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The anti-inflammatory potential of berberine in vitro and in vivo

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Investigation of the Interaction between Berberine and Human Serum Albumin

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Quaternary protoberberine alkaloids

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Regulation of "Nutraceuticals"

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Physicochemical Characterization of Berberine Chloride: A Perspective in the Development of a Solution Dosage Form for Oral Delivery

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Acute toxicity of berberine and its correlation with the blood concentration in mice

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Bile acid structure-activity relationship: evaluation of bile acid lipophilicity using 1-octanol/water partition coefficient and reverse phase HPLC.

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Palmatine and Berberine Isolation Artifacts

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Antimalarial activity and structure-activity relationships of protoberberine alkaloids

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Induction of interleukin‐12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response

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Antifungal activity of berberine iodide, a constituent ofFumaria indica

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Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine

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The Identity of Chileninone with Berberrubine. The Problem of True Natural Products vs. Artifacts of Isolation

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Solubility of Berberine Chloride in Various Solvents

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Antitumor activity of 13-methyl-berberrubine derivatives.

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CONVERSION OF BERBERINE INTO BERBERRUBINE BY SELECTIVE DEMETHYLATION UNDER MICROWAVE IRRADIATION[1]

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Enhanced Production of the Polysaccharide Arabinogalactan Using Immobilized Cultures of Tinospora cordifolia by Elicitation and In Situ Adsorption

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NMR Studies on Antitumor Drug Candidates, Berberine and Berberrubine

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β-Phenylethylamines and the isoquinoline alkaloids

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Syntheses and absorption spectra of some compounds with the berbine structure

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A novel oxidation stage in the chemistry of protoberberine alkaloids. Synthesis of 7,8-dehydroberbines

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Novel proton transfer fluorescence probe 2-hydroxy-pyridine and 5-(4-fluorophenyl)-2-hydroxypyridine for studying native, denatured and renatured state of protein Bovine Serum Albumin

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R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies

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The pseudobase formation in some isoquinoline alkaloids

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The fluorescence properties of protoberberine and tetrahydroprotoberberine alkaloids

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The metabolism of berberine and its contribution to the pharmacological effects

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Gut microbiota, a new frontier to understand traditional Chinese medicines

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Berberine and barberry ( Berberis vulgaris ): A clinical review

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Gut Microbiota, Short-Chain Fatty Acids, and Herbal Medicines

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Research progress on berberine with a special focus on its oral bioavailability

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Berberine as a Potential Anticancer Agent: A Comprehensive Review

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Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence

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Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases

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Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine

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Therapeutic effect of oral Gastrografin in adhesive, partial small-bowel obstruction: a prospective randomized trial.

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Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways

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Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Peng, J., Zheng, T., Li, X., Liang, Y., Wang, L., Huang, Y., & Xiao, H. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00351 · Cited by 135 · see citing works

Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats

Feng, X., Wang, K., Cao, S., Ding, L., & Qiu, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.594852 · Cited by 130 · see citing works

Metformin and berberine, two versatile drugs in treatment of common metabolic diseases

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Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Duan, L., Cheng, S.-Y., Li, L., Liu, Y., Wang, D., & Liu, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.684486 · Cited by 124 · see citing works

Natural Deep Eutectic Solvents (NADES) to Enhance Berberine Absorption: An In Vivo Pharmacokinetic Study

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Berberine: A novel therapeutic strategy for cancer

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Metformin and metabolic diseases: a focus on hepatic aspects

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Berberine: New Insights from Pharmacological Aspects to Clinical Evidences in the Management of Metabolic Disorders

Caliceti, C., Franco, P., Spinozzi, S., Roda, A., & Cicero, A. F. G. (2016) · Current Medicinal Chemistry · doi:10.2174/0929867323666160411143314 · Cited by 91 · see citing works

Pharmacokinetic of berberine, the main constituent of Berberis vulgaris L.: A comprehensive review

Khoshandam, A., Imenshahidi, M., & Hosseinzadeh, H. (2022) · Phytotherapy Research · doi:10.1002/ptr.7589 · Cited by 90 · see citing works

Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders

Kong, W., Vernieri, C., Foiani, M., & Jiang, J. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107496 · Cited by 88 · see citing works

Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro

Paudel, K. R., Mehta, M., Yin, G. H. S., Yen, L. L., Malyla, V., Patel, V. K., Panneerselvam, J., Madheswaran, T., MacLoughlin, R. J., Jha, N. K., et al. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19158-2 · Cited by 85 · see citing works

Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice

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Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer

