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Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
Abstract
IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of responsive genes. IFNs were the first human proteins to be effective in cancer therapy and were among the first recombinant DNA products to be used clinically. Both quality and quantity of life has been improved in response to IFNs in various malignancies. Despite its beneficial effects, unraveling the mechanisms of the anti-tumor effects of IFN has proven to be a complex task. IFNs may mediate anti-tumor effects either indirectly by modulating immunomodulatory and anti-angiogenic responses or by directly affecting proliferation or cellular differentiation of tumor cells. Both direct or indirect effects of IFNs result from induction of a subset of genes, called IFN stimulated genes (ISGs). In addition to the ISGs implicated in anti-viral, anti-angiogenic, immunomodulatory and cell cycle inhibitory effects, oligonucleotide microarray studies have identified ISGs with apoptotic functions. These include TNF-alpha related apoptosis inducing ligand (TRAIL/Apo2L), Fas/FasL, XIAP associated factor-1 (XAF-1), caspase-4, caspase-8, dsRNA activated protein kinase (PKR), 2'5'A oligoadenylate synthetase (OAS), death activating protein kinases (DAP kinase), phospholipid scramblase, galectin 9, IFN regulatory factors (IRFs), promyelocytic leukemia gene (PML) and regulators of IFN induced death (RIDs). In vitro IFN-alpha, IFN-beta and IFN-gamma induced apoptosis in multiple cell lines of varied histologies. This review will emphasize possible mechanisms and the role of ISGs involved in mediating apoptotic function of IFNs.
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Inflammatory cytokines influence neuronal development and apoptosis, and both stress and inflammatory cytokine activity may adversely influence neurogenesis and neuroplasticity.
“Inflammatory cytokines have repeatedly been observed to influence both neuronal development and apoptosis (Chawla-Sarkar et al., 2003, Hayley et al., 2005) (Mehler and Kessler, 1997, Zhao and Schwartz, 1998), (Peng et al., 2008, Anisman, 2009, Koo et al., 2010b). In fact, both stress and subsequent inflammatory cytokine activity may adversely influence neurogenesis and neuroplasticity (Patel et al”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Chawla-Sarkar et al., 2003
Citations
Cites
Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Death Receptors: Signaling and Modulation
Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
Self-citationIdentification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,758
Bronner, C. E., Baker, S. M., Morrison, P. T., Warren, G., Smith, L. G., Lescoe, M. K., Kane, M., Earabino, C., Lipford, J. R., Lindblom, A., et al. (1994) · Nature · doi:10.1038/368258a0 · Cited by 2,050
X-linked IAP is a direct inhibitor of cell-death proteases
Deveraux, Q. L., Takahashi, R., Salvesen, G. S., & Reed, J. C. (1997) · Nature · doi:10.1038/40901 · Cited by 1,956
Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,840
Self-citationInduction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12687 · Cited by 1,777
MEURS, E. F., Chong, K. L., GALABRU, J., Thomas, N. S. B., Kerr, I. M., Williams, B. R. G., & Hovanessian, A. G. (1990) · Cell · doi:10.1016/0092-8674(90)90374-n · Cited by 1,017
Self-citationThe inhibitors of apoptosis (IAPs) and their emerging role in cancer
LaCasse, E. C., Baird, S. D., Korneluk, R. G., & MacKenzie, A. (1998) · Oncogene · doi:10.1038/sj.onc.1202569 · Cited by 980
Sen, G. C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.255 · Cited by 969
Self-citationFunctional classification of interferon-stimulated genes identified using microarrays
de Veer, M. J., Holko, M., Frevel, M. A. E., Walker, E. M., Der, S., Paranjape, J. M., Silverman, R. H., & Williams, B. R. G. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.912 · Cited by 902
Self-citationPKR; a sentinel kinase for cellular stress
Williams, B. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203127 · Cited by 820
Self-citationType I Interferons Keep Activated T Cells Alive
Marrack, P., Kappler, J. W., & Mitchell, T. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.3.521 · Cited by 763
RAFF, M. C. (1998) · Nature · doi:10.1038/24055 · Cited by 690
Deiss, L. P., Feinstein, E., Berissi, H., Cohen, O., & Kimchi, A. (1995) · Genes & Development · doi:10.1101/gad.9.1.15 · Cited by 591
Pml is essential for multiple apoptotic pathways
Wang, Z., Ruggero, D., Ronchetti, S., Zhong, S., Gaboli, M. P., Rivi, R., & Pandolfi, P. P. (1998) · Nature Genetics · doi:10.1038/3073 · Cited by 568
