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Cited by 175Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanismsMesenchymal stem cell research

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS

Reynolds, Richard, Dawson, Mary, Papadopoulos, Dimitrios, Polito, Annabella, di Bello, Isabelle Cenci, Pham-Dinh, Danielle, Levine, Joel·2002·Journal of Neurocytology
DOI 10.1023/a:1025747832215
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Abstract

Remyelination of primary demyelinated lesions is a common feature of experimental models of multiple sclerosis (MS) and is also suggested to be the normal response to demyelination during the early stages of MS itself. Many lines of evidence have shown that remyelination is preceded by the division of endogenous oligodendrocyte precursor cells (OPCs) in the lesion and its borders. It is suggested that this rapid response of OPCs to repopulate the lesion site and their subsequent differentiation into new oligodendrocytes is the key to the rapid remyelination. Antibodies to the NG2 chondroitin sulphate proteoglycan have proved exceedingly useful in following and quantitating the response of endogenous OPCs to demyelination. Here we review the literature on the response of NG2-expressing OPCs to demyelination and provide some new evidence on their response to the chronic inflammatory demyelinating environment seen in recombinant myelin oligodendrocyte glycoprotein (MOG) induced experimental allergic encephalomyelitis (EAE) in the DA rat. NG2-expressing OPCs responded to the inflammatory demyelination in this model by becoming reactive and increasing in number in a very focal manner. Evidence of NG2+ OPCs in lesioned areas beginning to express the oligodendrocyte marker CNP was also seen. The response of OPCs appeared to occur following successive relapses but did not always lead to remyelination, with areas of chronic demyelination observed in the spinal cord. The presence of OP…

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  • Oligodendrocyte progenitor cells are a population of adult stem cells responsible for mediating central nervous system myelin repair in demyelinating conditions such as multiple sclerosis.

    “Furthermore, oligodendrocyte progenitor cells (OPCs) are a population of adult stem cells responsible for mediating CNS myelin repair in demyelinating conditions such as MS [113,114].”

    From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [113]

Citations

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Metadata

Authors
Reynolds, R., Dawson, M., Papadopoulos, D., Polito, A., di Bello, I. C., Pham-Dinh, D., & Levine, J.
Affiliations
  • Imperial College London (GB)
  • Inserm (FR)
  • Stony Brook University (US)
ORCID
Venue
Journal of Neurocytology
Publisher
Springer Science and Business Media LLC
Published
2002-07
Volume
31
Issue
6-7
Pages
523-536
ISSN
  • 0300-4864 (ISSN-L)
  • 1573-7381
DOI
10.1023/a:1025747832215
OpenAlex
W1536744532
Cited by
175
References
5
Citations by year
2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 15 · 2012: 12
FWCI
3.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Neurocytology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords
oligodendrocyte precursor cells, remyelination, demyelination, multiple sclerosis, experimental autoimmune encephalomyelitis, myelin oligodendrocyte glycoprotein, CNP, oligodendrocyte differentiation, relapse, chronic demyelination, spinal cord lesions, microglia
MeSH terms
Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Gliosis, Humans, Middle Aged, Multiple Sclerosis, Myelin Proteins, Myelin Sheath, Nerve Regeneration, Oligodendroglia, Proteoglycans, Recombinant Fusion Proteins, Stem Cells, Biomarkers, Myelin-Associated Glycoprotein, Cell Lineage, Rats, Myelin-Oligodendrocyte Glycoprotein

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