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Cited by 955

The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

Danhier, Fabienne, Le Breton, Aude, Préat, Véronique·2012·Molecular Pharmaceutics
DOI 10.1021/mp3002733
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Abstract

The integrin α(v)β(3) plays an important role in angiogenesis. It is expressed on tumoral endothelial cells as well as on some tumor cells. RGD peptides are well-known to bind preferentially to the α(v)β(3) integrin. In this context, targeting tumor cells or tumor vasculature by RGD-based strategies is a promising approach for delivering anticancer drugs or contrast agents for cancer therapy and diagnosis. RGD-based strategies include antagonist drugs (peptidic or peptidomimetic) of the RGD sequence, RGD-conjugates, and the grafting of the RGD peptide or peptidomimetic, as targeting ligand, at the surface of nanocarriers. Although all strategies are overviewed, this review aims to particularly highlight the position of RGD-based nanoparticles in cancer therapy and imaging. This review is divided into three parts: the first one describes the context of angiogenesis, the role of the integrin α(v)β(3), and the binding of the RGD peptide to this integrin; the second one focuses on RGD-based strategies in cancer therapy; while the third one focuses on RGD-based strategies in cancer diagnosis.

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Crossref · 10.1021/mp3002733

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Metadata

Authors
Danhier, F., Le Breton, A., & Préat, V.
Venue
Molecular Pharmaceutics
Publisher
American Chemical Society (ACS)
Published
2012-10-04
Volume
9
Issue
11
Pages
2961-2973
ISSN
  • 1543-8384 (ISSN-L)
  • 1543-8392
DOI
10.1021/mp3002733
OpenAlex
W2025344276
Cited by
955
References
98
FWCI
35.37
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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