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Cited by 867

The DOI matches its Crossref record; 316 of the 316 references it cites were found in a registry or an index.

Oxidative Stress and Neurotoxicity

Open access
Sayre, Lawrence M., Perry, George, Smith, Mark A.·2008·Chemical Research in Toxicology
DOI 10.1021/tx700210j
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Abstract

There is increasing awareness of the ubiquitous role of oxidative stress in neurodegenerative disease states. A continuing challenge is to be able to distinguish between oxidative changes that occur early in the disease from those that are secondary manifestations of neuronal degeneration. This perspective highlights the role of oxidative stress in Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and multiple sclerosis, neurodegenerative and neuroinflammatory disorders where there is evidence for a primary contribution of oxidative stress in neuronal death, as opposed to other diseases where oxidative stress more likely plays a secondary or by-stander role. We begin with a brief review of the biochemistry of oxidative stress as it relates to mechanisms that lead to cell death, and why the central nervous system is particularly susceptible to such mechanisms. Following a review of oxidative stress involvement in individual disease states, some conclusions are provided as to what further research should hope to accomplish in the field.

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Crossref · 10.1021/tx700210j

Cites

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Citations

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Metadata

Authors
Sayre, L. M., Perry, G., & Smith, M. A.
Venue
Chemical Research in Toxicology
Publisher
American Chemical Society (ACS)
Published
2007-12-04
Volume
21
Issue
1
Pages
172-188
ISSN
  • 0893-228X (ISSN-L)
  • 1520-5010
DOI
10.1021/tx700210j
OpenAlex
W2124603205
Cited by
867
References
316
FWCI
16.04
Type
journal article
Language
en
Open access
hybrid

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.