The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Engineered Iron-Oxide-Based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging
Open accessAbstract
We report the design and synthesis of small-sized zwitterion-coated gadolinium-embedded iron oxide (GdIO) nanoparticles, which exhibit a strong T1 contrast effect for tumor imaging through enhanced permeation and retention effect and the ability to clear out of the body in living subjects. The combination of spin-canting effects and the collection of gadolinium species within small-sized GdIO nanoparticles led to a significantly enhanced T1 contrast effect. For example, GdIO nanoparticles with a diameter of ∼4.8 nm exhibited a high r1 relaxivity of 7.85 mM(-1)·S(-1) and a low r2/r1 ratio of 5.24. After being coated with zwitterionic dopamine sulfonate molecules, the 4.8 nm GdIO nanoparticles showed a steady hydrodynamic diameter (∼5.2 nm) in both PBS buffer and fetal bovine serum solution, indicating a low nonspecific protein absorption. This study provides a valuable strategy for the design of highly sensitive iron-oxide-based T1 contrast agents with relatively long circulation half-lives (∼50 min), efficient tumor passive targeting (SKOV3, human ovarian cancer xenograft tumor as a model), and the possibility of rapid renal clearance after tumor imaging.
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Zhou, M., Li, J., Liang, S., Sood, A. K., Liang, D., & Li, C. (2015) · ACS Nano · doi:10.1021/acsnano.5b02635 · Cited by 324
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Metadata
- Authors
- Zhou, Z., Wang, L., Chi, X., Bao, J., Yang, L., Zhao, W., Chen, Z., Wang, X., Chen, X., & Gao, J.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-14
- Volume
- 7
- Issue
- 4
- Pages
- 3287-3296
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2079679540
- Cited by
- 249
- References
- 9
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- green
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