Zhou, A., Paranjape, J., Brown, T. L., Nie, H., Naik, S., Dong, B., Chang, A., Trapp, B., Fairchild, R., Colmenares, C., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6355 · Cited by 559
Self-citationYork, J. D., John, A. R. O., Murphy, R., Ives, E. B., & Wente, S. R. (1999) · Science · doi:10.1126/science.285.5424.96 · Cited by 547
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1
Carpten, J. D., Nupponen, N. N., Isaacs, S. D., Sood, R. B., Robbins, C. M., Xu, J., Faruque, M. U., Moses, T. Y., Ewing, C. M., Gillanders, E. M., et al. (2002) · Nature Genetics · doi:10.1038/ng823 · Cited by 525
Self-citationExpression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action
Zhou, A. (1993) · Cell · doi:10.1016/0092-8674(93)90403-d · Cited by 515
Sidky, Y. A., & Borden, E. C. (1987) · PubMed · Cited by 494
Self-citationTanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491
Pfeffer, L. M., Dinarello, C. A., Herberman, R. B., Williams, B. R. G., Borden, E. C., Bordens, R. W., Walter, M. R., Nagabhushan, T. L., Trotta, P. P., & Pestka, S. (1998) · PubMed · Cited by 481
Self-citationThe growing family of interferon regulatory factors
Nguyen, H., Hiscott, J., & Pitha, P. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00019-1 · Cited by 480
Kayagaki, N., Yamaguchi, N., NAKAYAMA, M., Eto, H., Okumura, K., & Yagita∥, H. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.9.1451 · Cited by 476
Identification of XAF1 as an antagonist of XIAP anti-Caspase activity
Liston, P., Fong, W. G., Kelly, N. L., Toji, S., Miyazaki, T., Conte, D., Tamai, K., Craig, C. G., McBurney, M. W., & Korneluk, R. G. (2001) · Nature Cell Biology · doi:10.1038/35055027 · Cited by 441
Clemens, M. J., & Williams, B. (1978) · Cell · doi:10.1016/0092-8674(78)90329-x · Cited by 440
Self-citationAn IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431
DAP kinase links the control of apoptosis to metastasis
Inbal, B., Cohen, O., Polak‐Charcon, S., Kopolovic, J., Vadai, E., Eisenbach, L., & Kimchi, A. (1997) · Nature · doi:10.1038/36599 · Cited by 399
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
Der, S. D., Yang, Y.-L., Weissmann, C., & Williams, B. R. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3279 · Cited by 389
Self-citationBalachandran, S., Kim, C. N., Yeh, W., Mak, T., Bhalla, K., & Barber, G. (1998) · EMBO Journal · doi:10.1093/emboj/17.23.6888 · Cited by 385
Hovanessian, A. G., BROWN, R. E., & Kerr, I. M. (1977) · Nature · doi:10.1038/268537a0 · Cited by 369
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
石原, 正. (1997) · Cited by 366
RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
Casey, G., Neville, P. J., Plummer, S. J., Xiang, Y., Krumroy, L. M., Klein, E. A., Catàlona, W. J., Nupponen, N. N., Carpten, J. D., Trent, J. M., et al. (2002) · Nature Genetics · doi:10.1038/ng1021 · Cited by 308
Self-citationBalachandran, S., Roberts, P. C., Kipperman, T., Bhalla, K. N., Compans, R. W., Archer, D. R., & Barber, G. N. (2000) · Journal of Virology · doi:10.1128/jvi.74.3.1513-1523.2000 · Cited by 296
Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression
Ossina, N., Cannas, A., Powers, V. C., Fitzpatrick, P., Knight, J. D., Gilbert, J. R., Shekhtman, E. M., Tomei, L., Umansky, S. R., & Kiefer, M. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.26.16351 · Cited by 271
Dinney, C. P., Bielenberg, D. R., Perrotte, P., Reich, R., Eve, B. Y., BUCANA, C. D., & Fidler, I. J. (1998) · PubMed · Cited by 271
A Study of the Interferon Antiviral Mechanism: Apoptosis Activation by the 2–5A System
Castelli, J. C., Hassel, B. A., Wood, K. A., Li, X., Amemiya, K., Dalakas, M. C., Torrence, P. F., & Youle, R. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.967 · Cited by 270
Binding of Inositol Phosphate to DNA-PK and Stimulation of Double-Strand Break Repair
Hanakahi, L. A., Bartlet‐Jones, M., Chappell, C., Pappin, D., & West, S. C. (2000) · Cell · doi:10.1016/s0092-8674(00)00061-1 · Cited by 263
2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A
Dong, B., & Silverman, R. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4133 · Cited by 261
Self-citationChawla‐Sarkar, M., Leaman, D. W., & Borden, E. C. (2001) · PubMed · Cited by 249
Self-citationMechanisms of Interferon-alpha induced apoptosis in malignant cells
Thyrell, L., Erickson, S., Zhivotovsky, B., Tamm, K. P., Sangfelt, O., Castro, J., Einhorn, S., & Grandér, D. (2002) · Oncogene · doi:10.1038/sj.onc.1205179 · Cited by 239
Rökman, A., Ikonen, T., Seppälä, E. H., Nupponen, N. N., Autio, V., Mononen, N., Wilson, J., Trent, J. M., Carpten, J. D., Matikainen, M. P., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/340450 · Cited by 236
The acute promyelocytic leukaemia-associated PML gene is induced by interferon.
