The growing family of interferon regulatory factors

Nguyen, Hannah; Hiscott, John; Pitha, Paula M.

doi:10.1016/s1359-6101(97)00019-1

Cited by 482interferon and immune responsesCytokine Signaling Pathways and InteractionsImmune Response and Inflammation

The growing family of interferon regulatory factors

Open access

Nguyen, Hannah, Hiscott, John, Pitha, Paula M.·1997·Cytokine & Growth Factor Reviews

DOI 10.1016/s1359-6101(97)00019-1

Open this paper in CoChat — free account

Abstract

Interferons (IFN) exert their multiple biological effects through the induction of expression of over 30 genes encoding proteins with antiviral, antiproliferative and immunomodulatory functions. Among the many IFN-inducible proteins are the Interferon Regulatory Factors (IRFs), a family of transcription regulators, originally consisting of the well-characterized IRF-1 and IRF-2 proteins; the family has now expanded to over 10 members and is still growing. The present review provides a detailed description of recently characterized IRF family members. Studies analyzing IRF-expressing cell lines and IRF knockout mice reveal that each member of the IRF family exerts distinct roles in biological processes such as pathogen response, cytokine signalling, cell growth regulation and hematopoietic development. Understanding the molecular mechanisms by which the IRFs affect these important cellular events and IFN expression will contribute to a greater understanding of events leading to various viral, immune and malignant disease states and will suggest novel strategies for antiviral and immune modulatory therapy.

Integrity signals

Registry

Crossref · 10.1016/s1359-6101(97)00019-1

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

ICSBP/IRF-8 is an IFN-γ-inducible transcription factor of the IRF family that regulates transcription through multiple target DNA elements, including ISRE, EICE, and GAS.
“Interferon (IFN) consensus sequence binding protein (ICSBP)/IFN regulatory factor (IRF)-8 is an IFN g -inducible transcription factor of the IRF family and regulates transcription through multiple target DNA elements, such as IFN-stimulated response element (ISRE), Ets/IRF composite element, and IFNg activation site (GAS).”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [2]
ICSBP has a conserved DNA-binding domain (DBD) at the N-terminal region and an IRF association domain (IAD) in the C-terminal region.
“ICSBP has the DNAbinding domain (DBD) conserved in the IRF family at the Nterminal region and the IRF association domain (IAD) in the C-terminal region (Fig. 1). (2-5)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [2]
ICSBP belongs to the IRF transcription factor family, which includes nine mammalian members and four virally encoded homologs.
“It belongs to the family of IRF transcription factors, which includes nine mammalian members and four virally encoded homologs. (2,3)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [2]

