Cited by 64Genetics, Aging, and Longevity in Model OrganismsAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

Lack of an effect of vitamin E on lifespan of mice

Morley, Alexander A., Trainor, Kevin J.·2001·Biogerontology

Abstract

It has been speculated that ageing results from accumulation of damage to macromolecules, particularly DNA, owing to the action of oxidising free radicals. This possibility would predict that administration of anti-oxidants might prolong lifespan, but previous data on this prediction are conflicting. Three groups of mice were exposed throughout life, from the time of conception until death, to 20, 40 and 400 mg/kg of vitamin E in the diet. No effect on lifespan was observed and the median lifespans in the three groups were 804, 830 and 801 days, respectively. The design of the study also enabled an effect of parental age on lifespan of female progeny to be sought, but no effect was detected.

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Crossref · 10.1023/a:1011589218219

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Authors
Morley, A. A., & Trainor, K. J.
Affiliations
Flinders University (AU)
Corresponding author
Morley, Alexander A.
Venue
Biogerontology
Published
2001-06
Volume
2
Issue
2
Pages
109-112
ISSN
  • 1389-5729 (ISSN-L)
  • 1573-6768
OpenAlex
W149809163
Cited by
64
References
29
Citations by year
2023: 3 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 3
FWCI
1.08
Type
journal article
Language
en
Open access
closed
Locations
  • Biogerontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
vitamin E, lifespan, aging, antioxidants, free radicals, oxidative DNA damage, dietary supplementation, parental age, mice
MeSH terms
Animals, Antioxidants, Female, Longevity, Male, Mice, Inbred BALB C, Vitamin E, Mice

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