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Biodegradation of Iron Oxide Nanocubes: High-Resolution In Situ Monitoring

Lartigue, Lénaic, Alloyeau, Damien, Kolosnjaj-Tabi, Jelena, Javed, Yasir, Guardia, Pablo, Riedinger, Andreas, Péchoux, Christine, Pellegrino, Teresa, Wilhelm, Claire, Gazeau, Florence·2013·ACS Nano
DOI 10.1021/nn305719y
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Abstract

The long-term fate of nanomaterials in biological environment represents a critical matter, which determines environmental effects and potential risks for human health. Predicting these risks requires understanding of nanoparticle transformations, persistence, and degradation, some issues somehow ignored so far. Safe by design, inorganic nanostructures are being envisioned for therapy, yet fundamental principles of their processing in biological systems, change in physical properties, and in situ degradability have not been thoroughly assessed. Here we report the longitudinal visualization of iron oxide nanocube transformations inflicted by the intracellular-like environment. Structural degradation of individual nanocubes with two different surface coatings (amphiphilic polymer shell and polyethylene glycol ligand molecules) was monitored at the atomic scale with aberration-corrected high-resolution transmission electron microscopy. Our results suggest that the polymer coating controls surface reactivity and that availability and access of chelating agents to the crystal surface govern the degradation rate. This in situ study of single nanocube degradation was compared to intracellular transformations observed in mice over 14 days after intravenous injection, revealing the role of nanoparticle clustering, intracellular sorting within degradation compartments, and iron transfer and recycling into ferritin storage proteins. Our approach reduces the gap between in situ nanoscale…

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Metadata

Authors
Lartigue, L., Alloyeau, D., Kolosnjaj-Tabi, J., Javed, Y., Guardia, P., Riedinger, A., Péchoux, C., Pellegrino, T., Wilhelm, C., & Gazeau, F.
Affiliations
  • Inserm U970, Paris Cardiovascular Research Center-PARCC/Université Paris-Descartes, 56 rue Leblanc, 75015 France
  • Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy
  • UR1196 Génomique et Physiologie de la Lactation, INRA, Plateau de Microscopie Electronique 78352 Jouy-en-Josas, France
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2013-05-07
Volume
7
Issue
5
Pages
3939-3952
ISSN
  • 1936-0851
  • 1936-086X
DOI
10.1021/nn305719y
Cited by
274
References
5
Language
en

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