Effect of Sterol Inhibitors on the Incorporation of14C-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from Artemisia annua Tissue Cultures and Plants

Kudakasseril, G.; Lam, Luke; Staba, E.

doi:10.1055/s-2006-962706

Cited by 70Plant biochemistry and biosynthesisPlant tissue culture and regenerationSesquiterpenes and Asteraceae Studies

Effect of Sterol Inhibitors on the Incorporation of14C-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from Artemisia annua Tissue Cultures and Plants

Kudakasseril, G., Lam, Luke, Staba, E.·1987·Planta Medica

DOI 10.1055/s-2006-962706

Open this paper in CoChat — free account

Abstract

A cell-free system from ARTEMISIA ANNUA L. shoot cultures and plants (shoots and roots) which is capable of incorporating (14)C-isopentenyl pyrophosphate ( (14)C-IPP) into artemisinin has been developed. The sterol inhibitors miconazole, AMO 1618, CCC, and MER 29 increased both the incorporation of (14)C-IPP into artemisinin by cell-free extracts and the production of artemisinin in shoot cultures of ARTEMISIA ANNUA.

Integrity signals

Registry

Crossref · 10.1055/s-2006-962706

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The IPP used in artemisinin biosynthesis comes from both the mevalonate and the mevalonate-independent pathways.
“It has been proposed that the IPP used in the biosynthesis of artemisinin comes from both the mevalonate and the mevalonate-independent pathways [287]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [287]

Sorted by citations

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
Localization of Artemisinin and Artemisitene in Foliar Tissues of Glanded and Glandless Biotypes of Artemisia annua L.
Duke, M. V., Paul, R. N., Elsohly, H. N., Sturtz, G., & Duke, S. O. (1994) · International Journal of Plant Sciences · doi:10.1086/297173 · Cited by 252 · see citing works
Current status of artemisinin and its derivatives as antimalarial drugs
Dhingra, V., Rao, K. V., & Narasu, M. L. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00356-2 · Cited by 241 · see citing works
Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation
Chen, D.-H., Ye, H.-C., & Li, G.-F. (2000) · Plant Science · doi:10.1016/s0168-9452(00)00217-x · Cited by 225 · see citing works
Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti‐malarial drug, by hairpin‐RNA‐mediated gene silencing
Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., & Tang, K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080068 · Cited by 206 · see citing works
In vivo transformations of dihydroartemisinic acid in Artemisia annua plants
Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183 · see citing works
Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways
Towler, M. J., & Weathers, P. J. (2007) · Plant Cell Reports · doi:10.1007/s00299-007-0420-x · Cited by 170 · see citing works
“4, 6) confirming the earlier work of Kudakasseril et al. (1987).”
Result
Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua
Baldi, A., & Dixit, V. K. (2007) · Bioresource Technology · doi:10.1016/j.biortech.2007.06.061 · Cited by 176 · see citing works
Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug
Liu, C., Zhao, Y., & Wang, Y. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0452-0 · Cited by 158 · see citing works
Artemisinin (qinghaosu): a new type of antimalarial drug
Butler, A. R., & Wu, Y. (1992) · Chemical Society Reviews · doi:10.1039/cs9922100085 · Cited by 127 · see citing works
Production of the new antimalarial drug artemisinin in shoot cultures of Artemisia annua L.
Woerdenbag, H. J., Lüers, J. F. J., van Uden, W., Pras, N., Malingré, T. M., & Alfermann, A. W. (1993) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/bf00029850 · Cited by 120 · see citing works
Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content
Alam, P., & Abdin, M. Z. (2011) · Plant Cell Reports · doi:10.1007/s00299-011-1099-6 · Cited by 108 · see citing works
Artemisinin: the biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species
Weathers, P. J., Elkholy, S., & Wobbe, K. K. (2006) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1079/ivp2006782 · Cited by 97 · see citing works
Regulation of Monoterpene Biosynthesis in Higher Plants
Gershenzon, J., & Croteau, R. (1990) · Springer eBooks · doi:10.1007/978-1-4684-8789-3_3 · Cited by 89 · see citing works
State of the art of the production of the antimalarial compound artemisinin in plants
Geldre, E. V., Vergauwe, A., & den Eeckhout, E. V. (1997) · Plant Molecular Biology · doi:10.1023/a:1005716600612 · Cited by 84 · see citing works
Enhancement of artemisinin content by constitutive expression of the HMG-CoA reductase gene in high-yielding strain of Artemisia annua L.
Nafis, T., Akmal, M., Ram, M., Alam, P., Ahlawat, S., Mohd, A., & Abdin, M. Z. (2011) · Plant Biotechnology Reports · doi:10.1007/s11816-010-0156-x · Cited by 83 · see citing works
Methyl jasmonate and miconazole differently affect arteminisin production and gene expression in Artemisia annua suspension cultures
Caretto, S., Quarta, A., Durante, M., Nisi, R., Paolis, A. D., Blando, F., & Mita, G. (2010) · Plant Biology · doi:10.1111/j.1438-8677.2009.00306.x · Cited by 79 · see citing works
Effect of triacontanol and chlormequat on growth, plant hormones and artemisinin yield in Artemisia annua L.
Shukla, A., Abad Farooqi, A. H., Shukla, Y. N., & Sharma, S. (1992) · Plant Growth Regulation · doi:10.1007/bf00024071 · Cited by 79 · see citing works
Modulation of artemisinin biosynthesis by elicitors, inhibitor, and precursor in hairy root cultures of Artemisia annua L.
Ahlawat, S., Saxena, P., Alam, P., Wajid, S., & Abdin, M. Z. (2014) · Journal of Plant Interactions · doi:10.1080/17429145.2014.949885 · Cited by 78 · see citing works
Roots as an enhancing factor for the production of artemisinin in shoot cultures of Artemisia annua
Ferreira, J. F. S., & Janick, J. (1996) · Plant Cell, Tissue and Organ Culture · doi:10.1007/bf00048526 · Cited by 75 · see citing works
Artemisia annua L.: dedifferentiated and differentiated cultures
Paniego, N. B., & Giulietti, A. M. (1994) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/bf00037715 · Cited by 73 · see citing works
Artemisia annua L.: a source of novel antimalarial drugs
Woerdenbag, H. J., Lugt, C., & Pras, N. (1990) · Pharmacy World & Science · doi:10.1007/bf01980041 · Cited by 73 · see citing works
Biotransformation of arteannuic acid into arteannuin-B and artemisinin in Artemisia annua
Sangwan, R. S., Agarwal, K., Luthra, R., Thakur, R. S., & Sangwan, N. S. (1993) · Phytochemistry · doi:10.1016/0031-9422(91)80019-w · Cited by 68 · see citing works
Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.
Nguyen, K. T., Arsenault, P. R., & Weathers, P. J. (2011) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-011-9343-x · Cited by 66 · see citing works
“Later Maes et al. (2010) sprayed and soil-drenched two A.”
Ri-mediated transformation of Artemisia annua with a recombinant farnesyl diphosphate synthase gene for artemisinin production
Chen, D.-H., Liu, C.-J., Ye, H.-C., Li, G.-F., Liu, B.-Y., Meng, Y.-L., & Chen, X.-Y. (1999) · Plant Cell, Tissue and Organ Culture · doi:10.1023/a:1006326818509 · Cited by 65 · see citing works
Artemisinin biosynthesis in Artemisia annua and metabolic engineering: questions, challenges, and perspectives
Xie, D.-Y., Ma, D.-M., Judd, R., & Jones, A. L. (2016) · Phytochemistry Reviews · doi:10.1007/s11101-016-9480-2 · Cited by 63 · see citing works
The Production of Artemisinin in Artemisia annua L. Tissue Cultures
Martinez, B. C., & Staba, E. J. (1988) · Advances in cell culture · doi:10.1016/b978-0-12-007906-3.50009-7 · Cited by 63 · see citing works
Self-citation
HMG-CoA reductase limits artemisinin biosynthesis and accumulation in Artemisia annua L. plants
Ram, M., Khan, M. A., Jha, P., Khan, S., Kiran, U., Ahmad, M. M., Javed, S., & Abdin, M. Z. (2010) · Acta Physiologiae Plantarum · doi:10.1007/s11738-010-0470-5 · Cited by 59 · see citing works
Taxus sp. cell, tissue and organ cultures as alternative sources for taxoids production: a literature survey
Jaziri, M. E., Zhiri, A., Guo, Y., et al. (1996) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/bf00039697 · Cited by 53 · see citing works
Bioconversion of naturally occurring precursors and related synthetic compounds using plant cell cultures
Pras, N. (1992) · Journal of Biotechnology · doi:10.1016/0168-1656(92)90068-k · Cited by 46 · see citing works
Quantitative Transcript Profiling Reveals Down-Regulation of A Sterol Pathway Relevant Gene and Overexpression of Artemisinin Biogenetic Genes in TransgenicArtemisia annuaPlants
Yang, R.-Y., Feng, L.-L., Yang, X.-Q., Yin, L.-L., Xu, X.-L., & Zeng, Q.-P. (2008) · Planta Medica · doi:10.1055/s-2008-1081333 · Cited by 41 · see citing works
Synergistic re-channeling of mevalonate pathway for enhanced artemisinin production in transgenic Artemisia annua
Feng, L.-L., Yang, R.-Y., Yang, X.-Q., Zeng, X.-M., Lu, W.-J., & Zeng, Q.-P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.03.014 · Cited by 39 · see citing works
In Vitro Micropropagation and Flowering in Artemisia annua
Gulati, A., Bharel, S., Jain, S. K., Abdin, M. Z., & Srivastava, P. S. (1996) · Journal of Plant Biochemistry and Biotechnology · doi:10.1007/bf03262976 · Cited by 37 · see citing works
Comparative study on artemisinin, 2,4-D and glyphosate
Chen, P. K., Polatnick, M., & Leather, G. R. (1991) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00005a038 · Cited by 30 · see citing works
Cellular engineering of Artemisia annua and Artemisia dubia with the rol ABC genes for enhanced production of potent anti-malarial drug artemisinin
Kiani, B. H., Suberu, J., & Mirza, B. (2016) · Malaria Journal · doi:10.1186/s12936-016-1312-8 · Cited by 27 · see citing works
Enzymatic Synthesis of Artemisinin from Natural and Synthetic Precursors
Bharel, S., Gulati, A., Abdin, M. Z., Srivastava, P. S., Vishwakarma, R. A., & Jain, S. K. (1998) · Journal of Natural Products · doi:10.1021/np970024s · Cited by 26 · see citing works
Genetic engineering of artemisinin biosynthesis: prospects to improve its production
Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25 · see citing works
“It was proved by a study, where inhibition of sterol biosynthesis was achieved with metabolic inhibitors (naftifine and miconazole or chlorocholine) that caused an increase in artemisinin content in A. annua L. plants (Woerdenbag et al. 1993, Kudakasseril et al. 1987).”
Background
Effect of Development Stage on the Artemisinin Content and the Sequence Characterized Amplified Region (SCAR) Marker of High‐Artemisinin Yielding Strains of Artemisia annua L.
Zhang, L., Ye, H., & Li, G. (2006) · Journal of Integrative Plant Biology · doi:10.1111/j.1744-7909.2006.00288.x · Cited by 25 · see citing works
Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin
Kong, J., Yang, Y., Wang, W., Cheng, K.-D., & Zhu, P. (2013) · RSC Advances · doi:10.1039/c3ra40525g · Cited by 24 · see citing works
High Peroxidase Activity In Cell Cultures ofArtemisia AnnuaWith Minute Artemisinin Contents
Woerdenbag, H. J., Pras, N., Uden, W. V., Boer, A. D., Batterman, S., Visser, J. F., & Malingré, T. M. (1992) · Natural product letters · doi:10.1080/10575639208048899 · Cited by 24 · see citing works
Synthesis of labelled dihydroartemisinic acid
Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.069 · Cited by 23 · see citing works
Artemisinin: An Endoperoxidic Antimalarial from Artemisia annua L.
Ziffer, H., Highet, R. J., & Klayman, D. L. (1997) · Springer eBooks · doi:10.1007/978-3-7091-6527-0_2 · Cited by 23 · see citing works
Densitometric Thin-Layer Chromatographic Determination of Artemisinin and its Lipophilic Derivatives, Artemether and Arteether
Gabriëls, M., & Plaizier-vercammen, J. A. (2003) · Journal of Chromatographic Science · doi:10.1093/chromsci/41.7.359 · Cited by 21 · see citing works
A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu
Li, Y., & Wu, Y. (2010) · Frontiers of Chemistry in China · doi:10.1007/s11458-010-0214-5 · Cited by 20 · see citing works
Production of Taxol and its Analogues from Cell Cultures of Taxus wallichiana
Veeresham, C., Mamatha, R., Babu, C. P., et al. (2003) · Pharmaceutical Biology · doi:10.1076/phbi.41.6.426.17822 · Cited by 18 · see citing works
The biosynthesis of C 5 —C 20 terpenoid compounds
Beale, M. H. (1990) · Natural Product Reports · doi:10.1039/np9900700025 · Cited by 18 · see citing works
RNAi-mediated modulation of squalene synthase gene expression in Artemisia annua L. and its impact on artemisinin biosynthesis
Ali, A., Ahmad, M. M., Khan, M. A., Saxena, P., Khan, S., & Abdin, M. Z. (2017) · RENDICONTI LINCEI · doi:10.1007/s12210-017-0647-6 · Cited by 17 · see citing works
Enhanced artemisinin accumulation and metabolic profiling of transgenic Artemisia annua L. plants over-expressing by rate-limiting enzymes from isoprenoid pathway
Alam, P., Kamaluddin, K., Khan, M. A., Mohammad, A., Khan, R., & Abdin, M. Z. (2014) · Journal of Plant Interactions · doi:10.1080/17429145.2014.893030 · Cited by 18 · see citing works
Studies on the biosynthesis of arteannuin. IV. The biosynthesis of arteanniuin and arteannuin B by the leaf homogenate of Artemisia annua L.
Wang, Y., Xia, Z., Feng-Yi, Z., Wu, Y., Huang, J., & Zhi-zhong, W. (1993) · Chinese Journal of Chemistry · doi:10.1002/cjoc.19930110512 · Cited by 15 · see citing works
The Regulation of Accumulation of Lower Isoprenoids in Plant Cell Cultures
Charlwood, B. V., Moustou, C., Brown, J. T., et al. (1989) · Springer eBooks · doi:10.1007/978-3-642-74551-5_8 · Cited by 11 · see citing works
Characterization of a class III peroxidase from Artemisia annua: relevance to artemisinin metabolism and beyond
Nair, P., Mall, M., Sharma, P., Khan, F., Nagegowda, D. A., Rout, P. K., Gupta, M. M., Pandey, A., Shasany, A. K., Gupta, A. K., et al. (2019) · Plant Molecular Biology · doi:10.1007/s11103-019-00879-x · Cited by 8 · see citing works
Recent Advances to Enhance Yield of Artemisinin: A Novel Antimalarial Compound, in Artemisia annua L. Plants
Ram, M., Jain, D. C., Mishra, H., Mandal, S., & Abdin, M. Z. (2013) · Springer eBooks · doi:10.1007/978-3-642-41027-7_11 · Cited by 5 · see citing works
Computational characterization and in vivo expression of squalene synthase gene in different tissues of Artemisia annua L. plants
Ali, A., Ahmad, M. M., Khan, M. A., Ganai, A. A., Kiran, U., Prakash, A., Hassan, M. I., Saxena, P., Khan, S., Ahlawat, S., et al. (2016) · South African Journal of Botany · doi:10.1016/j.sajb.2016.03.009 · Cited by 5 · see citing works
Metabolic Engineering of Artemisia annua L.
Tu, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811655-5.00008-8 · Cited by 5 · see citing works
Studies on the biosynthesis of arteannuin: I. The biosynthesis of arteannuinic acid in Artemisia annua L
Huang, J., Feng-Yi, Z., Lian-Fen, W., et al. (1988) · Acta Chimica Sinica · doi:10.1002/cjoc.19880060417 · Cited by 4 · see citing works
Effect of Miconazole and Terbinafine on Artemisinin Content of Shooty Teratoma of Artemisia annua
Jain, R., & Dixit, V. K. (2010) · Natural Product Communications · doi:10.1177/1934578x1000500203 · Cited by 3 · see citing works
INVITED REVIEW: ARTEMISININ: THE BIOSYNTHETIC PATHWAY AND ITS REGULATION IN ARTEMISIA ANNUA, A TERPENOID-RICH SPECIES
Weathers, P. J., Elkholy, S. F., & Wobbe, K. K. (2006) · Cited by 3 · see citing works
Transfer Of Rol Genes And Evaluation Of Artemisinin Synthesis In Transgenic Artemisia Annua L. And Artemisia Dubia Wall
Kiani, B. H. (2012) · HEC National Digital Library · Cited by 3 · see citing works
Studies on the biosynthesis of arteannuin: III. Arteannuic acid as a key intermediate in the biosyntheses of arteannuin and arteannuin B
Wang, Y., Zhi-Qiang, X., Feng-Yi, Z., Wu, Y., Huang, J., & Zhi-Zhong, W. (1988) · Acta Chimica Sinica · doi:10.1002/cjoc.19880060418 · Cited by 3 · see citing works
Artemisinin: Controlling Its Production in Artemisia annua
Weathers, P. J., Towler, M. J., Wang, Y., et al. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4063-5_8 · Cited by 2 · see citing works
Cellular Engineering for Enhanced Production of Potent Antimalarial Drug: Artemisinin
Ram, M., Niranjan, R., & Jain, D. C. (2013) · Cited by 1 · see citing works
Biosynthesis and Production of Artemisinin: A Novel Class of Molecule
Ali, A., Khan, M. A., & Zainul, M. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_133 · Cited by 1 · see citing works
Use of RNAi Technology in Medicinal Plants
Alam, P., Ali, A., Khan, M. A., & Abdin, M. Z. (2011) · CRC Press eBooks · doi:10.1201/b10882-15 · Cited by 1 · see citing works
Agronomics and Biology of Artemisia annua L.
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813133-6.00002-0 · Cited by 1 · see citing works
Antimalarial Compound Synthesis from Transgenic Cultures
Kundu, S., Mukherjee, S., & Ghosh, B. (2017) · Reference series in phytochemistry · doi:10.1007/978-3-319-28669-3_22
Artemisinin: A Potent Antimalarial Drug
Malaviya, A., Malhotra, K., Agarwal, A., & Saikia, K. (2019) · Wiley eBooks · doi:10.1002/9781119460053.ch15
Roots and hormones: synergistic control of artemisinin production in Artemisia annua L. shoots
Nguyen, K. V. (2011) · Digital WPI
Antimalarial Compound Synthesis from Transgenic Cultures
Kundu, S., Mukherjee, S., & Ghosh, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-27490-4_22-1
Metabolic Engineering von Artemisia annua L.
Tu, Y. (2024) · Springer eBooks · doi:10.1007/978-3-662-68757-4_8
Biosynthesis and Production of Artemisinin
Mathew, G., Lakshmaiah, V. V., Al-Khayri, J. M., & Nagella, P. (2026) · Springer eBooks · doi:10.1007/978-3-642-36202-6_221-1

