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Molecular and Cellular Evidence for an Oligodendrocyte Abnormality in Schizophrenia
Abstract
Our previous analyses in postmortem prefrontal cortex samples from a well-characterized cohort of severely affected schizophrenics and in matched controls demonstrated decreased expression of myelin and oligodendrocyte-related genes in the disease state. This decreased expression, now replicated in independent studies, suggests that there is a disruption of oligodendrocyte function and/or a loss of oligodendrocytes in schizophrenia. In the current report, we review expression studies in schizophrenia and present data demonstrating consistently fewer oligodendrocytes in schizophrenics compared to controls. The decrease in density reached 22% (p < 0.01) in layer III of area 9 and 20% (p < 0.02) in the white matter of the superior frontal gyrus. These data, when taken together with expression studies carried out by us and by other groups, and by imaging and other microscopic studies, point to a major involvement of oligodendrocyte abnormalities in schizophrenia. Therapies modulating oligodendrocyte survival and differentiation may therefore be beneficial in schizophrenia.
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In schizophrenia, a reduction of oligodendrocytes has been reported in the frontal cortex.
“in particular, in schizophrenia a reduction of oligodendrocytes has also been reported in the frontal cortex (Hof et al, 2002(Hof et al, , 2003)).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Hof et al, 2002
Decreases in oligodendrocyte density are probably not specific to mood disorders.
“Finally, decreases in oligodendrocyte density are probably not specific to mood disorders; in particular, in schizophrenia a reduction of oligodendrocytes has also been reported in the frontal cortex (Hof et al, 2002(Hof et al, , 2003)).”
From Neurocircuitry of Mood Disorders (2010) · cites this paper as Hof et al, 2002
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- Copland, C., Dracheva, S., Davis, K. L., and Haroutunian, V. 2002. mRNA expression of three isoforms of myelin associated glycoprotein (MAG) in patients with schizophrenia. Soc. Neurosci. Abs., in press.
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Metadata
- Authors
- Hof, P. R., Haroutunian, V., Copland, C., Davis, K. L., & Buxbaum, J. D.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Buxbaum, Joseph D.
- Venue
- Neurochemical Research
- Published
- 2002-10
- Volume
- 27
- Issue
- 10
- Pages
- 1193-1200
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W132008894
- Cited by
- 199
- References
- 24
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 10 · 2016: 5 · 2015: 12 · 2014: 10 · 2013: 6 · 2012: 13
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01mh045212-05)
- National Institute of Mental Health (MH 45212)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, oligodendrocytes, myelin, oligodendrocyte loss, prefrontal cortex, gene expression, white matter, superior frontal gyrus, oligodendrocyte differentiation, oligodendrocyte survival
- MeSH terms
- Aged, Aged, 80 and over, Brain, Cell Count, Female, Humans, Male, Oligodendroglia, Reference Values, Schizophrenia
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