Cited by 133Nanocluster Synthesis and ApplicationsGold and Silver Nanoparticles Synthesis and ApplicationsNanoparticle-Based Drug Delivery

Water-Soluble Nitric Oxide-Releasing Gold Nanoparticles

Polizzi, Mark A., Stasko, Nathan A., Schoenfisch, Mark H.·2007·Langmuir

Abstract

The synthesis and characterization of water-soluble nitric oxide (NO)-releasing monolayer-protected gold clusters (MPCs) are reported. Tiopronin-protected MPCs ( approximately 3 nm) were functionalized with amine ligands and subsequently exposed to 5 atm of NO to form diazeniumdiolate NO donors covalently bound to the gold MPC. Diazeniumdiolate formation conditions, NO-release, and nanoparticle stability were examined as a function of the structure of the protecting ligand, pH, and storage time. Despite their aqueous solubility, proton-initiated decomposition of the diazeniumdiolate-modified Tio-MPCs resulted in only modest NO-release (<0.023 micromol/mg) for short durations (<1.5 h). To increase the NO storage capacity of gold nanoparticles, polyamine-stabilized MPCs ( approximately 5 nm) were synthesized with significantly enhanced NO-release properties (0.386 micromol/mg) and durations (up to 16 h). Transmission electron microscopy, thermogravimetric analysis, nuclear magnetic resonance spectroscopy, elemental analysis, and UV-vis spectroscopy were used to characterize both nanoparticle systems before and after NO exposure. The MPCs represent the smallest water-soluble NO-release nanoparticles to date (3-5 nm).

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Crossref · 10.1021/la0633841

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Authors
Polizzi, M. A., Stasko, N. A., & Schoenfisch, M. H.
Affiliations
University of North Carolina at Chapel Hill (US)
Venue
Langmuir
Published
2007-03-22
Volume
23
Issue
9
Pages
4938-4943
ISSN
  • 0743-7463 (ISSN-L)
  • 1520-5827
OpenAlex
W2092385563
Cited by
133
References
24
Citations by year
2025: 2 · 2024: 1 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 9 · 2012: 12
FWCI
4.79
Type
journal article
Language
en
Open access
closed
Locations
  • Langmuir (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Nanocluster Synthesis and Applications
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
nitric oxide release, gold nanoparticles, monolayer-protected clusters, diazeniumdiolates, nitric oxide donors, tiopronin, water-soluble nanoparticles, ligand structure effects, pH-dependent release, nanoparticle stability
MeSH terms
Gold, Tiopronin, Nitric Oxide, Particle Size, Polyamines, Solubility, Surface Properties, Time Factors, Water, Molecular Structure, Nanoparticles

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