Zhu, Y. Z., Xie, N., Chai, Y., Nie, Y., Liu, K., Liu, Y., Yang, Y., Su, J., & Zhang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.803717 · Cited by 75 · see citing works

Attenuation of Cigarette-Smoke-Induced Oxidative Stress, Senescence, and Inflammation by Berberine-Loaded Liquid Crystalline Nanoparticles: In Vitro Study in 16HBE and RAW264.7 Cells

Paudel, K. R., Panth, N., Manandhar, B., Singh, S. K., Gupta, G., Wich, P. R., Nammi, S., MacLoughlin, R. J., Adams, J., Warkiani, M. E., et al. (2022) · Antioxidants · doi:10.3390/antiox11050873 · Cited by 67 · see citing works

Liquid Crystalline Nanoreservoir Releasing A Highly Skin-Penetrating Berberine Oleate Complex for Psoriasis Management

Freag, M. S., Torky, A. S., Nasra, M. M. A., Abdelmonsif, D. A., & Abdallah, O. Y. (2019) · Nanomedicine · doi:10.2217/nnm-2018-0345 · Cited by 63 · see citing works

Encapsulation of berberine into liquid crystalline nanoparticles to enhance its solubility and anticancer activity in MCF7 human breast cancer cells

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Research progress on pharmacological effects and bioavailability of berberine

Cui, Y., Zhou, Q., Jin, M., Jiang, S., Shang, P., Dong, X., & Li, L. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03199-0 · Cited by 70 · see citing works

Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway

Lin, G., Yu, Q., Xu, L., Huang, Z., Mai, L., Jiang, L., Su, Z., Xie, J., Li, Y., Liu, Y., et al. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174592 · Cited by 60 · see citing works

Berberine and berberine nanoformulations in cancer therapy: Focusing on lung cancer

Hsu, C., Pallathadka, H., Gupta, J., Ma, H., Al-Shukri, H. H. K., Kareem, A. K., Zwamel, A. H., & Mustafa, Y. F. (2024) · Phytotherapy Research · doi:10.1002/ptr.8255 · Cited by 60 · see citing works

Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy

Jin, J., Xu, M. X., Liu, Y., Ji, Z., Dai, K., Zhang, L., Wang, L., Ye, F., Chen, G., & Lv, Z. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111168 · Cited by 58 · see citing works

Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota

Yang, S., Cao, S., Li, C., Zhang, J., Liu, C., Qiu, F., & Kang, N. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.913378 · Cited by 57 · see citing works

A bird's eye view on a therapeutically ‘wonder molecule’: Berberine

Patel, P. K. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100070 · Cited by 57 · see citing works

Berberine-Loaded Liposomes for the Treatment of Leishmania infantum-Infected BALB/c Mice

Calvo, A., Moreno, E., Larrea, E., Sanmartín, C., Irache, J. M., & Espuelas, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090858 · Cited by 54 · see citing works

Therapeutic potential and recent delivery systems of berberine: A wonder molecule

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A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

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Novel skin penetrating berberine oleate complex capitalizing on hydrophobic ion pairing approach

Torky, A. S., Freag, M. S., Nasra, M. M. A., & Abdallah, O. Y. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.07.051 · Cited by 53 · see citing works

Novel berberine-loaded hyalurosomes as a promising nanodermatological treatment for vitiligo: Biochemical, biological and gene expression studies

Elhalmoushy, P. M., Elsheikh, M. A., Matar, N. A., El-Hadidy, W. F., Kamel, M. A. E.-N., Omran, G. A., & Elnaggar, Y. S. R. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121523 · Cited by 49 · see citing works

The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids

Ciebiera, M., Ali, M. K., Prince, L., Jackson-Bey, T., Atabiekov, I., Zgliczyński, S., & Al-Hendy, A. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051479 · Cited by 49 · see citing works

Berberine activates peroxisome proliferator‐activated receptor gamma to increase atherosclerotic plaque stability in Apoe−/− mice with hyperhomocysteinemia

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Characterization and Pharmacokinetic Assessment of a New Berberine Formulation with Enhanced Absorption In Vitro and in Human Volunteers

Solnier, J., Zhang, Y., Kuo, Y., Du, M., Roh, K., Gahler, R., Wood, S., & Chang, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112567 · Cited by 47 · see citing works

AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants

Basavarajappa, S. C., & Nandini, C. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.12.031 · Cited by 46 · see citing works

Phytantriol-Based Berberine-Loaded Liquid Crystalline Nanoparticles Attenuate Inflammation and Oxidative Stress in Lipopolysaccharide-Induced RAW264.7 Macrophages

