Lack of an effect of vitamin E on lifespan of mice
Abstract
It has been speculated that ageing results from accumulation of damage to macromolecules, particularly DNA, owing to the action of oxidising free radicals. This possibility would predict that administration of anti-oxidants might prolong lifespan, but previous data on this prediction are conflicting. Three groups of mice were exposed throughout life, from the time of conception until death, to 20, 40 and 400 mg/kg of vitamin E in the diet. No effect on lifespan was observed and the median lifespans in the three groups were 804, 830 and 801 days, respectively. The design of the study also enabled an effect of parental age on lifespan of female progeny to be sought, but no effect was detected.
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Life-long supplementation of vitamin E in mice showed no overall improvement in life span.
“One study examining life-long supplementation of vitamin E in mice showed no overall improvement in life span [50].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [50]
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- Authors
- Morley, A. A., & Trainor, K. J.
- Affiliations
- Flinders University (AU)
- Corresponding author
- Morley, Alexander A.
- ORCID
- Morley, Alexander A.
- Venue
- Biogerontology
- Published
- 2001-06
- Volume
- 2
- Issue
- 2
- Pages
- 109-112
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W149809163
- Cited by
- 64
- References
- 29
- Citations by year
- 2023: 3 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- vitamin E, lifespan, aging, antioxidants, free radicals, oxidative DNA damage, dietary supplementation, parental age, mice
- MeSH terms
- Animals, Antioxidants, Female, Longevity, Male, Mice, Inbred BALB C, Vitamin E, Mice
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