114
References: 92
Citations by year: 2026: 4 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 18 · 2020: 6 · 2019: 13 · 2018: 6 · 2017: 10 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 3
FWCI: 0.78
Type: journal article
Language: en
Open access: closed
Locations: Journal of Agricultural and Food Chemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: cranberry proanthocyanidins, cranberry, periodontitis, periodontal disease prevention, alveolar bone loss, osteoclastogenesis, protease inhibition, anti-inflammatory activity, antioxidant activity, antimicrobial activity, adhesion prevention, flavonoids, phytochemicals
MeSH terms: Anti-Inflammatory Agents, Flavonoids, Fruit, Humans, Periodontal Diseases, Plant Extracts, Vaccinium macrocarpon, Proanthocyanidins, Phytochemicals

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cranberry proanthocyanidins: Natural weapons against periodontal diseases

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks