Artemisinin: the biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species
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Terpene biosynthesis and its regulation in A. annua have been well reviewed, including the central role of amorpha-4,11-diene (451) in artemisinin biosynthesis and the likelihood that glandular trichomes are the location of artemisinin biosynthesis.
“Terpene biosynthesis [271,272,273,274,275,276] and its regulation [277,278] in A. annua have been well reviewed, including the central role of amorpha-4,11-diene (451) in the biosynthesis of artemisinin (495) [279] and the likelihood that glandular trichomes are the location wherein artemisinin biosynthesis actually occurs [244,280]”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [277]
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- Authors
- Weathers, P. J., Elkholy, S., & Wobbe, K. K.
- Affiliations
- Worcester Polytechnic Institute (US)
- Corresponding author
- Weathers, Pamela J.
- Venue
- In Vitro Cellular & Developmental Biology - Plant
- Published
- 2006-07
- Volume
- 42
- Issue
- 4
- Pages
- 309-317
- ISSN
- 1054-5476 (ISSN-L)
- 1475-2689
- OpenAlex
- W2097457822
- Cited by
- 97
- References
- 81
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 6
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- In Vitro Cellular & Developmental Biology - Plant (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant tissue culture and regeneration
- Keywords
- artemisinin, Artemisia annua, sesquiterpene lactone biosynthesis, terpenoid biosynthesis, biosynthetic pathway regulation, in vitro production, Plasmodium falciparum, malaria drugs, antimalarial compounds
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