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Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal
Abstract
Methylglyoxal (MGO) and glyoxal (GO) not only are endogenous metabolites but also exist in exogenous resources, such as foods, beverages, urban atmosphere, and cigarette smoke. They have been identified as reactive dicarbonyl precursors of advanced glycation end products (AGEs), which have been associated with diabetes-related long-term complications. In this study, quercetin, a natural flavonol found in fruits, vegetables, leaves, and grains, could effectively inhibit the formation of AGEs in a dose-dependent manner via trapping reactive dicarbonyl compounds. More than 50.5% of GO and 80.1% of MGO were trapped at the same time by quercetin within 1 h under physiological conditions. Quercetin and MGO (or GO) were combined at different ratios, and the products generated from this reaction were analyzed with LC-MS. Both mono-MGO and di-MGO adducts of quercetin were detected in this assay using LC-MS, but only tiny amounts of mono-GO adducts of quercetin were found. Additionally, di-MGO adducts were observed as the dominant product with prolonged incubation time. In the bovine serum albumin (BSA)-MGO/GO system, quercetin traps MGO and GO directly and then significantly inhibits the formation of AGEs.
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Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Advanced glycation endproducts—role in pathology of diabetic complications
Ahmed, N. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.09.004 · Cited by 1,455
Advanced protein glycosylation in diabetes and aging
Brownlee, M. D. (1995) · Annual Review of Medicine · doi:10.1146/annurev.med.46.1.223 · Cited by 1,312
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216
Afanas'ev, I. B., Dcrozhko, A. I., Brodskii, A. V., Kostyuk, V. A., & Potapovitch, A. I. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90410-3 · Cited by 982
Diabetes and advanced glycation endproducts
Vlassara, H., & Palace, M. R. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.00932.x · Cited by 697
Lo, T. W., Westwood, M. E., McLellan, A. C., Selwood, T., & Thornalley, P. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31635-1 · Cited by 693
Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts
Thornalley, P. J. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.013 · Cited by 682
Comalada, M., Camuesco, D., Sierra, S., Ballester, I., Xaus, J., Gálvez, J., & Zarzuelo, A. (2005) · European Journal of Immunology · doi:10.1002/eji.200425778 · Cited by 647
Wu, C.-H., & Yen, G.-C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048550u · Cited by 400
Flavonoids and Cancer Prevention: A Review of the Evidence
Romagnolo, D. F., & Selmin, O. I. (2012) · Journal of Nutrition in Gerontology and Geriatrics · doi:10.1080/21551197.2012.702534 · Cited by 354
Inhibition of advanced glycation endproduct formation by foodstuffs
Wu, C.-H., Huang, S.-M., Lin, J.-A., & Yen, G.-C. (2011) · Food & Function · doi:10.1039/c1fo10026b · Cited by 328
Chelating Activity of Advanced Glycation End-product Inhibitors
Price, D. L., Rhett, P. M., Thorpe, S. R., & Baynes, J. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108196200 · Cited by 308
Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls
Aldini, G., Dalle‐Donne, I., Facino, R. M., Milzani, A., & Carini, M. (2007) · Medicinal Research Reviews · doi:10.1002/med.20073 · Cited by 289
Peng, X., Cheng, K.-W., Ma, J., Chen, B., Ho, C.-T., Lo, C., Chen, F., & Wang, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073065v · Cited by 263
Advanced glycation endproducts (AGEs): pharmacological inhibition in diabetes
Peyroux, J., & Sternberg, M. (2006) · Pathologie Biologie · doi:10.1016/j.patbio.2006.07.006 · Cited by 247
Flavour chemistry of methylglyoxal and glyoxal
Wang, Y., & Ho, C.-T. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35025d · Cited by 227
Tea Polyphenol (−)-Epigallocatechin-3-Gallate: A New Trapping Agent of Reactive Dicarbonyl Species
Sang, S., Shao, X., Bai, N., Lo, C.-Y., Yang, C. S., & Ho, C.-T. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700190s · Cited by 212
Self-citationApple Polyphenols, Phloretin and Phloridzin: New Trapping Agents of Reactive Dicarbonyl Species
Shao, X., Bai, N., He, K., Ho, C.-T., Yang, C. S., & Sang, S. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800227v · Cited by 185
