Roasted Coffees High in Lipophilic Antioxidants and Chlorogenic Acid Lactones Are More Neuroprotective than Green Coffees
Abstract
Oxidative stress is involved in many neurodegenerative processes leading to age-related cognitive decline. Coffee, a widely consumed beverage, is rich in many bioactive components, including polyphenols with antioxidant potential. In this study, regular and decaffeinated samples of both roasted and green coffee all showed high hydrophilic antioxidant activity in vitro, whereas lipophilic antioxidant activities were on average 30-fold higher in roasted than in green coffee samples. In primary neuronal cell culture, pretreatment with green and roasted coffees (regular and decaffeinated) protected against subsequent H(2)O(2)-induced oxidative stress and improved neuronal cell survival (green coffees increased neuron survival by 78%, compared to 203% by roasted coffees). All coffee extracts inhibited ERK1/2 activation, indicating a potential attenuating effect in stress-induced neuronal cell death. Interestingly, only roasted coffee extracts inhibited JNK activation, evidencing a distinctive neuroprotective benefit. Analysis of coffee phenolic compounds revealed that roasted coffees contained high levels of chlorogenic acid lactones (CGLs); a significant correlation between CGLs and neuroprotective efficacy was observed (R(2) = 0.98). In conclusion, this study showed that roasted coffees are high in lipophilic antioxidants and CGLs, can protect neuronal cells against oxidative stress, and may do so by modulation of the ERK1/2 and JNK signaling pathways.
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Roasted coffees contained higher antioxidant capacities and higher chlorogenic acid and phenolic concentrations than green coffee beans.
“Work by Chu et al.28 found that roasted coffees contained higher antioxidant capacities and higher chlorogenic acid and phenolic concentrations than green coffee beans.”
From Acidity and Antioxidant Activity of Cold Brew Coffee (2018) · cites this paper as [28]
A strong correlation exists between neuroprotective efficacy of roasted coffee and total chlorogenic acid concentration.
“Chu et al.'s work also found a strong correlation between neuroprotective efficacy of roasted coffee and total chlorogenic acid concentration28.”
From Acidity and Antioxidant Activity of Cold Brew Coffee (2018) · cites this paper as [28]
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- Authors
- Chu, Y.-F., Brown, P. H., Lyle, B. J., Chen, Y., Black, R. M., Williams, C. E., Lin, Y.-C., Hsu, C.-W., & Cheng, I. H.
- Affiliations
- Kraft Heinz (United States) (US)
- National Yang Ming University (TW)
- Corresponding author
- Cheng, Irene H.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-10-28
- Volume
- 57
- Issue
- 20
- Pages
- 9801-9808
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2080529779
- Cited by
- 89
- References
- 59
- Citations by year
- 2025: 3 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 14 · 2013: 11 · 2012: 13
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- roasted coffee, green coffee beans, lipophilic antioxidants, neuroprotection, oxidative stress, ERK signaling, JNK signaling, decaffeinated coffee, age-related cognitive decline
- MeSH terms
- Animals, Antioxidants, Cell Survival, Cells, Cultured, Chlorogenic Acid, Coffee, Food Handling, Lactones, Mice, Inbred C57BL, Neurons, Signal Transduction, Oxidative Stress, Neuroprotective Agents, Coffea, Mice
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