Alnuqaydan, A. M., Almutary, A. G., Azam, M., Manandhar, B., Rubis, G. D., Madheswaran, T., Paudel, K. R., Hansbro, P. M., Chellappan, D. K., & Dua, K. (2022) · Nanomaterials · doi:10.3390/nano12234312 · Cited by 44 · see citing works

In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine

Yang, N., Sun, R., Chen, X., Zhen, L., Ge, C., Zhao, Y., He, J. B., Geng, J., Guo, J., Yu, X., et al. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.120 · Cited by 43 · see citing works

Polyethylene glycol 400 (PEG400) affects the systemic exposure of oral drugs based on multiple mechanisms: taking berberine as an example

Ma, B., Yang, Y., Dai, Y., Li, Q., Lin, G., & Ma, Y. (2017) · RSC Advances · doi:10.1039/c6ra26284h · Cited by 43 · see citing works

Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs

Li, D., Yu, P., Xiao, W., Wang, Z., & Zhao, L.-G. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200908165913 · Cited by 44 · see citing works

Multi-Target Potential of Berberine as an Antineoplastic and Antimetastatic Agent: A Special Focus on Lung Cancer Treatment

Achi, I. T., Sarbadhikary, P., George, B. P. A., & Abrahamse, H. (2022) · Cells · doi:10.3390/cells11213433 · Cited by 42 · see citing works

Multiple target and regulatory pathways of berberine

Zhou, W., Asif, A., Situ, C., Wang, J., & Hao, H. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157030 · Cited by 41 · see citing works

The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

Aquila, G., Marracino, L., Martino, V., Calabria, D., Campo, G. C., Caliceti, C., & Rizzo, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5470470 · Cited by 41 · see citing works

Assessing Transporter‐Mediated Natural Product‐Drug Interactions Via <i>In vitro</i> ‐ <i>In Vivo</i> Extrapolation: Clinical Evaluation With a Probe Cocktail

Nguyen, J. T., Tian, D., Tanna, R. S., Hadi, D. L., Bansal, S., Calamia, J. C., Arian, C. M., Shireman, L. M., Molnár, B., Horváth, M., et al. (2021) · Clinical Pharmacology &amp; Therapeutics · doi:10.1002/cpt.2107 · Cited by 40 · see citing works

An Updated Review on Therapeutic Potential and Recent Advances in Drug Delivery of Berberine: Current Status and Future Prospect

Mujtaba, M. A., Akhter, M. H., Alam, M. S., Ali, M. D., & Hussain, A. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210208152113 · Cited by 41 · see citing works

Unlocking the potential of Berberine: Advancing cancer therapy through chemosensitization and combination treatments

Sajeev, A., Sailo, B., Unnikrishnan, J., Talukdar, A., Alqahtani, M. S., Abbas, M. A. E., Alqahtani, A., Sethi, G., & Kunnumakkara, A. B. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217019 · Cited by 40 · see citing works

Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model

Wu, J., Li, J., Li, W., Sun, B., Xie, J., Cheng, W., & Zhang, Q. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.04.025 · Cited by 39 · see citing works

Applications for natural deep eutectic solvents in Chinese herbal medicines

Li, M., Rao, C., Ye, X., Wang, M., Yang, B., Wang, C., Guo, L., Xiong, Y., & Cui, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1104096 · Cited by 40 · see citing works

Novel role of the nutraceutical bioactive compound berberine in lectin-like OxLDL receptor 1-mediated endothelial dysfunction in comparison to lovastatin

Caliceti, C., Rizzo, P., Ferrari, R., Fortini, F., Aquila, G., Leoncini, E., Zambonin, L., Rizzo, B., Calabria, D., Simoni, P., et al. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.04.002 · Cited by 36 · see citing works

A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens

Dehau, T., Cherlet, M., Croubels, S., Immerseel, F. V., & Goossens, E. (2023) · mSystems · doi:10.1128/msystems.01239-22 · Cited by 34 · see citing works

Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites

Dehau, T., Cherlet, M., Croubels, S., Van De Vliet, M., Goossens, E., & Van Immerseel, F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1281090 · Cited by 33 · see citing works

Neuroprotective effect and preparation methods of berberine

Sunhe, Y.-X., Zhang, Y., Fu, R., Xu, D., & Tang, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1429050 · Cited by 33 · see citing works

Inhibition of Bacteroidetes and Firmicutes by select phytochemicals

Lakes, J. E., Richards, C. I., & Flythe, M. D. D. (2019) · Anaerobe · doi:10.1016/j.anaerobe.2019.102145 · Cited by 32 · see citing works