Self-citationMetformin inhibition of glycation processes
Beisswenger, P., & Ruggiero-Lopez, D. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(03)72793-1 · Cited by 182
Wang, W., Yagiz, Y., Buran, T. J., Nunes, C. D. N., & Gu, L. (2011) · Food Research International · doi:10.1016/j.foodres.2011.05.022 · Cited by 172
Genistein Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal
Lv, L., Shao, X., Chen, H., Ho, C.-T., & Sang, S. (2011) · Chemical Research in Toxicology · doi:10.1021/tx100457h · Cited by 165
Self-citationEssential Structural Requirements and Additive Effects for Flavonoids to Scavenge Methylglyoxal
Shao, X., Chen, H., Zhu, Y., Sedighi, R., Ho, C.-T., & Sang, S. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500204s · Cited by 162
Self-citationThe Role of AGEs and AGE Inhibitors in Diabetic Cardiovascular Disease
Thomas, M., Baynes, J., Thorpe, S., & Cooper, M. (2005) · Current Drug Targets · doi:10.2174/1389450054021873 · Cited by 159
Inhibition of advanced glycation end product formation on collagen by rutin and its metabolites
Cervantes-Laurean, D., Schramm, D. D., Jacobson, E. L., Halaweish, I., Bruckner, G. G., & Boissonneault, G. A. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.10.002 · Cited by 158
Shibamoto, T. (2006) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2006.01.047 · Cited by 142
α-Oxoaldehyde metabolism and diabetic complications
Beisswenger, P. J., Howell, S. K., Nelson, R. G., Mauer, M. S., & Szwergold, B. S. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311358 · Cited by 121
Immunological Evidence for Methylglyoxal-derived Modifications in vivo
Shamsi, F. A., Partal, A. E., Sady, C., Glomb, M. A., & Nagaraj, R. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.6928 · Cited by 106
Schurman, L., McCarthy, A. D., Sedlinsky, C., Gangoiti, M. V., Arnol, V., Bruzzone, L., & Cortizo, A. M. (2008) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-992786 · Cited by 98
Fructose and carbonyl metabolites as endogenous toxins
Lee, O., Bruce, W. R., Dong, Q., Bruce, J., Mehta, R., & O'Brien, P. J. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.011 · Cited by 95
Sadowska‐Bartosz, I., Galiniak, S., & Bartosz, G. (2014) · Molecules · doi:10.3390/molecules19044880 · Cited by 91
Site-Selective Modifications of Arginine Residues in Human Hemoglobin Induced by Methylglyoxal
Gao, Y., & Wang, Y. (2006) · Biochemistry · doi:10.1021/bi061410o · Cited by 90
Protein Glycation Inhibitors from Thyme ( Thymus vulgaris )
Morimitsu, Y., Yoshida, K., Esaki, S., et al. (1995) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.59.2018 · Cited by 88
Webster, J. A., Urban, C., Berbaum, K., Loske, C., Alpár, A., Gärtner, U., de Arriba, S. G., Arendt, T., & Münch, G. W. (2005) · Neurotoxicity Research · doi:10.1007/bf03033780 · Cited by 86
Klöpfer, A., Spanneberg, R., & Glomb, M. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103116c · Cited by 73
Kilhovd, B. K., Juutilainen, A., Lehto, S., Rönnemaa, T., Torjesen, P. A., Hanssen, K. F., & Laakso, M. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.12.041 · Cited by 72
Oxidative damage of DNA induced by methylglyoxal in vitro
Kang, J. H. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00305-9 · Cited by 68
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Schalkwijk, C. G., & Stehouwer, C. D. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00001.2019 · Cited by 622
Perrone, A., Giovino, A., Benny, J., & Martinelli, F. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3818196 · Cited by 459
Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings
Yeh, W.-J., Hsia, S.-M., Lee, W.-H., & Wu, C.-H. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.10.017 · Cited by 353
Li, Y., Peng, Y., Shen, Y., Zhang, Y., Liu, L., & Yang, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2076064 · Cited by 156
Sampath, C., Zhu, Y., Sang, S., & Ahmedna, M. (2016) · Phytomedicine · doi:10.1016/j.phymed.2015.12.013 · Cited by 48
Self-citation
Metadata
- Authors
- Li, X., Zheng, T., Sang, S., & Lv, L.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-12-08
- Volume
- 62
- Issue
- 50
- Pages
- 12152-12158
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2328190526
- Cited by
- 288
- References
- 37
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- closed
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