Cited by 150Nanoparticle-Based Drug DeliveryAngiogenesis and VEGF in CancerNanoplatforms for cancer theranostics

Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging and Therapeutic Angiogenesis

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Kim, Jaeyun, Cao, Lan, Shvartsman, Dmitry, Silva, Eduardo A., Mooney, David J.·2011·Nano Letters

Abstract

Targeting of nanoparticles to ischemic tissues was studied in a murine ischemic hindlimb model. Intravenously injected fluorescent nanoparticles allowed ischemia-targeted imaging of ischemic muscles due to increased permeability of blood vessels in hypoxic tissues. Targeting efficiency correlated with blood perfusion after induction of ischemia and was enhanced in early stages of ischemia (<7 days). Therapeutic delivery of vascular endothelial growth factor (VEGF) was achieved by VEGF-conjugated nanoparticles and resulted in a 1.7-fold increase in blood perfusion, as compared to control mice. This work supports the application of nanoparticles as imaging and therapeutic modalities for ischemia treatment.

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  1. [24]Diaz-Sandoval LJ Losordo DW Exp. Opin. Biol. Ther 2003 3 599 616 12831365

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Authors
Kim, J., Cao, L., Shvartsman, D., Silva, E. A., & Mooney, D. J.
Affiliations
Harvard University (US)
Corresponding author
Mooney, David J.
Venue
Nano Letters
Published
2011-02-09
Volume
11
Issue
2
Pages
694-700
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W2037590348
Cited by
150
References
45
Citations by year
2026: 1 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 19 · 2019: 5 · 2018: 11 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 5
FWCI
3.30
Type
journal article
Language
en
Open access
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Harvard University
  • National Institutes of Health
  • Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University
  • National Heart, Lung, and Blood Institute (R01HL069957)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
nanoparticle targeting, ischemic muscle, therapeutic angiogenesis, vascular endothelial growth factor, fluorescent nanoparticles, blood perfusion, hypoxic tissue, hindlimb ischemia, vascular permeability
MeSH terms
Animals, Ischemia, Treatment Outcome, Muscle, Skeletal, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Mice, Nanocapsules

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