Is Artemisinin the Only Antiplasmodial Compound in the Artemisia annua Tea Infusion? An in Vitro Study
Mouton, J., Jansen, O., Frédérich, M., & van der Kooy, F. (2013) · Planta Medica · doi:10.1055/s-0032-1328324 · Cited by 20 · see citing works
Artemisia annua glandular secretory trichomes： the biofactory of antimalarial agent artemisinin
Ling, Xiao, X., Hexin, et al. (2016) · 中国科学通报：英文版
A review of various efforts to increase artemisinin and other antimalarial compounds in Artemisia Annua L plant
Aidah, N., Bazira, J., Tolo, C. U., & Engeu, P. O. (2018) · Cogent Biology · doi:10.1080/23312025.2018.1513312 · Cited by 16 · see citing works
Self-immobilized aggreage culture of Artemisia annua L. for imroved artemisinin
Hu, F., Chen, C.-L., & Guanlin, W. (2003) · Zhiwu yanjiu
Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.
Liu, B., Wang, H., Du, Z., Li, G., & Ye, H. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0967-9 · Cited by 82 · see citing works

Authors: Kudakasseril, G., Lam, L., & Staba, E.
Affiliations: Kenyon College (US)
University of Minnesota (US)
Venue: Planta Medica
Publisher: Georg Thieme Verlag KG
Published: 1987-06
Volume: 53
Issue: 03
Pages: 280-284
ISSN: 0032-0943 (ISSN-L)
1439-0221
DOI: 10.1055/s-2006-962706
OpenAlex: W2083000665
Cited by: 70
References: 0
Citations by year: 2026: 1 · 2024: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 2
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Locations: Planta Medica (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
Keywords: artemisinin biosynthesis, isopentenyl pyrophosphate, miconazole, AMO-1618, chlormequat chloride, cell-free system, Artemisia annua, shoot culture, carbon-14 incorporation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of Sterol Inhibitors on the Incorporation of14C-Isopentenyl Pyrophosphate into Artemisinin by a Cell-Free System from Artemisia annua Tissue Cultures and Plants

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cited by

Related

Record

About these checks