Lavau, C., Marchio, A., Fagioli, M., Jansen, J. H., Falini, B., Lebon, P., Grosveld, F. G., Pandolfi, P. P., Pelicci, P. G., & Dejean, A. (1995) · PubMed · Cited by 228
Zhou, Q., Zhao, J., Wiedmer, T., & Sims, P. J. (2002) · Blood · doi:10.1182/blood-2001-12-0271 · Cited by 221
Gene structure and function of the 2′-5′-oligoadenylate synthetase family
Justesen, J., Hartmann, R., & Kjeldgaard, N. O. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000644 · Cited by 213
Expression and Genetic Analysis of XIAP-Associated Factor 1 (XAF1) in Cancer Cell Lines
Fong, W. G., Liston, P., Rajcan‐Separovic, E., Jean, M. S., Craig, C. G., & Korneluk, R. G. (2000) · Genomics · doi:10.1006/geno.2000.6364 · Cited by 213
Chen, Q., Gong, B., Mahmoud-Ahmed, A. S., Zhou, A., Hsi, E. D., Hussein, M. A., & Almasan, A. (2001) · Blood · doi:10.1182/blood.v98.7.2183 · Cited by 202
Iordanov, M. S., Paranjape, J. M., Zhou, A., Wong, J. W., Williams, B. R. G., MEURS, E. F., Silverman, R. H., & Magun, B. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.617-627.2000 · Cited by 201
Self-citationKageshita, T., Kashio, Y., Yamauchi, A., Seki, M., Abedin, M. J., Nishi, N., Shoji, H., Nakamura, T., Ono, T., & Hirashima, M. (2002) · International Journal of Cancer · doi:10.1002/ijc.10436 · Cited by 198
Jagus, R., Joshi, B., & Barber, G. N. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00136-8 · Cited by 190
Xaus, J., Cardó, M., Valledor, A. F., Soler, C., Lloberas, J., & Celada, A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80085-0 · Cited by 182
Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth
Balkwill, F. R., & Taylor‐Papadimitriou, J. (1978) · Nature · doi:10.1038/274798a0 · Cited by 181
The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis
Castelli, J. C., Hassel, B. A., Maran, A., Paranjape, J. M., Hewitt, J., Li, X.-L., Hsu, Y., Silverman, R. H., & Youle, R. J. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400352 · Cited by 181
Self-citationModular Structure of PACT: Distinct Domains for Binding and Activating PKR
Peters, G. A., Hartmann, R., Qin, J., & Sen, G. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.1908-1920.2001 · Cited by 178
Self-citationLeaman, D. W., Chawla‐Sarkar, M., Vyas, K., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204851200 · Cited by 177
Self-citationMorrison, B., Bauer, J. A., Kalvakolanu, D. V., & Lindner, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101161200 · Cited by 165
Self-citationLiu, S., Yu, Y., Zhang, M., Wang, W., & Cao, X. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5407 · Cited by 165
The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis
Heylbroeck, C., Balachandran, S., Servant, M. J., DeLuca, C., Barber, G. N., Lin, R., & Hiscott, J. B. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3781-3792.2000 · Cited by 162
Selleri, C., Sato, T., Vecchio, L. D., Luciano, L., Barrett, A. J., Rotoli, B., Young, N. S., & Maciejewski, J. P. (1997) · Blood · doi:10.1182/blood.v89.3.957 · Cited by 142
Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells
Díaz‐Guerra, M., Rivas, C., & Estéban, M. (1997) · Virology · doi:10.1006/viro.1997.8719 · Cited by 139
Kano, A., Haruyama, T., Akaike, T., & Watanabe, Y. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0276 · Cited by 137
Wright, K., Wilson, P. J., Morland, S. J., Campbell, I., Walsh, M. D., Hurst, T., Ward, B. G., Cummings, M. C., & Chenevix‐Trench, G. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990827)82:5 · Cited by 134
Ruiz‐Ruiz, C., Muñoz‐Pinedo, C., & López‐Rivas, A. (2000) · PubMed · Cited by 130
Rennert, H., Bercovich, D., Hubert, A., Abeliovich, D., Rozovski, U., Bar‐Shira, A., Soloviov, S., Schreiber, L., Matzkin, H., Rennert, G., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342775 · Cited by 128
