Water-Soluble Nitric Oxide-Releasing Gold Nanoparticles
Abstract
The synthesis and characterization of water-soluble nitric oxide (NO)-releasing monolayer-protected gold clusters (MPCs) are reported. Tiopronin-protected MPCs ( approximately 3 nm) were functionalized with amine ligands and subsequently exposed to 5 atm of NO to form diazeniumdiolate NO donors covalently bound to the gold MPC. Diazeniumdiolate formation conditions, NO-release, and nanoparticle stability were examined as a function of the structure of the protecting ligand, pH, and storage time. Despite their aqueous solubility, proton-initiated decomposition of the diazeniumdiolate-modified Tio-MPCs resulted in only modest NO-release (<0.023 micromol/mg) for short durations (<1.5 h). To increase the NO storage capacity of gold nanoparticles, polyamine-stabilized MPCs ( approximately 5 nm) were synthesized with significantly enhanced NO-release properties (0.386 micromol/mg) and durations (up to 16 h). Transmission electron microscopy, thermogravimetric analysis, nuclear magnetic resonance spectroscopy, elemental analysis, and UV-vis spectroscopy were used to characterize both nanoparticle systems before and after NO exposure. The MPCs represent the smallest water-soluble NO-release nanoparticles to date (3-5 nm).
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- Authors
- Polizzi, M. A., Stasko, N. A., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Schoenfisch, Mark H.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-03-22
- Volume
- 23
- Issue
- 9
- Pages
- 4938-4943
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2092385563
- Cited by
- 133
- References
- 24
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 10 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 9 · 2012: 12
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Langmuir (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanocluster Synthesis and Applications
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- nitric oxide release, gold nanoparticles, monolayer-protected clusters, diazeniumdiolates, nitric oxide donors, tiopronin, water-soluble nanoparticles, ligand structure effects, pH-dependent release, nanoparticle stability
- MeSH terms
- Gold, Tiopronin, Nitric Oxide, Particle Size, Polyamines, Solubility, Surface Properties, Time Factors, Water, Molecular Structure, Nanoparticles
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