Berberine alleviates intestinal barrier dysfunction in glucolipid metabolism disorder hamsters by modulating gut microbiota and gut‐microbiota‐related tryptophan metabolites

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Development and Percutaneous Permeation Study of Escinosomes, Escin-Based Nanovesicles Loaded with Berberine Chloride

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Elucidating Berberine’s Therapeutic and Photosensitizer Potential through Nanomedicine Tools

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Potential Benefits of Berberine in the Management of Perimenopausal Syndrome

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In Vitro and In Vivo Evaluations of Berberine-Loaded Microparticles Filled In-House 3D Printed Hollow Capsular Device for Improved Oral Bioavailability

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Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents

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Highly efficient synthesis and monoamine oxidase B inhibitory profile of demethyleneberberine, columbamine and palmatine

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Berberine neuroprotection and antioxidant activity

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MgAl monolayer hydrotalcite increases the hypoglycemic effect of berberine by enhancing its oral bioavailability

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Electrosprayed zein nanoparticles as antibacterial and anti-thrombotic coatings for ureteral stents

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Unraveling Berberine's Molecular Mechanisms in Neuroprotection Against Neurodegeneration

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Rapid Identification of Berberine Metabolites in Rat Plasma by UHPLC-Q-TOF-MS

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Nanostructured biloalbuminosomes loaded with berberine and berberrubine for Alleviating heavy Metal-Induced male infertility in rats

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Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high‐performance liquid chromatography with diode array detection

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Nanoparticles based on complex of berberine chloride and polymethacrylic or polyacrylic acid with antioxidant and in vitro antitumor activities

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Berberine in fish nutrition: Impact on hepatoenteric health, antioxidative and immune status

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Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives

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A novel turn-on fluorescent probe based on berberine for detecting Hg2+ and ClO− with the different fluorescence signals

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Spray-dried Solid Lipid Nanoparticles for Enhancing Berberine Bioavailability via Oral Administration

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Detection of New Human Metabolic Urinary Markers in Chronic Alcoholism and Their Reversal by Aqueous Extract of Tinospora cordifolia Stem

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Berberine affects mitochondrial activity and cell growth of leukemic cells from chronic lymphocytic leukemia patients

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Improvement of intestinal transport, absorption and anti-diabetic efficacy of berberine by using Gelucire44/14: In vitro, in situ and in vivo studies

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Gut Microbiome: The Interplay of an “Invisible Organ” with Herbal Medicine and Its Derived Compounds in Chronic Metabolic Disorders

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Characterization of chemical constituents and metabolites in rat plasma after oral administration of San Miao Wan by ultra-high performance liquid chromatography tandem Q-Exactive Orbitrap mass spectrometry

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Berberine's impact on health: Comprehensive biological, pharmacological, and nutritional perspectives

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Targeting human telomeric DNA quadruplex with novel berberrubine derivatives: insights from spectroscopic and docking studies

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Combined analytical approaches to define biodistribution and biological activity of semi-synthetic berberrubine, the active metabolite of natural berberine

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AChE inhibitory alkaloids from Coptis chinensis

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A novel berberine-based colorimetric and fluorimetric probe for hydrazine detection

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Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges

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Pharmacological effects of Berberine – A Chinese medicine, against xenobiotics toxicity

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Dissecting and Evaluating the Therapeutic Targets of Coptis Chinensis Franch in the Treatment of Urinary Tract Infections Induced by Escherichia coli

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Natural Products as Potential Human Ether-a-Go-Go-Related Gene Channel Inhibitors – Outcomes from a Screening of Widely Used Herbal Medicines and Edible Plants

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Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib

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Recent Progress in Nano-TCM Active Ingredient Co-Delivery Systems for Inflammation-Mediated Diseases

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A Comprehensive Review on Botany, Ethnopharmacology, Phytochemistry, Biosynthesis, Pharmacology, Toxicity, Quality Control and Metabolomics of Coptidis Rhizome

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The Effect of Oxidation on Berberine-Mediated CYP1 Inhibition: Oxidation Behavior and Metabolite-Mediated Inhibition

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Synthesis and Anticancer Activity of 9-O-Pyrazole Alkyl Substituted Berberine Derivatives

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A potential cocrystal strategy to tailor in-vitro dissolution and improve Caco-2 permeability and oral bioavailability of berberine

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An insight into the potential of berberine in animal nutrition: Current knowledge and future perspectives

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Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats

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Biodistribution and pharmacokinetic profile of berberine and its metabolites in hepatocytes

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Pharmacokinetic of berberine, the main constituent of Berberis vulgaris L.: A comprehensive review

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Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry

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Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats

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