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Cited by 272

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Antioxidant Activity of trans-Resveratrol toward Hydroxyl and Hydroperoxyl Radicals: A Quantum Chemical and Computational Kinetics Study

Iuga, Cristina, Alvarez-Idaboy, J. Raúl, Russo, Nino·2012·The Journal of Organic Chemistry
DOI 10.1021/jo3002134
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Abstract

In this work, we have carried out a systematic study of the antioxidant activity of trans-resveratrol toward hydroxyl ((•)OH) and hydroperoxyl ((•)OOH) radicals in aqueous simulated media using density functional quantum chemistry and computational kinetics methods. All possible mechanisms have been considered: hydrogen atom transfer (HAT), proton-coupled electron transfer (PCET), sequential electron proton transfer (SEPT), and radical adduct formation (RAF). Rate constants have been calculated using conventional transition state theory in conjunction with the Collins-Kimball theory. Branching ratios for the different paths contributing to the overall reaction, at 298 K, are reported. For the global reactivity of trans-resveratrol toward (•)OH radicals, in water at physiological pH, the main mechanism of reaction is proposed to be the sequential electron proton transfer (SEPT). However, we show that trans-resveratrol always reacts with (•)OH radicals at a rate that is diffusion-controlled, independent of the reaction pathway. This explains why trans-resveratrol is an excellent but very unselective (•)OH radical scavenger that provides antioxidant protection to the cell. Reaction between trans-resveratrol and the hydroperoxyl radical occurs only by phenolic hydrogen abstraction. The total rate coefficient is predicted to be 1.42 × 10(5) M(-1) s(-1), which is much smaller than the ones for reactions of trans-resveratrol with (•)OH radicals, but still important. Since the (•)OOH half-life time is several orders larger than the one of the (•)OH radical, it should contribute significantly to trans-resveratrol oxidation in aqueous biological media. Thus, trans-resveratrol may act as an efficient (•)OOH, and also presumably (•)OOR, radical scavenger.

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Metadata

Authors
Iuga, C., Alvarez-Idaboy, J. R., & Russo, N.
Venue
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Published
2012-04-11
Volume
77
Issue
8
Pages
3868-3877
ISSN
  • 0022-3263 (ISSN-L)
  • 1520-6904
DOI
10.1021/jo3002134
OpenAlex
W2003395155
Cited by
272
References
74
FWCI
8.02
Type
journal article
Language
en
Open access
closed

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