TGF-β SIGNAL TRANSDUCTION
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745 · see citing works
Functional Role of Type I and Type II Interferons in Antiviral Defense
Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453 · see citing works
TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway
Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808 · see citing works
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)
Russo, J. J., Bohenzky, R. A., Chien, M.-C., Chen, J., Yan, M., Maddalena, D., Parry, J. P., Peruzzi, D., Edelman, I. S., Chang, Y., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14862 · Cited by 1,457 · see citing works
STATs: Signal Transducers and Activators of Transcription
Ihle, J. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81277-5 · Cited by 1,381 · see citing works
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Miyamoto, M., Fujita, T., Kimura, Y., Maruyama, M., Harada, H., Sudo, Y., Miyata, T., & Taniguchi, T. (1988) · Cell · doi:10.1016/s0092-8674(88)91307-4 · Cited by 977 · see citing works
Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T., & Taniguchi, T. (1989) · Cell · doi:10.1016/0092-8674(89)90107-4 · Cited by 957 · see citing works
Casein kinase 2: An ‘eminence grise’ in cellular regulation?
Pinna, L. A. (1990) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(90)90098-x · Cited by 920 · see citing works
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
Moore, P. S., Boshoff, C., Weiss, R. A., & Chang, Y. (1996) · Science · doi:10.1126/science.274.5293.1739 · Cited by 900 · see citing works
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
Kamijo, R., Harada, H., Matsuyama, T., Bosland, M. C., Gerecitano, J. F., Shapiro, D., Le, J., Koh, S. I., Kimura, T., Green, S. J., et al. (1994) · Science · doi:10.1126/science.7510419 · Cited by 843 · see citing works
Cytokine therapeutics: lessons from interferonalpha.
Gutterman, J. U. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1198 · Cited by 703 · see citing works
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) · Cell · doi:10.1016/s0092-8674(05)80086-8 · Cited by 649 · see citing works
Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene
Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644 · see citing works
Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.
Yang, Y. L., Reis, L. F. L., Pavlovic, J., Aguzzi, A., Schäfer, R., Kumar, A., Williams, B. R. G., Aguet, M., & Weissmann, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00300.x · Cited by 632 · see citing works
Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
Mittrücker, H.-W., Matsuyama, T., Grossman, A., Kündig, T. M., Potter, J., Shahinian, A., Wakeham, A., Patterson, B., Ohashi, P. S., & Mak, T. W. (1997) · Science · doi:10.1126/science.275.5299.540 · Cited by 583 · see citing works
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M. S., Aizawa, S., Mak, T. W., & Taniguchi, T. (1994) · Cell · doi:10.1016/0092-8674(94)90132-5 · Cited by 491 · see citing works
Role of interferon regulatory factor 1 in induction of nitric oxide synthase.
Martin, E., Nathan, C. F., & Xie, Q. W. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.3.977 · Cited by 477 · see citing works
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development · doi:10.1101/gad.9.11.1377 · Cited by 447 · see citing works
Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2
Harada, H., Kitagawa, M., Tanaka, N., Yamamoto, H., Harada, K., Ishihara, M., & Taniguchi, T. (1993) · Science · doi:10.1126/science.8438157 · Cited by 436 · see citing works
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
Tamura, T., Ishihara, M., Lamphier, M. S., Tanaka, N., Oishi, I., Aizawa, S., Matsuyama, T., Mak, T. W., Taki, S., & Taniguchi, T. (1995) · Nature · doi:10.1038/376596a0 · Cited by 431 · see citing works
Subunit of an Alpha-Interferon-Responsive Transcription Factor Is Related to Interferon Regulatory Factor and Myb Families of DNA-Binding Proteins
Veals, S. A., Schindler, C., Leonard, D. G. B., Fu, X.-Y., Aebersold, R. H., Darnell, J. E., Jr., & Levy, D. E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3315 · Cited by 389 · see citing works
Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes.
Au, W.-C., Moore, P. A., Lowther, W. J., Juang, Y., & Pitha, P. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11657 · Cited by 388 · see citing works
Self-citation
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins
Veals, S. A., Schindler, C., Leonard, D., Fu, X., Aebersold, R. H., Darnell, J. E., & Levy, D. E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3315-3324.1992 · Cited by 386 · see citing works
Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia
Willman, C. L., Sever, C. E., Pallavicini, M. G., Harada, H., Tanaka, N., Slovak, M. L., Yamamoto, H., Harada, K., Meeker, T. C., List, A. F., et al. (1993) · Science · doi:10.1126/science.8438156 · Cited by 380 · see citing works
Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated
Harada, H., Willison, K. R., Sakakibara, J., Miyamoto, M., Fujita, T., & Taniguchi, T. (1990) · Cell · doi:10.1016/0092-8674(90)90163-9 · Cited by 368 · see citing works
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes
石原, 正. (1997) · Cited by 366 · see citing works
Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1
Fujita, T., Kimura, Y., Miyamoto, M., Barsoumian, E. L., & Taniguchi, T. (1989) · Nature · doi:10.1038/337270a0 · Cited by 358 · see citing works
An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.
Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W. H., Marks, M. S., Levi, B. Z., Flanagan, J. R., Appella, E., & Ozato, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3743 · Cited by 356 · see citing works
Interferons and Other Cytokines
Hendrzak, J. A., & Brunda, M. J. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-717-8_13 · Cited by 356 · see citing works
Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80443-4 · Cited by 353 · see citing works
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF‐1 and NF‐κB
Kumar, A., Yang, Y., Flati, V., Der, S., Kadereit, S., Deb, A., Haque, J., Reis, L. F. L., Weissmann, C., & Williams, B. R. G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.406 · Cited by 350 · see citing works
Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF‐1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.
Pine, R., Canova, A., & Schindler, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06245.x · Cited by 347 · see citing works
Evidence for a nuclear factor(s), IRF‐1, mediating induction and silencing properties to human IFN‐beta gene regulatory elements.
Fujita, T., Sakakibara, J., Sudo, Y., Miyamoto, M., Kimura, Y., & Taniguchi, T. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03213.x · Cited by 347 · see citing works
Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either
Pine, R. I., Decker, T., Kessler, D. S., Levy, D. E., & Darnell, J. E., Jr. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.2448 · Cited by 331 · see citing works
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage
Tanaka, N., Ishihara, M., Lamphier, M. S., Nozawa, H., Matsuyama, T., Mak, T. W., Aizawa, S., Tokino, T., Oren, M., & Taniguchi, T. (1996) · Nature · doi:10.1038/382816a0 · Cited by 324 · see citing works
Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.
Kessler, D. S., Veals, S. A., Fu, X. Y., & Levy, D. E. (1990) · Genes & Development · doi:10.1101/gad.4.10.1753 · Cited by 312 · see citing works
Involvement of the IRF-1 Transcription Factor in Antiviral Responses to Interferons
Kimura, T., Nakayama, K., Penninger, J. M., Kitagawa, M., Harada, H., Matsuyama, T., Tanaka, N., Kamijo, R., Vilček, J., Mak, T. W., et al. (1994) · Science · doi:10.1126/science.8009222 · Cited by 304 · see citing works
Structure and Regulation of the Human Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Genes: Implications for a Gene Network in the Interferon System
Harada, H., Takahashi, E., Itoh, S., Harada, K., Hori, T.-A., & Taniguchi, T. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.2.1500 · Cited by 298 · see citing works
α, β, γ, and δ T Cell Antigen Receptor Genes Arose Early in Vertebrate Phylogeny
Rast, J. P., Anderson, M. K., Strong, S. J., Luer, C. A., Litman, R. T., & Litman, G. W. (1997) · Immunity · doi:10.1016/s1074-7613(00)80237-x · Cited by 288 · see citing works
Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.
Fujita, T., Reis, L. F. L., Watanabe, N., Kimura, Y., Taniguchi, T., & Vilček, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.24.9936 · Cited by 287 · see citing works
Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3