Alpha Interferon Suppresses the Cyclin D3 and cdc25A Genes, Leading to a Reversible G 0 -Like Arrest
Tiefenbrun, N., Melamed, D., Levy-Strumpf, N., Resnitzky, D., Hoffmann, I., Reed, S. I., & Kimchi, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3934 · Cited by 126
Sangfelt, O., Erickson, S., Castro, J., Heiden, T., Einhorn, S., & Grandér, D. (1997) · PubMed · Cited by 122
Analysis of the RNASEL Gene in Familial and Sporadic Prostate Cancer
Wang, L., McDonnell, S. K., Elkins, D. A., Slager, S. L., Christensen, E., Marks, A. F., Cunningham, J. M., Peterson, B. J., Jacobsen, S. J., Cerhan, J. R., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341281 · Cited by 121
Buechner, S. A., Wernli, M., Harr, T., Hahn, S., Itin, P., & Erb, P. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119814 · Cited by 120
Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence–Binding Protein
Gabriele, L., Phung, J., Fukumoto, J., Segal, D., Wang, I.-M., Giannakakou, P., Giese, N. A., Ozato, K., & Morse, H. C. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.3.411 · Cited by 114
Basham, T. Y., Bourgeade, M., Creasey, A. A., et al. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.10.3265 · Cited by 112
Tan, S., & Katze, M. G. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313677 · Cited by 109
Molecular Cross-talk between the TRAIL and Interferon Signaling Pathways
Kumar‐Sinha, C., Varambally, S., Sreekumar, A., & Chinnaiyan, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107795200 · Cited by 100
Sun, J., Nanjundan, M., PIKE, L. J., et al. (2002) · Biochemistry · doi:10.1021/bi025610l · Cited by 98
Izawa, J. I., Sweeney, P., Perrotte, P., Kedar, D. J., Dong, Z., Slaton, J. W., Karashima, T., Inoue, K., Benedict, W. F., & Dinney, C. P. (2002) · PubMed · Cited by 95
High IL-13 production by human neonatal T cells: neonate immune system regulator?
Ribeiro-do-Couto, L. M., Boeije, L. C. M., Kroon, J., Hooibrink, B., Breur-Vriesendorp, B. S., Aarden, L. A., & Boog, C. J. P. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200111)31:11 · Cited by 91
Caspase-Dependent Apoptosis by 2′,5′-Oligoadenylate Activation of RNase L Is Enhanced by IFN-β
Rusch, L. M., Zhou, A., & Silverman, R. H. (2000) · Journal of Interferon & Cytokine Research · doi:10.1089/107999000750053762 · Cited by 90
Self-citationKumar, R., & Atlas, I. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6599 · Cited by 89
Zhou, Q., Zhao, J., Al-Zoghaibi, F., Zhou, A., Wiedmer, T., Silverman, R. H., & Sims, P. J. (2000) · Blood · doi:10.1182/blood.v95.8.2593 · Cited by 87
Self-citationKleinerman, E. S., Kurzrock, R., Wyatt, D., et al. (1986) · PubMed · Cited by 84
Ahn, E.-Y. E., Pan, G., Vickers, S. M., & McDonald, J. M. (2002) · International Journal of Cancer · doi:10.1002/ijc.10516 · Cited by 83
Ghosh, A., Sarkar, S. N., Rowe, T. M., & Sen, G. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100496200 · Cited by 80
Self-citationIFN-β Pretreatment Sensitizes Human Melanoma Cells to TRAIL/Apo2 Ligand-Induced Apoptosis
Chawla‐Sarkar, M., Leaman, D. W., Jacobs, B., & Borden, E. C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.847 · Cited by 79
Self-citationImpact of RNase L Overexpression on Viral and Cellular Growth and Death
Zhou, A., Paranjape, J. M., HASSEL, B. A., et al. (1998) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1998.18.953 · Cited by 77
Spets, H., Georgii‐Hemming, P., Siljason, J., Nilsson, K., & Jernberg‐Wiklund, H. (1998) · Blood · doi:10.1182/blood.v92.8.2914 · Cited by 76
Donzé, O., Dostie, J., & Sonenberg, N. (1999) · Virology · doi:10.1006/viro.1999.9618 · Cited by 75
Interferons as antiangiogenic agents
Lindner, D. J. (2002) · Current Oncology Reports · doi:10.1007/s11912-002-0065-4 · Cited by 72
Self-citationMorrison, B., Bauer, J. A., Hu, J., Grane, R., Ozdemir, A. M., Chawla‐Sarkar, M., Gong, B., Almasan, A., Kalvakolanu, D. V., & Lindner, D. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205265 · Cited by 68
Self-citationThe role of caspase-8 in resistance to cancer chemotherapy
Kim, P. K. M., Mahidhara, R. S., & Seol, D. (2001) · Drug Resistance Updates · doi:10.1054/drup.2001.0223 · Cited by 65
Subramaniam, P. S., Cruz, P. E., Hobeika, A. C., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1201712 · Cited by 65
Ruiz‐Ruiz, C., & López‐Rivas, A. (2002) · Biochemical Journal · doi:10.1042/bj20020184 · Cited by 63
c-Abl Tyrosine Kinase Binds and Phosphorylates Phospholipid Scramblase 1
Sun, J., Zhao, J., Schwartz, M. A., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102505200 · Cited by 63
Silverman, R. H., Halloum, A., Zhou, A., et al. (2002) · PubMed · Cited by 62
Self-citationStoichiometry of 2′,5′-Oligoadenylate-induced Dimerization of Ribonuclease L
Cole, J. L., Carroll, S. S., & Kuo, L. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.3979 · Cited by 62
Association of Galectin-9 with Eosinophil Apoptosis
Saita, N., Goto, E., Yamamoto, T., et al. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000058002 · Cited by 62
Interferon and Malignant Disease - How Does it Work and Why Doesn't it Always?
Grandér, D., & Einhorn, S. (1998) · Acta Oncologica · doi:10.1080/028418698430548 · Cited by 58
Human myeloma cell apoptosis induced by interferon‐α
Otsuki, T., Yamada, O., Sakaguchi, H., et al. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.01000.x · Cited by 49
Matin, S. F., Rackley, R. R., Sadhukhan, P. C., et al. (2001) · PubMed · Cited by 41
Rusch, L. M., Dong, B., & Silverman, R. H. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)42531-6 · Cited by 18
Self-citationAnalysis and origins of the human and mouse RNase L genes: mediators of interferon action
Zhou, A., Nie, H., & Silverman, R. H. (2000) · Mammalian Genome · doi:10.1007/s003350010194 · Cited by 16
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Research works printed but not linked: 2
- Borden EC, Williams BRG. Interferons. In: Bast RC Jr, Holland JF, Gansler TS, eds. Cancer Medicine, 5th edition, Toronto: B.C. Decker Inc 2000: 815–824.
- Lavau C, Marchio A, Fagioli M, et al. The acute promyelocytic leukaemia-associatedPMLgene is induced by interferon. Oncogene 1995; 11871–876.
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Metadata
- Authors
- Chawla-Sarkar, M., Lindner, D. J., Liu, Y.-F., Williams, B. R., Sen, G. C., Silverman, R. H., & Borden, E. C.
- Affiliations
- Cleveland Clinic (US)
- ORCID
- Williams, B. R.
- Venue
- Apoptosis
- Published
- 2003-06
- Volume
- 8
- Issue
- 3
- Pages
- 237-249
- ISSN
- 1360-8185 (ISSN-L)
- 1573-675X
- OpenAlex
- W65867874
- Cited by
- 829
- References
- 103
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 31 · 2023: 32 · 2022: 35 · 2021: 33 · 2020: 29 · 2019: 33 · 2018: 34 · 2017: 29 · 2016: 34 · 2015: 45 · 2014: 29 · 2013: 50 · 2012: 41
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- APOPTOSIS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA44059, R01 CA 90914, R01CA044059, R01CA090914)
- National Institute of Allergy and Infectious Diseases (AI 34039)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interferon, interferon-stimulated genes, anti-tumor effect, TRAIL, Fas/FasL, caspase-4, caspase-8, PKR, 2',5'-oligoadenylate synthetase, DAP kinase, galectin-9, PML, interferon-alpha, interferon-beta, interferon-gamma, cancer cell death
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Gene Expression Regulation, Humans, Interferons, Receptors, Cell Surface, Signal Transduction, Apoptosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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