Production of artemisinin in tissue cultures of Artemisia annua
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProduction of Artemisinin in Tissue Cultures of Artemisia AnnuaM. S. R. Nair, Nancy Acton, Daniel L. Klayman, Karolyn Kendrick, Dominick V. Basile, and Seth ManteCite this: J. Nat. Prod. 1986, 49, 3, 504–507Publication Date (Print):May 1, 1986Publication History Published online1 July 2004Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/np50045a021https://doi.org/10.1021/np50045a021research-articleACS PublicationsRequest reuse permissionsArticle Views414Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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Artemisinin can be obtained in reasonable quantities from differentiated shoot cultures of A. annua, but is produced in only small or undetectable amounts by callus or suspension cell cultures.
“Although artemisinin can be obtained in reasonable quantities from differentiated shoot cultures [343,344,345], it is produced in only small or undetectable amounts [346,347,348] by callus or suspension cell cultures of A. annua.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [345]
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
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Current status of artemisinin and its derivatives as antimalarial drugs
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“It is acknowledged that there is high functional diversity among AM fungal species that results in variations in plant responses ( Munkrold et al. 2004 ).”
BackgroundAntimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures
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“annua during their cultivation in vitro (He et al. 1983; Tawfiq et al. 1989; Weathers et al. 1994; Paniego and Giulietti 1996; Liu et al. 1997; Nair et al. 1986; Teo et al. 1995).”
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“The current study was conducted to evaluate the application of AIP to reduce tissue browning using Artemisia annua callus cultures, which often exhibit tissue browning [36–39], as a model system.”
MethodArtemisia annua as a self-reliant treatment for malaria in developing countries
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“Plant tissue culture has also been investigated to establish a production of artemisinin in A. annua hairy root or cell suspension cultures (Nair et al., 1986; Baldi and Dixit, 2008).”
BackgroundSesquiterpene Lactones: More Than Protective Plant Compounds With High Toxicity
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“Trace amounts of artemisinin, a widely known antimalarial compound, have also been reported in the secondary roots of Artemisia annua (Nair et al., 1986; Woerdenbag et al., 1991).”
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“This result was consistent with the previous report that only trace amount of artemisinin existed in A. annua cell suspension cultures (Nair et al. 1986; Tawfiq et al. 1989).”
Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L.
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“for antimalarial activity, and they have been found to be a potentially useful means of producing AN (Nair et al., 1986; Liu et al., 1992), although it is thought that the production of AN is correlated with”
BackgroundState of the art of the production of the antimalarial compound artemisinin in plants
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“At most, traces of this compound have been found [29, 32, 36, 43, 52, 55, 78, 92].”
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“Although whether callus, cell, shoot, and hairy root cultures can produce artemisinin was debated, most of investigations provided solid data that the artemisinin biosynthesis occurred in cultures in vitro (Brown 1994; Cai et al. 1995; Elhag et al. 1992; Ferreira and Janick 1996; Ferreira et al. 1995b; Gupta et al. 19…”
BackgroundThe Production of Artemisinin in Artemisia annua L. Tissue Cultures
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“The production of artemisinin by means of cell, tissue, or organ cultures is not viable (Nair et al., 1986; Ferreira and Janick, 1996).”
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“The clinically important artemisinins include artesunate, artemether, and dihydroartemisin (DHA) (Figure 1), which were discovered and developed in 1986 (Nair et al., 1986).”
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“In term of the cost and feasibility in industry (Nair et al. 1986; Paniego and Giulietti 1996; Liu et al. 1997; Delabays et al. 2001; Weathers et al. 2005), Saccharomyces cerevisiae is recognized as a better platform to synthesize artemisinic acid, the precursor of artemisinin (Kirby and Keasling…”
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“Although the pathway for the synthesis of artemisinin is well known [89], it has been widely assumed that the trichomes are the only source of artemisinin production in the plant [40, 50, 57, 58] despite several papers describing its presence within roots [12, 51, 56, 60], reports that the artemisinin content of the p…”
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Enhanced production of artemisinin by
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High Peroxidase Activity In Cell Cultures of<i>Artemisia Annua</i>With Minute Artemisinin Contents
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“Indeed, some attempts have been made to this approach (6,8,11,13,18,20), but”
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InfluentialEssential Oil Production by BelgianArtemisia alba(Turra) before and after Micropropagation
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“It was favorable to culture the callus under 16:8 photoperiods, since complete darkness led easily to browning of the callus, similar finding was previously reported by Paniego et al. (1993) and Nair et al. (1986).”
ResultMicropropagation ofArtemisia annuavia the Inflorescence
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“annua is easily propagated in vitro, the production of artemisinin by cultures of cells or tissues (Nair et al. 1986; Kudakasseril et al. 1987; Martinez and Staba 1988; Tawfiq et al. 1989; Paniego et al. 1994), transformed hairy root (Qin et al.”
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“The application of cell, tissue or organ cultures towards enhanced artemisinin production has been relatively successful (Nair et al. 1986; Ferreira and Janick 1996; Wetzstein et al. 2018).”
The Artemisia Genus: Panacea to Several Maladies
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“They were then placed on sterilised MS 1.3% agar medium ( Murashige and Skoog 1962 ) containing 10 11M kinetin (kin, 111M 2,4-dichlorophenoxy acetic acid (2,4 D), 10 11M ascorbic acid and cysteine and incubated for 2 months in the dark at 25°C.”
MethodInfluentialEnhancement of Artemisinin production: a Biotherapeutic Agent
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“Artemisia Annua Artemisinin Callus [67]”
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“Artemisinin has quick activity and is compelling against chloroquine-safe malarial parasites and has an alternate method of activity from existing blood schizonticides (Nair et al.1986).”
MethodIn Vitro and In Vitro production of artemisinin by artemisia species
Kruger, F. J. L. (2013)
Singh, B., & Sharma, R. A. (2020) · Secondary Metabolites of Medicinal Plants · doi:10.1002/9783527825578.c02-13
Molecular Markers for the Evaluation of Clonal Fidelity in Medicinal Plants
(2020) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789811439315120010018
Cusati, R. C. (2024) · Seven Editora eBooks · doi:10.56238/livrosindi202425-001
Studien zur Kultivierung und Zucht von Artemisia annua L.
Tu, Y. (2024) · Springer eBooks · doi:10.1007/978-3-662-68757-4_7
- Authors
- Nair, M. S. R., Acton, N., Klayman, D. L., Kendrick, K., Basile, D. V., & Mante, S.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1986-05
- Volume
- 49
- Issue
- 3
- Pages
- 504-507
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2062825423
- Cited by
- 98
- References
- 0
- Citations by year
- 2024: 2 · 2023: 2 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 5 · 2014: 4 · 2013: 4 · 2012: 5
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Keywords
- artemisinin, Artemisia annua, tissue culture, secondary metabolite production, sesquiterpene lactones, plant cell culture
- MeSH terms
- Antimalarials, China, Plants, Medicinal, Sesquiterpenes, Artemisinins
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