Schafer, S. L., Lin, R., Moore, P. A., Hiscott, J. B., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2714 · Cited by 266 · see citing works
Self-citation
A Novel Interferon-Inducible Domain: Structural and Functional Analysis of the Human Interferon Regulatory Factor 1 Gene Promoter
Sims, S. H., Cha, Y., Romine, M. F., Gao, P. Q., Gottlieb, K., & Deisseroth, A. B. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.690 · Cited by 262 · see citing works
Critical role of a common transcription factor, IRF‐1, in the regulation of IFN‐beta and IFN‐inducible genes.
Reis, L. F. L., Harada, H., Wolchok, J. D., Taniguchi, T., & Vilček, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05041.x · Cited by 243 · see citing works
Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
Brass, A. L., Kehrli, E., Eisenbeis, C. F., Storb, U., & Singh, H. (1996) · Genes & Development · doi:10.1101/gad.10.18.2335 · Cited by 242 · see citing works
Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies
Kimura, T., Kadokawa, Y., Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Tarutani, M., Tan, R. S., Takasugi, T., Matsuyama, T., et al. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.08008.x · Cited by 233 · see citing works
Activation of the human beta-interferon gene requires an interferon-inducible factor.
Enoch, T., Zinn, K., & Maniatis, T. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.3.801 · Cited by 232 · see citing works
Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
Matsuyama, T., Grossman, A., Mittrücker, H.-W., Siderovski, D. P., Kiefer, F., Kawakami, T., Richardson, C. D., Taniguchi, T., Yoshinaga, S. K., & Mak, T. W. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2127 · Cited by 232 · see citing works
Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras
Contente, S., Kenyon, K., Rimoldi, D., & Friedman, R. M. (1990) · Science · doi:10.1126/science.1697103 · Cited by 221 · see citing works
Activation of IFN-βelement by IRF-1 requires a post-translational event in addition to IRF-1 synthesis
Watanabe, N., Sakakibara, J., Hovanessian, A. G., Taniguchi, T., & Fujita, T. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.16.4421 · Cited by 199 · see citing works
A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes
Yamagata, T., Nishida, J., Tanaka, T., Sakai, R., Mitani, K., Yoshida, M., Taniguchi, T., Yazaki, Y., & Hirai, H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1283 · Cited by 196 · see citing works
Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588 · Cited by 192 · see citing works
Interferon Consensus sequence-Binding Protein, a Member of the Interferon Regulatory Factor Family, Suppresses Interferon-Induced Gene Transcription
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588-599.1993 · Cited by 192 · see citing works
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2
Vaughan, P. S., Aziz, F., van Wijnen, A. J., Wu, S., Harada, H., Taniguchi, T., Soprano, K. J., Stein, J. L., & Stein, G. S. (1995) · Nature · doi:10.1038/377362a0 · Cited by 189 · see citing works
Mice devoid of interferon regulatory factor 1 (IRF‐1) show normal expression of type I interferon genes.
Reis, L. F. L., Ruffner, H., Stark, G., Aguet, M., & Weissmann, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06805.x · Cited by 184 · see citing works
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.
Kanno, Y., Kozak, C. A., Schindler, C., Driggers, P. H., Ennist, D. L., Gleason, S. L., Darnell, J. E., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3951 · Cited by 180 · see citing works
Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity
Kondo, T., Minamino, N., Nagamura‐Inoue, T., Matsumoto, M., Taniguchi, T., & Tanaka, N. (1997) · Oncogene · doi:10.1038/sj.onc.1201286 · Cited by 177 · see citing works
Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.
Bovolenta, C., Driggers, P. H., Marks, M. S., Medin, J. A., Politis, A. D., Vogel, S. N., Levy, D. E., Sakaguchi, K., Appella, E., & Coligan, J. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5046 · Cited by 167 · see citing works
Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA
Sharf, R., Meraro, D., Azriel, A., Thornton, A. M., Ozato, K., Petricoin, E. F., Larner, A. C., Schaper, F., Hauser, H., & Levi, B.-Z. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9785 · Cited by 162 · see citing works
Inactivation of IκBβ by the Tax Protein of Human T-Cell Leukemia Virus Type 1: a Potential Mechanism for Constitutive Induction of NF-κB
McKinsey, T. A., Brockman, J. A., Scherer, D. C., Al-Murrani, S. W. K., Green, P. L., & Ballard, D. W. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2083 · Cited by 160 · see citing works
Regulation of LMP2 and TAP1 Genes by IRF-1 Explains the Paucity of CD8+ T Cells in IRF-1−/− Mice
White, L. C., Wright, K. L., Felix, N. J., Ruffner, H., Reis, L. F. L., Pine, R. I., & Ting, J. P. ‐. (1996) · Immunity · doi:10.1016/s1074-7613(00)80262-9 · Cited by 157 · see citing works
Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
Weisz, A., Marx, P., Sharf, R., Appella, E., Driggers, P. H., Ozato, K., & Levi, B. Z. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74081-2 · Cited by 152 · see citing works
Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.
Abdollahi, A., Lord, K. A., Hoffman‐Liebermann, B., & Liebermann, D. A. (1991) · PubMed · Cited by 151 · see citing works
Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity
Lint, C. M. V., Amella, C. A., Emiliani, S., John, M., Jie, T., & Verdin, E. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.8.6113-6127.1997 · Cited by 149 · see citing works
Isolation and Characterization of a New Mutant Human Cell Line Unresponsive to Alpha and Beta Interferons
John, J., McKendry, R., Pellegrini, S., Flavell, D. M., Kerr, I. M., & Stark, G. R. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.4189 · Cited by 148 · see citing works
Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.
Raj, N. B., & Pitha, P. M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7426 · Cited by 147 · see citing works
Self-citation
Autocrine Amplification of Type I Interferon Gene Expression Mediated by Interferon Stimulated Gene Factor 3 (ISGF3)
Yoneyama, M., Suhara, W., Fukuhara, Y., Sato, M., Ozato, K., & Fujita, T. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021379 · Cited by 138 · see citing works
Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity
Veals, S. A., Maria, T. S., & Levy, D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.196-206.1993 · Cited by 136 · see citing works
ISGF3γ p48, a specificity switch for interferon activated transcription factors
Bluyssen, H. A. R. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/1359-6101(96)00005-6 · Cited by 135 · see citing works
The transcription factor interferon regulatory factor-1 is essential for natural killer cell function in vivo.
Duncan, G. S., Mittrücker, H.-W., Kägi, D., Matsuyama, T., & Mak, T. W. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.2043 · Cited by 135 · see citing works
IRF-1: the transcription factor linking the interferon response and oncogenesis
Taniguchi, T., Lamphier, M. S., & Tanaka, N. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(97)00014-0 · Cited by 121 · see citing works
Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation.
Harada, H., Kondo, T., Ogawa, S., Tamura, T., Kitagawa, M., Tanaka, N., Lamphier, M. S., Hirai, H., & Taniguchi, T. (1994) · PubMed · Cited by 114 · see citing works
Purification and Cloning of Interferon-Stimulated Gene Factor 2 (ISGF2): ISGF2 (IRF-1) Can Bind to the Promoters of Both Beta Interferon- and Interferon-Stimulated Genes but Is Not a Primary Transcriptional Activator of Either
Pine, R., Decker, T., Kessler, D. S., et al. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.2448-2457.1990 · Cited by 114 · see citing works
p300 and CBP as transcriptional regulators and targets of oncogenic events.
Eckner, R. (1996) · PubMed · Cited by 110 · see citing works
IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.
Kirchhoff, S., Koromilas, A. E., Schaper, F., Grashoff, M., Sonenberg, N., & Häuser, H. (1995) · PubMed · Cited by 110 · see citing works
The Ets family of proteins: weak modulators of gene expression in quest for transcriptional partners.
Crépieux, P., Coll, J., & Stéhelin, D. (1994) · PubMed · Cited by 103 · see citing works
Functional Domain Analysis of Interferon Consensus Sequence Binding Protein (ICSBP) and Its Association with Interferon Regulatory Factors
Sharf, R., Azriel, A., Lejbkowicz, F., Winograd, S. S., Ehrlich, R., & Levi, B.-Z. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13063 · Cited by 100 · see citing works
Regulation of IFN‐α/β genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN‐α/β
Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Kimura, T., Kitagawa, M., Yokochi, T., Tan, R. S., Takasugi, T., Kadokawa, Y., et al. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.870287.x · Cited by 97 · see citing works
The oncogenic transcription factor IRF-2 possesses a transcriptional repression and a latent activation domain.
Yamamoto, H., Lamphier, M. S., Fujita, T., Taniguchi, T., & Harada, H. (1994) · PubMed · Cited by 91 · see citing works
A Novel Interferon-Inducible Domain: Structural and Functional Analysis of the Human Interferon Regulatory Factor 1 Gene Promoter
Sims, S. H., Cha, Y., Romine, M. F., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.690-702.1993 · Cited by 88 · see citing works
Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1, and its possible role in tumor suppression.
Tan, R. S., Taniguchi, T., & Harada, H. (1996) · PubMed · Cited by 83 · see citing works
Constitutive activation of Epstein-Barr virus (EBV) nuclear antigen 1 gene transcription by IRF1 and IRF2 during restricted EBV latency
Schaefer, B. C., Paulson, E. J., Strominger, J., & Speck, S. H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.873 · Cited by 82 · see citing works
Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1
Tanaka, N., Ishihara, M., & Taniguchi, T. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90318-2 · Cited by 80 · see citing works
Protein-DNA interactions within DNase I-hypersensitive sites located downstream of the HIV-1 promoter.
Kharroubi, A. E., & Verdin, E. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32107-5 · Cited by 77 · see citing works
Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-beta gene expression
Lin, R., Mustafa, A., Nguyen, H. T. T., Gewert, D. R., & Hiscott, J. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32475-4 · Cited by 69 · see citing works
Self-citation
Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma
Nonkwelo, C., Ruf, I. K., & Sample, J. T. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6887-6897.1997 · Cited by 68 · see citing works
Up-regulation of lysyl oxidase in spontaneous revertants of H-ras-transformed rat fibroblasts.
Hajnal, A., Klemenz, R., & Schäfer, R. (1993) · PubMed · Cited by 67 · see citing works
Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins
Nguyen, H., Lin, R., & Hiscott, J. (1997) · Oncogene · doi:10.1038/sj.onc.1201318 · Cited by 67 · see citing works
Self-citation
Inducible Processing of Interferon Regulatory Factor-2
Palombella, V. J., & Maniatis, T. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3325 · Cited by 66 · see citing works
Interferon Regulatory Factors and TFIIB Cooperatively Regulate Interferon-Responsive Promoter Activity In Vivo and In Vitro
Wang, I.-M., Blanco, J. C. G., Tsai, S. Y., Tsai, M.-J., & Ozato, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6313 · Cited by 64 · see citing works
Identification of novel factors that bind to the PRD I region of the human β-interferon promoter
Whiteside, S. T., Visvanathan, K. V., & Goodbourn, S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.7.1531 · Cited by 62 · see citing works
clRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA
Grant, C. E., Vasa, M. Z., & Deeley, R. G. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.12.2137 · Cited by 56 · see citing works
Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain.
Nguyen, H. T. T., Mustafa, A., Hiscott, J. B., & Lin, R. (1995) · PubMed · Cited by 51 · see citing works
Self-citation
Virus-mediated induction of interferon A gene requires cooperation between multiple binding factors in the interferon alpha promoter region.
Au, W. C., Su, Y., Raj, N. B., & Pitha, P. M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80488-8 · Cited by 50 · see citing works
Self-citation
Possible involvement of the transcription factor ISGF3γ in virus‐induced expression of the IFN‐β gene
Kawakami, T., Matsumoto, M., Sato, M., Harada, H., Taniguchi, T., & Kitagawa, M. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01426-2 · Cited by 48 · see citing works
Distinct activation of murine interferon-αpromoter region by IRF-1/ISFG-2 and virus infection
Au, W.-C., Raj, N. B. K., Pine, R. I., & Pitha, P. M. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.11.2877 · Cited by 46 · see citing works
Self-citation
Molecular mechanisms of interferon beta gene induction
Hiscott, J., Nguyen, H., & Lin, R. (1995) · Seminars in Virology · doi:10.1006/smvy.1995.0021 · Cited by 42 · see citing works
Self-citation
Molecular Interactions between HTLV-1 Tax Protein and the NF-κB/IκB Transcription Complex
Hiscott, J., Petropoulos, L., & Lacoste, J. (1995) · Virology · doi:10.1006/viro.1995.9960 · Cited by 41 · see citing works
Self-citation
Interferon induction of gene expression through the Jak–Stat pathway
Levy, D. E. (1995) · Seminars in Virology · doi:10.1006/smvy.1995.0023 · Cited by 41 · see citing works
Human interferon regulatory factor 2 gene. Intron-exon organization and functional analysis of 5'-flanking region.
Cha, Y., & Deisseroth, A. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37685-8 · Cited by 39 · see citing works
Synergism between Multiple Virus-induced Factor-binding Elements Involved in the Differential Expression of Interferon A Genes*
Bragança, J., Génin, P., Bandu, M., Darracq, N., Vignal, M., Cassé, C., Doly, J., & Civas, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22154 · Cited by 38 · see citing works
Signal Transduction, Mitotic Catastrophes, and Death in T‐Cell Development
Penninger, J. M., & Mak, T. W. (1994) · Immunological Reviews · doi:10.1111/j.1600-065x.1994.tb00892.x · Cited by 36 · see citing works
A novel PRD I and TG binding activity involved in virus-induced transcription of IFN-A genes
Génin, P., Bragança, J., Darracq, N., Doly, J., & Civas, A. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5055 · Cited by 35 · see citing works
Sequence elements downstream of the human immunodeficiency virus type 1 long terminal repeat are required for efficient viral gene transcription
Liang, C., Li, X., Quan, Y., Laughrea, M., Kleiman, L., Hiscott, J. B., & Wainberg, M. A. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1239 · Cited by 34 · see citing works
Self-citation
Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by a dominant negative factor of the interferon regulatory factor family expressed in monocytic cells.
Thornton, A. M., Buller, R. M. L., DeVico, A. L., Wang, I. M., & Ozato, K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.383 · Cited by 34 · see citing works
The Epstein-Barr virus EBNA-1 promoter Qp requires an initiator-like element
Nonkwelo, C., Ruf, I. K., & Sample, J. T. (1997) · Journal of Virology · doi:10.1128/jvi.71.1.354-361.1997 · Cited by 33 · see citing works
Induction of interferon alpha genes expression
Pitha, P. M., & Au, W.-C. (1995) · Seminars in Virology · doi:10.1006/smvy.1995.0020 · Cited by 31 · see citing works
Self-citation
The Effect of Priming with Interferon on Interferon Production by Two Lines of L Cells
Stewart, W. E., Gosser, L. B., & Lockart, R. Z. (1972) · Journal of General Virology · doi:10.1099/0022-1317-15-1-85 · Cited by 26 · see citing works
A dominant negative mutant of an IFN regulatory factor family protein inhibits both type I and type II IFN-stimulated gene expression and antiproliferative activity of IFNs
Thornton, A. M., Ogryzko, V. V., Dent, A., Sharf, R., Levi, B. Z., Kanno, Y., Staudt, L. M., Howard, B. H., & Ozato, K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.11.5145 · Cited by 25 · see citing works
A truncated form of the IRF-2 transcription factor has the properties of a postinduction repressor of interferon-beta gene expression.
Whiteside, S. T., King, P., & Goodbourn, S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47125-6 · Cited by 24 · see citing works
Isolation and Characterization of a New Mutant Human Cell Line Unresponsive to Alpha and Beta Interferons
John, J., McKendry, R., Pellegrini, S., et al. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.8.4189-4195.1991 · Cited by 21 · see citing works
Characterization of TH3, an induction-specific protein interacting with the interferon β promoter
Cohen, L., & Hiscott, J. (1992) · Virology · doi:10.1016/0042-6822(92)90234-g · Cited by 17 · see citing works
Self-citation
Characterization of the DNA binding domain of the mouse IRF-2 protein
Uegaki, K., Shirakawa, M., Fujita, T., Taniguchi, T., & Kyogoku, Y. (1993) · Protein Engineering Design and Selection · doi:10.1093/protein/6.2.195 · Cited by 17 · see citing works
Priming affects the activity of a specific region of the promoter of the human beta interferon gene.
Dron, M., Lacasa, M., & Tovey, M. G. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.854 · Cited by 16 · see citing works

