Near-Infrared Fluorescent Dye-Doped Semiconducting Polymer Dots
Open accessAbstract
Near-infrared (NIR) fluorescence sensing is desirable for in vivo biological measurements, but the method is currently limited by the availability of NIR fluorescent markers as well as by their poor performance, such as self-aggregation and dim fluorescence, in a physiological environment. To address this issue, this paper describes a NIR fluorescent polymer dot (Pdot) that emits at 777 nm. This Pdot was comparable in size to a water-soluble NIR quantum dot that emits at 800 nm (ITK Qdot800) but was about four times brighter and with a narrower emission peak. We formed the NIR Pdot by doping the NIR dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775), into the matrix of poly (9,9-dioctylfluorene-co-benzothiadiazole) (PFBT) as the Pdot formed using a nanoscale precipitation technique. Free molecules of NIR775 aggregate in aqueous solution, but encapsulating them into the hydrophobic Pdot matrix effectively introduced them into aqueous solution for use in biological studies. Most importantly, the brightness of NIR775 was dramatically enhanced because of the excellent light-harvesting ability of PFBT and the very efficient energy transfer from PFBT to NIR775. We anticipate this bright NIR Pdot will be useful in biological measurements and cellular imaging where strong NIR emission is beneficial.
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The careful pairing of CP energy donors with suitable energy-acceptor dyes allows one to obtain brighter fluorescence probes due to the signal amplification provided by the energy donor.
“The careful pairing of CP energy donors with suitable energy-acceptor dyes allows one to obtain brighter fluorescence probes due to the signal amplification provided by the energy donor.129,130”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [130]
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- Authors
- Jin, Y., Ye, F., Zeigler, M., Wu, C., & Chiu, D. T.
- Affiliations
- University of Washington (US)
- Corresponding author
- Chiu, Daniel T.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-01-31
- Volume
- 5
- Issue
- 2
- Pages
- 1468-1475
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- PMC
- PMC3043135
- OpenAlex
- W2094205807
- Cited by
- 211
- References
- 29
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 14 · 2021: 16 · 2020: 14 · 2019: 9 · 2018: 29 · 2017: 14 · 2016: 20 · 2015: 16 · 2014: 21 · 2013: 23 · 2012: 18
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 147837, R21CA147831)
- National Institute of Neurological Disorders and Stroke (NS062725, R01NS062725)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Keywords
- near-infrared fluorescence, polymer dots, silicon naphthalocyanine, energy transfer, light harvesting, nanoscale precipitation, fluorescence enhancement, self-aggregation, cell imaging
- MeSH terms
- Energy Transfer, Fluorenes, Fluorescent Dyes, Infrared Rays, Polymers, Semiconductors, Silanes, Spectrometry, Fluorescence, Nanoparticles, Optical Phenomena
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