Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging and Therapeutic Angiogenesis
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Targeting of nanoparticles to ischemic tissues was studied in a murine ischemic hindlimb model. Intravenously injected fluorescent nanoparticles allowed ischemia-targeted imaging of ischemic muscles due to increased permeability of blood vessels in hypoxic tissues. Targeting efficiency correlated with blood perfusion after induction of ischemia and was enhanced in early stages of ischemia (<7 days). Therapeutic delivery of vascular endothelial growth factor (VEGF) was achieved by VEGF-conjugated nanoparticles and resulted in a 1.7-fold increase in blood perfusion, as compared to control mice. This work supports the application of nanoparticles as imaging and therapeutic modalities for ischemia treatment.
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Nanoparticle conjugates of VEGF are being developed to improve gene transfer.
“There are ongoing efforts to improve gene transfer, including the use of nanoparticle conjugates of VEGF111 (FIG. 3d).”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [111]
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- Authors
- Kim, J., Cao, L., Shvartsman, D., Silva, E. A., & Mooney, D. J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Mooney, David J.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-02-09
- Volume
- 11
- Issue
- 2
- Pages
- 694-700
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- PMC
- PMC3073422
- OpenAlex
- W2037590348
- Cited by
- 150
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 19 · 2019: 5 · 2018: 11 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 5
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Harvard University
- National Institutes of Health
- Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University
- National Heart, Lung, and Blood Institute (R01HL069957)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- nanoparticle targeting, ischemic muscle, therapeutic angiogenesis, vascular endothelial growth factor, fluorescent nanoparticles, blood perfusion, hypoxic tissue, hindlimb ischemia, vascular permeability
- MeSH terms
- Animals, Ischemia, Treatment Outcome, Muscle, Skeletal, Angiogenesis Inhibitors, Vascular Endothelial Growth Factor A, Mice, Nanocapsules
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