Flagged first, then by citations

5 of the 121 references couldn’t be matched to a known paper.

Sorted by citations

The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,867 · see citing works
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743 · see citing works
Systematic variation in gene expression patterns in human cancer cell lines
Ross, D. T., Scherf, U., Eisen, M. B., Perou, C. M., Rees, C., Spellman, P., Iyer, V., Jeffrey, S. S., Van de Rijn, M., Waltham, M., et al. (2000) · Nature Genetics · doi:10.1038/73432 · Cited by 2,088 · see citing works
Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays
Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,805 · see citing works
IRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658 · see citing works
Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419 · see citing works
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00053-4 · Cited by 1,342 · see citing works
Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7
Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049 · see citing works
Viruses and Interferons
Sen, G. C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.255 · Cited by 969 · see citing works
Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation
Lin, R., Heylbroeck, C., Pitha, P. M., & Hiscott, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.5.2986 · Cited by 915 · see citing works
Self-citation
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis
Chawla-Sarkar, M., Lindner, D. J., Liu, Y.-F., Williams, B. R., Sen, G. C., Silverman, R. H., & Borden, E. C. (2003) · Apoptosis · doi:10.1023/a:1023668705040 · Cited by 829 · see citing works
TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages
Toshchakov, V. Y., Jones, B. W., Perera, P., Thomas, K., Cody, M. J., Zhang, S., Williams, B. R. G., Major, J. A., Hamilton, T. A., Fenton, M. J., et al. (2002) · Nature Immunology · doi:10.1038/ni774 · Cited by 803 · see citing works
Inflammation and Stroke: Putative Role for Cytokines, Adhesion Molecules and iNOS in Brain Response to Ischemia
del Zoppo, G., Ginis, I., Hallenbeck, J. M., Iadecola, C., Wang, X., & Feuerstein, G. Z. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00247.x · Cited by 660 · see citing works
Host defense, viruses and apoptosis
Barber, G. N. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400823 · Cited by 576 · see citing works
Interferon regulatory factors: the next generation
Mamane, Y., Heylbroeck, C., Génin, P., Algarté-Génin, M., Servant, M. J., Page, C. L., DeLuca, C., Kwon, H., Lin, R., & Hiscott, J. B. (1999) · Gene · doi:10.1016/s0378-1119(99)00262-0 · Cited by 570 · see citing works
Self-citation
Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7
Sato, M., Hata, N., Asagiri, M., Nakaya, T., Taniguchi, T., & Tanaka, N. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01514-2 · Cited by 553 · see citing works
A weak signal for strong responses: interferon-alpha/beta revisited
Taniguchi, T., & Takaoka, A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073080 · Cited by 483 · see citing works
The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
Taniguchi, T., & Takaoka, A. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00305-3 · Cited by 476 · see citing works
ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8α+ Dendritic Cells
Schiavoni, G., Mattei, F., Sestili, P., Borghi, P., Venditti, M., Morse, H. C., Belardelli, F., & Gabriele, L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021263 · Cited by 423 · see citing works
Activation with CpG-A and CpG-B Oligonucleotides Reveals Two Distinct Regulatory Pathways of Type I IFN Synthesis in Human Plasmacytoid Dendritic Cells
Kerkmann, M., Rothenfußer, S., Hornung, V., Towarowski, A., Wagner, M., Sarris, A., Giese, T., Endres, S., & Hartmann, G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4465 · Cited by 351 · see citing works
Regulation of the type I IFN induction: a current view
Honda, K., Yanai, H., Takaoka, A., & Taniguchi, T. (2005) · International Immunology · doi:10.1093/intimm/dxh318 · Cited by 347 · see citing works
Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells
Izaguirre, A. G., Barnes, B. J., Amrute, S. B., Yeow, W.-S., Megjugorac, N. J., Dai, J., Feng, D., Chung, E., Pitha, P. M., & Fitzgerald-Bocarsly, P. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603255 · Cited by 346 · see citing works
Self-citation
The role of gamma interferon in antimicrobial immunity
Shtrichman, R., & Samuel, C. E. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00199-5 · Cited by 334 · see citing works
Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains
Lin, R., Mamane, Y., & Hiscott, J. B. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2465 · Cited by 321 · see citing works
Self-citation
Review: On the Role of IRF in Host Defense
Barnes, B. J., Lubyová, B., & Pitha, P. M. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452665 · Cited by 318 · see citing works
Self-citation
The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2
Chistiakov, D. A., Myasoedova, V. A., Revin, V. V., Orekhov, A. N., & Bobryshev, Y. V. (2018) · Immunobiology · doi:10.1016/j.imbio.2017.10.005 · Cited by 311 · see citing works
ICSBP Directs Bipotential Myeloid Progenitor Cells to Differentiate into Mature Macrophages
Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T., & Ozato, K. (2000) · Immunity · doi:10.1016/s1074-7613(00)00016-9 · Cited by 305 · see citing works
Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes
Au, W.-C., Moore, P. A., LaFleur, D. W., TOMBAL, B. F., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29210 · Cited by 295 · see citing works
Self-citation
The IRF family, revisited
Paun, A., & Pitha, P. M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.01.014 · Cited by 277 · see citing works
Self-citation
Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription
Lin, R., Heylbroeck, C., Génin, P., Pitha, P., & Hiscott, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.959 · Cited by 325 · see citing works
Self-citation
Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3
Juang, Y.-T., Lowther, W. J., Kellum, M. J., Au, W.-C., Lin, R., Hiscott, J. B., & Pitha, P. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9837 · Cited by 266 · see citing works
Self-citation
The IRF family of transcription factors: Inception, impact and implications in oncogenesis
Yanai, H., Negishi, H., & Taniguchi, T. (2012) · OncoImmunology · doi:10.4161/onci.22475 · Cited by 261 · see citing works
Multiple Regulatory Domains of IRF-5 Control Activation, Cellular Localization, and Induction of Chemokines That Mediate Recruitment of T Lymphocytes
Barnes, B. J., Kellum, M. J., Field, A. E., & Pitha, P. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5721-5740.2002 · Cited by 251 · see citing works
Self-citation
CD8+ T Cell–Mediated Skin Disease in Mice Lacking IRF-2, the Transcriptional Attenuator of Interferon-α/β Signaling
Hida, S., Ogasawara, K., Sato, K., Abe, M., Takayanagi, H., Yokochi, T., Sato, T., Hirose, S., Shirai, T., Taki, S., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00064-9 · Cited by 251 · see citing works
Triggering the Interferon Response: The Role of IRF-3 Transcription Factor
Hiscott, J. B., Pitha, P. M., Génin, P., Nguyen, H., Heylbroeck, C., Mamane, Y., Algarté-Génin, M., & Lin, R. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099314360 · Cited by 241 · see citing works
Self-citation
A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation
Zhu, F. X., King, S. M., Smith, E., Levy, D. E., & Yuan, Y. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082420599 · Cited by 241 · see citing works
Multiple Regulatory Domains Control IRF-7 Activity in Response to Virus Infection
Lin, R., Mamane, Y., & Hiscott, J. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002814200 · Cited by 241 · see citing works
Self-citation
Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus–related lymphomas
Carbone, A., Gloghini, A., Larocca, L. M., Capello, D., Pierconti, F., Canzonieri, V., Tirelli, U., Dalla‐Favera, R., & Gaïdano, G. (2001) · Blood · doi:10.1182/blood.v97.3.744 · Cited by 234 · see citing works
IRF3 and IRF7 Phosphorylation in Virus-infected Cells Does Not Require Double-stranded RNA-dependent Protein Kinase R or IκB Kinase but Is Blocked by Vaccinia Virus E3L Protein
Smith, E., Marié, I., Prakash, A., García‐Sastre, A., & Levy, D. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008717200 · Cited by 224 · see citing works
Global and Distinct Targets of IRF-5 and IRF-7 during Innate Response to Viral Infection
Barnes, B. J., Richards, J. O., Mancl, M. E., Hanash, S., Beretta, L., & Pitha, P. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400726200 · Cited by 223 · see citing works
Self-citation
Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences
Fujii, Y., Shimizu, T., Kusumoto, M., Kyogoku, Y., Taniguchi, T., & Hakoshima, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5028 · Cited by 223 · see citing works
Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300
Burýšek, L., Yeow, W.-S., Lubyová, B., Kellum, M. J., Schafer, S. L., Huang, Y. Q., & Pitha, P. M. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7334-7342.1999 · Cited by 212 · see citing works
Self-citation
HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
Lin, R., Génin, P., Mamane, Y., Sgarbanti, M., Battistini, A., Harrington, W. J., Barber, G. N., & Hiscott, J. B. (2001) · Oncogene · doi:10.1038/sj.onc.1204163 · Cited by 212 · see citing works
Self-citation
Lactobacilli and Streptococci Activate NF-κB and STAT Signaling Pathways in Human Macrophages
Miettinen, M., Lehtonen, A., Julkunen, I., & Matikainen, S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3733 · Cited by 210 · see citing works
The Multiple Roles of Interferon Regulatory Factor family in Health and Disease
Wang, L., Zhu, Y., Zhang, N., Xian, Y., Tang, Y., Ye, J., Reza, F., He, G., Wen, X., & Jiang, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01980-4 · Cited by 178 · see citing works
Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes
Grumont, R. J., & Gerondakis, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1281 · Cited by 198 · see citing works
Lipopolysaccharide-induced Expression of Interferon-β Mediates the Timing of Inducible Nitric-oxide Synthase Induction in RAW 264.7 Macrophages
Jacobs, A. T., & Ignarro, L. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106639200 · Cited by 197 · see citing works
An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages
Wang, I.-M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., & Ozato, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.271 · Cited by 187 · see citing works
Two Distinct Gamma Interferon-Inducible Promoters of the Major Histocompatibility Complex Class II Transactivator Gene Are Differentially Regulated by STAT1, Interferon Regulatory Factor 1, and Transforming Growth Factor β
Piskurich, J. F., Linhoff, M. W., Wang, Y., & Ting, J. P. ‐. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.431 · Cited by 186 · see citing works
Gene Induction Pathways Mediated by Distinct IRFs during Viral Infection
Nakaya, T., Sato, M., Hata, N., Asagiri, M., Suemori, H., Noguchi, S., Tanaka, N., & Taniguchi, T. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4913 · Cited by 186 · see citing works
Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells
Tamura, T., & Ozato, K. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452755 · Cited by 183 · see citing works
Characterization of a Novel Human Herpesvirus 8-Encoded Protein, vIRF-3, That Shows Homology to Viral and Cellular Interferon Regulatory Factors
Lubyová, B., & Pitha, P. M. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.8194-8201.2000 · Cited by 174 · see citing works
Self-citation
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia
Rao, V. L. R., Bowen, K. K., Dhodda, V. K., Song, G., Franklin, J. L., Gavva, N. R., & Dempsey, R. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01208.x · Cited by 173 · see citing works
Interferon-Regulatory Factors Determine Macrophage Phenotype Polarization
Günthner, R., & Anders, H. (2013) · Mediators of Inflammation · doi:10.1155/2013/731023 · Cited by 164 · see citing works
Inhibition of IFN-γ Signaling by an Epstein-Barr Virus Immediate-Early Protein
Morrison, T. E., Mauser, A., Wong, A. W., Ting, J. P.-Y., & Kenney, S. C. (2001) · Immunity · doi:10.1016/s1074-7613(01)00226-6 · Cited by 166 · see citing works
Regulation of the Promoter Activity of Interferon Regulatory Factor-7 Gene
Lu, R., Au, W.-C., Yeow, W.-S., Hageman, N. S., & Pitha, P. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005288200 · Cited by 162 · see citing works
Self-citation
The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis
Heylbroeck, C., Balachandran, S., Servant, M. J., DeLuca, C., Barber, G. N., Lin, R., & Hiscott, J. B. (2000) · Journal of Virology · doi:10.1128/jvi.74.8.3781-3792.2000 · Cited by 162 · see citing works
Self-citation
The interferon system and interferon regulatory factor transcription factors – studies from gene knockout mice
Sato, M., Taniguchi, T., & Tanaka, N. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00032-0 · Cited by 166 · see citing works
Interferon Regulatory Factor-Two Restricts Expression of Interferon-Stimulated Genes to the Endometrial Stroma and Glandular Epithelium of the Ovine Uterus1
Choi, Y., Johnson, G. A., Burghardt, R. C., Berghman, L. R., Joyce, M. M., Taylor, K. M., Stewart, M. D., Bazer, F. W., & Spencer, T. E. (2001) · Biology of Reproduction · doi:10.1095/biolreprod65.4.1038 · Cited by 161 · see citing works
Crystal structure of PU. 1/IRF-4/DNA ternary complex
Escalante, C. R., Brass, A. L., Pongubala, J. M. R., Shatova, E., Shen, L., Singh, H., & Aggarwal, A. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00703-7 · Cited by 154 · see citing works
Emerging pathways in the development of AIDS-related lymphomas
Carbone, A. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)00957-4 · Cited by 150 · see citing works
Protein-Protein and DNA-Protein Interactions Affect the Activity of Lymphoid-Specific IFN Regulatory Factors
Meraro, D., Hashmueli, S., Koren, B., Azriel, A., Oumard, A., Kirchhoff, S., Hauser, H., Nagulapalli, S., Atchison, M. L., & Levi, B.-Z. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6468 · Cited by 147 · see citing works
Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain
Marié, I., Smith, E., Prakash, A., & Levy, D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8803-8814.2000 · Cited by 161 · see citing works
Reactive Oxygen Species Mediate Virus-induced STAT Activation
Liu, T., Castro, S. M., Brasier, A. R., Jamaluddin, M., Garofalo, R. P., & Casola, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307251200 · Cited by 146 · see citing works
Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses
Negishi, H., Yanai, H., Nakajima, A., Koshiba, R., Atarashi, K., Matsuda, A., Matsuki, K., Miki, S., Doi, T., Aderem, A. A., et al. (2012) · Nature Immunology · doi:10.1038/ni.2307 · Cited by 144 · see citing works
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview
Rezaee, S. A., Cunningham, C., Davison, A. J., & Blackbourn, D. J. (2006) · Journal of General Virology · doi:10.1099/vir.0.81919-0 · Cited by 144 · see citing works
Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder
Hao, S. X., & Ren, R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1149-1161.2000 · Cited by 143 · see citing works
ISG15: the immunological kin of ubiquitin
Ritchie, K. J., & Zhang, D. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2003.12.005 · Cited by 140 · see citing works
Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3
Joo, C. H., Shin, Y. C., Gack, M. U., Wu, L., Levy, D. E., & Jung, J. U. (2007) · Journal of Virology · doi:10.1128/jvi.00235-07 · Cited by 142 · see citing works
Traumatic brain injury‐induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis
Rao, V. L. R., Dhodda, V. K., Song, G., Bowen, K. K., & Dempsey, R. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10486 · Cited by 139 · see citing works
IRF-8/Interferon (IFN) Consensus Sequence-binding Protein Is Involved in Toll-like Receptor (TLR) Signaling and Contributes to the Cross-talk between TLR and IFN-γ Signaling Pathways
Zhao, J., Kong, H. J., Li, H., Huang, B., Yang, M., Zhu, C. Y., Bogunovic, M., Zheng, F., Mayer, L., Ozato, K., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m507788200 · Cited by 140 · see citing works
Selective Expression of Type I IFN Genes in Human Dendritic Cells Infected with Mycobacterium tuberculosis
Remoli, M. E., Giacomini, E., Lutfalla, G., Dondi, E., Orefici, G., Battistini, A., Uzé, G., Pellegrini, S., & Coccia, E. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.366 · Cited by 134 · see citing works
Interferon-gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death.
Bernabei, P., Coccia, E. M., Rigamonti, L., Bosticardo, M., Forni, G., Pestka, S., Krause, C. D., Battistini, A., & Novelli, F. (2001) · PubMed · Cited by 133 · see citing works
Respiratory Syncytial Virus Nonstructural Proteins Decrease Levels of Multiple Members of the Cellular Interferon Pathways
Swedan, S. F., Musiyenko, A., & Barik, S. (2009) · Journal of Virology · doi:10.1128/jvi.00715-09 · Cited by 132 · see citing works
B Lymphocyte-Induced Maturation Protein (Blimp)-1, IFN Regulatory Factor (IRF)-1, and IRF-2 Can Bind to the Same Regulatory Sites
Kuo, T. C., & Calame, K. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5556 · Cited by 132 · see citing works
Is there a role for microorganisms in the pathogenesis of sarcoidosis?
du Bois, R. M., Goh, N. S. L., McGrath, D. S., & Cullinan, P. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01073.x · Cited by 130 · see citing works
Interferon-γ receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death
Bernabei, P., Coccia, E. M., Rigamonti, L. M., Bosticardo, M., Forni, G., Pestka, S., Krause, C. D., Battistini, A., & Novelli, F. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.950 · Cited by 128 · see citing works
MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
Saikh, K. U. (2021) · Immunologic Research · doi:10.1007/s12026-021-09188-2 · Cited by 127 · see citing works
STAT2 Nuclear Trafficking
Banninger, G. P., & Reich, N. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400815200 · Cited by 127 · see citing works
Lipopolysaccharide Activates the Expression of ISG15-specific Protease UBP43 via Interferon Regulatory Factor 3
Malakhova, O. A., Malakhov, M. P., Hetherington, C. J., & Zhang, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111527200 · Cited by 126 · see citing works
The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness
Masumi, A., Wang, I.-M., Lefebvre, B., Yang, X.-J., Nakatani, Y., & Ozato, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1810 · Cited by 124 · see citing works
Review: IRF-1 as a Negative Regulator of Cell Proliferation
Romeo, G., Fiorucci, G., Chiantore, M. V., Percario, Z. A., Vannucchi, S., & Affabris, E. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452647 · Cited by 123 · see citing works
Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors
Oritani, K., Medina, K. L., Tomiyama, Y., Ishikawa, J., Okajima, Y., Ogawa, M., Yokota, T., Aoyama, K., Takahashi, I., Kincade, P. W., et al. (2000) · Nature Medicine · doi:10.1038/76233 · Cited by 121 · see citing works
Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy
Messmer, M. N., Netherby, C. S., Banik, D., & Abrams, S. I. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1639-3 · Cited by 120 · see citing works
Oxidant Tone Regulates RANTES Gene Expression in Airway Epithelial Cells Infected with Respiratory Syncytial Virus
Casola, A., Burger, N., Liu, T., Jamaluddin, M., Brasier, A. R., & Garofalo, R. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101526200 · Cited by 120 · see citing works
Virus-induced Heterodimer Formation betweenIRF-5 and IRF-7 Modulates Assembly of theIFNA Enhanceosome in Vivo and Transcriptional Activity of IFNA Genes
Barnes, B. J., Field, A. E., & Pitha-Rowe, P. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212609200 · Cited by 119 · see citing works
Natural Interferon-α Producing Cells: The Plasmacytoid Dendritic Cells
Fitzgerald-Bocarsly, P. A. (2002) · BioTechniques · doi:10.2144/oct0203 · Cited by 119 · see citing works
IFN-β induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7
Sancéau, J., Hiscott, J. B., Delattre, O., & Wietzerbin, J. (2000) · Oncogene · doi:10.1038/sj.onc.1203670 · Cited by 117 · see citing works
Self-citation
Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence–Binding Protein
Gabriele, L., Phung, J., Fukumoto, J., Segal, D., Wang, I.-M., Giannakakou, P., Giese, N. A., Ozato, K., & Morse, H. C. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.3.411 · Cited by 114 · see citing works
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction
Pham, A. M., Maria, F. G. S., Lahiri, T., Friedman, E., Marié, I. J., & Levy, D. E. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005489 · Cited by 111 · see citing works
A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein
Nehyba, J., Hrdličková, R., Burnside, J., & Bose, H. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3942-3957.2002 · Cited by 114 · see citing works
Impaired Antiviral Response in Human Hepatoma Cells
Keskinen, P., Nyqvist, M., Sareneva, T., Pirhonen, J., Melén, K., & Julkunen, I. (1999) · Virology · doi:10.1006/viro.1999.9983 · Cited by 113 · see citing works
Type I Interferon in Systemic Lupus Erythematosus
Crow, M. K. (2007) · Springer eBooks · doi:10.1007/978-3-540-71329-6_17 · Cited by 113 · see citing works
Interferon-γ in the Treatment of Infectious Diseases
Holland, S. M., & Gallin, J. I. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-309-5_23 · Cited by 113 · see citing works
PU.1 and Multiple IFN Regulatory Factor Proteins Synergize to Mediate Transcriptional Activation of the Human IL-1β Gene
Marecki, S., Riendeau, C. J., Liang, M. D., & Fenton, M. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6829 · Cited by 111 · see citing works
Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's disease
Carbone, A., Gloghini, A., Aldinucci, D., Gattei, V., Dalla‐Favera, R., & Gaïdano, G. (2002) · British Journal of Haematology · doi:10.1046/j.1365-2141.2002.03456.x · Cited by 111 · see citing works
The Transcription Factor Interferon Regulatory Factor 1 Is Expressed after Cerebral Ischemia and Contributes to Ischemic Brain Injury
Iadecola, C., Salkowski, C. A., Zhang, F., Aber, T., Nagayama, M., Vogel, S. N., & Ross, M. E. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.719 · Cited by 111 · see citing works
Cloning and expression analysis of rainbow trout Oncorhynchus mykiss interferon regulatory factor 1 and 2 (IRF-1 and IRF-2)
Collet, B., Hovens, G. C., Mazzoni, D., Hırono, I., Aoki, T., & Secombes, C. J. (2003) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(02)00072-1 · Cited by 111 · see citing works
Regulation of the Transcriptional Activity of the IRF7 Promoter by a Pathway Independent of Interferon Signaling
Ning, S., Huye, L. E., & Pagano, J. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404260200 · Cited by 110 · see citing works
The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cells
Wies, E., Mori, Y., Hahn, A. S., Kremmer, E., Stürzl, M., Fleckenstein, B., & Neipel, F. (2007) · Blood · doi:10.1182/blood-2007-05-092288 · Cited by 110 · see citing works

Interferon regulatory factors: the next generation
Mamane, Y., Heylbroeck, C., Génin, P., Algarté-Génin, M., Servant, M. J., Page, C. L., DeLuca, C., Kwon, H., Lin, R., & Hiscott, J. B. (1999) · Gene · doi:10.1016/s0378-1119(99)00262-0 · Cited by 570 · see citing works
Self-citation
The role of interferon regulatory factors in the interferon system and cell growth control
Harada, H., Taniguchi, T., & Tanaka, N. (1998) · Biochimie · doi:10.1016/s0300-9084(99)80017-0 · Cited by 131 · see citing works
The interferon regulatory factors and oncogenesis
Tanaka, N., & Taniguchi, T. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0310 · Cited by 85 · see citing works
The Interferon Regulatory Factor Family in Host Defense: Mechanism of Action
Ozato, K., Tailor, P. B., & Kubota, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700003200 · Cited by 191 · see citing works
Interferon Regulatory Factor Family
Han-chun, C. (2002) · Life Science Research

Authors: Nguyen, H., Hiscott, J., & Pitha, P. M.
Affiliations: Lady Davis Institute for Medical Research (CA)
Johns Hopkins University (US)
Corresponding author: Hiscott, John
ORCID: Hiscott, John
Venue: Cytokine & Growth Factor Reviews
Publisher: Elsevier BV
Published: 1997-12
Volume: 8
Issue: 4
Pages: 293-312
ISSN: 1359-6101 (ISSN-L)
DOI: 10.1016/s1359-6101(97)00019-1
OpenAlex: W2028850807
Cited by: 480
References: 121
Citations by year: 2026: 3 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 12 · 2016: 9 · 2015: 4 · 2014: 12 · 2013: 10 · 2012: 17
FWCI: 3.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 473 d)
Locations: Cytokine & Growth Factor Reviews (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: Medical Research Council Canada
National Institutes of Health
Medical Research Council
National Cancer Institute
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: interferon regulatory factors, interferon, transcription factors, IRF1, IRF2, cytokine signaling, antiviral response, cell growth regulation, hematopoietic development, antiviral therapy, immunomodulation
MeSH terms: Interferon Regulatory Factor-8, Interferon Regulatory Factor-4, Amino Acid Sequence, Animals, Bacterial Proteins, Cell Division, DNA-Binding Proteins, Gene Expression Regulation, Humans, Immunity, Interferon Type I, Interferons, Molecular Sequence Data, Phosphoproteins, Repressor Proteins, Transcription Factors, Sequence Homology, Amino Acid, Virulence Factors, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, Interferon Regulatory Factors, Interferon Regulatory Factor-2, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7, Interferon Regulatory Factor-1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The growing family of interferon regulatory factors

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks